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Information on EC 2.7.7.18 - nicotinate-nucleotide adenylyltransferase and Organism(s) Staphylococcus aureus and UniProt Accession Q5HFG7

for references in articles please use BRENDA:EC2.7.7.18
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Staphylococcus aureus
UNIPROT: Q5HFG7 not found.
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The taxonomic range for the selected organisms is: Staphylococcus aureus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
nicotinate mononucleotide adenylyltransferase, nicotinic acid mononucleotide adenylyltransferase, pfnmnat, namn at, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nicotinic acid mononucleotide adenylyltransferase
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adenylyltransferase, nicotinate mononucleotide
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deamido-NAD+ pyrophosphorylase
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deamidonicotinamide adenine dinucleotide pyrophosphorylase
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NaMN AT
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NaMN-ATase
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nicotinic acid mononucleotide adenylyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:nicotinate-ribonucleotide adenylyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9026-98-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
nicotinic acid mononucleotide + ATP
nicotinic acid dinucleotide + diphosphate
show the reaction diagram
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
nicotinic acid mononucleotide + ATP
nicotinic acid dinucleotide + diphosphate
show the reaction diagram
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Tithonia diversifolia oil
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i.e Mexican sunflower, its essential oil is mostly active against Staphylococcus aureus with a halo of 14 mm. The essential oil selectively inhibits in vitro the pure NadD from S. aureus (IC50 of about 60 x02g/mL), with basically none or only minor effects on mammalian orthologue enzymes
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additional information
Tithonia diversifolia (Mexican sunflower, flowerheads harvested in Dschang, West Province of Cameroon, Campus of Dschang University) essential oil is mostly active against Staphylococcusaureus and inhibits in vitro the pure NAD biosyntheticenzyme NadD from Staphylococcus aureus with IC50of of about 0.06 mg/ml, with basically none or only minor effects on mammalian orthologue enzymes, GC and NMR spectroemtric analysis of the essential oil composition, detailed overview. The essential oil of Maxican sunflower shows antibacterialand antioxidant activity, and cytotoxicity on human tumor cells
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
44000
by gel filtration
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Crystals of saNaMNAT were initially obtained at 22°C from polyethylene glycol 3000 and phosphatecitrate buffer.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Han, S.; Forman, M.D.; Loulakis, P.; Rosner, M.H.; Xie, Z.; Wang, H.; Danley, D.E.; Yuan, W.; Schafer, J.; Xu, Z.
Crystal structure of nicotinic acid mononucleotide adenylyltransferase from Staphyloccocus aureus: structural basis for NaAD interaction in functional dimer
J. Mol. Biol.
360
814-825
2006
Bacillus subtilis (P54455), Methanothermobacter thermautotrophicus, Staphylococcus aureus (Q5HFG7), Staphylococcus aureus, Staphylococcus aureus COL (Q5HFG7)
Manually annotated by BRENDA team
Orsomando, G.; Agostinelli, S.; Bramucci, M.; Cappellacci, L.; Damiano, S.; Lupidi, G.; Maggi, F.; Ngahang Kamte, S.; Biapa Nya, P.; Papa, F.; Petrelli, D.; Quassinti, L.; Sorci, L.; Vitali, L.; Petrelli, R.
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD)
Ind. Crops Prod.
85
181-189
2016
Staphylococcus aureus (P65502), Staphylococcus aureus N315 (P65502)
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Manually annotated by BRENDA team
Orsomando, G.; Agostinelli, S.; Bramucci, M.; Cappellacci, L.; Damiano, S.; Lupidi, G.; Maggi, F.; Ngahang Kamte, S.; Biapa Nya, P.; Papa, F.; Petrelli, D.; Quassinti, L.; Sorci, L.; Vitali, L.; Petrelli, R.
Mexican sunflower (Tithonia diversifolia, Asteraceae) volatile oil as a selective inhibitor of Staphylococcus aureus nicotinate mononucleotide adenylyltransferase (NadD)
Ind. Crops Prod.
85
181-189
2016
Staphylococcus aureus, Staphylococcus aureus ATCC 25923
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Manually annotated by BRENDA team