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Information on EC 2.7.4.21 - inositol-hexakisphosphate 5-kinase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FLT2

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EC Tree
IUBMB Comments
Three mammalian isoforms are known to exist.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9FLT2
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The enzyme appears in selected viruses and cellular organisms
Synonyms
ip6k1, ip6k2, ip6k3, ppip5k1, ppip5k2, insp6k2, inositol hexakisphosphate kinase, inositol hexakisphosphate kinase 1, ihpk2, atvip1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
inositol polyphosphate kinase
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ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
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diphosphoinositol pentakisphosphate synthetase
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inositol hexakisphosphate kinase
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inositol polyphosphate kinase
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InsP6 kinase
InsP6K3
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IP6 kinase
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kinase (phosphorylating), inositol hexakisphosphate
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho-group transfer
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase
Three mammalian isoforms are known to exist.
CAS REGISTRY NUMBER
COMMENTARY hide
176898-37-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,3-bis(diphosphate) 2,4,5,6-tetrakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1-triphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
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-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
show the reaction diagram
-
-
-
?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol 1-diphosphate pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol 5-diphosphate 2,3,4,5,6-pentakisphosphate
ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate
show the reaction diagram
-
-
-
-
?
ATP + 1D-myo-inositol hexakisphosphate
ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
male, isozymes AtIPK2alpha and AtIPK2beta have overlapping expression in male gametophyte
Manually annotated by BRENDA team
male, isozymes AtIPK2alpha and AtIPK2beta have overlapping expression in male gametophyte
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
expressing either catalytically inactive or substrate specificity-altered variants of AtIPK2beta cannot rescue the male gametophyte and embryogenesis defects of the atipk2alpha/atipk2beta double mutant. The mutation of AtIPK2alpha and AtIPK2beta results in severely reduced transmission of male gametophyte as a result of abnormal pollen development and defective pollen tube guidance. Overexpression or reduction of the expression of AtIPK2alpha and AtIPK2beta reveal their roles in auxiliary shoot branching, abiotic stress responses and root growth. Phenotype, detailed overview
physiological function
the enzyme is a key component for inositol polyphosphate turnover. The kinase activity of AtIPK2 is required for pollen development, pollen tube guidance and embryogenesis, requirement of inositol polyphosphate signaling in plant sexual reproduction. Isozymes AtIPK2alpha and AtIPK2beta act redundantly during pollen development, pollen tube guidance and embryogenesis
malfunction
expressing either catalytically inactive or substrate specificity-altered variants of AtIPK2beta cannot rescue the male gametophyte and embryogenesis defects of the atipk2alpha/atipk2beta double mutant. The mutation of AtIPK2alpha and AtIPK2beta results in severely reduced transmission of male gametophyte as a result of abnormal pollen development and defective pollen tube guidance. Overexpression or reduction of the expression of AtIPK2alpha and AtIPK2beta reveal their roles in auxiliary shoot branching, abiotic stress responses and root growth. Phenotype, detailed overview
physiological function
additional information
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
IPMKB_ARATH
300
0
33487
Swiss-Prot
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D292A
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site-directed mutagenesis, inactive mutant
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene vip1, phylogenetic analysis, AtVip1 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant
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gene vip2, phylogenetic analysis, AtVip2 restores InsP7 synthesis in a Saccharomyces cerevisiae kcs1 mutant
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Desai, M.; Rangarajan, P.; Donahue, J.L.; Williams, S.P.; Land, E.S.; Mandal, M.K.; Phillippy, B.Q.; Perera, I.Y.; Raboy, V.; Gillaspy, G.E.
Two inositol hexakisphosphate kinases drive inositol pyrophosphate synthesis in plants
Plant J.
80
642-653
2014
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Manually annotated by BRENDA team
Zhan, H.; Zhong, Y.; Yang, Z.; Xia, H.
Enzyme activities of Arabidopsis inositol polyphosphate kinases AtIPK2? and AtIPK2? are involved in pollen development, pollen tube guidance and embryogenesis.
Plant J.
82
758-771
2015
Arabidopsis thaliana (Q9FLT2), Arabidopsis thaliana (Q9LY23)
Manually annotated by BRENDA team