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Adenocarcinoma
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Adenocarcinoma
Cytokines stimulate expression of inducible nitric oxide synthase in DLD-1 human adenocarcinoma cells by activating poly(A) polymerase.
Alzheimer Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Amebiasis
Amino acid residues Leu135 and Tyr236 are required for RNA binding activity of CFIm25 in Entamoeba histolytica.
Amyotrophic Lateral Sclerosis
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Arthritis, Rheumatoid
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Ataxia
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Ataxia
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Ataxia
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Autoimmune Diseases
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Azoospermia
The poly(A) polymerase beta gene may not be associated with azoospermia caused by Sertoli-cell-only syndrome in Japanese patients by comparing patients and normal controls.
Bone Diseases
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Brain Diseases
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Brain Injuries
Expression of Pancreatitis-Associated Protein after Traumatic Brain Injury: A Mechanism Potentially Contributing to Neuroprotection in Human Brain.
Breast Neoplasms
Gene expression profiles for predicting the efficacy of the anticancer drug 5-fluorouracil in breast cancer.
Breast Neoplasms
PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation.
Breast Neoplasms
Polyadenylate polymerase enzymatic activity in mammary tumor cytosols: A new independent prognostic marker in primary breast cancer.
Breast Neoplasms
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction.
Breast Neoplasms
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
Breast Neoplasms
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
Carcinogenesis
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
Carcinogenesis
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
Carcinogenesis
[Polyadenylate polymerase in the diagnosis of the early stages of chemical carcinogenesis]
Carcinoma
Early 5-fluorouracil-induced changes of poly(A) polymerase in HeLa and WISH cells.
Carcinoma
The potential functions of FAM46C in oral squamous cell carcinoma.
Carcinoma, Ehrlich Tumor
Primer specificity of ribosome-associated poly(A) polymerase from Ehrlich ascites tumour cells.
Carcinoma, Hepatocellular
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Carcinoma, Hepatocellular
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Carcinoma, Hepatocellular
Association of newly synthesized poly(A) polymerase with four distinct polypeptides.
Carcinoma, Hepatocellular
Association of poly(A) polymerase with U1 RNA.
Carcinoma, Hepatocellular
Author Correction: FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Comparison of cytosolic and nuclear poly(A) polymerases from rat liver and a hepatoma: structural and immunological properties and response to NI-type protein kinases.
Carcinoma, Hepatocellular
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis.
Carcinoma, Hepatocellular
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Carcinoma, Hepatocellular
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
Carcinoma, Hepatocellular
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Carcinoma, Hepatocellular
Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions.
Carcinoma, Hepatocellular
Phosphorylation and immunology of poly(A) polymerase.
Carcinoma, Hepatocellular
Phosphorylation of nuclear poly(A) polymerase. Comparison of liver and hepatoma enzymes.
Carcinoma, Hepatocellular
Polyadenylate polymerases from normal and cancer cells and their potential role in messenger RNA processing: a review.
Carcinoma, Hepatocellular
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Carcinoma, Hepatocellular
Structural and immunological identity of rat hepatoma and fetal liver nuclear poly(A) polymerase.
Carcinoma, Hepatocellular
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
Carcinoma, Hepatocellular
Studies on the inhibition of poly(A) polymerase from rat liver and hepatoma 3924A by rifamycin SV derivatives.
Cardiomegaly
A Splicing-Independent Function of RBM10 Controls Specific 3' UTR Processing to Regulate Cardiac Hypertrophy.
Colorectal Neoplasms
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
Colorectal Neoplasms
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Congenital Abnormalities
Exome sequencing identifies a nonsense mutation in Fam46a associated with bone abnormalities in a new mouse model for skeletal dysplasia.
Crohn Disease
Pancreatitis-Associated Protein I Suppresses NF-{kappa}B Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells.
Cystadenoma
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Diabetes, Gestational
miR-657 Promotes Macrophage Polarization toward M1 by Targeting FAM46C in Gestational Diabetes Mellitus.
Diabetes, Gestational
Transcriptome meta-analysis of peripheral lymphomononuclear cells indicates that gestational diabetes is closer to type 1 diabetes than to type 2 diabetes mellitus.
Dyskeratosis Congenita
Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita.
Endometrial Neoplasms
TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer.
Enzootic Bovine Leukosis
Poly (A) polymerase of bovine lymphosarcoma.
Frontotemporal Dementia
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Glioblastoma
FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients.
Glioma
Identification of the Potential Biomarkers in Patients with Glioma: A Weighted Gene Co-Expression Network Analysis.
Hepatitis
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Hepatitis B
Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA.
Hepatitis B
Host RNA quality control as a hepatitis B antiviral target.
Hepatitis B
The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Hepatitis C
Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
Hepatitis C
The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
Hepatitis, Chronic
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Infections
Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis.
Infections
Dramatic increase in poly(A) synthesis after infection of Molt-3 cells with HIV.
Infections
Non-ribosomal poly A polymerase in E. coli: effects of T 4 phage infection.
Infections
Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression.
Infections
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Infections
[HPV genotypes in repeated PAP II smears of group of women in Slovenia]
Infertility, Male
Non-canonical RNA polyadenylation polymerase FAM46C is essential for fastening sperm head and flagellum in mice.
Infertility, Male
PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors.
Infertility, Male
Unusual structure of the double-stranded RNA associated with the '447' cytoplasmic male sterility in Vicia faba.
Leukemia
A simple and fast method for profiling microRNA expression from low-input total RNA by microarray.
Leukemia
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Leukemia
Poly(A)-polymerase levels in leukemia.
Leukemia
Polyadenylic acid polymerase activity in chronic myelogenous leukemia.
Leukemia
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
Leukemia
The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner.
Leukemia
[Polyadenylate polymerase in blood serum from hemoblastosis patients]
Leukemia, Lymphocytic, Chronic, B-Cell
Poly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell type.
Leukemia, Lymphocytic, Chronic, B-Cell
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
Leukemia, Lymphoid
12-0-Tetradecanoylphorbol 13-acetate (TPA)-induced enzymatic change of human non-T, non-B lymphoid leukemia cell lines.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polyadenylic acid polymerase activity in chronic myelogenous leukemia.
Liver Cirrhosis
Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.
Liver Neoplasms, Experimental
Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions.
Liver Neoplasms, Experimental
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
Liver Neoplasms, Experimental
Phosphorylation and immunology of poly(A) polymerase.
Liver Neoplasms, Experimental
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Liver Neoplasms, Experimental
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
Lung Neoplasms
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
Lupus Erythematosus, Systemic
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Lymphoma
The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner.
Lymphoma, Follicular
Systematic analysis of the frequently amplified 2p15-p16.1 locus reveals PAPOLG as a potential proto-oncogene in follicular and transformed follicular lymphoma.
Molluscum Contagiosum
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Mouth Neoplasms
The potential functions of FAM46C in oral squamous cell carcinoma.
Multiple Myeloma
Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Multiple Myeloma
FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases.
Multiple Myeloma
FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy.
Multiple Myeloma
FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma.
Multiple Myeloma
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Multiple Myeloma
Loss of FAM46C Promotes Cell Survival in Myeloma.
Multiple Myeloma
Structural and Functional Analyses of the FAM46C/Plk4 Complex.
Multiple Myeloma
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Multiple Myeloma
The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
Multiple Myeloma
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.
Multiple Myeloma
The potential functions of FAM46C in oral squamous cell carcinoma.
Multiple Myeloma
[The clinical significance of M proteins]
Muscle Spasticity
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Muscle Spasticity
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Muscle Spasticity
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Neoplasm Metastasis
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Neoplasms
A combined blood based gene expression and plasma protein abundance signature for diagnosis of epithelial ovarian cancer--a study of the OVCAD consortium.
Neoplasms
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
Neoplasms
Anti-poly(A) polymerase antibodies in the sera of tumor-bearing rats can inhibit specific cleavage and polyadenylation reactions.
Neoplasms
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Neoplasms
Antimetastatic effects of norcantharidin on hepatocellular carcinoma cells by up-regulating FAM46C expression.
Neoplasms
Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Neoplasms
Cell-free synthesis of tumor-type poly(A) polymerase.
Neoplasms
Early 5-fluorouracil-induced changes of poly(A) polymerase in HeLa and WISH cells.
Neoplasms
FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients.
Neoplasms
FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of ?-catenin.
Neoplasms
FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis.
Neoplasms
FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy.
Neoplasms
FAM46C controls antibody production by the polyadenylation of immunoglobulin mRNAs and inhibits cell migration in multiple myeloma.
Neoplasms
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
Neoplasms
FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells.
Neoplasms
FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.
Neoplasms
FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin.
Neoplasms
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
Neoplasms
Identification of FAM46D as a novel cancer/testis antigen using EST data and serological analysis.
Neoplasms
Identification of the Potential Biomarkers in Patients with Glioma: A Weighted Gene Co-Expression Network Analysis.
Neoplasms
Increased sensitivity and accuracy of a single-stranded DNA splint-mediated ligation assay (sPAT) reveals poly(A) tail length dynamics of developmentally regulated mRNAs.
Neoplasms
Induction of a distinct nuclear poly(A) polymerase and the production of anti-tumor poly(A) polymerase antibodies in hepatocarcinogenesis.
Neoplasms
Inhibition of mammalian and oncornavirus nucleic acid polymerase activities by alkoxybenzophenanthridine alkaloids.
Neoplasms
Mitochondrial poly(A) polymerase from a poorly differentiated hepatoma: purification and characteristics.
Neoplasms
MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3'-deoxyadenosine) in vitro.
Neoplasms
Molecular aspects of small molecules-poly(a) interaction: an approach to RNA based drug design.
Neoplasms
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.
Neoplasms
NCTD elicits proapoptotic and antiglycolytic effects on colorectal cancer cells via modulation of Fam46c expression and inhibition of ERK1/2 signaling.
Neoplasms
Nuclear poly(A) polymerase from rat liver and a hepatoma. Comparison of properties, molecular weights and amino acid compositions.
Neoplasms
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
Neoplasms
p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
Neoplasms
Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region.
Neoplasms
PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.
Neoplasms
PAPOLA contributes to cyclin D1 mRNA alternative polyadenylation and promotes breast cancer cell proliferation.
Neoplasms
Phosphorylation and immunology of poly(A) polymerase.
Neoplasms
Polyadenylate polymerase enzymatic activity in mammary tumor cytosols: A new independent prognostic marker in primary breast cancer.
Neoplasms
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction.
Neoplasms
Primer specificity of ribosome-associated poly(A) polymerase from Ehrlich ascites tumour cells.
Neoplasms
Purification and characterization of a nuclear protein kinase from rat liver and a hepatoma that is capable of activating poly(A) polymerase.
Neoplasms
Star-PAP controls HPV E6 regulation of p53 and sensitizes cells to VP-16.
Neoplasms
Star-PAP regulates tumor protein D52 through modulating miR-449a/34a in breast cancer.
Neoplasms
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model.
Neoplasms
Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C.
Neoplasms
Structurally and immunologically distinct poly(A) polymerases in rat liver. Occurrence of a tumor-type enzyme in normal liver.
Neoplasms
The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
Neoplasms
The potential functions of FAM46C in oral squamous cell carcinoma.
Neoplasms
Tissue and species distribution of liver type and tumor type nuclear poly(A) polymerases.
Neoplasms
[Distribution of a polyadenylate synthetase in adult and embryonal normal tissues and in tumor tissues]
Neuroblastoma
Induction of polyadenylate polymerase and differentiation in neuroblastoma cells.
Obesity
A novel nuclear-encoded mitochondrial poly(A) polymerase PAPD1 is a potential candidate gene for the extreme obesity related phenotypes in mammals.
Obesity
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
Optic Atrophy
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Optic Atrophy
Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
Optic Atrophy
Defective Mitochondrial mRNA Maturation Is Associated with Spastic Ataxia.
Osteoarthritis
Genetic inactivation of ZCCHC6 suppresses IL-6 expression and reduces the severity of experimental osteoarthritis in mice.
Osteoarthritis
Susceptibility to large-joint osteoarthritis (hip and knee) is associated with BAG6 rs3117582 SNP and the VNTR polymorphism in the second exon of the FAM46A gene on chromosome 6.
Osteogenesis Imperfecta
Cytoplasmic polyadenylation by TENT5A is required for proper bone formation.
Osteosarcoma
Down-regulation of miR-10b represses cell vitality in osteosarcoma and is inversely associated with prognosis via interacting with FAM46C: Running title: MiR-10b/FAM46C axis modulates OS progression.
Pancreatitis
Coordinate regulation of secretory stress proteins (PSP/reg, PAP I, PAP II, and PAP III) in the rat exocrine pancreas during experimental acute pancreatitis.
Pancreatitis
Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis.
Pancreatitis
p8 improves pancreatic response to acute pancreatitis by enhancing the expression of the anti-inflammatory protein pancreatitis-associated protein I.
Pancreatitis
Pancreatitis-associated protein I (PAP I), an acute phase protein induced by cytokines. Identification of two functional interleukin-6 response elements in the rat PAP I promoter region.
Pancreatitis
Pancreatitis-Associated Protein I Suppresses NF-{kappa}B Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells.
Pancreatitis
Pancreatitis-associated protein is upregulated in mouse pancreas during acute pancreatitis.
Pancreatitis
The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene, whose expression is up-regulated during pancreatic inflammation.
Papillomavirus Infections
Detection of human papillomavirus DNA by the hybrid capture assay.
Papillomavirus Infections
[Prevalence of human papillomavirus infection in Slovenian women with repeated Pap II smears]
Paraproteinemias
Compendium of FAM46C gene mutations in plasma cell dyscrasias.
Parkinson Disease
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Pneumonia
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Polycythemia Vera
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
polynucleotide adenylyltransferase deficiency
The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polyadenylic acid polymerase activity in normal and leukemic human leukocytes.
Prostatic Neoplasms
FAM46B inhibits cell proliferation and cell cycle progression in prostate cancer through ubiquitination of ?-catenin.
Prostatic Neoplasms
FAM46B Promotes Apoptosis and Inhibits Glycolysis of Prostate Cancer Through Inhibition of the MYC-LDHA Axis.
Prostatic Neoplasms
FAM46C inhibits cell proliferation and cell cycle progression and promotes apoptosis through PTEN/AKT signaling pathway and is associated with chemosensitivity in prostate cancer.
Pulmonary Disease, Chronic Obstructive
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles.
Retinal Diseases
Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs.
Retinitis Pigmentosa
Genetic analysis of FAM46A in Spanish families with autosomal recessive retinitis pigmentosa: characterisation of novel VNTRs.
Retinitis Pigmentosa
Overexpression of FAM46A, a Non-canonical Poly(A) Polymerase, Promotes Hemin-Induced Hemoglobinization in K562 Cells.
Seizures
Expression of Pancreatitis-Associated Protein after Traumatic Brain Injury: A Mechanism Potentially Contributing to Neuroprotection in Human Brain.
Sepsis
FAM46C inhibits lipopolysaccharides-induced myocardial dysfunction via downregulating cellular adhesion molecules and inhibiting apoptosis.
Sjogren's Syndrome
Antibodies against nuclear poly(A) polymerases in rheumatic autoimmune diseases.
Small Cell Lung Carcinoma
Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.
Squamous Cell Carcinoma of Head and Neck
Induction of ZCCHC6 expression in peripheral blood mononuclear cells by HNSCC secretions.
Squamous Cell Carcinoma of Head and Neck
The potential functions of FAM46C in oral squamous cell carcinoma.
Stomach Neoplasms
FAM46C Serves as a Predictor of Hepatic Recurrence in Patients with Resectable Gastric Cancer.
Stomach Neoplasms
FAM46C suppresses gastric cancer by inhibition of Wnt/beta-catenin.
Tuberculosis
Association of Variable Number of Tandem Repeats in the Coding Region of the FAM46A Gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP with Susceptibility to Tuberculosis.
Uterine Cervical Neoplasms
Clinical audit of patients with cervical cancer in Slovenia--data analysis for the year 2003.
Vaccinia
A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.
Vaccinia
A polyadenylylation-specific RNA-contact site on the surface of the bifunctional vaccinia virus RNA modifying protein VP39 that is distinct from the mRNA 5' end-binding "cleft".
Vaccinia
An Amsacta moorei entomopoxvirus ortholog of the poly(A) polymerase small subunit exhibits methyltransferase activity and is non-essential for virus growth.
Vaccinia
Cap-specific mRNA (nucleoside-O2'-)-methyltransferase and poly(A) polymerase stimulatory activities of vaccinia virus are mediated by a single protein.
Vaccinia
Characterization of a polyriboadenylate polymerase from vaccinia virions.
Vaccinia
Crystal structures of the vaccinia virus polyadenylate polymerase heterodimer: insights into ATP selectivity and processivity.
Vaccinia
Domain-level rocking motion within a polymerase that translocates on single-stranded nucleic acid.
Vaccinia
Evidence that the RNA methylation and poly(A) polymerase stimulatory activities of vaccinia virus protein VP39 do not impinge upon one another.
Vaccinia
Identification and properties of the genes encoding the poly(A) polymerase and a small (22 kDa) and the largest subunit (147 kDa) of the DNA-dependent RNA polymerase of molluscum contagiosum virus.
Vaccinia
Inhibition of host protein synthesis by vaccinia virus: fate of cell mRNA and synthesis of small poly (A)-rich polyribonucleotides in the presence of actinomycin D.
Vaccinia
Interaction between the J3R subunit of vaccinia virus poly(A) polymerase and the H4L subunit of the viral RNA polymerase.
Vaccinia
Interplay of two uridylate-specific RNA binding sites in the translocation of poly(A) polymerase from vaccinia virus.
Vaccinia
Methyltransferase-specific domains within VP-39, a bifunctional protein that participates in the modification of both mRNA ends.
Vaccinia
Molecular flexibility and discontinuous translocation of a non-templated polymerase.
Vaccinia
Mutational analysis of a multifunctional protein, with mRNA 5' cap-specific (nucleoside-2'-O-)-methyltransferase and 3'-adenylyltransferase stimulatory activities, encoded by vaccinia virus.
Vaccinia
Path of an RNA ligand around the surface of the vaccinia VP39 subunit of its cognate VP39-VP55 protein heterodimer.
Vaccinia
Poly(A) polymerase and a dissociable polyadenylation stimulatory factor encoded by vaccinia virus.
Vaccinia
Poly(A) polymerase from vaccinia virus-infected cells. I. Partial purification and characterization.
Vaccinia
Poly(A) polymerase from vaccinia virus-infected cells. II. Product and primer characterization.
Vaccinia
Poly(riboadenylic acid) preferentially inhibits in vitro translation of cellular mRNAs compared with vaccinia virus mRNAs: possible role in vaccinia virus cytopathology.
Vaccinia
Polyadenylate polymerase from vaccinia virions.
Vaccinia
Saltatory forward movement of a poly(A) polymerase during poly(A) tail addition.
Vaccinia
Specific recognition of an rU2-N15-rU motif by VP55, the vaccinia virus poly(A) polymerase catalytic subunit.
Vaccinia
Stable chelating linkage for reversible immobilization of oligohistidine tagged proteins in the BIAcore surface plasmon resonance detector.
Vaccinia
Stimulation of poly(A) tail elongation by the VP39 subunit of the vaccinia virus-encoded poly(A) polymerase.
Vaccinia
Terminal riboadenylate transferase: a poly A polymerase in purified vaccinia virus.
Vaccinia
The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends.
Vaccinia
The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-2'-O-) methyltransferase and poly(A) polymerase stimulatory functions.
Vaccinia
The surface region of the bifunctional vaccinia RNA modifying protein VP39 that interfaces with Poly(A) polymerase is remote from the RNA binding cleft used for its mRNA 5' cap methylation function.
Vaccinia
The vaccinia virus bifunctional gene J3 (nucleoside-2'-O-)-methyltransferase and poly(A) polymerase stimulatory factor is implicated as a positive transcription elongation factor by two genetic approaches.
Vaccinia
Transcription elongation activity of the vaccinia virus J3 protein in vivo is independent of poly(A) polymerase stimulation.
Vaccinia
Transition from rapid processive to slow nonprocessive polyadenylation by vaccinia virus poly(A) polymerase catalytic subunit is regulated by the net length of the poly(A) tail.
Vaccinia
Uridylate-containing RNA sequences determine specificity for binding and polyadenylation by the catalytic subunit of vaccinia virus poly(A) polymerase.
Vaccinia
Use of vaccinia virus poly(A) polymerase for RNA 3'-end labeling with a chain-terminating nucleotide or a short 3' homopolymer tract.
Vaccinia
Vaccinia virus poly(A) polymerase. Specificity for nucleotides and nucleotide analogs.
Vaccinia
Widespread but small-scale changes in the structural and dynamic properties of vaccinia virus poly(A) polymerase upon association with its processivity factor in solution.
Vesicular Stomatitis
The L protein of vesicular stomatitis virus modulates the response of the polyadenylic acid polymerase to S-adenosylhomocysteine.
Vesicular Stomatitis
Vesicular stomatitis virus mutant with altered polyadenylic acid polymerase activity in vitro.
Wilms Tumor
Anti-poly(A) polymerase antibodies in sera of tumor-bearing rats and human cancer patients.
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Edmonds, M.
Poly(A) adding enzymes
The Enzymes,3rd Ed. (Boyer,P. D. ,ed. )
15
217-244
1982
Bos taurus, Cricetulus griseus, Coturnix sp., Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus, Vaccinia virus
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brenda
Nevins, J.R.; Joklik, W.K.
Isolation and partial characterization of the poly(A) polymerases from HeLa cells infected with vaccinia virus
J. Biol. Chem.
252
6939-6947
1977
Homo sapiens, Vaccinia virus
brenda
Ryner, L.C.; Takagaki, Y.; Manley, J.L.
Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3-end formation
Mol. Cell. Biol.
9
4229-4238
1989
Homo sapiens
brenda
Takagaki, Y.; Ryner, L.C.; Manley, J.L.
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation
Cell
52
731-742
1988
Homo sapiens
brenda
Christofori, G.; Keller, W.
Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitro
Mol. Cell. Biol.
9
193-203
1989
Homo sapiens
brenda
Blakesley, R.W.; Boezi, J.A.
A kinetic and structural characterization of adenosine-5-triphosphate: ribonucleic acid adenylyltransferase from Pseudomonas putida
Biochim. Biophys. Acta
414
133-145
1975
Homo sapiens, Pseudomonas putida
brenda
Brakel, C.; Kates, J.R.
Poly(A) polymerase from vaccinia virus-infected cells. I. Partial purification and characterization
J. Virol.
14
715-723
1974
Homo sapiens
brenda
Scorilas, A.; Talieri, M.; Ardavanis, A.; Courtis, N.; Dimitriadis, E.; Yotis, J.; Tsiapalis, C.M.; Trangas, T.
Polyadenylate polymerase enzymatic activity in mammary tumor cytosols: a new independent prognostic marker in primary breast cancer
Cancer Res.
60
5427-5433
2000
Homo sapiens
brenda
Kyriakopoulou, C.; Tsiapalis, C.M.; Havredaki, M.
Biochemical and immunological identification and enrichment of poly(A) polymerase from human thymus
Mol. Cell. Biochem.
154
9-16
1996
Homo sapiens
brenda
Topalian, S.L.; Kaneko, S.; Gonzales, M.I.; Bond, G.L.; Ward, Y.; Manley, J.L.
Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors
Mol. Cell. Biol.
21
5614-5623
2001
Homo sapiens (Q9BWT3), Homo sapiens
brenda
Thomadaki, H.; Tsiapalis, C.M.; Scorilas, A.
Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction
Biol. Chem.
386
471-480
2005
Homo sapiens
brenda
Nagaike, T.; Suzuki, T.; Katoh, T.; Ueda, T.
Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase
J. Biol. Chem.
280
19721-19727
2005
Homo sapiens
brenda
Tomecki, R.; Dmochowska, A.; Gewartowski, K.; Dziembowski, A.; Stepien, P.P.
Identification of a novel human nuclear-encoded mitochondrial poly(A) polymerase
Nucleic Acids Res.
32
6001-6014
2004
Homo sapiens (Q9NVV4), Homo sapiens
brenda
Rouhana, L.; Wang, L.; Buter, N.; Kwak, J.E.; Schiltz, C.A.; Gonzalez, T.; Kelley, A.E.; Landry, C.F.; Wickens, M.
Vertebrate GLD2 poly(A) polymerases in the germline and the brain
RNA
11
1117-1130
2005
Homo sapiens, Mus musculus, Xenopus laevis
brenda
Slomovic, S.; Portnoy, V.; Yehudai-Resheff, S.; Bronshtein, E.; Schuster, G.
Polynucleotide phosphorylase and the archaeal exosome as poly(A)-polymerases
Biochim. Biophys. Acta
1779
247-255
2008
Homo sapiens
brenda
Thuresson, A.; Kirsebom, L.A.; Virtanen, A.
Inhibition of poly(A) polymerase by aminoglycosides
Biochimie
89
1221-1227
2007
Homo sapiens
brenda
Rissland, O.S.; Mikulasova, A.; Norbury, C.J.
Efficient RNA polyuridylation by noncanonical poly(A) polymerases
Mol. Cell. Biol.
27
3612-3624
2007
Homo sapiens
brenda
Bai, Y.; Srivastava, S.K.; Chang, J.H.; Manley, J.L.; Tong, L.
Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase
Mol. Cell
41
311-320
2011
Homo sapiens (Q9NVV4), Homo sapiens
brenda
Burns, D.M.; DAmbrogio, A.; Nottrott, S.; Richter, J.D.
CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation
Nature
473
105-108
2011
Homo sapiens (Q6PIY7), Homo sapiens
brenda
Rammelt, C.; Bilen, B.; Zavolan, M.; Keller, W.
PAPD5, a noncanonical poly(A) polymerase with an unusual RNA-binding motif
RNA
17
1737-1746
2011
Homo sapiens (Q8NDF8), Homo sapiens
brenda
Ogami, K.; Cho, R.; Hoshino, S.
Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7
Biochem. Biophys. Res. Commun.
432
135-140
2013
Homo sapiens (Q5XG87)
brenda
Yang, Q.; Nausch, L.W.; Martin, G.; Keller, W.; Doublie, S.
Crystal structure of human poly(A) polymerase gamma reveals a conserved catalytic core for canonical poly(A) polymerases
J. Mol. Biol.
426
43-50
2014
Homo sapiens (Q9BWT3), Homo sapiens
brenda
Muniz, L.; Davidson, L.; West, S.
Poly(A) polymerase and the nuclear poly(A) binding protein, PABPN1, coordinate the splicing and degradation of a subset of human pre-mRNAs
Mol. Cell. Biol.
35
2218-2230
2015
Homo sapiens
brenda
Fiedler, M.; Rossmanith, W.; Wahle, E.; Rammelt, C.
Mitochondrial poly(A) polymerase is involved in tRNA repair
Nucleic Acids Res.
43
9937-9949
2015
Homo sapiens (Q9NVV4)
brenda
Bresson, S.M.; Conrad, N.K.
The human nuclear poly(a)-binding protein promotes RNA hyperadenylation and decay
PLoS Genet.
9
e1003893
2013
Homo sapiens (P51003), Homo sapiens (Q9BWT3)
brenda
Yu, C.; Gong, Y.; Zhou, H.; Wang, M.; Kong, L.; Liu, J.; An, T.; Zhu, H.; Li, Y.
Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic human breast cancer model
Cell Death Dis.
8
e2582
2017
Homo sapiens (Q9H6E5), Homo sapiens
brenda
Furuya, N.; Kakuta, S.; Sumiyoshi, K.; Ando, M.; Nonaka, R.; Suzuki, A.; Kazuno, S.; Saiki, S.; Hattori, N.
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy
EMBO Rep.
19
e46363
2018
Homo sapiens (Q9NVV4)
brenda
Mroczek, S.; Chlebowska, J.; Kulinski, T.M.; Gewartowska, O.; Gruchota, J.; Cysewski, D.; Liudkovska, V.; Borsuk, E.; Nowis, D.; Dziembowski, A.
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
Nat. Commun.
8
619
2017
Mus musculus (Q5SSF7), Mus musculus, Homo sapiens (Q5VWP2)
brenda
Kuchta, K.; Muszewska, A.; Knizewski, L.; Steczkiewicz, K.; Wyrwicz, L.S.; Pawlowski, K.; Rychlewski, L.; Ginalski, K.
FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases
Nucleic Acids Res.
44
3534-3548
2016
Homo sapiens (Q5VWP2), Homo sapiens (Q8NEK8), Homo sapiens (Q96A09), Homo sapiens (Q96IP4), Homo sapiens
brenda
Shin, J.; Paek, K.; Ivshina, M.; Stackpole, E.; Richter, J.
Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism
Nucleic Acids Res.
45
6793-6804
2017
Homo sapiens (Q8NDF8)
brenda
Li, W.; Li, W.; Laishram, R.S.; Hoque, M.; Ji, Z.; Tian, B.; Anderson, R.A.
Distinct regulation of alternative polyadenylation and gene expression by nuclear poly(A) polymerases
Nucleic Acids Res.
45
8930-8942
2017
Homo sapiens
brenda
Hu, J.L.; Liang, H.; Zhang, H.; Yang, M.Z.; Sun, W.; Zhang, P.; Luo, L.; Feng, J.X.; Bai, H.; Liu, F.; Zhang, T.; Yang, J.Y.; Gao, Q.; Long, Y.; Ma, X.Y.; Chen, Y.; Zhong, Q.; Yu, B.; Liao, S.; Wang, Y.; Zhao, Y.; Zeng, M.S.; Cao, N.; Wang, J.; Chen, W.; Yang, H.T.; Gao, S.
FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells
Nucleic Acids Res.
48
2733-2748
2020
Xenopus tropicalis (F7E7M3), Homo sapiens (Q96A09), Homo sapiens
brenda
Newie, I.; Sokilde, R.; Persson, H.; Jacomasso, T.; Gorbatenko, A.; Borg, A.; de Hoon, M.; Pedersen, S.F.; Rovira, C.
HER2-encoded mir-4728 forms a receptor-independent circuit with miR-21-5p through the non-canonical poly(A) polymerase PAPD5
Sci. Rep.
6
35664
2016
Homo sapiens (Q8NDF8), Homo sapiens
brenda