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Information on EC 2.7.7.18 - nicotinate-nucleotide adenylyltransferase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P53204

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Saccharomyces cerevisiae
UNIPROT: P53204 not found.
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
nicotinate mononucleotide adenylyltransferase, nicotinic acid mononucleotide adenylyltransferase, pfnmnat, namn at, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NMN/NaMN adenylyltransferase 2
-
adenylyltransferase, nicotinate mononucleotide
-
-
-
-
deamido-NAD+ pyrophosphorylase
-
-
-
-
deamidonicotinamide adenine dinucleotide pyrophosphorylase
-
-
-
-
NaMN AT
-
-
-
-
NaMN-ATase
-
-
-
-
nicotinic acid mononucleotide adenylyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
ATP:nicotinate-ribonucleotide adenylyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9026-98-6
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + nicotinamide ribonucleotide
diphosphate + NAD+
show the reaction diagram
-
-
-
r
nicotinic acid mononucleotide + ATP
nicotinic acid adenine dinucleotide + diphosphate
show the reaction diagram
activity observed with dATP, ITP
-
-
r
ATP + 3-acetyl-pyridine-NAD+
?
show the reaction diagram
-
reaction at 76% the rate of nicotinamide ribonucleotide
-
-
?
ATP + 3-pyridinealdehyde-NAD+
?
show the reaction diagram
-
reaction at 28% the rate of nicotinamide ribonucleotide
-
-
?
ATP + nicotinate ribonucleotide
diphosphate + deamido-NAD+
show the reaction diagram
deoxy-ATP + nicotinamide ribonucleotide
?
show the reaction diagram
-
-
-
-
?
deoxy-ATP + nicotinate ribonucleotide
?
show the reaction diagram
-
-
-
-
?
NAD+ + diphosphate
ATP + nicotinamide nucleotide
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + nicotinate ribonucleotide
diphosphate + deamido-NAD+
show the reaction diagram
-
-
-
-
r
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
requirement
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.083
diphosphate
-
0.17
nicotinamide mononucleotide
-
0.27
3-acetylpyridine-NAD+
-
37°C, pH 7.5
0.74
3-pyridinealdehyde-NAD+
-
37°C, pH 7.5
0.06
ATP
-
37°C, pH 7.5, + nicotinate ribonucleotide
0.029
deamido-NAD+
-
37°C, pH 7.5
0.65
diphosphate
-
37°C, pH 7.5
0.069
NAD+
-
37°C, pH 7.5
0.4
nicotinamide ribonucleotide
-
37°C, pH 7.5
0.13
nicotinate ribonucleotide
-
37°C, pH 7.5
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.42
-
3-pyridinealdehyde-NAD+ as substrate
3.82
-
3-acetyl-pyridine-NAD+ as substrate
3.85
-
deamido-NAD+ as substrate
5
-
NAD+ as substrate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
48000
4 * 48000, calculated: 45859
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homotetramer
4 * 48000, calculated: 45859
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60
-
5 min 39% loss of activity
65
-
5 min 65% loss of activity
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
0-3°C, 22% loss of activity within 31 days
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dahmen, W.; Webb, B.; Preiss, J.
The deamido-diphosphopyridine nucleotide and diphosphopyridine nucleotide pyrophosphorylases of Escherichia coli and yeast
Arch. Biochem. Biophys.
120
440-450
1967
Escherichia coli, Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lau, C.; Niere, M.; Ziegler, M.
The NMN/NaMN adenylyltransferase (NMNAT) protein family
Front. Biosci.
14
410-431
2009
Arabidopsis thaliana, Escherichia coli (P0A752), Homo sapiens (Q96T66), Saccharomyces cerevisiae (P53204)
Manually annotated by BRENDA team