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Information on EC 2.7.13.3 - histidine kinase and Organism(s) Streptococcus pneumoniae and UniProt Accession Q8DPL8

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.13 Protein-histidine kinases
                2.7.13.3 histidine kinase
IUBMB Comments
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
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This record set is specific for:
Streptococcus pneumoniae
UNIPROT: Q8DPL8
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Word Map
The taxonomic range for the selected organisms is: Streptococcus pneumoniae
The enzyme appears in selected viruses and cellular organisms
Synonyms
histidine kinase, sensor kinase, sensor protein, phytochrome a, ethylene receptor, sensor histidine kinase, bacteriophytochrome, ornithine decarboxylase antizyme, chemotaxis protein, hybrid histidine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
histidine kinase
histidine protein kinase
-
VncS, histidine kinase
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine N-phosphotransferase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
99283-67-7
protein-histidine kinases, EC 2.7.13.1, EC 2.7.13.2, and EC 2.7.13.3 are not distinguished in Chemical Abstracts
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
enzyme is involved in early steps of competence regulation
-
-
?
ATP + VicR protein L-histidine
ADP + VicR protein N-phospho-L-histidine
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + a protein
ADP + a phosphoprotein
show the reaction diagram
enzyme is involved in early steps of competence regulation
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-(3,4-dimethoxyphenyl)-N-[(5-phenylfuran-2-yl)methyl]ethanaminium
-
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[4-(thiophen-2-ylmethoxy)benzyl]ethanaminium
-
2-[[(4-amino-1,2,5-oxadiazol-3-yl)carbonyl]amino]-N-[[5-(3-chloro-4-methoxyphenyl)furan-2-yl]methyl]ethanaminium
-
N,N'-bis(1H-benzimidazol-2-yl)biphenyl-4,4'-diamine
-
N-[[5-(2-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
N-[[5-(3-chloro-4-fluorophenyl)furan-2-yl]methyl]-3-[(1-methyl-1H-tetrazol-5-yl)sulfanyl]propan-1-aminium
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain ATCC BAA-255/R6
SwissProt
Manually annotated by BRENDA team
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guenzi, E.; Gasc, A.M.; Sicard, M.A.; Hakenbeck, R.
A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae
Mol. Microbiol.
12
505-515
1994
Streptococcus pneumoniae (P0A4I6), Streptococcus pneumoniae
Manually annotated by BRENDA team
Hoskins, J.; Alborn, W.E., Jr.; Arnold, J.; Blaszczak, L.C.; et al.
Genome of the bacterium Streptococcus pneumoniae strain R6
J. Bacteriol.
183
5709-5717
2001
Streptococcus pneumoniae (P0A4I6), Streptococcus pneumoniae (Q8DMW4), Streptococcus pneumoniae (Q8DN03), Streptococcus pneumoniae (Q8DN65), Streptococcus pneumoniae (Q8DNC1), Streptococcus pneumoniae (Q8DNX7), Streptococcus pneumoniae (Q8DPL8), Streptococcus pneumoniae (Q8DQN7), Streptococcus pneumoniae (Q8DQR9), Streptococcus pneumoniae (Q8DR46), Streptococcus pneumoniae (Q8DRK0), Streptococcus pneumoniae (Q9F2F5)
Manually annotated by BRENDA team
Tettelin, H.; Nelson, K.E.; Paulsen, I.T.; Eisen, J.A.; et al.
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae
Science
293
498-506
2001
Streptococcus pneumoniae (P0A4I6)
Manually annotated by BRENDA team
Reichmann, P.; Hakenbeck, R.
Allelic variation in a peptide-inducible two-component system of Streptococcus pneumoniae
FEMS Microbiol. Lett.
190
231-236
2000
Streptococcus pneumoniae (Q9F2F5)
Manually annotated by BRENDA team
Li, N.; Wang, F.; Niu, S.; Cao, J.; Wu, K.; Li, Y.; Yin, N.; Zhang, X.; Zhu, W.; Yin, Y.
Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)
BMC Microbiol.
9
129
2009
Streptococcus pneumoniae (Q9S1J9), Streptococcus pneumoniae, Streptococcus pneumoniae D39 / ATCC 7466 (Q9S1J9)
Manually annotated by BRENDA team