Reference on EC 2.7.12.2 - mitogen-activated protein kinase kinase and Organism(s) Mus musculus and UniProt Accession O09110
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; et al.
Functional annotation of a full-length mouse cDNA collection
Nature
409
685-690
2001
Mus musculus (O09110)
Moriguchi, T.; Toyoshima, F.; Gotoh, Y.; Iwamatsu, A.; et al.
Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2
J. Biol. Chem.
271
26981-26988
1996
Mus musculus (O09110), Mus musculus, Homo sapiens (P46734)
Tobiume, K.; Inage, T.; Takeda, K.; Enomoto, S.; Miyazono, K.; Ichijo, H.
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1
Biochem. Biophys. Res. Commun.
239
905-910
1997
Mus musculus (O35099)
Crews, C.M.; Alessandrini, A.; Erikson, R.L.
The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
Science
258
478-480
1992
Mus musculus (P31938)
Crews, C.M.; Erikson, R.L.
Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product
Proc. Natl. Acad. Sci. USA
89
8205-8209
1992
Mus musculus (P31938), Mus musculus (Q63932), Mus musculus
Duesbery, N.S.; Webb, C.P.; Leppla, S.H.; Gordon, V.M.; Klimpel, K.R.; Copeland, T.D.; Ahn, N.G.; Oskarsson, M.K.; Fukasawa, K.; Paull, K.D.; Vande Woude, G.F.
Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor
Science
280
734-737
1998
Mus musculus (P31938), Homo sapiens (P36507), Homo sapiens (Q02750)
Sanchez, I.; Hughes, R.T.; Mayer, B.J.; Yee, K.; Woodgett, J.R.; Avruch, J.; Kyriakis, J.M.; Zon, L.I.
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
Nature
372
794-798
1994
Mus musculus (P47809)
Cuenda, A.; Alonso, G.; Morrice, N.; Jones, M.; Meier, R.; Cohen, P.; Nebreda, A.R.
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells
EMBO J.
15
4156-4164
1996
Homo sapiens (P52564), Homo sapiens, Mus musculus (P70236), Mus musculus
Blank, J.L.; Gerwins, P.; Elliott, E.M.; Sather, S.; Johnson, G.L.
Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase
J. Biol. Chem.
271
5361-5368
1996
Mus musculus (Q61083), Mus musculus (Q61084)
Brott, B.K.; Alessandrini, A.; Largaespada, D.A.; Copeland, N.G.; Jenkins, N.A.; Crews, C.M.; Erikson, R.L.
MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues
Cell Growth Differ.
4
921-929
1993
Mus musculus (Q63932)
Karim, F.; Hu, H.J.; Adwanikar, H.; Kaplan, D.R.; Gereau, R.W.T.
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)
Mol. Pain
2
2
2006
Mus musculus
Gibbs, G.M.; Bianco, D.M.; Jamsai, D.; Herlihy, A.; Ristevski, S.; Aitken, R.J.; Kretser, D.M.; OBryan, M.K.
Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm
Biol. Reprod.
77
108-114
2007
Mus musculus
Hsu, C.L.; Kikuchi, K.; Kondo, M.
Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment
Blood
110
1420-1428
2007
Mus musculus
Xia, D.; Srinivas, H.; Ahn, Y.H.; Sethi, G.; Sheng, X.; Yung, W.K.; Xia, Q.; Chiao, P.J.; Kim, H.; Brown, P.H.; Wistuba, I.I.; Aggarwal, B.B.; Kurie, J.M.
Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway
J. Biol. Chem.
282
3507-3519
2007
Mus musculus
Spicer, J.A.; Rewcastle, G.W.; Kaufman, M.D.; Black, S.L.; Plummer, M.S.; Denny, W.A.; Quin, J.; Shahripour, A.B.; Barrett, S.D.; Whitehead, C.E.; Milbank, J.B.; Ohren, J.F.; Gowan, R.C.; Omer, C.; Camp, H.S.; Esmaeil, N.; Moore, K.; Sebolt-Leopold, J.S.; Pryzbranowski, S.; Merriman, R.L.; Ortwine, D.F.; Warmus,
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase
J. Med. Chem.
50
5090-5102
2007
Mus musculus, Mus musculus (P31938), Mus musculus (Q63932)
Whitmarsh, A.J.; Davis, R.J.
Role of mitogen-activated protein kinase kinase 4 in cancer
Oncogene
26
3172-3184
2007
Drosophila melanogaster, Homo sapiens, Homo sapiens (O14733), Homo sapiens (P45985), Mus musculus, Mus musculus (P47809), Mus musculus (Q8CE90), Rattus norvegicus, Xenopus laevis
Kang, N.J.; Lee, K.W.; Lee, D.E.; Rogozin, E.A.; Bode, A.M.; Lee, H.J.; Dong, Z.
Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
J. Biol. Chem.
283
20664-20673
2008
Mus musculus (P31938), Mus musculus
Wang, J.; Chen, L.; Ko, C.I.; Zhang, L.; Puga, A.; Xia, Y.
Distinct signaling properties of mitogen-activated protein kinase kinases 4 (MKK4) and 7 (MKK7) in embryonic stem cell (ESC) differentiation
J. Biol. Chem.
287
2787-2797
2012
Mus musculus (P47809), Mus musculus (Q8CE90)
Uchida, Y.; Osaki, T.; Yamasaki, T.; Shimomura, T.; Hata, S.; Horikawa, K.; Shibata, S.; Todo, T.; Hirayama, J.; Nishina, H.
Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock
J. Biol. Chem.
287
8318-8326
2012
Homo sapiens (O14733), Mus musculus (Q8CE90), Mus musculus
