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ATP + 2-ethylbutyrate
ADP + 2-ethylbutyryl phosphate
ATP + 2-methylbutyrate
ADP + 2-methylbutyryl phosphate
ATP + 2-methylpentanoate
ADP + 2-methylpentanoyl phosphate
ATP + 3-methylpentanoate
ADP + 3-methylpentanoyl phosphate
-
-
-
-
?
ATP + acetate
ADP + acetyl phosphate
ATP + butanoate
ADP + butanoyl phosphate
ATP + hexanoate
ADP + hexanoyl phosphate
ATP + isobutanoate
ADP + isobutanoyl phosphate
ATP + isobutyrate
ADP + isobutyroyl phosphate
ATP + isovalerate
ADP + isopentanoyl phosphate
-
32% of the activity with butanoate
-
-
?
ATP + isovalerate
ADP + isovaleroyl phosphate
ATP + pentanoate
ADP + pentanoyl phosphate
-
best substrate
-
-
?
ATP + propionate
ADP + propanoyl phosphate
ATP + propionate
ADP + propionyl phosphate
ATP + valerate
ADP + pentanoyl phosphate
ATP + valerate
ADP + valeroyl phosphate
100% activity
-
-
?
ATP + vinyl acetate
ADP + vinylacetyl phosphate
-
23% of the activity with butanoate
-
-
?
additional information
?
-
ATP + 2-ethylbutyrate
ADP + 2-ethylbutyryl phosphate
2.0% activity compared to valerate
-
-
?
ATP + 2-ethylbutyrate
ADP + 2-ethylbutyryl phosphate
2.0% activity compared to valerate
-
-
?
ATP + 2-ethylbutyrate
ADP + 2-ethylbutyryl phosphate
-
-
-
-
?
ATP + 2-methylbutyrate
ADP + 2-methylbutyryl phosphate
22.8% activity compared to valerate
-
-
?
ATP + 2-methylbutyrate
ADP + 2-methylbutyryl phosphate
22.8% activity compared to valerate
-
-
?
ATP + 2-methylbutyrate
ADP + 2-methylbutyryl phosphate
-
-
-
-
?
ATP + 2-methylpentanoate
ADP + 2-methylpentanoyl phosphate
7.8% activity compared to valerate
-
-
?
ATP + 2-methylpentanoate
ADP + 2-methylpentanoyl phosphate
-
-
-
-
?
ATP + acetate
ADP + acetyl phosphate
-
6% of the activity with butanoate
-
-
?
ATP + acetate
ADP + acetyl phosphate
-
poor substrate
-
-
?
ATP + acetate
ADP + acetyl phosphate
3.8% activity compared to valerate
-
-
?
ATP + acetate
ADP + acetyl phosphate
3.8% activity compared to valerate
-
-
?
ATP + acetate
ADP + acetyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
r
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
r
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
52.3% activity compared to valerate
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
52.3% activity compared to valerate
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
third best substrate
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
?
ATP + butanoate
ADP + butanoyl phosphate
-
-
-
r
ATP + hexanoate
ADP + hexanoyl phosphate
16.3% activity compared to valerate
-
-
?
ATP + hexanoate
ADP + hexanoyl phosphate
-
-
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
54% of the activity with butanoate
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
-
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
50% of the activity with butanoate
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
-
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
-
-
?
ATP + isobutanoate
ADP + isobutanoyl phosphate
-
-
-
r
ATP + isobutyrate
ADP + isobutyroyl phosphate
43.1% activity compared to valerate
-
-
?
ATP + isobutyrate
ADP + isobutyroyl phosphate
-
second best substrate
-
-
?
ATP + isovalerate
ADP + isovaleroyl phosphate
32.1% activity compared to valerate
-
-
?
ATP + isovalerate
ADP + isovaleroyl phosphate
-
-
-
-
?
ATP + propionate
ADP + propanoyl phosphate
-
43% of the activity with butanoate
-
-
?
ATP + propionate
ADP + propanoyl phosphate
-
-
-
-
?
ATP + propionate
ADP + propanoyl phosphate
-
as active as butanoate
-
-
?
ATP + propionate
ADP + propanoyl phosphate
-
-
-
-
?
ATP + propionate
ADP + propionyl phosphate
60.8% activity compared to valerate
-
-
?
ATP + propionate
ADP + propionyl phosphate
60.8% activity compared to valerate
-
-
?
ATP + propionate
ADP + propionyl phosphate
-
-
-
-
?
ATP + valerate
ADP + pentanoyl phosphate
-
89% of the activity with butanoate
-
-
?
ATP + valerate
ADP + pentanoyl phosphate
-
-
-
-
?
ATP + valerate
ADP + pentanoyl phosphate
-
12% of the activity with butanoate
-
-
?
ATP + valerate
ADP + pentanoyl phosphate
-
-
-
-
?
additional information
?
-
-
the enzyme is not regulated by the end-product, its specific activity is constant during the fermentation
-
-
?
additional information
?
-
-
semi-automated reverse engineering algorithm. The reconstructed metabolic network was used to create a genome-scale model that correctly characterized the butyrate kinase knock-out and the asolventogenic M5 pSOL1 megaplasmid degenerate strains. Systematic gene knock-out simulations performed to identify a set of genes encoding clostridial enzymes essential for growth in silico.
-
-
?
additional information
?
-
-
overexpressed PhaP1 from Ralstonia eutropha H16 affected poly(3-mercaptopropionate) [poly(3MP)] and poly(3-hydroxybutyrate) [poly(3HB)] accumulation in recombinant Escherichia coli, which expresses the non-natural BPEC pathway consisting of butyrate kinase and phosphotransbutyrylase from Clostridium acetobutylicum and PHA synthase from Thiococcus pfennigii
-
-
?
additional information
?
-
-
enzyme is involved in production of butyrate
-
-
?
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Yarlett, N.; Lloyd, D.; Williams, A.G.
Butyrate formation from glucose by the rumen protozoon Dasytricha ruminantium
Biochem. J.
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187-192
1985
Dasytricha ruminantium
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Cloning and expression of Clostridium acetobutylicum phosphotransbutyrylase and butyrate kinase genes in Escherichia coli
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Clostridium acetobutylicum
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Exploitation of butyrate kinase and phosphotransbutyrylase from Clostridium acetobutylicum for the in vitro biosynthesis of poly(hydroxyalkanoic acid)
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Clostridium acetobutylicum
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Enzymic phosphorylation of butyrate
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Clostridium butyricum
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Butyrate kinase from Clostridium acetobutylicum
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Clostridium acetobutylicum
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Regulation of acetate kinase and butyrate kinase by acids in Clostridium acetobutylicum
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-
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Role of butyryl phosphate in the energy metabolism of Clostridium tetanomorphum
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Clostridium butyricum, Clostridium pasteurianum, Clostridium tetanomorphum, Clostridium tyrobutyricum
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2
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brenda
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Relation between phylogenetic position, lipid metabolism and butyrate production by different Butyrivibrio-like bacteria from the rumen
Antonie van Leeuwenhoek
91
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Butyrivibrio fibrisolvens, Butyrivibrio proteoclasticus, Butyrivibrio hungatei, Butyrivibrio fibrisolvens ATCC 19171 / D1, Butyrivibrio proteoclasticus B316T, Butyrivibrio hungatei JK615T
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Butyric acid and hydrogen production by Clostridium tyrobutyricum ATCC 25755 and mutants
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Clostridium tyrobutyricum
-
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Heat-shock protein HspA mimics the function of phasins sensu stricto in recombinant strains of Escherichia coli accumulating polythioesters or polyhydroxyalkanoates
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153
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2007
Clostridium acetobutylicum
brenda
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Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
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101
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brenda
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Isolation and characterisation of new putative probiotic bacteria from human colonic flora
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97
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Enterococcus durans
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Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
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10
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Clostridium acetobutylicum, Clostridium acetobutylicum M5
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Structural correlations of activity of Clostridium acetobutylicum ATCC 824 butyrate kinase isozymes
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46
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Clostridium acetobutylicum
-
brenda
Diao, J.; Hasson, M.S.
Crystal structure of butyrate kinase 2 from Thermotoga maritima, a member of the ASKHA superfamily of phosphotransferases
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191
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brenda
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Open and closed conformations reveal induced fit movements in butyrate kinase 2 activation
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80
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Thermotoga maritima (Q9X278), Thermotoga maritima
brenda
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Utilization of multiple substrates by butyrate kinase from Listeria monocytogenes
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1862
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Listeria monocytogenes, Listeria monocytogenes 10403S
brenda
Yoo, M.; Croux, C.; Meynial-Salles, I.; Soucaille, P.
Metabolic flexibility of a butyrate pathway mutant of Clostridium acetobutylicum
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40
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Clostridium acetobutylicum (Q45829), Clostridium acetobutylicum (Q97II1), Clostridium acetobutylicum
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CRISPR interference-mediated metabolic engineering of Corynebacterium glutamicum for homo-butyrate production
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Clostridium acetobutylicum
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Characterization of a butyrate kinase from Desulfovibrio vulgaris str. Hildenborough
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Wu, Q.; Liu, T.; Zhu, L.; Huang, H.; Jiang, L.
Insights from the complete genome sequence of Clostridium tyrobutyricum provide a platform for biotechnological and industrial applications
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44
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no activity in Clostridium tyrobutyricum CCTCC W428
brenda