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Information on EC 2.7.2.4 - aspartate kinase
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EC Tree
2.7.2.4 aspartate kinaseIUBMB Comments
The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction.
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Word Map
- 2.7.2.4
- corynebacterium
- glutamicum
-
threonine-sensitive
- l-lysine
- l-threonine
- dihydrodipicolinate
-
i-homoserine
- diaminopimelate
- semialdehyde
-
feedback-resistant
-
aspartate-derived
-
feedback-insensitive
- aec
- l-isoleucine
- s-2-aminoethyl-l-cysteine
-
lysine-producing
- flavum
- thialysine
- meso-diaminopimelate
- ectoine
- synthesis
- agriculture
- medicine
- nutrition
- food industry
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
aspartokinase, aspartate kinase, thra1, aspartokinase ii, aspartokinase iii, aspartokinase i, akiii, thra2, ak iii, ak ii, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AK
AK III
AK-HseDH
AK-R7
AK-ts31d
AK1
AK3
AKbeta
AKII
AKIII
Ask
aspartate kinase
aspartate kinase (phosphorylating)
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-
-
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aspartate kinase II
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also acts as homoserine dehydrogenase (EC 1.1.1.3)
aspartic kinase
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-
-
-
aspartokinase
aspartokinase 1-homoserine dehydrogenase 1
aspartokinase 2
aspartokinase II
aspartokinase III
aspartokinase-homoserine dehydrogenase
beta-aspartokinase
-
-
-
-
BT
BTT
HOM3-R7 product
HOM3-ts31d product
lysC
MtbAKbeta
thrA
additional information
AK
-
-
-
-
AK-HseDH
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bifunctional enzyme with aspartate kinase and homoserine dehydrogenase activities
aspartokinase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + L-aspartate = ADP + 4-phospho-L-aspartate
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-
-
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ATP + L-aspartate = ADP + 4-phospho-L-aspartate
The enzyme from E. coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
phospho group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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, Biosynthesis of secondary metabolites, Cysteine and methionine metabolism, Cysteine and methionine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Glycine, serine and threonine metabolism, Monobactam biosynthesis, Monobactam biosynthesis, Monobactam biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
ATP:L-aspartate 4-phosphotransferase
The enzyme from Escherichia coli is a multifunctional protein, which also catalyses the reaction of EC 1.1.1.3 homoserine dehydrogenase. This is also the case for two of the four isoenzymes in Arabidopsis thaliana. The equilibrium constant strongly favours the reaction from right to left, i.e. the non-physiological direction of reaction.
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CAS REGISTRY NUMBER
COMMENTARY
9012-50-4
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + DL-threo-3-methyl aspartate
ADP + 3-methyl-4-phosphoaspartate
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aspartokinase III
-
-
?
ATP + L-aspartic acid amide
ADP + 4-phospho-L-aspartic acid amide
-
aspartokinase III
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-
?
ATP + N-acetyl-L-aspartate
ADP + N-acetyl-4-phospho-L-aspartate
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aspartokinase III
-
-
?
ATP + N-chloroacetyl-L-aspartate
ADP + N-chloroacetyl-4-phospho-L-aspartate
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aspartokinase III
-
-
?
ATP + N-formyl-L-aspartate
ADP + N-formyl-4-phospho-L-aspartate
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aspartokinase III
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
first and third step of the synthesis of methionine, catalyzed by a bifunctional enzyme
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step of a branched biosynthetic pathway for L-lysine, L-threonine, L-isoleucine and L-methionine, regulated by the end products through feedback inhibition, the 3 aspartate kinases I, II and II are regulated by different end products
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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physiological role of aspartokinase II is to supply precursors for the amino acid pool
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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first specific step in the biosynthesis of L-lysine, L-threonine and L-methionine
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first specific step in the biosynthesis of L-lysine, L-threonine and L-methionine
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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-
-
r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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first step common to the biosynthesis of L-lysine, L-threonine, isoleucine and methionine
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
transfer of the gamma-phosphate group of ATP to aspartate, substrate binding site structures, overview
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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-
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?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
Deinococcus radiodurans R1 / ATCC 13939 / DSM 20539
disruption analyes of Deinococcus radiodurans AK indicates that the AK is not used for lysine biosynthesis, but for threonine and methionine biosyntheses
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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maximum velocity of the reverse reaction is only one-twelfth that of the forward reaction, but has the advantage of using commercial substrates
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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part of the aspartate pathway of amino acid biosynthesis
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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aspartate kinase activity
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
Escherichia coli B / ATCC 11303
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first step in the branched biosynthetic pathway for the synthesis of L-lysine, L-methionine, L-threonine, L-isoleucine and diaminopimelic acid
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
-
-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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-
-
-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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first and key enzyme of the aspartate pathway leading to the biosynthesis of essential amino acids L-lysine and L-threonine
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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branched pathway for biosynthesis of isoleucine, threonine, homoserine, methionine and lysine
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r
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
L-aspartate binds to this recombinant enzyme in two different orientations
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-
?
ATP + L-aspartate
ADP + 4-phospho-L-aspartate
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first enzyme of aspartic acid metabolic pathway, leads to synthesis of lysine, threonine, methionine and isoleucine
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r