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Information on EC 2.7.7.13 - mannose-1-phosphate guanylyltransferase and Organism(s) Danio rerio and UniProt Accession Q6DBU5

for references in articles please use BRENDA:EC2.7.7.13
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IUBMB Comments
The bacterial enzyme can also use ITP and dGTP as donors.
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This record set is specific for:
Danio rerio
UNIPROT: Q6DBU5
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Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
gmppb, gdp-mannose pyrophosphorylase, vtc1-1, gdp-d-mannose pyrophosphorylase, gdp-mp, osvtc1-1, osvtc1-3, nspase, mannose-1-phosphate guanylyltransferase, gdp-man pyrophosphorylase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mannose-1-phosphate guanyltransferase beta
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GDP-mannose pyrophosphorylase
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GTP-mannose 1-phosphate guanylyltransferase
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GTP-mannose-1-phosphate guanylyltransferase
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guanosine 5'-diphospho-D-mannose pyrophosphorylase
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guanosine diphosphomannose pyrophosphorylase
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guanosine triphosphate-mannose 1-phosphate guanylyltransferase
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guanylyltransferase, mannose 1-phosphate
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mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
GTP:alpha-D-mannose-1-phosphate guanylyltransferase
The bacterial enzyme can also use ITP and dGTP as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
37278-24-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
knockdown of GMPPB in zebrafish causes structural muscle defects with decreased motility, eye abnormalities, and reduced glycosylation of alpha-dystroglycan
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
GMPPB_DANRE
360
0
40144
Swiss-Prot
Mitochondrion (Reliability: 3)
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Carss, K.J.; Stevens, E.; Foley, A.R.; Cirak, S.; Riemersma, M.; Torelli, S.; Hoischen, A.; Willer, T.; van Scherpenzeel, M.; Moore, S.A.; Messina, S.; Bertini, E.; Boennemann, C.G.; Abdenur, J.E.; Grosmann, C.M.; Kesari, A.; Punetha, J.; Quinlivan, R.; Waddell, L.B.; Young, H.K.; Wraige, E.; Yau, S.; Bro, L. et al.
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of alpha-dystroglycan
Am. J. Hum. Genet.
93
29-41
2013
Danio rerio (Q6DBU5), Danio rerio, Homo sapiens (Q9Y5P6)
Manually annotated by BRENDA team