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EC unknown
The expected taxonomic range for this enzyme is: Cupriavidus necator
Synonyms
PPK2c, more
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NTP + (phosphate)n = NDP + (phosphate)n+1
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NTP:polyphosphate phosphotransferase
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ADP + (phosphate)n+1
ATP + (phosphate)n
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Substrates: about 80% compared to the activity with UDP. Additional formation of adenosine tetraphosphate
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ATP + (phosphate)n
ADP + (phosphate)n+1
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Substrates: 98% compared to the activity with CTP
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CDP + (phosphate)n+1
CTP + (phosphate)n
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Substrates: about 80% compared to the activity with UDP. Additional formation of cytidine tetraphosphate
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CTP + (phosphate)n
CDP + (phosphate)n+1
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Substrates: -
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dTDP + (phosphate)n+1
dTTP + (phosphate)n
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Substrates: about 80% compared to the activity with UDP. Additional formation of deoxythymidine tetraphosphate
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dTTP + (phosphate)n
dTDP + (phosphate)n+1
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Substrates: 98% compared to the activity with CTP
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GDP + (phosphate)n+1
GTP + (phosphate)n
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Substrates: about 95% compared to the activity with UDP. Additional formation of guanidine tetraphosphate
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GTP + (phosphate)n
GDP + (phosphate)n+1
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Substrates: about 90% compared to the activity with CTP
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UDP + (phosphate)n+1
UTP + (phosphate)n
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Substrates: additional formation of uridine tetraphosphate
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UTP + (phosphate)n
UDP + (phosphate)n+1
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Substrates: about 90% compared to the activity with CTP
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additional information
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Substrates: thiamine pyrophosphate is not used as a substrate by PPK2c
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Ca2+
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divalent cation required for activity. 5 mM CaCl2 show 48% of the activity compared to 5 mM MnCl2
Mg2+
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divalent cation required for activity. 5 mM MgCl2 show 84% of the activity compared to 5 mM MnCl2
Mn2+
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divalent cation required for activity. Highest activity with 5 mM MnCl2
Zn2+
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divalent cation required for activity. 5 mM ZnCl2 show 21% of the activity compared to 5 mM MnCl2
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6.5 - 10.5
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pH 6.5: about 85% of maximal activity, pH 10.5: about 70% of maximal activity
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10 - 40
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10°C: about 55% of maximal activity, 28°C-40°C: maximal activity, 45°C: less than 5% of maximal activcity
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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40
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rapid inactivation above
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expression in Escherichia coli JM109
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synthesis
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the enzyme can used to replenish ATP in ATP-consuming biochemical reactions
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Hildenbrand, J.C.; Teleki, A.; Jendrossek, D.
A universal polyphosphate kinase PPK2c of Ralstonia eutropha accepts purine and pyrimidine nucleotides including uridine diphosphate
Appl. Microbiol. Biotechnol.
104
6659-6667
2020
Cupriavidus necator
brenda
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