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Information on EC 2.7.12.2 - mitogen-activated protein kinase kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession Q9Y884

for references in articles please use BRENDA:EC2.7.12.2
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IUBMB Comments
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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This record set is specific for:
Schizosaccharomyces pombe
UNIPROT: Q9Y884
Word Map
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
apoptosis signal-regulating kinase 1, ASK1, At3g21220, BcOs4, BOS5, CaSTE7, cdc7 protein kinase, Cdc7p kinase, cell division control protein 7, cpkk1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cdc7 protein kinase
266325
-
Cdc7p kinase
266325
-
cell division control protein 7
266325
-
MAP kinase kinase skh1/pek1
266370
-
p120cdc7 protein kinase
266325
-
protein kinase byr1
266313
-
protein kinase wis1
266321
-
wis1 protein kinase
266321
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKKK-activated)
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142805-58-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ATP + protein
ADP + phosphoprotein
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
66000
-
x * 66000, calculation from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 66000, calculation from nucleotide sequence
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
Pek1 has a dual stimulatory and inhibitory function which depends on its phosphorylation state
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (P10506), Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe (Q9Y884)
Manually annotated by BRENDA team
Nadin-Davis, S.A.; Nasim, A.
A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast
EMBO J.
7
985-993
1988
Schizosaccharomyces pombe (P10506)
Manually annotated by BRENDA team
Warbrick, E.; Fantes, P.A.
The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe
EMBO J.
10
4291-4299
1991
Schizosaccharomyces pombe (P33886), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Fankhauser, C.; Simanis, V.
The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast
EMBO J.
13
3011-3019
1994
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Schmidt, S.; Sohrmann, M.; Hofmann, K.; Woollard, A.; Simanis, V.
The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe
Genes Dev.
11
1519-1534
1997
Schizosaccharomyces pombe (P41892), Schizosaccharomyces pombe
Manually annotated by BRENDA team
Loewith, R.; Hubberstey, A.; Young, D.
Skh1, the MEK component of the mkh1 signaling pathway in Schizosaccharomyces pombe
J. Cell Sci.
113
153-160
2000
Schizosaccharomyces pombe (Q9Y884)
Manually annotated by BRENDA team
Sugiura, R.; Toda, T.; Dhut, S.; Shuntoh, H.; Kuno, T.
The MAPK kinase Pek1 acts as a phosphorylation-dependent molecular switch
Nature
399
479-483
1999
Schizosaccharomyces pombe (Q9Y884), Schizosaccharomyces pombe
Manually annotated by BRENDA team
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