Reference on EC 2.7.7.12 - UDP-glucose-hexose-1-phosphate uridylyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fukasawa, T.; Segawa, T.; Nogi, Y.
Uridine diphosphate glucose-4-epimerase and galactose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae
Methods Enzymol.
89
584-592
1982
Saccharomyces cerevisiae, Saccharomyces cerevisiae 106-3D
Tamada, Y.; Swanson, B.A.; Arabshahi, A.; Frey, P.A.
Preparation and characterization of a bifunctional fusion enzyme composed of UDP-galactose 4-epimerase and galactose-1-P uridylyltransferase
Bioconjug. Chem.
5
660-665
1994
Escherichia coli
Feusi, M.E.S.; Burton, J.D.; Williamson, J.D.; Pharr, D.M.
Galactosyl-sucrose metabolism and UDP-galactose pyrophosphorylase from Cucumis melo L. fruit
Physiol. Plant.
106
9-16
1999
Cucumis melo, Glycine max
-
Saito, S.; Ozutsumi, M.; Kurahashi, K.
Galactose 1-phosphate uridylyltransferase of Escherichia coli. II. Further purification and characterization
J. Biol. Chem.
242
2362-2368
1967
Escherichia coli
Arabshahi, A.; Brody, R.S.; Smallwood, A.; Tsai, T.C.; Frey, P.A.
Galactose-1-phosphate uridylyltransferase. Purification of the enzyme and stereochemical course of each step of the double-displacement mechanism
Biochemistry
25
5583-5589
1986
Escherichia coli
Wedekind, J.E.; Frey, P.A.; Rayment, I.
Crystallization and preliminary crystallographic analysis of galactose-1-phosphate uridylyltransferase from Escherichia coli
Acta Crystallogr. Sect. D
50
329-331
1994
Escherichia coli
Lee, L.; Kimura, A.; Tochikura, T.
Purification and properties of hexose 1-phosphate uridylyltransferase from Bifidobacterium bifidum
Agric. Biol. Chem.
42
723-730
1978
Bifidobacterium bifidum
-
Segawa, T.; Fukasawa, T.
The enzymes of the galactose cluster in Saccharomyces cerevisiae. Purification and characterization of galactose-1-phosphate uridylyltransferase
J. Biol. Chem.
254
10707-10709
1979
Saccharomyces cerevisiae, Saccharomyces cerevisiae 106-3D
Mayes, J.S.; Hansen, R.G.
Galactose 1-phosphate uridyl transferase
Methods Enzymol.
9
708-713
1966
Bos taurus, Homo sapiens
-
Mayes, J.S.
Purification, properties, and isozyme pattern of galactose-1-phosphate uridyl transferase from calf liver
Arch. Biochem. Biophys.
172
715-720
1976
Bos taurus
Helmer, G.R.; Williams, V.P.
Purification of galactose-1-phosphate uridylyltransferase from human placenta
Arch. Biochem. Biophys.
210
573-580
1981
Homo sapiens
Williams, V.P.; Helmer, G.R.; Fried, C.
Human galactose-1-phosphate uridylyltransferase: purification and comparison of the red blood cell and placental enzymes
Arch. Biochem. Biophys.
216
503-511
1982
Homo sapiens
Williams, V.P.
Purification and some properties of galactose 1-phosphate uridylyltransferase from human red cells
Arch. Biochem. Biophys.
191
182-191
1978
Homo sapiens
Kelly, S.; Sweeney, P.; Schedlbauer, L.
Galactose-l-phosphate uridyl transferase activity in red cells of various animal species
Experientia
37
550-553
1981
Chlorocebus aethiops, Bos taurus, Capra hircus, Cavia porcellus, Oryctolagus cuniculus, Equus caballus, Ovis aries, Homo sapiens, Rattus norvegicus, Cavia porcellus Hartley
Chowdhury, R.R.
Purification & some properties of galactose-1-phosphate uridylyl transferase from E. coli
Indian J. Biochem. Biophys.
16
273-277
1979
Escherichia coli
Ellis, G.; Goldberg, D.M.
Galactose-1-phosphate uridylytransferase. UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase, EC 2.7.7.12
Methods Enzym. Anal. , 3rd. Ed. (Bergmeyer, H. U. , ed. )
3
560-571
1983
Bos taurus, Homo sapiens
-
Banroques, J.; Gregori, C.; Schapira, F.
Purification and characterization of human erythrocyte uridylyl transferase
Biochim. Biophys. Acta
657
374-382
1981
Homo sapiens
Frey, P.A.; Wong, L.J.; Sheu, K.F.; Yang, S.L.
Galactose-1-phosphate uridylyltransferase: detection, isolation, and characterization of the uridylyl enzyme
Methods Enzymol.
87
20-36
1982
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens
Arabshahi, A.; Ruzicka, F.J.; Geeganage, S.; Frey, P.A.
Standard free energies for uridylyl group transfer by hexose-1-P uridylyltransferase and UDP-hexose synthase and for the hydrolysis of uridine 5'-phosphoimidazolate
Biochemistry
35
3426-3428
1996
Escherichia coli
Daude, N.; Lestage, J.; Reichardt, J.K.; Petry, K.G.
Expression of galactose-1-phosphate uridyltransferase in the anterior pituitary of rat during the estrous cycle
Neuroendocrinology
64
42-48
1996
Homo sapiens, Rattus norvegicus
Podskarbi, T.; Kohlmetz, T.; Gathof, B.S.; Kleinlein, B.; Bieger, W.P.; Gresser, U.; Shin, Y.S.
Molecular characterization of Duarte-1 and Duarte-2 variants of galactose-1-phosphate uridyltransferase
J. Inherit. Metab. Dis.
19
638-644
1996
Homo sapiens
Wells, L.; Fridovich-Keil, J.L.
Biochemical characterization of the S135L allele of galactose-1-phosphate uridylyltransferase associated with galactosaemia
J. Inherit. Metab. Dis.
20
633-642
1997
Homo sapiens
Ruzicka, F.J.; Geeganage, S.; Frey, P.A.
Kinetic mechanism of UDP-hexose synthase, a point variant of hexose-1-phosphate uridylyltransferase from Escherichia coli
Biochemistry
37
11385-11392
1998
Escherichia coli
Lai, K.; Langley, S.D.; Dembure, P.P.; Hjelm, L.N.; Elsas, L.J.2nd.
Duarte allele impairs biostability of galactose-1-phosphate uridyltransferase in human lymphoblasts
Hum. Mutat.
11
28-38
1998
Homo sapiens
Lai, K.; Willis, A.C.; Elsas, L.J.
The biochemical role of glutamine 188 in human galactose-1-phosphate uridyltransferase
J. Biol. Chem.
274
6559-6566
1999
Homo sapiens, Escherichia coli (P09148)
Leslie, N.D.; Bai, S.
Functional analysis of the mouse galactose-1-phosphate uridyl transferase (GALT)promoter
Mol. Genet. Metab.
72
31-38
2001
Mus musculus (Q03249)
Thoden, J.B.; Ruzicka, F.J.; Frey, P.A.; Rayment, I.; Holden, H.M.
Structural analysis of the H166G site-directed mutant of galactose 1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site
Biochemistry
36
1212-1222
1997
Escherichia coli (P09148)
Wedekind, J.E.; Frey, P.A.; Rayment, I.
The structure of nucleotidylated histidine-166 of galactose-1-phosphate uridylyltransferase provides insight into phosphoryl group transfer
Biochemistry
35
11560-11569
1996
Escherichia coli (P09148)
Davit-Spraul, A.; Pourci, M.L.; Ng, K.H.; Soni, T.; Lemonnier, A.
Regulatory effects of galactose on galactose-1-phosphate uridyltransferase activity on human hepatoblastoma HepG2 cells
FEBS Lett.
354
232-236
1994
Homo sapiens
Gross, W.; Schnarrenberger, C.
Purification and characterization of a galactose-1-phosphate: UDP-glucose uridyltransferase from the red alga Galdieria sulphuraria
Eur. J. Biochem.
234
258-263
1995
Galdieria sulphuraria
Ruzicka, F.J.; Wedekind, J.E.; Kim, J.; Rayment, I.; Frey, P.A.
Galactose-1-phosphate uridylyltransferase from Escherichia coli, a zinc and iron metalloenzyme
Biochemistry
34
5610-5617
1995
Escherichia coli
Shin, Y.S.; Zschocke, J.; Das, A.M.; Podskarbi, T.
Molecular and biochemical basis for variants and deficiency forms of galactose-1-phosphate uridyltransferase
J. Inherit. Metab. Dis.
22
327-329
1999
Homo sapiens
Quimby, B.B.; Wells, L.; Wilkinson, K.D.; Fridovich-Keil, J.L.
Functional requirements of the active site position 185 in the human enzyme galactose-1-phosphate uridylyltransferase
J. Biol. Chem.
271
26835-26842
1996
Escherichia coli, Homo sapiens
Elsevier, J.P.; Wells, L.; Quimby, B.B.; Fridovich-Keil, J.L.
Heterodimer formation and activity in the human enzyme galactose-1-phosphate uridylyltransferase
Proc. Natl. Acad. Sci. USA
93
7166-7171
1996
Homo sapiens
Geeganage, S.; Frey, P.A.
Transient kinetics of formation and reaction of the uridylyl-enzyme form of galactose-1-P uridylyltransferase and its Q168R-variant: insight into the molecular basis of galactosemia
Biochemistry
37
14500-14507
1998
Escherichia coli
Geeganage, S.; Frey, P.A.
Significance of metal ions in galactose-1-phosphate uridylyltransferase: an essential structural zinc and a nonessential structural iron
Biochemistry
38
13398-13406
1999
Escherichia coli (P09148)
Crews, C.; Wilkinson, K.D.; Wells, L.; Perkins, C.; Fridovich-Keil, J.L.
Functional consequence of substitutions at residue 171 in human galactose-1-phosphate uridylyltransferase
J. Biol. Chem.
275
22847-22853
2000
Homo sapiens
Geeganage, S.; Ling, V.W.; Frey, P.A.
Roles of two conserved amino acid residues in the active site of galactose-1-phosphate uridylyltransferase: an essential serine and a nonessential cysteine
Biochemistry
39
5397-5404
2000
Escherichia coli (P09148)
Riehman, K.; Crews, C.; Fridovich-Keil, J.L.
Relationship between genotype, activity, and galactose sensitivity in yeast expressing patient alleles of human galactose-1-phosphate uridylyltransferase
J. Biol. Chem.
276
10634-10640
2001
Homo sapiens
Christacos, N.C.; Fridovich-Keil, J.L.
Impact of patient mutations on heterodimer formation and function in human galactose-1-P uridylyltransferase
Mol. Genet. Metab.
76
319-326
2002
Homo sapiens
Geeganage, S.; Frey, P.A.
Galactose-1-phosphate uridylyltransferase: kinetics of formation and reaction of uridylyl-enzyme intermediate in wild-type and specifically mutated uridylyltransferases
Methods Enzymol.
354
134-148
2002
Escherichia coli, Homo sapiens
Coffee, B.; Hjelm, L.N.; DeLorenzo, A.; Courtney, E.M.; Yu, C.; Muralidharan, K.
Characterization of an unusual deletion of the galactose-1-phosphate uridyl transferase (GALT) gene
Genet. Med.
8
635-640
2006
Homo sapiens
Karas-Kuzelicki, N.; Pfeifer, V.; Lukac-Bajalo, J.
Synergistic effect of high lactase activity genotype and galactose-1-phosphate uridyl transferase (GALT) mutations on idiopathic presenile cataract formation
Clin. Biochem.
41
869-874
2008
Homo sapiens (P07902)
Prodan-Zitnik, I.; Karas-Kuzelicki, N.; Lukac-Bajalo, J.
Positive correlation between galactose-1-phosphate uridyltransferase (GALT) and UDP-galactose-4-epimerase (GALE) activities
Clin. Biochem.
42
1561-1564
2009
Homo sapiens
Carney, A.E.; Sanders, R.D.; Garza, K.R.; McGaha, L.A.; Bean, L.J.; Coffee, B.W.; Thomas, J.W.; Cutler, D.J.; Kurtkaya, N.L.; Fridovich-Keil, J.L.
Origins, distribution and expression of the Duarte-2 (D2) allele of galactose-1-phosphate uridylyltransferase
Hum. Mol. Genet.
18
1624-1632
2009
Homo sapiens (P07902)
Satomura, T.; Hiraki, A.; Kawai, T.; Kawakami, R.; Ohshima, T.; Sakuraba, H.
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a galactose 1-phosphate uridylyltransferase from the hyperthermophilic archaeon Pyrobaculum aerophilum
Acta Crystallogr. Sect. F
68
330-332
2012
Pyrobaculum aerophilum (Q8ZXN7), Pyrobaculum aerophilum DSM 7523 (Q8ZXN7)
Lindhout, M.; Rubio-Gozalbo, M.E.; Bakker, J.A.; Bierau, J.
Direct non-radioactive assay of galactose-1-phosphate:uridyltransferase activity using high performance liquid chromatography
Clin. Chim. Acta
411
980-983
2010
Homo sapiens
McCorvie, T.J.; Timson, D.J.
The structural and molecular biology of type I galactosemia: enzymology of galactose 1-phosphate uridylyltransferase
IUBMB Life
63
694-700
2011
Escherichia coli, Homo sapiens
Li, M.; Sui, Z.; Kang, K.; Zhang, X.; Zhu, M.; Yan, B.
Cloning and analysis of the galactose-1-phosphate uridylyltransferase (galt) gene of Gracilariopsis lemaneiformis (Rhodophyta) and correlation between gene expression and agar synthesis
J. Appl. Phycol.
22
157-164
2010
Gracilariopsis lemaneiformis
-
Siow, R.; Teo, S.; Ho, W.; Shukor, M.; Phang, S.; Ho, C.
Molecular cloning and biochemical characterization of galactose-1-phosphate uridylyltransferase from Gracilaria changii (Rhodophyta)
J. Phycol.
48
155-162
2012
Gracilaria changii
De Bruyn, F.; Beauprez, J.; Maertens, J.; Soetaert, W.; De Mey, M.
Unraveling the Leloir pathway of Bifidobacterium bifidum: significance of the uridylyltransferases
Appl. Environ. Microbiol.
79
7028-7035
2013
Bifidobacterium bifidum (M4M7K7), Bifidobacterium bifidum (M4MCS2), Bifidobacterium bifidum, Bifidobacterium bifidum PRL2010 (M4M7K7), Bifidobacterium bifidum PRL2010 (M4MCS2)
Balakrishnan, B.; Chen, W.; Tang, M.; Huang, X.; Cakici, D.D.; Siddiqi, A.; Berry, G.; Lai, K.
Galactose-1 phosphate uridylyltransferase (GalT) gene: A novel positive regulator of the PI3K/Akt signaling pathway in mouse fibroblasts
Biochem. Biophys. Res. Commun.
470
205-212
2016
Mus musculus (A2AMS3)
McCorvie, T.J.; Gleason, T.J.; Fridovich-Keil, J.L.; Timson, D.J.
Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia
Biochim. Biophys. Acta
1832
1279-1293
2013
Homo sapiens (P07902), Homo sapiens
Choi, R.; Jo, K.I.; Ko, D.H.; Lee, D.H.; Song, J.; Jin, D.K.; Ki, C.S.; Lee, S.Y.; Kim, J.W.; Lee, Y.W.; Park, H.D.
Novel GALT variations and mutation spectrum in the Korean population with decreased galactose-1-phosphate uridyltransferase activity
BMC Med. Genet.
15
94
2014
Homo sapiens (P07902), Homo sapiens
McCorvie, T.J.; Kopec, J.; Pey, A.L.; Fitzpatrick, F.; Patel, D.; Chalk, R.; Shrestha, L.; Yue, W.W.
Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase
Hum. Mol. Genet.
25
2234-2244
2016
Homo sapiens (P07902)
Papachristoforou, R.; Petrou, P.P.; Sawyer, H.; Williams, M.; Drousiotou, A.
A novel large deletion encompassing the whole of the galactose-1-phosphate uridyltransferase (GALT) gene and extending into the adjacent interleukin 11 receptor alpha (IL11RA) gene causes classic galactosemia associated with additional phenotypic abnormalities
JIMD Rep.
12
91-98
2014
Homo sapiens (P07902), Homo sapiens
Tran, T.T.; Liu, Y.; Zwick, M.E.; Ramachandran, D.; Cutler, D.J.; Huang, X.; Berry, G.T.; Fridovich-Keil, J.L.
A de novo variant in galactose-1-P uridylyltransferase (GALT) leading to classic galactosemia
JIMD Rep.
19
1-6
2015
Homo sapiens (P07902), Homo sapiens
Janes, V.; Grabany, S.; Delbrouck, J.; Vincent, S.P.; Gottschalk, J.; Elling, L.; Hanisch, F.G.
Fluorinated galactoses inhibit galactose-1-phosphate uridyltransferase and metabolically induce galactosemia-like phenotypes in HEK-293 cells
Cells
9
607
2020
Homo sapiens (P07902)
Kumar S, U.; Kumar D, T.; R, S.; Doss C, G.P.; Zayed, H.
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
Comput. Biol. Med.
117
103583
2020
Homo sapiens (P07902)
McCorvie, T.J.; Kopec, J.; Pey, A.L.; Fitzpatrick, F.; Patel, D.; Chalk, R.; Shrestha, L.; Yue, W.W.
Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase
Hum. Mol. Genet.
25
2234-2244
2016
Homo sapiens (P07902)
Chen, W.; Caston, R.; Balakrishnan, B.; Siddiqi, A.; Parmar, K.; Tang, M.; Feng, M.; Lai, K.
Assessment of ataxia phenotype in a new mouse model of galactose-1 phosphate uridylyltransferase (GALT) deficiency
J. Inherit. Metab. Dis.
40
131-137
2017
Mus musculus (Q03249)
Rasmussen, S.A.; Daenzer, J.M.I.; MacWilliams, J.A.; Head, S.T.; Williams, M.B.; Geurts, A.M.; Schroeder, J.P.; Weinshenker, D.; Fridovich-Keil, J.L.
A galactose-1-phosphate uridylyltransferase-null rat model of classic galactosemia mimics relevant patient outcomes and reveals tissue-specific and longitudinal differences in galactose metabolism
J. Inherit. Metab. Dis.
43
518-528
2020
Rattus norvegicus (P43424)
Quan, K.; Zhu, Z.; Cao, S.; Zhang, F.; Miao, C.; Wen, X.; Huang, X.; Wen, Y.; Wu, R.; Yan, Q.; Huang, Y.; Ma, X.; Han, X.; Zhao, Q.
Escherichia coli-derived outer membrane vesicles deliver galactose-1-phosphate uridyltransferase and yield partial protection against Actinobacillus pleuropneumoniae in mice
J. Microbiol. Biotechnol.
28
2095-2105
2018
Actinobacillus pleuropneumoniae, Actinobacillus pleuropneumoniae L20
De Lucca, M.; Casique, L.; Cornejo, V.
Alterations of galactose metabolism caused by deficit of galactose-1-phosphate uridylyltransferase activity An overview of galactosemia type I
Molecular Nutrition: Carbohydrates (ed. Patel V.B.)
2019
369-395
2019
Homo sapiens (P07902)
-
Zhang, F.; Zhao, Q.; Quan, K.; Zhu, Z.; Yang, Y.; Wen, X.; Chang, Y.F.; Huang, X.; Wu, R.; Wen, Y.; Yan, Q.; Huang, Y.; Ma, X.; Han, X.; Cao, S.
Galactose-1-phosphate uridyltransferase (GalT), an in vivo-induced antigen of Actinobacillus pleuropneumoniae serovar 5b strain L20, provided immunoprotection against serovar 1 strain MS71
PLoS ONE
13
e0198207
2018
Actinobacillus pleuropneumoniae, Actinobacillus pleuropneumoniae L20
Ohshida, T.; Hayashi, J.; Yoneda, K.; Ohshima, T.; Sakuraba, H.
Unique active site formation in a novel galactose 1-phosphate uridylyltransferase from the hyperthermophilic archaeon Pyrobaculum aerophilum
Proteins
88
669-678
2020
Pyrobaculum aerophilum (Q8ZXN7), Pyrobaculum aerophilum ATCC 51768 (Q8ZXN7)
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