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Information on EC 2.7.4.18 - farnesyl-diphosphate kinase
for references in articles please use BRENDA:EC2.7.4.18
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EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.4 Phosphotransferases with a phosphate group as acceptor
2.7.4.18 farnesyl-diphosphate kinase
IUBMB Comments
ADP can also act as donor.
The expected taxonomic range for this enzyme is: Fusarium fujikuroi
showSynonyms
farnesyl pyrophosphate kinase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
farnesyl pyrophosphate kinase
-
-
-
-
kinase (phosphorylating), farnesyl diphosphate
-
-
-
-
kinase, farnesyl diphosphate (phosphorylating)
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + farnesyl diphosphate = ADP + farnesyl triphosphate
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:farnesyl-diphosphate phosphotransferase
ADP can also act as donor.
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CAS REGISTRY NUMBER
COMMENTARY
50936-43-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxy-adenosine 5'-phosphate + trans-farnesyl diphosphate
2'-deoxyadenosine + trans-farnesyl triphosphate
-
Substrates: 24.1% of the activity with ATP
Products: -
Products: -
?
2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate
2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
2'-deoxy-uridine 5'-phosphate + trans-farnesyl diphosphate
2'-deoxyuridine + trans-farnesyl triphosphate
-
Substrates: 6% of the activity with ATP
Products: -
Products: -
?
AMP + trans-farnesyl diphosphate
adenosine + trans-farnesyl triphosphate
-
Substrates: 6% of activity compared to ATP
Products: -
Products: -
?
ATP + trans-farnesyl diphosphate
?
-
Substrates: possibly involved in control of biosynthesis of terpenoids in Gibberella fujikuroi
Products: -
Products: -
?
GDP + trans-farnesyl diphosphate
GMP + trans-farnesyl triphosphate
-
Substrates: 8% of activity compared to ATP
Products: -
Products: -
?
GMP + trans-farnesyl diphosphate
CDP + trans-farnesyl triphosphate
-
Substrates: 8.5% of the activity with ATP
Products: -
Products: -
?
2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate
2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
-
Substrates: 9% of activity compared to ATP
Products: -
Products: -
?
2'-deoxy-adenosine 5'-triphosphate + trans-farnesyl diphosphate
2'-deoxyadenosine 5'-diphosphate + trans-farnesyl triphosphate
-
Substrates: 9% of activity compared to ATP
Products: -
Products: -
?
ADP + trans-farnesyl diphosphate
AMP + trans-farnesyl triphosphate
-
Substrates: 5'-ADP, 32% of activity compared to ATP
Products: -
Products: -
?
ADP + trans-farnesyl diphosphate
AMP + trans-farnesyl triphosphate
-
Substrates: 5'-ADP, 32% of activity compared to ATP
Products: -
Products: -
?
AMP + trans-farnesyl triphosphate
?
-
Substrates: possible physiological role in biosynthesis of C15 and higher terpenoids in Gibberella fujikuroi
Products: -
Products: -
?
AMP + trans-farnesyl triphosphate
ADP + ATP + trans-farnesyl diphosphate
-
Substrates: -
Products: ADP and ATP are produced when the reaction is performed in the presence of AMP. ADP is the immediate product of the reaction. The formation of ATP is a second order reaction with respect to farnesyl triphosphate and lags the formation of ADP
Products: ADP and ATP are produced when the reaction is performed in the presence of AMP. ADP is the immediate product of the reaction. The formation of ATP is a second order reaction with respect to farnesyl triphosphate and lags the formation of ADP
r
AMP + trans-farnesyl triphosphate
ADP + ATP + trans-farnesyl diphosphate
-
Substrates: -
Products: ADP and ATP are produced when the reaction is performed in the presence of AMP. ADP is the immediate product of the reaction. The formation of ATP is a second order reaction with respect to farnesyl triphosphate and lags the formation of ADP
Products: ADP and ATP are produced when the reaction is performed in the presence of AMP. ADP is the immediate product of the reaction. The formation of ATP is a second order reaction with respect to farnesyl triphosphate and lags the formation of ADP
r
AMP + trans-farnesyl triphosphate
ADP + trans-farnesyl diphosphate
-
Substrates: 5'-AMP, 82.8% of the activity with ATP
Products: -
Products: -
?
AMP + trans-farnesyl triphosphate
ADP + trans-farnesyl diphosphate
-
Substrates: 5'-AMP, 82.8% of the activity with ATP
Products: -
Products: -
?
ATP + trans-farnesyl diphosphate
ADP + trans-farnesyl triphosphate
-
Substrates: -
Products: -
Products: -
?
ATP + trans-farnesyl diphosphate
ADP + trans-farnesyl triphosphate
-
Substrates: -
Products: -
Products: -
r
ATP + trans-farnesyl diphosphate
ADP + trans-farnesyl triphosphate
-
Substrates: -
Products: -
Products: -
r
ATP + trans-farnesyl diphosphate
ADP + trans-farnesyl triphosphate
-
Substrates: -
Products: -
Products: -
?
CMP + trans-farnesyl diphosphate
GDP + trans-farnesyl triphosphate
-
Substrates: 10% of the activity with ATP
Products: -
Products: -
?
CMP + trans-farnesyl diphosphate
GDP + trans-farnesyl triphosphate
-
Substrates: 10% of the activity with ATP
Products: -
Products: -
?
CTP + trans-farnesyl diphosphate
?
-
Substrates: 9% of activity compared to ATP
Products: -
Products: -
?
CTP + trans-farnesyl diphosphate
?
-
Substrates: 9% of activity compared to ATP
Products: -
Products: -
?
UTP + trans-farnesyl diphosphate
?
-
Substrates: 20% of activity compared to ATP
Products: -
Products: -
?
UTP + trans-farnesyl diphosphate
?
-
Substrates: 20% of activity compared to ATP
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + trans-farnesyl diphosphate
?
-
Substrates: possibly involved in control of biosynthesis of terpenoids in Gibberella fujikuroi
Products: -
Products: -
?
AMP + trans-farnesyl triphosphate
?
-
Substrates: possible physiological role in biosynthesis of C15 and higher terpenoids in Gibberella fujikuroi
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mg2+
Mn2+
-
substituted for Mg2+ in reaction ATP + trans-farnesyl diphosphate: about 36% of activity compared to Mg2+
Mg2+
-
absolute requirement for reaction AMP + trans-farnesyl triphosphate, Mn2+ is ineffective in this reaction
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shechter, I.
Phosphate transfer from trans-farnesyl triphosphate to AMP in Gibberella fujikuroi
Biochim. Biophys. Acta
362
233-244
1974
Fusarium fujikuroi, Fusarium fujikuroi LiLy-I
brenda
Shechter, I.
Biosynthesis of trans-farnesyl triphosphate in Gibberella fujikuroi
Biochim. Biophys. Acta
316
222-234
1973
Fusarium fujikuroi, Fusarium fujikuroi LiLy-I
brenda
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Release 2023.1 (January 2023)
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