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Information on EC 2.7.13.3 - histidine kinase and Organism(s) Staphylococcus aureus

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.13 Protein-histidine kinases
                2.7.13.3 histidine kinase
IUBMB Comments
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
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Select one or more organisms in this record: ?
This record set is specific for:
Staphylococcus aureus
Word Map
The taxonomic range for the selected organisms is: Staphylococcus aureus
The enzyme appears in selected viruses and cellular organisms
Synonyms
33277 FimS, AaHSK1, adaptive-response sensory-kinase A, aerobic respiration control sensor protein arcB, aerobic respiration control sensor protein arcB homolog, aerobic respiration control sensor/response regulatory protein, AfGcHK, AgrC, AHK, AHK5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
receptor histidine kinase
-
-
sensor histidine kinase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein-L-histidine N-phosphotransferase
This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine). A number of histones can act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
99283-67-7
protein-histidine kinases, EC 2.7.13.1, EC 2.7.13.2, and EC 2.7.13.3 are not distinguished in Chemical Abstracts
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
in vitro autokinase activity of recombinant truncated enzyme mutant AgrCTM5-6C in N,N-dimethyldodecylamine N-oxide proteoliposomes
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + protein L-histidine
ADP + protein N-phospho-L-histidine
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
required
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(4-[2-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)methanaminium chloride
-
-
2-(4-[2-[4-(4-chlorobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)ethanaminium chloride
-
-
2-(4-[2-[4-(4-cyanobenzyl)-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl]ethoxy]phenyl)ethanaminium chloride
-
-
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
auto-inducible protein I
-
dose-dependent activation by autoinducing peptide
-
DTT
-
required
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
-
kinase activity of recombinant enzyme AgrCTM5-6C in N,N-dimethyldodecylamine N-oxide micelles or proteoliposomes
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
an integral membrane protein, protein transmembrane topology in proteoliposomes is determined using membrane-impermeable and membrane-permeable thiol-reactive reagents, overview
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
WALK_STAAU
415
0
47818
Swiss-Prot
-
SRRB_STAAU
583
2
66106
Swiss-Prot
-
A0A0Z0Z682_STAAU
554
2
63928
TrEMBL
-
A0A380EKY6_STAAU
157
0
17622
TrEMBL
-
A0A7D8E6E8_STAAU
85
1
9974
TrEMBL
-
A0A7D8IA80_STAAU
84
0
9378
TrEMBL
-
A0A5C8XC75_STAAU
292
0
33234
TrEMBL
-
A0A6G4N4G2_STAAU
551
2
63517
TrEMBL
-
A0A5C8XAZ0_STAAU
513
4
59265
TrEMBL
-
A0A6B5I754_STAAU
608
2
69884
TrEMBL
-
A0A380DJP6_STAAU
94
1
10970
TrEMBL
-
A0A1Q8DD01_STAAU
488
2
56731
TrEMBL
-
A0A142G9G0_STAAU
451
2
52363
TrEMBL
-
A0A1L6C0A3_STAAU
347
2
40002
TrEMBL
-
A0A068A3K4_STAAU
583
2
66076
TrEMBL
-
A0A6H4I6Q3_STAAU
537
4
62214
TrEMBL
-
Q2VG18_STAAU
430
6
49881
TrEMBL
-
A0A6B5HKE4_STAAU
298
1
34736
TrEMBL
-
A0A1Q8DD40_STAAU
369
0
41779
TrEMBL
-
A0A658WZE4_STAAU
351
2
39695
TrEMBL
-
A0A6J9IUE2_STAAU
885
4
102201
TrEMBL
-
A0A1L6C0C0_STAAU
608
2
69938
TrEMBL
-
A0A6B5LZG1_STAAU
457
2
52362
TrEMBL
-
A0A0U1MPI5_STAAU
554
2
63877
TrEMBL
-
A0A6B5HQ05_STAAU
457
2
52442
TrEMBL
-
A0A380DHJ9_STAAU
317
0
36964
TrEMBL
-
A0A6H3V7I9_STAAU
885
4
102191
TrEMBL
-
A0A6B0B9T6_STAAU
242
0
28193
TrEMBL
-
A0A641A666_STAAU
553
2
63774
TrEMBL
-
W8U6X2_STAAU
584
6
65029
TrEMBL
-
D2J6A4_STAAU
200
0
22848
TrEMBL
-
A0A6B5S3I8_STAAU
344
0
39134
TrEMBL
-
A0A163UZE5_STAAU
363
6
41834
TrEMBL
-
A0A1L6C0D8_STAAU
608
2
69905
TrEMBL
-
A0A6B0CGH8_STAAU
457
2
52382
TrEMBL
-
A0A1L6C0B3_STAAU
347
2
40057
TrEMBL
-
A0A6J9U446_STAAU
554
2
63889
TrEMBL
-
A0A6B0CTT5_STAAU
457
2
52402
TrEMBL
-
A0A6B5K8L9_STAAU
337
2
39255
TrEMBL
-
A0A6H3XG35_STAAU
608
2
69877
TrEMBL
-
A0A6H3YT26_STAAU
430
6
49965
TrEMBL
-
A0A659IAU5_STAAU
363
5
41671
TrEMBL
-
A0A2H4UXJ1_STAAU
608
2
69892
TrEMBL
-
A0A5C8X4S7_STAAU
368
0
42178
TrEMBL
-
A0A6G4JLY7_STAAU
280
2
32071
TrEMBL
-
A0A1L6C0I7_STAAU
608
2
69938
TrEMBL
-
A0A380E1Y4_STAAU
233
0
26519
TrEMBL
-
A0A6H3ZLQ4_STAAU
430
6
49965
TrEMBL
-
A0A0C5HV46_STAAU
363
5
41631
TrEMBL
-
A0A168T1Y0_STAAU
344
0
39033
TrEMBL
-
H9BRP9_STAAU
351
2
39714
TrEMBL
-
A0A6B5LTZ5_STAAU
370
0
41827
TrEMBL
-
A0A1L6C0E0_STAAU
608
2
69944
TrEMBL
-
A0A6B5Q3T4_STAAU
346
2
41093
TrEMBL
-
A0A0U1MRG1_STAAU
347
2
40061
TrEMBL
-
A0A2S6DB07_STAAU
451
2
52395
TrEMBL
-
A0A2S6DQQ4_STAAU
553
2
63823
TrEMBL
-
A0A5C8XAS8_STAAU
275
0
30937
TrEMBL
-
A0A7D8CAH0_STAAU
313
2
36202
TrEMBL
-
A0A6B5IE86_STAAU
357
2
41725
TrEMBL
-
A0A380DPE0_STAAU
116
0
13598
TrEMBL
-
A0A380DUZ6_STAAU
256
0
28836
TrEMBL
-
A0A380E1P8_STAAU
256
0
29362
TrEMBL
-
A0A380EL19_STAAU
54
0
5901
TrEMBL
-
A0A6G4J8Z2_STAAU
414
2
47689
TrEMBL
-
A0A6B3IGH6_STAAU
583
2
66066
TrEMBL
-
A0A1L6C0F6_STAAU
608
2
69960
TrEMBL
-
A0A1L6C0J1_STAAU
608
2
69923
TrEMBL
-
D9IFM6_STAAU
347
2
39996
TrEMBL
-
A0A133Q5U3_STAAU
346
2
41148
TrEMBL
-
A0A6B5EEA7_STAAU
885
4
102186
TrEMBL
-
A0A6L0AUT2_STAAU
346
2
41078
TrEMBL
-
A0A380DVI0_STAAU
747
4
86348
TrEMBL
-
A0A6B5DM06_STAAU
370
0
41900
TrEMBL
-
A0A659I6G4_STAAU
885
4
102169
TrEMBL
-
A0A6B8QYJ7_STAAU
579
6
64454
TrEMBL
-
A0A7D8EEA1_STAAU
347
2
39991
TrEMBL
-
A0A6M1VFG2_STAAU
457
2
52313
TrEMBL
-
A0A5C8X5X8_STAAU
147
2
16562
TrEMBL
-
A0A380DXQ1_STAAU
117
0
13477
TrEMBL
-
A0A380EJV1_STAAU
124
0
14629
TrEMBL
-
A0A6B5FE29_STAAU
885
4
102186
TrEMBL
-
A0A1L6C0D6_STAAU
608
2
69960
TrEMBL
-
A0A1Q8DD73_STAAU
565
2
64858
TrEMBL
-
A0A6B5FNC3_STAAU
275
6
32143
TrEMBL
-
X5ELZ2_STAAU
370
0
41881
TrEMBL
-
A0A6D2HCG1_STAAU
457
2
52361
TrEMBL
-
A0A163QZ64_STAAU
889
4
102017
TrEMBL
-
A0A2U0IQC9_STAAU
583
2
66062
TrEMBL
-
A0A133PT61_STAAU
579
6
64483
TrEMBL
-
A0A0U1MRD2_STAAU
885
4
102213
TrEMBL
-
A0A6B0BMQ8_STAAU
424
2
49384
TrEMBL
-
A0A6H4GS88_STAAU
287
0
33942
TrEMBL
-
D9IFN3_STAAU
346
2
41065
TrEMBL
-
A0A6H4GZD0_STAAU
68
2
8253
TrEMBL
-
A0A380E3C4_STAAU
370
0
41909
TrEMBL
-
A0A380EN18_STAAU
200
0
23251
TrEMBL
-
Q7BWD9_STAAU
384
2
43916
TrEMBL
-
A0A659I779_STAAU
457
2
52351
TrEMBL
-
A0A2X2JR16_STAAU
163
0
18332
TrEMBL
-
A0A6K2LC37_STAAU
363
5
41603
TrEMBL
-
A0A7D8EAI9_STAAU
229
0
26052
TrEMBL
-
A0A1L6C0Y2_STAAU
346
2
41093
TrEMBL
-
A0A380DHI4_STAAU
32
0
3515
TrEMBL
-
A0A2X2M3R0_STAAU
84
0
9645
TrEMBL
-
A0A6H3QA77_STAAU
346
2
41045
TrEMBL
-
A0A2C9TKJ6_STAAU
885
4
102193
TrEMBL
-
A0A380EJM6_STAAU
148
0
16864
TrEMBL
-
A0A380EHZ6_STAAU
203
1
22841
TrEMBL
-
A0A389PZB6_STAAU
370
0
41880
TrEMBL
-
A0A2S6DP21_STAAU
295
2
34045
TrEMBL
-
A0A1L6C0V1_STAAU
346
2
41051
TrEMBL
-
A0A6B5H090_STAAU
346
2
41094
TrEMBL
-
A0A6H4IB01_STAAU
316
0
36090
TrEMBL
-
A0A5F0HN67_STAAU
457
2
52373
TrEMBL
-
A0A7D8IEK9_STAAU
47
0
5242
TrEMBL
-
H9BRN7_STAAU
592
2
67101
TrEMBL
-
A0A380DTJ8_STAAU
457
2
52427
TrEMBL
-
A0A6H3VXU7_STAAU
584
6
65014
TrEMBL
-
A0A641A519_STAAU
370
0
41891
TrEMBL
-
A0A6B5HPX6_STAAU
885
4
102160
TrEMBL
-
A0A659I938_STAAU
344
0
39155
TrEMBL
-
A0A6H5CVM4_STAAU
347
2
40034
TrEMBL
-
A0A1E8WWT6_STAAU
430
6
49931
TrEMBL
-
A0A641A6N0_STAAU
457
2
52348
TrEMBL
-
A0A641A3G4_STAAU
885
4
102124
TrEMBL
-
A0A6B1RKR7_STAAU
457
2
52386
TrEMBL
-
W8U600_STAAU
451
2
52400
TrEMBL
-
A0A5C8X2Z1_STAAU
457
2
52502
TrEMBL
-
A0A6H3Z7R0_STAAU
344
0
39062
TrEMBL
-
A0A7D8CAN6_STAAU
259
0
30055
TrEMBL
-
A0A6B5D8D1_STAAU
608
2
69952
TrEMBL
-
A0A6H3ZDI6_STAAU
344
0
39154
TrEMBL
-
A0A6K7J2G8_STAAU
238
1
27007
TrEMBL
-
A0A5S9EVI0_STAAU
546
2
62850
TrEMBL
-
A0A5S9EVQ4_STAAU
885
4
102124
TrEMBL
-
A0A6B0AQM5_STAAU
344
0
39019
TrEMBL
-
A0A1L6C0A1_STAAU
347
2
40079
TrEMBL
-
A0A7D8GER2_STAAU
76
0
8014
TrEMBL
-
A0A380EL64_STAAU
81
0
9480
TrEMBL
-
A0A1L6C0D3_STAAU
608
2
70028
TrEMBL
-
A0A1Q8DE55_STAAU
365
6
41762
TrEMBL
-
A0A380EKS1_STAAU
56
0
6685
TrEMBL
-
A0A2X2M8I9_STAAU
81
0
9190
TrEMBL
-
A0A1Q8DFF7_STAAU
453
2
52688
TrEMBL
-
A0A0D6G3C7_STAAU
346
2
41079
TrEMBL
-
A0A0D6H061_STAAU
457
2
52375
TrEMBL
-
A0A1K7Y4G1_STAAU
457
2
52386
TrEMBL
-
A0A1L6C0E5_STAAU
608
2
69967
TrEMBL
-
A0A6H4AGQ3_STAAU
885
4
102177
TrEMBL
-
A0A5C8X219_STAAU
314
1
36474
TrEMBL
-
A0A7D8CGH5_STAAU
73
0
8119
TrEMBL
-
A0A380DT97_STAAU
468
2
53938
TrEMBL
-
A0A1L6C118_STAAU
346
2
41013
TrEMBL
-
A0A6B0AMB5_STAAU
885
4
102075
TrEMBL
-
A0A6C0PQN4_STAAU
608
2
69871
TrEMBL
-
A0A2I7YBC3_STAAU
608
2
69938
TrEMBL
-
A0A6G4N4W2_STAAU
457
2
52351
TrEMBL
-
A0A1Q8DFH8_STAAU
608
2
69914
TrEMBL
-
A0A2X2LZ10_STAAU
67
1
7850
TrEMBL
-
A0A2X2K105_STAAU
145
0
16540
TrEMBL
-
A0A6H3X192_STAAU
608
2
69951
TrEMBL
-
A0A2X2K595_STAAU
141
0
16081
TrEMBL
-
A0A380EI17_STAAU
234
0
26484
TrEMBL
-
A0A6H4DIX4_STAAU
348
4
40248
TrEMBL
-
A0A380EKM0_STAAU
65
0
7450
TrEMBL
-
A0A6B5I4V4_STAAU
553
2
63787
TrEMBL
-
A0A380EF05_STAAU
247
0
28027
TrEMBL
-
D3X7X9_STAAU
100
0
11285
TrEMBL
-
A0A113WKH2_STAAU
351
2
39728
TrEMBL
-
A0A2X2UPT8_STAAU
885
4
102205
TrEMBL
-
A0A2S6DMU4_STAAU
885
4
102107
TrEMBL
-
Q309Z2_STAAU
430
6
49776
TrEMBL
-
A0A6M1F4U1_STAAU
553
2
63806
TrEMBL
-
A0A380EM18_STAAU
106
0
11706
TrEMBL
-
A0A6H4EQD7_STAAU
885
4
102295
TrEMBL
-
A0A6H3Q9I2_STAAU
885
4
102207
TrEMBL
-
A0A6A9GUJ1_STAAU
885
4
102137
TrEMBL
-
A0A6H3Q476_STAAU
518
2
61077
TrEMBL
-
A0A380EJF4_STAAU
125
1
14390
TrEMBL
-
A0A6H3VUQ3_STAAU
309
2
35656
TrEMBL
-
O07911_STAAU
430
6
49897
TrEMBL
-
A0A0Z2ZYA5_STAAU
583
2
66120
TrEMBL
-
W8U3I5_STAAU
344
0
39120
TrEMBL
-
A0A0U1MGT7_STAAU
346
2
40934
TrEMBL
-
A0A6B5DAP4_STAAU
885
4
102124
TrEMBL
-
A0A1L6C096_STAAU
344
2
39662
TrEMBL
-
A0A7I0YKZ8_STAAU
347
2
40045
TrEMBL
-
A0A6B5Q907_STAAU
885
4
102157
TrEMBL
-
A0A658X3I5_STAAU
363
6
41699
TrEMBL
-
A0A6B5FVQ4_STAAU
553
2
63796
TrEMBL
-
A0A6N3YPL3_STAAU
553
2
63765
TrEMBL
-
A0A6B5I8M9_STAAU
370
0
41877
TrEMBL
-
A0A5S9I361_STAAU
346
2
40996
TrEMBL
-
A0A6G4N4B4_STAAU
346
2
41030
TrEMBL
-
A0A6B5HQR6_STAAU
553
2
63723
TrEMBL
-
A0A5C8X9G3_STAAU
230
0
26004
TrEMBL
-
A0A6B5KVN9_STAAU
280
2
31889
TrEMBL
-
A0A6B0AZY3_STAAU
553
2
63810
TrEMBL
-
A0A6C0PQL0_STAAU
608
2
69943
TrEMBL
-
A0A2I6SBA4_STAAU
378
2
43220
TrEMBL
-
A0A380DU20_STAAU
554
2
63853
TrEMBL
-
A0A2X2KEZ5_STAAU
74
1
8476
TrEMBL
-
A0A6B0ACG1_STAAU
457
2
52399
TrEMBL
-
A0A6B5H0J9_STAAU
370
0
41952
TrEMBL
-
A0A3A3AB24_STAAU
346
2
41032
TrEMBL
-
A0A380ELM0_STAAU
140
0
15343
TrEMBL
-
A0A7D8E6H8_STAAU
263
2
30032
TrEMBL
-
A0A380E2K0_STAAU
156
0
18103
TrEMBL
-
A0A6M1V8T1_STAAU
451
2
52414
TrEMBL
-
A0A2X2JS19_STAAU
287
2
33416
TrEMBL
-
A0A6B5L4J9_STAAU
885
4
102188
TrEMBL
-
A0A6B5IAQ2_STAAU
240
1
27270
TrEMBL
-
A0A6G4JCW4_STAAU
196
0
21758
TrEMBL
-
A0A380EJP4_STAAU
138
0
15584
TrEMBL
-
A0A5C8X5X4_STAAU
491
1
55428
TrEMBL
-
A0A5C8X2R3_STAAU
386
0
44493
TrEMBL
-
A0A6B5I049_STAAU
885
4
102235
TrEMBL
-
A0A380DN01_STAAU
584
6
65015
TrEMBL
-
A0A380E0V5_STAAU
346
2
41058
TrEMBL
-
A0A6A8FHD2_STAAU
885
4
102213
TrEMBL
-
A0A0U1MTF1_STAAU
344
0
39061
TrEMBL
-
A0A660A1N0_STAAU
579
6
64482
TrEMBL
-
A0A391F3W4_STAAU
363
5
41661
TrEMBL
-
A0A6B5LV93_STAAU
457
2
52351
TrEMBL
-
A0A1L6C127_STAAU
346
2
41127
TrEMBL
-
A0A125SXT4_STAAU
877
4
100611
TrEMBL
-
A0A2X2K769_STAAU
334
1
38748
TrEMBL
-
A0A6K9JF50_STAAU
159
0
18520
TrEMBL
-
A0A1L6C0B2_STAAU
347
2
39984
TrEMBL
-
A0A133Q7H1_STAAU
376
0
42628
TrEMBL
-
A0A659IBM1_STAAU
351
2
39732
TrEMBL
-
A0A6M1F273_STAAU
583
2
66075
TrEMBL
-
A0A6H3YMW8_STAAU
346
2
41095
TrEMBL
-
A0A2H4UXI2_STAAU
346
2
41106
TrEMBL
-
A0A6B5I1Z9_STAAU
583
2
66018
TrEMBL
-
A0A2X2K273_STAAU
280
2
32089
TrEMBL
-
A0A6B5Q0Q3_STAAU
370
0
41854
TrEMBL
-
A0A658XCH9_STAAU
885
4
102125
TrEMBL
-
A0A168A956_STAAU
608
2
69954
TrEMBL
-
A0A6A9GX29_STAAU
583
2
66044
TrEMBL
-
A0A6N3YRP3_STAAU
608
2
69905
TrEMBL
-
A0A1L6C092_STAAU
347
2
40103
TrEMBL
-
A0A1L6C076_STAAU
347
2
40030
TrEMBL
-
A0A7D8IJ14_STAAU
567
4
65687
TrEMBL
-
A0A7D8G8H7_STAAU
311
0
35086
TrEMBL
-
A0A2X2K1M3_STAAU
231
0
26201
TrEMBL
-
A0A6B5HHC6_STAAU
252
0
28631
TrEMBL
-
A0A1L6C0F3_STAAU
608
2
69938
TrEMBL
-
A0A6B5BR50_STAAU
363
5
41621
TrEMBL
-
A0A1L6C0H3_STAAU
608
2
69929
TrEMBL
-
A0A6H4APQ4_STAAU
430
6
49952
TrEMBL
-
A0A6H3UQ81_STAAU
518
2
61016
TrEMBL
-
A0A6B5I067_STAAU
579
6
64482
TrEMBL
-
A0A380E4U1_STAAU
281
2
32738
TrEMBL
-
A0A380EEJ7_STAAU
52
0
5643
TrEMBL
-
A0A0Z0N8A3_STAAU
457
2
52343
TrEMBL
-
A0A1S5ZKP8_STAAU
363
5
41617
TrEMBL
-
A0A133PVY2_STAAU
414
6
47984
TrEMBL
-
A0A6H5E5E2_STAAU
885
4
102193
TrEMBL
-
A0A6H3YJ63_STAAU
885
4
102253
TrEMBL
-
A0A6B5KY86_STAAU
370
0
41858
TrEMBL
-
A0A6N8I794_STAAU
451
2
52404
TrEMBL
-
A0A6N3AU45_STAAU
584
6
65029
TrEMBL
-
A0A6B5H2Q8_STAAU
344
0
39178
TrEMBL
-
A0A6B5HUD1_STAAU
344
0
39200
TrEMBL
-
A0A380EMR4_STAAU
368
0
42261
TrEMBL
-
A0A659FKY8_STAAU
330
1
38067
TrEMBL
-
A0A1L6C0G1_STAAU
608
2
69965
TrEMBL
-
A0A2X2JWI5_STAAU
74
0
8733
TrEMBL
-
A0A6F9YS47_STAAU
546
2
62856
TrEMBL
-
A0A6G4N6R3_STAAU
264
0
30040
TrEMBL
-
A0A1L6C0D0_STAAU
608
2
69951
TrEMBL
-
A0A6B0ATP0_STAAU
583
2
66042
TrEMBL
-
A0A6B5J1Y5_STAAU
457
2
52357
TrEMBL
-
A0A1L6C0F8_STAAU
608
2
69992
TrEMBL
-
A0A6B5DNU2_STAAU
553
2
63721
TrEMBL
-
A0A658WF83_STAAU
608
2
69926
TrEMBL
-
A0A6B5S4S6_STAAU
346
2
41045
TrEMBL
-
A0A131JSM9_STAAU
584
6
65028
TrEMBL
-
A0A1L6C0Z8_STAAU
346
2
41079
TrEMBL
-
A0A2S6DD24_STAAU
457
2
52372
TrEMBL
-
A0A5F0HNZ3_STAAU
553
2
63745
TrEMBL
-
A0A6B5Q4Z6_STAAU
363
5
41677
TrEMBL
-
A0A1L6C0K2_STAAU
608
2
70000
TrEMBL
-
A0A5C8X7M5_STAAU
346
2
40903
TrEMBL
-
A0A380E508_STAAU
119
0
13558
TrEMBL
-
A0A7D8CC62_STAAU
46
0
4936
TrEMBL
-
A0A658X2X6_STAAU
451
2
52404
TrEMBL
-
A0A659I8R4_STAAU
608
2
69940
TrEMBL
-
A0A6M1VEB8_STAAU
266
0
30014
TrEMBL
-
A0A380EEI6_STAAU
253
2
30808
TrEMBL
-
A0A2X2JXC1_STAAU
94
1
11089
TrEMBL
-
A0A380ELZ9_STAAU
75
1
9039
TrEMBL
-
A0A1L6C0H1_STAAU
608
2
69917
TrEMBL
-
A0A1L6C136_STAAU
346
2
41111
TrEMBL
-
A0A6B5U8K6_STAAU
583
2
66061
TrEMBL
-
A0A1L6C0G9_STAAU
608
2
69932
TrEMBL
-
A0A6B5CXC5_STAAU
370
0
41755
TrEMBL
-
A0A0D6G263_STAAU
351
2
39741
TrEMBL
-
A0A0Z0BY62_STAAU
295
2
34105
TrEMBL
-
A0A6B1RKA9_STAAU
885
4
102155
TrEMBL
-
A0A6B5CK38_STAAU
885
4
102140
TrEMBL
-
A0A0U1MLF8_STAAU
583
2
66076
TrEMBL
-
A0A6B1RLI6_STAAU
553
2
63757
TrEMBL
-
A0A6M1V3F0_STAAU
363
5
41599
TrEMBL
-
A0A658X205_STAAU
554
2
63906
TrEMBL
-
A0A6H3YUK9_STAAU
451
2
52415
TrEMBL
-
A0A380E253_STAAU
97
2
10919
TrEMBL
-
A0A6B5IF64_STAAU
230
0
25978
TrEMBL
-
A0A6B5IJA3_STAAU
292
0
34542
TrEMBL
-
A0A2X2MD73_STAAU
664
3
76809
TrEMBL
-
A0A6B5DE64_STAAU
579
6
64499
TrEMBL
-
A0A1L6C0X5_STAAU
346
2
40961
TrEMBL
-
A0A2H4UXJ6_STAAU
608
2
69877
TrEMBL
-
A0A1L6C0H2_STAAU
608
2
69940
TrEMBL
-
A0A1Q8DEX1_STAAU
348
2
40117
TrEMBL
-
A0A133PUE0_STAAU
909
4
105089
TrEMBL
-
A0A6B1RJD9_STAAU
346
2
41017
TrEMBL
-
A0A0D6HAQ4_STAAU
885
4
102219
TrEMBL
-
A0A6B5SXW2_STAAU
457
2
52338
TrEMBL
-
A0A7D8E6J7_STAAU
231
0
27191
TrEMBL
-
A0A6J8P2Z7_STAAU
554
2
63938
TrEMBL
-
A0A2I7Y3I9_STAAU
579
6
64510
TrEMBL
-
A0A6I4I3D0_STAAU
579
6
64469
TrEMBL
-
A0A380EB30_STAAU
572
1
65747
TrEMBL
-
A0A2X2JYK7_STAAU
424
1
47295
TrEMBL
-
A0A6B0CUG0_STAAU
346
2
41011
TrEMBL
-
A0A6H3Z776_STAAU
608
2
69942
TrEMBL
-
A0A6H3ZMQ0_STAAU
608
2
69864
TrEMBL
-
A0A1L6C103_STAAU
346
2
41109
TrEMBL
-
A0A380DWZ6_STAAU
285
2
33030
TrEMBL
-
A0A1Q8DBN6_STAAU
585
2
66095
TrEMBL
-
A0A6B5M280_STAAU
351
2
39713
TrEMBL
-
A0A6B5HVU7_STAAU
346
2
40963
TrEMBL
-
V5YQR2_STAAU
608
2
69924
TrEMBL
-
A0A2S6DCR4_STAAU
346
2
40968
TrEMBL
-
A0A6B5TZ08_STAAU
370
0
41900
TrEMBL
-
A0A380E1P7_STAAU
83
0
9198
TrEMBL
-
A0A1L6C093_STAAU
347
2
40045
TrEMBL
-
A0A6G4N2I0_STAAU
719
4
82964
TrEMBL
-
A0A6B5DJ85_STAAU
363
6
41877
TrEMBL
-
A0A1Q8DHL6_STAAU
457
2
52863
TrEMBL
-
A0A380DUU1_STAAU
62
0
7041
TrEMBL
-
A0A380DT33_STAAU
279
6
32773
TrEMBL
-
A0A2X2LZB2_STAAU
70
0
8137
TrEMBL
-
A0A6H3ZEK6_STAAU
554
2
63887
TrEMBL
-
A0A2X2K4H4_STAAU
101
2
11806
TrEMBL
-
A0A0U1MWG6_STAAU
518
2
61038
TrEMBL
-
D5LFT5_STAAU
430
6
49966
TrEMBL
-
A0A167RS01_STAAU
885
4
102105
TrEMBL
-
A0A2I7YBL3_STAAU
553
2
63773
TrEMBL
-
A0A133Q146_STAAU
313
2
36168
TrEMBL
-
A0A5C8X4X0_STAAU
344
0
39047
TrEMBL
-
A0A0U1MKE0_STAAU
363
6
41841
TrEMBL
-
A0A658X6Y8_STAAU
370
0
41750
TrEMBL
-
A0A6M1XCN2_STAAU
133
0
15793
TrEMBL
-
A0A6H3XP71_STAAU
295
2
34105
TrEMBL
-
A0A2X2KEC7_STAAU
219
0
25269
TrEMBL
-
A0A6M1AJX3_STAAU
885
4
102189
TrEMBL
-
A0A2S6DJX9_STAAU
270
2
31479
TrEMBL
-
A0A380EP12_STAAU
340
2
39235
TrEMBL
-
A0A6B5ID28_STAAU
344
0
39175
TrEMBL
-
A0A2X2K2I7_STAAU
170
0
19721
TrEMBL
-
A0A6K0HUW1_STAAU
608
2
69940
TrEMBL
-
A0A6B5K318_STAAU
885
4
102200
TrEMBL
-
A0A133QC13_STAAU
451
2
52409
TrEMBL
-
A0A1L6C0D9_STAAU
608
2
69954
TrEMBL
-
A0A380EJH9_STAAU
69
0
7873
TrEMBL
-
A0A1L6C0E9_STAAU
608
2
69919
TrEMBL
-
A0A6H4DLI3_STAAU
363
5
41689
TrEMBL
-
A0A1L6C0J0_STAAU
608
2
70094
TrEMBL
-
A0A1Q8DCZ8_STAAU
584
6
65055
TrEMBL
-
A0A6G4IV78_STAAU
553
2
63762
TrEMBL
-
A0A266CLT2_STAAU
295
2
34019
TrEMBL
-
A0A090N2G8_STAAU
451
2
52386
TrEMBL
-
A0A6B5EDM9_STAAU
370
0
41909
TrEMBL
-
A0A0U1MSB2_STAAU
457
2
52372
TrEMBL
-
A0A5F0HQR4_STAAU
579
6
64509
TrEMBL
-
A0A6K7ICQ1_STAAU
881
4
101805
TrEMBL
-
A0A2X2MEF7_STAAU
137
0
15639
TrEMBL
-
A0A380E9S1_STAAU
42
1
4915
TrEMBL
-
A0A2X2JZ68_STAAU
98
0
11494
TrEMBL
-
Q5KTU8_STAAU
300
1
35080
TrEMBL
-
A0A380DWH0_STAAU
457
2
52287
TrEMBL
-
A0A2X2M8T1_STAAU
243
0
28218
TrEMBL
-
A0A6B0BKP2_STAAU
451
2
52046
TrEMBL
-
A0A380ENY4_STAAU
197
0
22905
TrEMBL
-
A0A6B0CSW2_STAAU
351
2
39748
TrEMBL
-
A0A0D6HHL7_STAAU
554
2
63905
TrEMBL
-
A0A7D8GEB4_STAAU
114
0
13074
TrEMBL
-
A0A6M1VJ68_STAAU
885
4
102138
TrEMBL
-
A0A658X1N3_STAAU
583
2
66048
TrEMBL
-
A0A6G4YTZ8_STAAU
370
0
41894
TrEMBL
-
A0A380DTJ7_STAAU
106
0
11955
TrEMBL
-
A0A6H3YV40_STAAU
435
6
50638
TrEMBL
-
A0A1Q8DC11_STAAU
332
2
38712
TrEMBL
-
A0A6B0D500_STAAU
885
4
102199
TrEMBL
-
A0A454GZN1_STAAU
351
2
39726
TrEMBL
-
A0A6B5S8C3_STAAU
457
2
52361
TrEMBL
-
A0A6H3Z9Q6_STAAU
608
2
69884
TrEMBL
-
A0A6G4JDC8_STAAU
338
0
38165
TrEMBL
-
A0A380EMU4_STAAU
146
3
17347
TrEMBL
-
A0A6B0CI62_STAAU
363
5
41677
TrEMBL
-
A0A380DT60_STAAU
367
0
42239
TrEMBL
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
oligomer
intact YycG HK can form higher-order oligomers at the cell membrane via combinations of the H- and L-dimeric interacting surfaces
additional information
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
AgrC forms ligand-independent dimers that undergo trans-autophosphorylation upon interaction with autoinducing peptide
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
G394A/G396A
-
completely inactive
L128C
site-directed mutagenesis
N44C/G142C
site-directed mutagenesis, the monomeric band intensities of the double mutant are dramatically decreased
N44C/G143C
site-directed mutagenesis, the monomeric band intensities of the double mutant are dramatically decreased
N44C/R146C
site-directed mutagenesis, introducing cysteine substitution at Arg146 of YycG N44C mutant does not show any high molecular weight bands, but it shows only the dimeric band of YycG N44C
S81C
site-directed mutagenesis
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant His-tagged truncated enzyme from Escherichia coli strain C43(DE3) membranes by ultracentrifugation and affinity chromatography, followed by gel filtration
-
recombinant wild-type and mutant His-tagged enzymes from Escherichia coli strain BL21(DE3) by ultracentrifugation, nickel affinity chromatography, and dialysis. His-tag removal by tobacco etch virus protease is followed by nickel affinity chromatography and gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene agrC, recombinant overexpression of His-tagged and GFP-tagged truncated enzyme from pET-28a-AgrCTM5-6C or pET-28-AgrCTM5-6C-GFP vector in Escherichia coli strain C43(DE3)
-
gene yycG, recombinant expression of wild-type and mutant His-tagged enzymes in Escherichia coli strain BL21(DE3), the SeMet-substituted YycG is produced in Escherichia coli methionine auxotrophic strain B834(DE3)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
2.5fold enhanced transcription of SaeS after incubation with Perform and SDS
RENATURED/Commentary
ORGANISM
UNIPROT
LITERATURE
purified recombinant truncated enzyme proteins are reconstituted into liposomes by a detergent-mediated method, effect of different detergents on protein reconstitution efficiency, overview. The highest incorporation is found with N,N-dimethyldode-cylamine N-oxide resulting in a yield of 85%, liposomes are consisting of dioleoyl-phosphatidyl-choline : 1,2-dipalmitoyl-sn-glycero-3-phosphocholine : egg L-alpha-phosphatidic acid : cholesterol at molar ratios of 4:4:1:1, pH 7.4. Determination of the morphology and size of liposome, overview
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mueller-Premru, M.; Zidar, N.; Spik, V.C.; Krope, A.; Kikelj, D.
Benzoxazine series of histidine kinase inhibitors as potential antimicrobial agents with activity against enterococci
Chemotherapy
55
414-417
2009
Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa
Manually annotated by BRENDA team
Schaefer, D.; Lam, T.T.; Geiger, T.; Mainiero, M.; Engelmann, S.; Hussain, M.; Bosserhoff, A.; Frosch, M.; Bischoff, M.; Wolz, C.; Reidl, J.; Sinha, B.
A point mutation in the sensor histidine kinase SaeS of Staphylococcus aureus strain Newman alters the response to biocide exposure
J. Bacteriol.
191
7306-7314
2009
Staphylococcus aureus (Q840P7), Staphylococcus aureus, Staphylococcus aureus Newman (Q840P7)
Manually annotated by BRENDA team
George Cisar, E.A.; Geisinger, E.; Muir, T.W.; Novick, R.P.
Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC
Mol. Microbiol.
74
44-57
2009
Staphylococcus aureus
Manually annotated by BRENDA team
Kim, T.; Choi, J.; Lee, S.; Yeo, K.J.; Cheong, H.K.; Kim, K.K.
Structural studies on the extracellular domain of sensor histidine kinase YycG from Staphylococcus aureus and its functional implications
J. Mol. Biol.
428
3074-3089
2016
Staphylococcus aureus, Staphylococcus aureus (Q2G2U4), Staphylococcus aureus NCTC 8325 (Q2G2U4), Staphylococcus aureus RN4220
Manually annotated by BRENDA team
Wang, L.; Quan, C.; Liu, B.; Wang, J.; Xiong, W.; Zhao, P.; Fan, S.
Functional reconstitution of Staphylococcus aureus truncated AgrC histidine kinase in a model membrane system
PLoS ONE
8
e80400
2013
Staphylococcus aureus
Manually annotated by BRENDA team
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