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Information on EC 2.7.12.2 - mitogen-activated protein kinase kinase and Organism(s) Oryza sativa and UniProt Accession Q5QN75

for references in articles please use BRENDA:EC2.7.12.2
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EC Tree
IUBMB Comments
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues . Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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Oryza sativa
UNIPROT: Q5QN75
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The taxonomic range for the selected organisms is: Oryza sativa
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
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ATP
+
a [protein]-(L-serine/L-threonine)
=
ADP
+
a [protein]-(L-serine/L-threonine) phosphate
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mek/erk, mitogen-activated protein kinase kinase, map kinase kinase, mapkk, mek-1, extracellular-signal-regulated kinase, mapk/erk kinase, map2k4, erk 1, mitogen-activated protein kinase kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MAP kinase kinase
-
MAP kinase kinase
-
MAPKK 10-2
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKKK-activated)
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142805-58-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MAPKK 1; cv. japonica and indica, var. Pusa Basmati 1, MAP kinase kinase isozyme MAPKK 1
UniProt
Manually annotated by BRENDA team
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isozymes MAPKK 1, DNA and amino acid sequence determination and analysis, quantitative expression analysis: the rice MAPKK isozymes are differentially regulated by cold, heat, salinity and drought stresses, sequence comparison, phylogenetic tree, overview
isozymes MAPKK 10-2, DNA and amino acid sequence determination and analysis, quantitative expression analysis: the rice MAPKK isozymes are differentially regulated by cold, heat, salinity and drought stresses, sequence comparison, phylogenetic tree, overview
isozymes MAPKK 3, DNA and amino acid sequence determination and analysis, quantitative expression analysis: the rice MAPKK isozymes are differentially regulated by cold, heat, salinity and drought stresses, sequence comparison, phylogenetic tree, overview
isozymes MAPKK 4, DNA and amino acid sequence determination and analysis, quantitative expression analysis: the rice MAPKK isozymes are differentially regulated by cold, heat, salinity and drought stresses, sequence comparison, phylogenetic tree, overview
isozymes MAPKK 6, DNA and amino acid sequence determination and analysis, quantitative expression analysis: the rice MAPKK isozymes are differentially regulated by cold, heat, salinity and drought stresses, sequence comparison, phylogenetic tree, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kumar, K.; Rao, K.P.; Sharma, P.; Sinha, A.K.
Differential regulation of rice mitogen activated protein kinase kinase (MKK) by abiotic stress
Plant Physiol. Biochem.
46
891-897
2008
Oryza sativa (A2XE35), Oryza sativa (A3FK65), Oryza sativa (Q0MSI2), Oryza sativa (Q0Z7Z4), Oryza sativa (Q5QN75), Oryza sativa
Manually annotated by BRENDA team