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Information on EC 2.7.2.1 - acetate kinase and Organism(s) Mycoplasma pneumoniae and UniProt Accession P75245

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EC Tree
IUBMB Comments
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate , others have found that the enzyme can also use propanoate as a substrate, but more slowly . Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate .
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This record set is specific for:
Mycoplasma pneumoniae
UNIPROT: P75245
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The taxonomic range for the selected organisms is: Mycoplasma pneumoniae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
acetate kinase, ack, acetokinase, acka2, acka1, ackase, urkinase, atp-ecoak, acetic kinase, stacka, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetate kinase (phosphorylating)
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acetic kinase
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acetokinase
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AK
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:acetate phosphotransferase
Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate [4], others have found that the enzyme can also use propanoate as a substrate, but more slowly [7]. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate [9].
CAS REGISTRY NUMBER
COMMENTARY hide
9027-42-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acetate
ADP + acetyl phosphate
show the reaction diagram
ATP + acetate
ADP + acetyl phosphate
show the reaction diagram
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + acetate
ADP + acetyl phosphate
show the reaction diagram
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-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
wild-type strain M129 and mutant strains
SwissProt
Manually annotated by BRENDA team
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli, reporter system used that allows cloning of promoter fragments in front of a promoterless lacZ gene and insertion in Mycoplasma pneumoniae
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ingram-Smith, C.; Martin, S.R.; Smith, K.S.
Acetate kinase: not just a bacterial enzyme
Trends Microbiol.
14
249-253
2006
Mesoplasma florum, Histoplasma capsulatum, Cupriavidus necator, Aspergillus fumigatus, Aspergillus nidulans, Bacillus subtilis, Borreliella burgdorferi, Chaetomium globosum, Chlamydomonas reinhardtii, Phanerodontia chrysosporium, Coccidioides immitis, Coprinopsis cinerea, Cryptococcus neoformans, Streptococcus pneumoniae, Entamoeba histolytica, Enterococcus faecalis, Salmonella enterica, Fusarium graminearum, Helicobacter pylori, Lactobacillus acidophilus, Lactococcus lactis, Listeria monocytogenes, Pyricularia grisea, Methanosarcina mazei, Methanosarcina thermophila, Staphylococcus aureus, Mycoplasma pneumoniae, Neurospora crassa, Oceanobacillus iheyensis, Phytophthora sojae, Sclerotinia sclerotiorum, Trichoderma reesei, Ustilago maydis, Methanosarcina acetivorans, Parastagonospora nodorum, Uncinocarpus reesii, Phytophthora ramorum
Manually annotated by BRENDA team
Halbedel, S.; Eilers, H.; Jonas, B.; Busse, J.; Hecker, M.; Engelmann, S.; Stuelke, J.
Transcription in Mycoplasma pneumoniae: analysis of the promoters of the ackA and ldh genes
J. Mol. Biol.
371
596-607
2007
Mycoplasma pneumoniae (P75245), Mycoplasma pneumoniae
Manually annotated by BRENDA team