Any feedback?
Information on EC 2.7.7.24 - glucose-1-phosphate thymidylyltransferase
for references in articles please use BRENDA:EC2.7.7.24Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.7.24 glucose-1-phosphate thymidylyltransferaseIUBMB Comments
Involved in the biosynthesis of L-rhamnose in bacteria.
Specify your search results
Word Map
- 2.7.7.24
- l-rhamnose
- dtdp-l-rhamnose
-
4,6-dehydratase
-
deoxysugars
-
uridylyltransferase
- dtdp-4-keto-6-deoxy-d-glucose
-
3,5-epimerase
-
deoxyhexose
- dtmp
- analysis
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
glucose-1-phosphate thymidylyltransferase, cps2l, dtdp-glucose synthase, sgca1, glc-1-p-tt, dtdp-d-glucose synthase, d-glucose-1-phosphate thymidylyltransferase, sugar-1-phosphate nucleotidyltransferase, dtdp-glucose-pyrophosphorylase, schs6, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Cps23FL
D-glucose-1-phosphate thymidylyltransferase
DnmL
dTDP-alpha-D-glucose pyrophosphorylase
dTDP-D-glucose synthase
dTDP-glucose synthase
-
-
-
-
dTDP-glucose-pyrophosphorylase
-
-
-
-
dTDPglucose pyrophosphorylase
-
-
-
-
Glc-1-P TTase
Glc1P-thymidylyltransferase
glucose 1-phosphate thymidylyltransferase
-
-
-
-
glucose-1-phosphate thymidylyltransferase
RfbA
RmlA
RmlA protein
-
protein encoded by rmlA gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
SchS6
ST0452
TDP-glucose pyrophosphorylase
-
-
-
-
thymidine diphosphate glucose pyrophosphorylase
-
-
-
-
thymidine diphosphoglucose pyrophosphorylase
-
-
-
-
thymidylyltransferase, glucose 1-phosphate
-
-
-
-
UgpG protein
-
protein encoded by ugpG gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
D-glucose-1-phosphate thymidylyltransferase
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
-
-
RmlA
Salmonella enterica typhimurium LT2
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
-
-
-
-
dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-alpha-D-glucose
ordered bi-bi mechanism
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
KEGG
-
Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
Involved in the biosynthesis of L-rhamnose in bacteria.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9026-03-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dATP + alpha-D-glucosamine 1-phosphate
diphosphate + dADP-alpha-D-glucosamine
-
21% yield with 0.06 mM enzyme
-
-
?
dCTP + alpha-D-glucose 1-phosphate
diphosphate + dCDP-alpha-D-glucose
-
35% yield with 0.006 mM enzyme, 87% yield with 0.06 mM enzyme
-
-
?
deoxythymidine 5'-tetraphosphate + alpha-D-glucose 1-phosphate
triphosphate + dTDP-alpha-D-glucose
-
-
alternative products dTTP-alpha-D-glucose and diphosphate are not detected
-
?
dGTP + alpha-D-glucose 1-phosphate
diphosphate + dGDP-alpha-D-glucose
-
53% yield with 0.006 mM enzyme, 89% yield with 0.06 mM enzyme
-
-
?
diphosphate + dTDP-alpha-D-glucose
dTTP + alpha-D-glucose 1-phosphate
-
-
-
r
dTTP + 2-deoxy-2-amino-alpha-D-glucose 1-phosphate
diphosphate + dTDP-2-deoxy-2-amino-alpha-D-glucose
-
-
-
-
?
dTTP + 3-deoxy-3-amino-alpha-D-glucose 1-phosphate
diphosphate + dTDP-3-deoxy-3-amino-alpha-D-glucose
-
-
-
-
?
dTTP + 3-deoxy-3-azido-alpha-D-glucose 1-phosphate
diphosphate + dTDP-3-deoxy-3-azido-alpha-D-glucose
-
-
-
-
?
dTTP + alpha-D-galactosamine 1-phosphate
diphosphate + dTDP-alpha-D-galactosamine
-
5% yield with 0.06 mM enzyme
-
-
?
dTTP + alpha-D-galactose 1-phosphate
diphosphate + dTDP-alpha-D-galactose
-
91% yield with 0.06 mM enzyme
-
-
?
dTTP + alpha-D-galactose-1-phosphate
dTDP-galactose + diphosphate
10% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
dTTP + alpha-D-glucosamine 1-phosphate
diphosphate + dTDP-alpha-D-glucosamine
-
71% yield with 0.06 mM enzyme
-
-
?
dTTP + alpha-D-glucosamine 1-phosphate
dTDP-glucosamine + diphosphate
23% activity compared to alpha-D-glucose 1-phosphate
-
-
r
dTTP + alpha-D-glucosamine-1-phosphate
dTDP-glucosamine + diphosphate
23% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-glucose
-
-
-
-
?
dTTP + alpha-D-mannose 1-phosphate
diphosphate + dTDP-alpha-D-mannose
-
88% yield with 0.06 mM enzyme
-
-
?
dTTP + alpha-D-mannose 1-phosphate
dTDP-mannose + diphosphate
11% activity compared to alpha-D-glucose 1-phosphate
-
-
r
dTTP + alpha-D-mannose-1-phosphate
dTDP-mannose + diphosphate
11% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
dTTP + [[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid
diphosphate + dTDP-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid
-
-
-
-
?
dUTP + alpha-D-galactose 1-phosphate
diphosphate + dUDP-alpha-D-galactose
-
83% yield with 0.06 mM enzyme
-
-
?
dUTP + alpha-D-glucose 1-phosphate
diphosphate + dUDP-alpha-D-glucose
-
88% yield with 0.006 mM enzyme, 95% yield with 0.06 mM enzyme
-
-
?
GTP + alpha-D-glucose 1-phosphate
GDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
13% yield with 0.06 mM enzyme
-
-
?
UTP + 2-deoxy-2-amino-alpha-D-glucose 1-phosphate
diphosphate + UDP-2-deoxy-2-amino-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-galactose 1-phosphate
diphosphate + UDP-alpha-D-galactose
-
86% yield with 0.06 mM enzyme
-
-
?
UTP + alpha-D-glucosamine 1-phosphate
diphosphate + UDP-alpha-D-glucosamine
-
12% yield with 0.06 mM enzyme
-
-
?
UTP + alpha-D-glucosamine 1-phosphate
UDP-glucosamine + diphosphate
8% activity compared to the reaction with alpha-D-glucose 1-phosphate and dTTP
-
-
r
UTP + alpha-D-glucosamine-1-phosphate
UDP-glucosamine + diphosphate
8% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
UTP + alpha-D-glucose-1-phosphate
UDP-glucose + diphosphate
12% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
UTP + alpha-D-mannose 1-phosphate
diphosphate + UDP-alpha-D-mannose
-
78% yield with 0.06 mM enzyme
-
-
?
UTP + [[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid
diphosphate + UMP-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]methyl]phosphonic acid
-
-
-
-
?
ATP + alpha-D-glucose 1-phosphate
ADP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
ATP + alpha-D-glucose 1-phosphate
ADP-glucose + diphosphate
1% activity compared to dTTP
-
-
r
ATP + alpha-D-glucose 1-phosphate
ADP-glucose + diphosphate
1% activity compared to dTTP
-
-
r
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-alpha-D-glucose
-
-
-
-
?
ATP + alpha-D-glucose 1-phosphate
diphosphate + ADP-alpha-D-glucose
-
13% yield with 0.006 mM enzyme, 78% yield with 0.06 mM enzyme
-
-
?
ATP + alpha-D-glucose-1-phosphate
ADP-glucose + diphosphate
1.0% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
ATP + alpha-D-glucose-1-phosphate
ADP-glucose + diphosphate
1.0% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose 1-phosphate
CDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
CTP + alpha-D-glucose 1-phosphate
CDP-glucose + diphosphate
1.2% activity compared to dTTP
-
-
r
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
CTP + alpha-D-glucose 1-phosphate
diphosphate + CDP-alpha-D-glucose
-
-
-
-
?
CTP + alpha-D-glucose-1-phosphate
CDP-glucose + diphosphate
1.2% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
CTP + alpha-D-glucose-1-phosphate
CDP-glucose + diphosphate
1.2% of the activity with dTTP and alpha-D-glucose 1-phosphate
-
-
?
dATP + alpha-D-glucose 1-phosphate
dADP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
dATP + alpha-D-glucose 1-phosphate
dADP-glucose + diphosphate
Salmonella enterica typhimurium LT2
-
-
-
-
?
dCTP + alpha-D-glucose 1-phosphate
dCDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
dCTP + alpha-D-glucose 1-phosphate
dCDP-glucose + diphosphate
Salmonella enterica typhimurium LT2
-
-
-
-
?
dGTP + alpha-D-glucose 1-phosphate
dGDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
dGTP + alpha-D-glucose 1-phosphate
dGDP-glucose + diphosphate
Salmonella enterica typhimurium LT2
-
-
-
-
?
dTDP-glucose + diphosphate
dTTP + alpha-D-glucose 1-phosphate
-
protein by ugpG gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
-
-
?
dTDP-glucose + diphosphate
dTTP + alpha-D-glucose 1-phosphate
-
protein encoded by rmlA gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
-
-
?
dTTP + alpha-D-galactose 1-phosphate
dTDP-galactose + diphosphate
-
12.6% of the activity with alpha-D-glucose 1-phosphate
-
-
?
dTTP + alpha-D-galactose 1-phosphate
dTDP-galactose + diphosphate
10% activity compared to alpha-D-glucose 1-phosphate
-
-
r
dTTP + alpha-D-galactose 1-phosphate
dTDP-galactose + diphosphate
-
12.6% of the activity with alpha-D-glucose 1-phosphate
-
-
?
dTTP + alpha-D-galactose 1-phosphate
dTDP-galactose + diphosphate
10% activity compared to alpha-D-glucose 1-phosphate
-
-
r
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
86% yield with 0.006 mM enzyme, 93% yield with 0.06 mM enzyme
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.9, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
r
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
the enzyme is involved in biosynthesis of L-rhamnose
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
maximal velocity of the reverse reaction is 11.4fold of the maximal velocity of the forward reaction. The multifunctional enzyme also shows activity with UTP + alpha-D-glucose 1-phosphate (EC 2.7.7.9, UTP-glucose-1-phosphate uridylyltransferase), UTP + N-acetylglucosamine 1-phosphate (EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase), dTTP + N-acetylglucosamine 1-phosphate (N-acetylglucosamine 1-phosphate thymidylyltransferase), dCTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate cytidylyltransferase), dGTP + alpha-D-glucose 1-phosphate (glucose-1-phosphate guanylyltransferase), dATP + alpha-D-glucose 1-phosphate (glucose-1-phosphate adenylyltransferase). No activity with: alpha-D-glucose 1-phosphate + dATP, alpha-D-glucose 1-phosphate + dCTP, alpha-D-glucose 1-phosphate + dGTP, UTP + alpha-D-mannose1-phosphate, UTP + alpha-D-galactose 1-phosphate, UTP + alpha-D-glucosamine 1-phosphate
-
-
r
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
the enzyme also shows activity of EC 2.7.7.23, UDP-N-acetylglucosamine diphosphorylase
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-alpha-D-glucose + diphosphate
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-alpha-D-glucose + diphosphate
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
probably involved in conversion of D-glucose to L-rhamnose in the biosynthesis of deoxy compound
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
Mycolicibacterium smegmatis mc(2)155 / ATCC 700084
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
first enzyme of the dTDP-L-rhamnose synthesis pathway
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
Salmonella enterica typhimurium LT2
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
Streptococcus zymogenes
-
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
sequential mechanism
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
the enzyme catalyzes the first step in the biosynthesis of 4-deoxy-4-(dimethylamino)-5,5-dimethyl-D-ribopyranose moiety
-
-
?
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
highly specific for dTDP-glucose and diphosphate
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
100% activity
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
in the opposite direction the enzyme is highly specific for dTDP-D-glucose and diphosphate
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
in the opposite direction the enzyme is highly specific for dTDP-D-glucose and diphosphate
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
highly specific for dTDP-glucose and diphosphate
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
100% activity
-
-
r
dTTP + alpha-D-glucose 1-phosphate
dTDP-glucose + diphosphate
-
-
-
?
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-alpha-D-glucose
-
-
-
-
?
GTP + alpha-D-glucose 1-phosphate
diphosphate + GDP-alpha-D-glucose
-
no product yield with 0.006 mM enzyme, 91% yield with 0.06 mM enzyme
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
RML-1 demonstrates a broad substrate range toward five nucleotides (dTTP, UTP, CTP, ATP and GTP) in the presence of alpha-D-glucose 1-phosphate, with higher activity toward dTTP and UTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
40% yield with 0.006 mM enzyme, 94% yield with 0.06 mM enzyme
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
Salmonella enterica typhimurium
-
-
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
-
5.5% of the activity with dTTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
12% activity compared to dTTP
-
-
r
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
-
5.5% of the activity with dTTP
-
-
?
UTP + alpha-D-glucose 1-phosphate
UDP-glucose + diphosphate
12% activity compared to dTTP
-
-
r
additional information
?
-
Salmonella enterica typhimurium
-
utilizes all eight naturally occurring NTPs with varying levels of catalytic efficiency, even in the presence of nonnative sugar-1-phosphates
-
-
?
additional information
?
-
Salmonella enterica typhimurium LT2
-
utilizes all eight naturally occurring NTPs with varying levels of catalytic efficiency, even in the presence of nonnative sugar-1-phosphates
-
-
?
additional information
?
-
-
no activity with alpha-D-galacturonic acid 1-phosphate
-
-
-
additional information
?
-
-
GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates
-
-
?
additional information
?
-
GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates
-
-
?
additional information
?
-
-
the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively
-
-
?
additional information
?
-
the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively
-
-
?
additional information
?
-
-
almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate
-
-
?
additional information
?
-
almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate
-
-
?
additional information
?
-
-
GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates
-
-
?
additional information
?
-
GTP, UTP/alpha-D-mannose-1-phosphate or UTP/alpha-D-galactose-1-phosphate are no substrates
-
-
?
additional information
?
-
-
the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively
-
-
?
additional information
?
-
the enzyme shows 102% relative activity for dTMP or dTDP compared to dTTP at 2 mM, respectively
-
-
?
additional information
?
-
-
almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate
-
-
?
additional information
?
-
almost no activity with ATP-D-glucose, CTP-D-glucose, UTP-D-Glucose, GTP, alpha-D-galactose-1-phosphate, and alpha-D-mannose-1-phosphate
-
-
?
additional information
?
-
the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms
-
-
?
additional information
?
-
the multifunctional enzyme is involved in biosynthesis of UDP-N-acetyl-alpha-D-glucosamine, an activated and essential form of N-acetyl-alpha-D-glucosamine that is an important component in the polysaccharide structure of most organisms
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UTP + alpha-D-glucose 1-phosphate
diphosphate + UDP-alpha-D-glucose
-
-
-
?
dTDP-glucose + diphosphate
dTTP + alpha-D-glucose 1-phosphate
-
protein by ugpG gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
-
-
?
dTDP-glucose + diphosphate
dTTP + alpha-D-glucose 1-phosphate
-
protein encoded by rmlA gene is involved in gellan gum biosynthesis and exhibits both dTDP- and UDP-glucose diphosphorylase activities
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate + dTDP-alpha-D-glucose
-
-
-
?
dTTP + alpha-D-glucose 1-phosphate
diphosphate