Information on EC 2.7.7.12 - UDP-glucose-hexose-1-phosphate uridylyltransferase

Reaction Schemes

hideshow

UDP-alpha-D-glucose

+

alpha-D-galactose 1-phosphate

=

alpha-D-glucose 1-phosphate

+

UDP-alpha-D-galactose

+

=

+

Synonyms
uridyltransferase, galt enzyme, uridyl transferase, hexose-1-phosphate uridylyltransferase, udp-glucose-hexose-1-phosphate uridylyltransferase, hexose 1-phosphate uridylyltransferase, galactose-1-phosphate:uridyltransferase, udp-glucose:alpha-d-galactose-1-phosphate uridylyltransferase, udpglucose:alpha-d-galactose-1-phosphate uridylyltransferase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

galactose 1-phosphate uridylyltransferase

5 entries

galactose-1-phosphate uridyl transferase

2 entries

galactose-1-phosphate uridyltransferase

4 entries

galactose-1-phosphate uridylyltransferase

6 entries

galactose-1-phosphate:uridyltransferase

Homo sapiens

-

-

722074

GALT

12 entries

GALT enzyme

Homo sapiens

-

-

673857

GalT1

2 entries

GalT2

2 entries

hexose 1-phosphate uridyltransferase

-

-

-

-

hexose 1-phosphate uridylyltransferase

-

-

-

-

hexose-1-phosphate uridylyltransferase

-

-

-

-

UDP-Glc-hexose-1-P uridylyltransferase

Cucumis melo

-

-

642821

UDP-glucose-hexose-1-P uridylyltransferase

Cucumis melo

-

-

642821

UDPGlc:Gal-1-P uridylyltransferase

3 entries

UDPglucose-hexose-1-phosphate uridylyltransferase

3 entries

UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase

-

-

-

-

uridine diphosphoglucose:alpha-D-galactose-1-phosphate uridilyltransferase

Homo sapiens

-

-

642830, 642831, 642832

uridyl transferase

-

-

-

-

uridyltransferase

-

-

-

-

uridylylgalactose-1-P uridylyltransferase

Escherichia coli

-

-

642838

uridylyltransferase, hexose 1-phosphate

-

-

-

-

galactose 1-phosphate uridylyltransferase

Escherichia coli

-

-

722427

galactose 1-phosphate uridylyltransferase

Homo sapiens

-

-

722427

galactose 1-phosphate uridylyltransferase

Homo sapiens

P07902

-

761227

galactose 1-phosphate uridylyltransferase

Pyrobaculum aerophilum

Q8ZXN7

-

762352

galactose 1-phosphate uridylyltransferase

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

-

-

galactose-1-phosphate uridyl transferase

Homo sapiens

-

-

673857

galactose-1-phosphate uridyl transferase

Homo sapiens

P07902

-

697365, 760919

galactose-1-phosphate uridyltransferase

Actinobacillus pleuropneumoniae

-

-

762239

galactose-1-phosphate uridyltransferase

Actinobacillus pleuropneumoniae L20

-

-

-

galactose-1-phosphate uridyltransferase

Homo sapiens

-

-

703249

galactose-1-phosphate uridyltransferase

Homo sapiens

P07902

-

760856

galactose-1-phosphate uridylyltransferase

Gracilaria changii

-

-

723038

galactose-1-phosphate uridylyltransferase

Gracilariopsis lemaneiformis

-

-

722471

galactose-1-phosphate uridylyltransferase

Homo sapiens

-

-

642830

galactose-1-phosphate uridylyltransferase

Homo sapiens

P07902

-

703954, 761946

galactose-1-phosphate uridylyltransferase

Pyrobaculum aerophilum

Q8ZXN7

-

721231

galactose-1-phosphate uridylyltransferase

Pyrobaculum aerophilum DSM 7523

Q8ZXN7

-

-

GALT

Actinobacillus pleuropneumoniae

-

-

761685, 762239

GALT

Actinobacillus pleuropneumoniae L20

-

-

-

GALT

Escherichia coli

-

-

642863, 722427

GALT

Escherichia coli

P09148

-

642858, 642860

GALT

Gracilaria changii

-

-

723038

GALT

Gracilariopsis lemaneiformis

-

-

722471

GALT

Homo sapiens

-

-

642840, 642841, 642842, 642844, 642845, 642851, 642855, 642856, 642859, 642861, 722074, 722427

GALT

Homo sapiens

P07902

-

738946, 760856, 760919, 761227

GALT

Mus musculus

Q03249

-

642847

GALT

Pyrobaculum aerophilum

Q8ZXN7

-

721231, 762352

GALT

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

-

-

GALT

Pyrobaculum aerophilum DSM 7523

Q8ZXN7

-

-

GalT1

Bifidobacterium bifidum

M4MCS2

-

737498

GalT1

Bifidobacterium bifidum PRL2010

M4MCS2

-

-

GalT2

Bifidobacterium bifidum

M4M7K7

-

737498

GalT2

Bifidobacterium bifidum PRL2010

M4M7K7

-

-

UDPGlc:Gal-1-P uridylyltransferase

Escherichia coli

-

-

642838

UDPGlc:Gal-1-P uridylyltransferase

Homo sapiens

-

-

642838

UDPGlc:Gal-1-P uridylyltransferase

Saccharomyces cerevisiae

-

-

642838

UDPglucose-hexose-1-phosphate uridylyltransferase

Escherichia coli

-

-

642838

UDPglucose-hexose-1-phosphate uridylyltransferase

Homo sapiens

-

-

642838

UDPglucose-hexose-1-phosphate uridylyltransferase

Saccharomyces cerevisiae

-

-

642838

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

26 entries

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gln168 engages hydrogen bonding with the phosphoryl oxygen of the UMP moiety in the covalently formed reaction intermediate UMP-enzyme, UMP is bound to His166

Escherichia coli

-

642857, 642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gln168 engages hydrogen bonding with the phosphoryl oxygen of the UMP moiety in the covalently formed reaction intermediate UMP-enzyme, UMP is bound to His166

Escherichia coli

P09148

642849

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

ping pong bi bi kinetic model

Escherichia coli

-

642838, 642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

double-displacement mechanism

Escherichia coli

-

642824, 642838

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

double-displacement mechanism

Escherichia coli

P09148

642849, 642858, 642860

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pro185 has a critical role in facilitating the transferase reaction

Escherichia coli

-

642855

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pro185 has a critical role in facilitating the transferase reaction

Homo sapiens

-

642855

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

mutant H166G, random equilibrium, intrinsically ordered substrate binding mechanism, ping pong kinetics

Escherichia coli

-

642843

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site triad: His164, His165, and His166, with His166 as nulceophilic catalyst, highly conserved

Escherichia coli

-

642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site triad: His164, His165, and His166, with His166 as nulceophilic catalyst, highly conserved

Escherichia coli

P09148

642858

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site nucleophil H166

Escherichia coli

-

642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site nucleophil H166

Homo sapiens

-

642842, 642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site nucleophil H166

Escherichia coli

P09148

642848

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

formation of a stable nucleotidylated histidine intermediate

Escherichia coli

-

642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

formation of a stable nucleotidylated histidine intermediate

Escherichia coli

P09148

642849

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

amino acid residues of both subunits contribute to the active site

Escherichia coli

P09148

642848

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

SH-group in the active site

Escherichia coli

-

642834

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

mechanism, modeling

Homo sapiens

-

642845

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site: C160SNPHP165

Escherichia coli

-

642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site structure, enzyme complexed with UDP-galactose

Escherichia coli

-

642863

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

active site structure, enzyme complexed with UDP-galactose

Escherichia coli

P09148

642860

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

mechanism model

Escherichia coli

P09148

642849

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

reaction mechanism of Duarte mutant N314D

Homo sapiens

-

642844

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

ping-pong catalytic mechanism, a UMP group is transferred from UDP-glucose to His186 in the active site of the enzyme, overview

Homo sapiens

-

722427

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

ping-pong catalytic mechanism, overview. A UMP group is transferred from UDP-glucose to His166 in the active site of the enzyme

Escherichia coli

-

722427

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

-

-

-

-

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

nucleotidyl group transfer

-

-

-

-

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PATHWAY SOURCE

PATHWAYS

BRENDA

degradation of hexoses

KEGG

Amino sugar and nucleotide sugar metabolism, Galactose metabolism

MetaCyc

D-galactose degradation I (Leloir pathway), stachyose degradation

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SYSTEMATIC NAME

IUBMB Comments

UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase

-

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CAS REGISTRY NUMBER

COMMENTARY

9026-21-5

-

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

2 entries

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

2 entries

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

3 entries

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

13 entries

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

2 entries

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

2 entries

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

6 entries

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

2 entries

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

2 entries

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

38 entries

UDP-glucose + D-galactose 1-phosphate

D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

703249

Substrates: -
Products: -

?

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

4 entries

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

2 entries

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

2 entries

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

2 entries

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

2 entries

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

2 entries

UTP + alpha-D-galactose 1-phosphate

diphosphate + UDP-alpha-D-galactose

Homo sapiens

-

722074

Substrates: -
Products: -

?

additional information

?

-

18 entries

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

Gracilaria changii

-

723038

Substrates: -
Products: -

r

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

Homo sapiens

P07902

737739

Substrates: -
Products: -

r

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

Bifidobacterium bifidum

-

642826

Substrates: no activity
Products: -

?

CDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + CDP-galactose

Bos taurus

-

642828

Substrates: low activity
Products: -

?

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Bifidobacterium bifidum

-

642826

Substrates: reaction at 60% the rate of UDP-glucose
Products: -

r

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Bos taurus

-

642828

Substrates: 8.7% activity compared to UDP-glucose
Products: -

r

TDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + TDP-galactose

Escherichia coli

-

642823

Substrates: no activity
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Bifidobacterium bifidum

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Escherichia coli

-

722427

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilaria changii

-

723038

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilariopsis lemaneiformis

-

722471

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Homo sapiens

-

722427

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Homo sapiens

P07902

737739

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

721231

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

762352

Substrates: the enzyme is involved in galactose metabolism via the Leloir pathway
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

762352

Substrates: binding of the glucose moiety of the substrate, but not the UDP moiety, gives rise to a large structural change around the active site
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

762352

Substrates: the enzyme is involved in galactose metabolism via the Leloir pathway
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

762352

Substrates: binding of the glucose moiety of the substrate, but not the UDP moiety, gives rise to a large structural change around the active site
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum DSM 7523

Q8ZXN7

721231

Substrates: -
Products: -

r

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

Bifidobacterium bifidum

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-galactosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-galactosamine

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

Bifidobacterium bifidum

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alpha-D-glucose + N-acetyl-alpha-D-glucosamine 1-phosphate

alpha-D-glucose 1-phosphate + UDP-N-acetyl-alpha-D-glucosamine

Bifidobacterium bifidum PRL2010

M4M7K7, M4MCS2

737498

Substrates: -
Products: -

?

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: stereochemistry: enzyme accepts (Rp)-UDP-alphaS-glucose converting it to (Rp)-UDP-alphaS-galactose, the overall retention of configuration arises from inversion in each of the two steps
Products: (Rp1)-UDP-alphaS-galactose

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: stereochemistry: enzyme accepts (Rp)-UDP-alphaS-glucose converting it to (Rp)-UDP-alphaS-galactose, the overall retention of configuration arises from inversion in each of the two steps
Products: i.e. uridine 5'-(1-thiodiphosphate) galactose

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: i.e. uridine 5'-(1-thiodiphosphate) glucose
Products: (Rp1)-UDP-alphaS-galactose

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: i.e. uridine 5'-(1-thiodiphosphate) glucose
Products: i.e. uridine 5'-(1-thiodiphosphate) galactose

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: (Rp1)-UDP-alphaS-glucose
Products: (Rp1)-UDP-alphaS-galactose

r

UDP-alphaS-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alphaS-galactose

Escherichia coli

-

642824

Substrates: (Rp1)-UDP-alphaS-glucose
Products: i.e. uridine 5'-(1-thiodiphosphate) galactose

r

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

UDP-glucose + 2-methylimidazole

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

UDP-glucose + 4-methylimidazole

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bifidobacterium bifidum

-

642826

Substrates: highly specific for the substrates
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bifidobacterium bifidum

-

642826

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

642828, 642829, 642833, 642835

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

642828

Substrates: important step in galactose metabolism
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Capra hircus

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cavia porcellus

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cavia porcellus Hartley

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Chlorocebus aethiops

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cucumis melo

-

642821

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cucumis melo

-

642821

Substrates: central enzyme in the classical Lelior pathway, but not in galactose metabolsim
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Equus caballus

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642824, 642825, 642834, 642838, 642839, 642853, 642855, 642863

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

P09148

642848, 642849, 642858, 642860

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642824

Substrates: stereochemistry: enzyme accepts (Rp)-UDP-alphaS-glucose converting it to (Rp)-UDP-alphaS-galactose, the overall retention of configuration arises from inversion in each of the two steps
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642824, 642857, 642863

Substrates: formation of a covalent uridylyl-enzyme intermediate, i.e. UMP-enzyme
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642823

Substrates: highly specific for the substrates
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

2335

Substrates: recombinant bifunctional chimeric fusion protein
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642838

Substrates: 2nd step of Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642857

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Galdieria sulphuraria

-

642852

Substrates: highly specific for the substrates
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Galdieria sulphuraria

-

642852

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Glycine max

-

642821

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642828, 642830, 642831, 642832, 642833, 642835, 642836, 642838, 642840, 642841, 642842, 642844, 642851, 642855, 642856, 642859, 642861, 642862, 642863

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642845

Substrates: 2-step mechanism
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840

Substrates: galactosemia with altered activity of the follicle-stimulating hormone FSH
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642828

Substrates: important step in galactose metabolism
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642854

Substrates: essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant
Products: -

?

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840, 642841, 642842, 642844, 642862

Substrates: essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642831, 642838

Substrates: 2nd step of Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840

Substrates: involved in the biosynthesis of follicle-stimulating hormone FSH
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Mus musculus

Q03249

642847

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Mus musculus

Q03249

642847

Substrates: transcriptional regulation is complex and not directly induced by substrate levels
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Oryctolagus cuniculus

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Ovis aries

-

642833

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Rattus norvegicus

-

642833, 642840

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

2309, 642827, 642838

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

642838

Substrates: 2nd step of Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae 106-3D

-

2309, 642827

Substrates: -
Products: -

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642863

Substrates: wild-type, 800fold reduced activity compared to normal reaction intermediate uridylyl-enzyme as substrate, pH-dependent
Products: -

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642843

Substrates: mutant H166A
Products: -

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642839, 642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

UDP-glucose + imidazole

uridine 5'-phosphoimidazole + alpha-D-glucose 1-phosphate

Escherichia coli

-

642839, 642843

Substrates: equilibrium study and constants
Products: -

r

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

uridine 5'-phospho-2,4,5-trimethylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2,4,5-trimethylimidazole

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

uridine 5'-phospho-2-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 2-methylimidazole

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

uridine 5'-phospho-3-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 3-methylimidazole

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

uridine 5'-phospho-4-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 4-methylimidazole

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

Escherichia coli

-

642843

Substrates: kinetic study
Products: -

r

uridine 5'-phospho-5-methylimidazole + alpha-D-glucose 1-phosphate

UDP-glucose + 5-methylimidazole

Escherichia coli

-

642843

Substrates: mutant H166G, i.e. UDP-hexose synthase
Products: -

r

additional information

?

-

Bifidobacterium bifidum

-

642826

Substrates: no activity with CDP-glucose
Products: -

?

additional information

?

-

Bifidobacterium bifidum

-

642826

Substrates: no activity with ADP-glucose or GDP-glucose
Products: -

?

additional information

?

-

Bifidobacterium bifidum

M4M7K7

737498

Substrates: no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate
Products: -

?

additional information

?

-

Bifidobacterium bifidum

M4MCS2

737498

Substrates: no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate
Products: -

?

additional information

?

-

Bifidobacterium bifidum

-

737498

Substrates: no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate
Products: -

?

additional information

?

-

Bifidobacterium bifidum PRL2010

M4M7K7

737498

Substrates: no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate
Products: -

?

additional information

?

-

Bifidobacterium bifidum PRL2010

M4MCS2

737498

Substrates: no substrates: N-acetyl-alpha-D-galactose 1-phosphate, N-acetyl-alpha-D-glucose 1-phosphate
Products: -

?

additional information

?

-

Bos taurus

-

642828

Substrates: no activity with fructose 1-phosphate and galactose 6-phosphate
Products: -

?

additional information

?

-

Bos taurus

-

642828

Substrates: no activity with ADP-glucose or GDP-glucose
Products: -

?

additional information

?

-

Bos taurus

-

642828

Substrates: no activity with xylose 1-phosphate, and IDP-glucose
Products: -

?

additional information

?

-

Escherichia coli

-

642823

Substrates: no activity with fructose 1-phosphate and galactose 6-phosphate
Products: -

?

additional information

?

-

Escherichia coli

-

642823

Substrates: no activity with ADP-glucose or GDP-glucose
Products: -

?

additional information

?

-

Escherichia coli

-

642823

Substrates: no activity with ribose 1-phosphate and mannose 6-phosphate
Products: -

?

additional information

?

-

Escherichia coli

-

722427

Substrates: the enzyme has a strict requirement for UDP-glucose or UDP-galactose as substrates, while GDP-glucose, ADP-glucose, TDP-glucose, CDP-glucose, UDPxylose, and UDP-mannose are all unable to support activity
Products: -

?

additional information

?

-

Galdieria sulphuraria

-

642852

Substrates: no activity with UDP-xylose, ADP-glucose, and galactose 6-phosphate
Products: -

?

additional information

?

-

Homo sapiens

-

642828

Substrates: -
Products: -

?

additional information

?

-

Homo sapiens

-

642861

Substrates: inverse relationship between enzyme activity and galactose sensitivity
Products: -

?

additional information

?

-

Homo sapiens

-

722427

Substrates: the enzyme has a strict requirement for UDP-glucose or UDP-galactose as substrates, while GDP-glucose, ADP-glucose, TDP-glucose, CDP-glucose, UDPxylose, and UDP-mannose are all unable to support activity
Products: -

?

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

8 entries

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

17 entries

UTP + alpha-D-galactose 1-phosphate

diphosphate + UDP-alpha-D-galactose

Homo sapiens

-

722074

Substrates: -
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Escherichia coli

-

722427

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilaria changii

-

723038

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Gracilariopsis lemaneiformis

-

722471

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Homo sapiens

-

722427

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

721231

Substrates: -
Products: -

r

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum

Q8ZXN7

762352

Substrates: the enzyme is involved in galactose metabolism via the Leloir pathway
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum ATCC 51768

Q8ZXN7

762352

Substrates: the enzyme is involved in galactose metabolism via the Leloir pathway
Products: -

?

UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose

Pyrobaculum aerophilum DSM 7523

Q8ZXN7

721231

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bifidobacterium bifidum

-

642826

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Bos taurus

-

642828

Substrates: important step in galactose metabolism
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Cucumis melo

-

642821

Substrates: central enzyme in the classical Lelior pathway, but not in galactose metabolsim
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642824, 642863

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642838

Substrates: 2nd step of Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Escherichia coli

-

642857

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Galdieria sulphuraria

-

642852

Substrates: involved in conversion of galactose into alpha-D-glucose 1-phosphate, Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Glycine max

-

642821

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642863

Substrates: -
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840

Substrates: galactosemia with altered activity of the follicle-stimulating hormone FSH
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642828

Substrates: important step in galactose metabolism
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642854

Substrates: essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant
Products: -

?

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840, 642841, 642842, 642844, 642862

Substrates: essential enzyme in galactose metabolism, deficiency causes genetic disorder galactosemia, e.g. mutant Duarte variant
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642831, 642838

Substrates: 2nd step of Leloir pathway
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Homo sapiens

-

642840

Substrates: involved in the biosynthesis of follicle-stimulating hormone FSH
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Mus musculus

Q03249

642847

Substrates: transcriptional regulation is complex and not directly induced by substrate levels
Products: -

r

UDP-glucose + alpha-D-galactose 1-phosphate

alpha-D-glucose 1-phosphate + UDP-galactose

Saccharomyces cerevisiae

-

642838

Substrates: 2nd step of Leloir pathway
Products: -

r

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METALS and IONS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Fe2+

14 entries

Mg2+

Gracilaria changii

-

required

723038

Zinc

Homo sapiens

P07902

zinc binding stabilizes the enzyme

761227

Zn2+

14 entries

additional information

4 entries

Fe2+

Escherichia coli

-

required

642853, 642857

Fe2+

Escherichia coli

-

can be replaced by other metal ions

642863

Fe2+

Escherichia coli

-

contains 0.67 mol per mol of wild-type enzyme, 0.59 mol per mol of mutant H166A enzyme, and 0.7-0.76 mol per mol of mutant H166G enzyme

642843

Fe2+

Escherichia coli

-

0.7 mol per mol of subunit

642853

Fe2+

Escherichia coli

P09148

0.7 mol per mol of subunit

642858, 642860

Fe2+

Escherichia coli

-

contains 0.67 mol per mol of wild-type enzyme subunit, 0.44 mol per mol of mutant Q168R subunit

642857

Fe2+

Escherichia coli

-

not essential

642863

Fe2+

Escherichia coli

P09148

not essential

642858

Fe2+

Escherichia coli

-

coordinated in a square pyramidal geometry with His296, His298, and Glu182 in a bidentate coordination providing the base ligands and His281 providing the axial ligand

642863

Fe2+

Escherichia coli

P09148

coordinated in a square pyramidal geometry with His296, His298, and Glu182 in a bidentate coordination providing the base ligands and His281 providing the axial ligand

642858

Fe2+

Escherichia coli

P09148

mutant C160A: 0.5 mol per mol of subunit, mutant S161A: 0.4 mol per mol of subunit

642860

Fe2+

Escherichia coli

-

the enzyme homodimer contains one zinc (II) and one iron (II) ion per subunit, pyramidial iron-binding site, structure, overview

722427

Fe2+

Gracilaria changii

-

required, enzyme-bound

723038

Fe2+

Gracilariopsis lemaneiformis

-

the iron-binding site involves residues H338, H360, H360 and G229

722471

Zn2+

Escherichia coli

-

required

642853, 642857, 642863

Zn2+

Escherichia coli

P09148

required

642858

Zn2+

Escherichia coli

-

contains 1.21 mol per mol of wild-type enzyme, 1.33 mol per mol of mutant H166A enzyme, and 0.99-1.16 mol per mol of mutant H166G enzyme

642843

Zn2+

Escherichia coli

-

1.2 mol tightly bound per mol of subunit

642853, 642857

Zn2+

Escherichia coli

P09148

1.2 mol tightly bound per mol of subunit

642858, 642860

Zn2+

Escherichia coli

-

0.91 mol per mol of mutant Q168R subunit

642857

Zn2+

Escherichia coli

-

can be replaced by other metal ions

642863

Zn2+

Escherichia coli

-

coordinated in a tetrahedral geometry by Cys52, Cys55, His115, and His164

642863

Zn2+

Escherichia coli

P09148

coordinated in a tetrahedral geometry by Cys52, Cys55, His115, and His164

642858

Zn2+

Escherichia coli

P09148

mutant C160A: 1.3 mol per mol of subunit, mutant S161A: 1.2 mol per mol of subunit like the wild-type

642860

Zn2+

Escherichia coli

-

the enzyme homodimer contains one zinc (II) and one iron (II) ion per subunit, tetrahedral zinc binding site, structure, overview

722427

Zn2+

Gracilaria changii

-

required, enzyme-bound

723038

Zn2+

Gracilariopsis lemaneiformis

-

the zinc site involves residues D76, G79, L154, and H173

722471

Zn2+

Homo sapiens

-

the zinc co-orientating residues are not conserved and therefore, it may only bind one metal ion per monomer

722427

additional information

Bos taurus

-

no requirement for divalent cations

642828

additional information

Bos taurus

-

no requirement for divalent cations

642829

additional information

Escherichia coli

P09148

metal content of mutants

642858

additional information

Escherichia coli

-

enzyme contains no Ca, Cd, Cu, Mo, Ni, Co, Mn, As, Pb, or Se

642853

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