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Information on EC 2.7.7.13 - mannose-1-phosphate guanylyltransferase
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2.7.7.13 mannose-1-phosphate guanylyltransferaseIUBMB Comments
The bacterial enzyme can also use ITP and dGTP as donors.
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Word Map
- 2.7.7.13
- asa
- phosphomannomutase
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l-ascorbic
-
limb-girdle
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myasthenic
- l-galactose
- dystroglycanopathies
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gmpase
- gdp-l-galactose
-
mannose-containing
- alpha-dystroglycan
- l-galactono-1,4-lactone
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smirnoff-wheeler
- acerola
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l-galactose-1-phosphate
- drug development
- synthesis
- medicine
- agriculture
The enzyme appears in viruses and cellular organisms
Synonyms
gmppb, gdp-mannose pyrophosphorylase, vtc1-1, gdp-d-mannose pyrophosphorylase, gdp-mp, osvtc1-1, osvtc1-3, nspase, mannose-1-phosphate guanylyltransferase, gdp-man pyrophosphorylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BceA
GDP-D-mannose pyrophosphorylase
GDP-Man pyrophosphorylase
GDP-mannose pyrophosphorylase
GDP-MP
GMP3
GMPase
GMPP
GMPPB
GTP-alpha-D-Man-1-P guanylyltransferase
GTP-mannose 1-phosphate guanylyltransferase
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GTP-mannose-1-phosphate guanylyltransferase
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guanidine diphosphomannose pyrophoyphorylase
guanosine 5'-diphospho-D-mannose pyrophosphorylase
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guanosine diphosphate-mannose pyrophosphorylase
guanosine diphosphomannose pyrophosphorylase
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guanosine triphosphate-mannose 1-phosphate guanylyltransferase
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guanosine-diphospho-D-mannose pyrophosphorylase
guanylyltransferase, mannose 1-phosphate
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LDBPK_230120
mannose 1-phosphate guanylyltransferase (guanosine triphosphate)
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mannose-1-phosphate guanylyltransferase
PH0925
RfbM
VTC1-1
VTC1-3
additional information
BceA
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bifunctional protein with phosphomannose isomerase and GDP-mannose pyrophosphorylase activities
BceA
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bifunctional protein with phosphomannose isomerase and GDP-mannose pyrophosphorylase activities
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GDP-mannose pyrophosphorylase
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GDP-mannose pyrophosphorylase
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type II phosphomannose isomerase, bifunctional phosphomannose isomerase/GDP-mannose pyrophosphorylase (manC), with both PMI (E.C. 5.3.1.8) and GMP (E.C.2.7.7.13) activities
guanosine-diphospho-D-mannose pyrophosphorylase
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
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-
additional information
bifunctional protein (type II PMI family) with phosphomannose isomerase (PMI, EC 5.3.1.8) and GDP-mannose pyrophosphorylase (GMP, EC 2.7.7.13) activities
additional information
bifunctional protein (type II PMI family) with phosphomannose isomerase (PMI, EC 5.3.1.8) and GDP-mannose pyrophosphorylase (GMP, EC 2.7.7.13) activities
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
PMI and GMP activities are most probably located in catalytically distinct domains
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
bifunctional enzyme with both phosphomannose isomerase and GDP-D-mannose pyrophosphorylase activity
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
enzyme has both phosphomannose isomerase, i.e. PIM, and guanosine 5'-diphospho-D-mannose pyrophosphorylase, i.e. GMP, activity
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
nucleotidyl group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
GTP:alpha-D-mannose-1-phosphate guanylyltransferase
The bacterial enzyme can also use ITP and dGTP as donors.
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CAS REGISTRY NUMBER
COMMENTARY
37278-24-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
8-Azido-GTP + mannose 1-phosphate
8-Azido-GDP mannose + diphosphate
-
-
-
?
ATP + alpha-D-mannose 1-phosphate
ADPmannose + diphosphate
-
recombinant beta subunit of GDPmannose pyrophosphorylase, 18% of activity with GTP
-
?
ATP + alpha-D-mannose 1-phosphate
alpha-ADP-mannose + diphosphate
-
-
-
-
?
ATP + alpha-D-mannose 1-phosphate
diphosphate + ADP-mannose
about 8% of the activity with GTP
-
-
?
CTP + alpha-D-mannose 1-phosphate
alpha-CDP-mannose + diphosphate
-
-
-
-
?
CTP + alpha-D-mannose 1-phosphate
diphosphate + CDP-alpha-D-mannose
-
recombinant beta subunit of GDPmannose pyrophosphorylase, 7% of activity with GTP
-
?
CTP + alpha-D-mannose 1-phosphate
diphosphate + CDP-mannose
about 8% of the activity with GTP
-
-
?
dGTP + alpha-D-mannose 1-phosphate
diphosphate + dGDP-mannose
high activity
-
-
?
dTTP + alpha-D-mannose 1-phosphate
alpha-dTDP-mannose + diphosphate
-
-
-
-
?
GDP-glucose + diphosphate
D-glucose 1-phosphate + GTP
-
most effective substrate in direction of nucleoside triphosphate formation, in the reverse direction GTP is a better glucose acceptor than ITP
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r
GTP + 2-deoxy-alpha-D-glucose-1-phosphate
GDP-2-deoxy-alpha-D-glucose + diphosphate
-
recombinant GDPmannose pyrophosphorylase, 15% of activity with mannose 1-phosphate
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?
GTP + 2-O-methyl-alpha-D-mannose 1-phosphate
diphosphate + GDP-2-O-methyl-alpha-D-mannose
-
-
-
-
?
GTP + 3-deoxy-alpha-D-arabino-hexose-1-phosphate
GDP-3-deoxy-alpha-D-arabino-hexose + diphosphate
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recombinant GDPmannose pyrophosphorylase, 70% of activity with mannose 1-phosphate
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?
GTP + 3-O-methyl-alpha-D-mannose 1-phosphate
diphosphate + GDP-3-O-methyl-alpha-D-mannose
-
-
-
-
?
GTP + 4-deoxy-alpha-D-lyxo-hexose 1-phosphate
GDP-4-deoxy-alpha-D-lyxo-hexose + diphosphate
-
-
-
-
?
GTP + 4-deoxy-alpha-D-lyxo-hexose-1-phosphate
GDP-4-deoxy-alpha-D-lyxo-hexose + diphosphate
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recombinant GDPmannose pyrophosphorylase, 22% of activity with mannose 1-phosphate
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?
GTP + 4-O-methyl-alpha-D-mannose 1-phosphate
diphosphate + GDP-4-O-methyl-alpha-D-mannose
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-
-
-
?
GTP + 6-O-methyl-alpha-D-mannose 1-phosphate
diphosphate + GDP-6-O-methyl-alpha-D-mannose
-
-
-
-
?
GTP + alpha-D-galactose 1-phosphate
GDP-alpha-D-galactose + diphosphate
-
-
-
-
?
GTP + alpha-D-glucosamine 1-phosphate
alpha-GDP-glucosamine + diphosphate
-
-
-
-
?
GTP + alpha-D-glucosamine 1-phosphate
diphosphate + GDP-alpha-D-glucosamine
-
-
-
?
GTP + alpha-D-glucose 1-phosphate
alpha-GDP-glucose + diphosphate
-
-
-
-
?
GTP + alpha-D-lyxose-1-phosphate
GDP-alpha-D-lyxose + diphosphate
-
-
-
-
?
GTP + alpha-D-lyxose-1-phosphate
GDPalpha-D-lyxose + diphosphate
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recombinant GDPmannose pyrophosphorylase, 12% of activity with mannose 1-phosphate
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?
GTP + alpha-D-mannose 1-phosphate
alpha-GDP-mannose + diphosphate
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in the presence of diphosphatase
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r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-D-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate + GTP
diphosphate + GDP-alpha-D-mannose
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-
-
-
?
GTP + alpha-L-fucose 1-phosphate
GDP-alpha-L-fucose + diphosphate
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-
-
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?
GTP + alpha-N-acetyl-D-glucosamine 1-phosphate
GDP-alpha-N-acetyl-D-glucosamine + diphosphate
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-
-
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?
IDPmannose + diphosphate
ITP + mannose 1-phosphate
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72% of activity with GDPglucose
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r
UTP + alpha-D-mannose 1-phosphate
alpha-UDP-mannose + diphosphate
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-
-
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?
UTP + alpha-D-mannose 1-phosphate
diphosphate + UDP-mannose
about 8% of the activity with GTP
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?
UTP + alpha-D-mannose 1-phosphate
UDPmannose + diphosphate
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recombinant beta subunit of GDPmannose pyrophosphorylase, 12% of activity with GTP
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?
dGTP + alpha-D-mannose 1-phosphate
dGDPmannose + diphosphate
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8% of activity with GDP-mannose
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r
dGTP + alpha-D-mannose 1-phosphate
dGDPmannose + diphosphate
Arthrobacter sp. NRRL B1973
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8% of activity with GDP-mannose
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r
dGTP + alpha-D-mannose 1-phosphate
dGDPmannose + diphosphate
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34% of the activity with GTP
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?
diphosphate + GDP-alpha-D-mannose
GTP + alpha-D-mannose 1-phosphate
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-
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?
diphosphate + GDP-alpha-D-mannose
GTP + alpha-D-mannose 1-phosphate
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-
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?
diphosphate + GDP-mannose
GTP + alpha-D-mannose 1-phosphate
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-
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?
diphosphate + GDP-mannose
GTP + alpha-D-mannose 1-phosphate
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-
-
?
diphosphate + GDP-mannose
GTP + alpha-D-mannose 1-phosphate
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-
-
?
diphosphate + GDP-mannose
GTP + alpha-D-mannose 1-phosphate
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-
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?
GDP-mannose + diphosphate
GTP + D-mannose 1-phosphate
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-
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
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60% activity with ITP, 2% activity with UTP, 1% activity with glucose-1-phosphate, and 2% activity with ATP and glucose-1-phosphate
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-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-alpha-D-mannose
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
best substrate
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
regulation of the enzyme expression, overview
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-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
the enzyme shows high specificity for synthesizing GDP-mannose, D-glucose 1-phosphate instead of alpha-D-mannose 1-phosphate is a poor substrate
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
regulation of the enzyme expression, overview
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
the enzyme shows high specificity for synthesizing GDP-mannose, D-glucose 1-phosphate instead of alpha-D-mannose 1-phosphate is a poor substrate
-
-
r
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
equilibrium constant: 2.5
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
Arthrobacter sp. NRRL B1973
-
equilibrium constant: 2.5
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
enzyme regulates GDP-D-mannose synthesis through feedback inhibition
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
no activity with glucose 1-phosphate, UTP, ATP and CTP
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
?
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
no activity with GDP-D-glucose, ADP-D-mannose and UDP-D-mannose
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
enzyme of alginate biosynthetic pathway
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
-
?
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
recombinant 37000 Da beta subunit of GDP-mannose pyrophosphorylase has only little GDPglucose synthetic activity but high GDP mannose synthetic activity
-
?
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
specific for mannose
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
no activity with ATP, CTP, TTP, UTP, ADP-alpha-D-glucose, ADP-alpha-D-mannose, CDP-alpha-D-choline, CDP-alpha-D-glucose, CDP-beta-L-fucose, GDP-alpha-D-glucose, dTPP-alpha-D-glucose, IDP-alpha-D-galactose, UDP-alpha-D-glucose, UDP-N-acetyl-alpha-D-glucosamine, UDP-alpha-D-mannose
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
r
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
overexpression leads to an increase in cellular GDPmannose levels
-
?
GTP + alpha-D-mannose 1-phosphate
GDPmannose + diphosphate
-
-
r
GTP + D-mannose 1-phosphate
diphosphate + GDP-mannose
-
-
-
-
r