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acyl-coa dehydrogenase deficiency
A Novel Truncating FLAD1 Variant, Causing Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in an 8-Year-Old Boy.
acyl-coa dehydrogenase deficiency
Bacterial Production, Characterization and Protein Modeling of a Novel Monofuctional Isoform of FAD Synthase in Humans: An Emergency Protein?
acyl-coa dehydrogenase deficiency
Infant with early onset bilateral facial and bulbar weakness: Successful treatment of riboflavin in multiple acyl-CoA dehydrogenase deficiency caused by biallelic nonsense FLAD1 variants.
Adenoma
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma.
Aggressive Periodontitis
[Association between FADS1 rs174537 polymorphism and serum proteins in patients with aggressive periodontitis].
Alzheimer Disease
Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.
Aortic Aneurysm, Abdominal
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Aortic Valve Stenosis
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Asthma
FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies.
Breast Neoplasms
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis.
Breast Neoplasms
Suppression of Nuclear Factor-?B by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells.
Carcinogenesis
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Carcinoma
Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma.
Carcinoma
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Carcinoma
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Cardiovascular Diseases
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Cardiovascular Diseases
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.
Cardiovascular Diseases
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Cardiovascular Diseases
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Cataract
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Coronary Artery Disease
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Coronary Artery Disease
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease.
Coronary Disease
Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk.
Deficiency Diseases
Patient with multiple acyl-CoA dehydrogenation deficiency disease and FLAD1 mutations benefits from riboflavin therapy.
Diabetes Mellitus, Type 2
Association of Polymorphism in Fatty Acid Desaturase Gene with the Risk of Type 2 Diabetes in Iranian Population.
Diabetes Mellitus, Type 2
Common Type 2 Diabetes Genetic Risk Variants Improve the Prediction of Gestational Diabetes.
Diabetes Mellitus, Type 2
Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men.
Diabetes Mellitus, Type 2
FADS Gene Polymorphisms, Fatty Acid Desaturase Activities, and HDL-C in Type 2 Diabetes.
Diabetes Mellitus, Type 2
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
Diabetes, Gestational
GCK, GCKR, FADS1, DGKB/TMEM195 and CDKAL1 Gene Polymorphisms in Women with Gestational Diabetes.
Dyslipidemias
Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Dyslipidemias
Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.
Eczema
Variants of the FADS1 FADS2 gene cluster, blood levels of polyunsaturated fatty acids and eczema in children within the first 2 years of life.
Esophageal Squamous Cell Carcinoma
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
fad synthase deficiency
Disorders of Riboflavin Metabolism.
fad synthase deficiency
FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening.
fad synthase deficiency
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Fatty Liver
Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver.
Fatty Liver
Heterozygous Nme7 Mutation Affects Glucose Tolerance in Male Rats.
Hyperglycemia
Effects of 34 Risk Loci for Type 2 Diabetes or Hyperglycemia on Lipoprotein Subclasses and Their Composition in 6,580 Nondiabetic Finnish Men.
Hypersensitivity
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Hypertension
A case-control study between gene polymorphisms of polyunsaturated fatty acid metabolic rate-limiting enzymes and acute coronary syndrome in Chinese Han population.
Hypertension
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Hypospadias
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Infections
Flavin metabolism during respiratory infection in mice.
Insulin Resistance
Abnormal Expression of Genes Involved in Inflammation, Lipid Metabolism, and Wnt Signaling in the Adipose Tissue of Polycystic Ovary Syndrome.
Insulin Resistance
Fatty Acid desaturase gene polymorphisms and metabolic measures in schizophrenia and bipolar patients taking antipsychotics.
Insulin Resistance
Gene Expression Signature in Adipose Tissue of Acromegaly Patients.
Insulin Resistance
Genetic loci associated with lipid concentrations and cardiovascular risk factors in a Korean population.
Ischemic Stroke
Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.
Ischemic Stroke
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Liver Diseases
Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPAR?-FGF21 Axis.
Liver Diseases
In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.
Lung Neoplasms
Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.
Malnutrition
Disorders of Riboflavin Metabolism.
Malnutrition
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
Metabolic Diseases
FLAD1-associated multiple acyl-CoA dehydrogenase deficiency identified by newborn screening.
Metabolic Syndrome
Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population.
Metabolic Syndrome
Carrying minor allele of FADS1 and haplotype of FADS1 and FADS2 increased the risk of metabolic syndrome and moderate but not low fat diets lowered the risk in two Korean cohorts.
Metabolic Syndrome
FADS1 modulates metabolic syndrome in schizophrenia patients receiving olanzapine monotherapy.
Metabolic Syndrome
Interaction of Dietary Linoleic Acid and ?-Linolenic Acids with rs174547 in FADS1 Gene on Metabolic Syndrome Components among Vegetarians.
Metabolic Syndrome
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Metabolism, Inborn Errors
Riboflavin-Responsive and -Non-responsive Mutations in FAD Synthase Cause Multiple Acyl-CoA Dehydrogenase and Combined Respiratory-Chain Deficiency.
Mitochondrial Diseases
Mutation of Aspartate 238 in FAD Synthase Isoform 6 Increases the Specific Activity by Weakening the FAD Binding.
Mitochondrial Diseases
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Mitochondrial Diseases
Use of whole-exome sequencing to determine the genetic basis of multiple mitochondrial respiratory chain complex deficiencies.
Mouth Neoplasms
FADS1 rs174549 Polymorphism May Predict a Favorable Response to Chemoradiotherapy in Oral Cancer Patients.
Mouth Neoplasms
Novel polymorphism in FADS1 gene and fish consumption on risk of oral cancer: A case-control study in southeast China.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
A Novel Truncating FLAD1 Variant, Causing Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) in an 8-Year-Old Boy.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Bacterial Production, Characterization and Protein Modeling of a Novel Monofuctional Isoform of FAD Synthase in Humans: An Emergency Protein?
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Infant with early onset bilateral facial and bulbar weakness: Successful treatment of riboflavin in multiple acyl-CoA dehydrogenase deficiency caused by biallelic nonsense FLAD1 variants.
Muscle Hypotonia
Post-mortem detection of FLAD1 mutations in 2 Turkish siblings with hypotonia in early infancy.
Muscular Diseases
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Neoplasms
Decreased Expression of FADS1 Predicts a Poor Prognosis in Patients with Esophageal Squamous Cell Carcinoma.
Neoplasms
Expression of SCD and FADS2 Is Lower in the Necrotic Core and Growing Tumor Area than in the Peritumoral Area of Glioblastoma Multiforme.
Neoplasms
FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data.
Neoplasms
Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids.
Neoplasms
FLAD1 is up-regulated in Gastric Cancer and is a potential prediction of prognosis.
Neoplasms
Genetic variation of the FADS1 FADS2 gene cluster and n-6 PUFA composition in erythrocyte membranes in the European Prospective Investigation into Cancer and Nutrition-Potsdam study.
Neoplasms
Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer.
Neoplasms
Prediction of Postoperative Recurrence-Free Survival in Non-small Cell Lung Cancer by Using an Internationally Validated Gene Expression Model.
Neoplasms
Reduced Expression of FADS1 Predicts Worse Prognosis in Non-Small-Cell Lung Cancer.
Neoplasms
Significant Diagnostic and Prognostic Value of FLAD1 and Related MicroRNAs in Breast Cancer after a Pan-Cancer Analysis.
Neoplasms
Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.
Neoplasms
[Desaturases of fatty acids (FADS) and their physiological and clinical implication].
Non-alcoholic Fatty Liver Disease
Fatty Acid Desaturase 1 Influences Hepatic Lipid Homeostasis by Modulating the PPAR?-FGF21 Axis.
Non-alcoholic Fatty Liver Disease
In a pilot study, reduced fatty acid desaturase 1 function was associated with nonalcoholic fatty liver disease and response to treatment in children.
Obesity
Association between rs174537 FADS1 polymorphism and immune cell profiles in abdominal and femoral subcutaneous adipose tissue: an exploratory study in adults with obesity.
Obesity
Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population.
Obesity
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Obesity
Gene-diet interaction of a common FADS1 variant with marine polyunsaturated fatty acids for fatty acid composition in plasma and erythrocytes among men.
Obesity
Liver DNA methylation of FADS2 associates with FADS2 genotypex.
Overweight
Associations among FADS1 rs174547, eicosapentaenoic acid/arachidonic acid ratio, and arterial stiffness in overweight subjects.
Scoliosis
FLAD1, encoding FAD synthase, is mutated in a patient with myopathy, scoliosis and cataracts.
Squamous Cell Carcinoma of Head and Neck
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Stomach Neoplasms
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
Stomach Neoplasms
Dietary n-3 and n-6 polyunsaturated fatty acids, the FADS gene, and the risk of gastric cancer in a Korean population.
Stomach Neoplasms
FLAD1 is up-regulated in Gastric Cancer and is a potential prediction of prognosis.
Stroke
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Urinary Bladder Neoplasms
FADS1 is a Prognostic Biomarker in Bladder Cancer: A Study Based on TCGA Data.
Urinary Bladder Neoplasms
Identification of FADS1 Through Common Gene Expression Profiles for Predicting Survival in Patients with Bladder Cancer.
Vascular System Injuries
Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.
Venous Thromboembolism
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Vitiligo
Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo.
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Brizio, C.; Galluccio, M.; Wait, R.; Torchetti, E.M.; Bafunno, V.; Accardi, R.; Gianazza, E.; Indiveri, C.; Barile, M.
Over-expression in Escherichia coli and characterization of two recombinant isoforms of human FAD synthetase
Biochem. Biophys. Res. Commun.
344
1008-1016
2006
Homo sapiens (Q8NFF5), Homo sapiens
brenda
Galluccio, M.; Brizio, C.; Torchetti, E.M.; Ferranti, P.; Gianazza, E.; Indiveri, C.; Barile, M.
Over-expression in Escherichia coli, purification and characterization of isoform 2 of human FAD synthetase
Protein Expr. Purif.
52
175-181
2007
Homo sapiens (Q8NFF5), Homo sapiens
brenda
Torchetti, E.M.; Brizio, C.; Colella, M.; Galluccio, M.; Giancaspero, T.A.; Indiveri, C.; Roberti, M.; Barile, M.
Mitochondrial localization of human FAD synthetase isoform 1
Mitochondrion
10
263-273
2010
Homo sapiens (Q8NFF5), Homo sapiens
brenda
Pedrolli, D.B.; Nakanishi, S.; Barile, M.; Mansurova, M.; Carmona, E.C.; Lux, A.; Gaertner, W.; Mack, M.
The antibiotics roseoflavin and 8-demethyl-8-amino-riboflavin from Streptomyces davawensis are metabolized by human flavokinase and human FAD synthetase
Biochem. Pharmacol.
82
1853-1859
2011
Homo sapiens
brenda
Torchetti, E.; Bonomi, F.; Galluccio, M.; Gianazza, E.; Giancaspero, T.; Iametti, S.; Indiveri, C.; Barile, M.
Human FAD synthase (isoform 2): A component of the machinery that delivers FAD to apo-flavoproteins
FEBS J.
278
4435-4449
2011
Homo sapiens (Q8NFF5)
-
brenda
Leone, P.; Galluccio, M.; Brizio, C.; Barbiroli, A.; Iametti, S.; Indiveri, C.; Barile, M.
The hidden side of the human FAD synthase 2
Int. J. Biol. Macromol.
138
986-995
2019
Homo sapiens
brenda
Leone, P.; Galluccio, M.; Barbiroli, A.; Eberini, I.; Tolomeo, M.; Vrenna, F.; Gianazza, E.; Iametti, S.; Bonomi, F.; Indiveri, C.; Barile, M.
Bacterial production, characterization and protein modeling of a novel monofuctional isoform of FAD synthase in humans An emergency protein?
Molecules
23
116
2018
Homo sapiens (Q8NFF5), Homo sapiens
brenda
2.7.7.2 FAD synthase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
