Reference on EC 2.7.12.1 - dual-specificity kinase and Organism(s) Homo sapiens and UniProt Accession P49761
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lee, K.; Du, C.; Horn, M.; Rabinow, L.
Activity and autophosphorylation of LAMMER protein kinases
J. Biol. Chem.
271
27299-27303
1996
Saccharomyces cerevisiae (P32350), Homo sapiens (P49760), Drosophila melanogaster (P49762)
Xia, J.; Yang, X.; Ruan, Q.; Pan, Q.; Liu, C.; Xie, W.; Deng, H.
Molecular cloning and characterization of novel protein kinase gene DYRK3
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
15
327-332
1998
Homo sapiens (O43781), Homo sapiens
Becker, W.; Weber, Y.; Wetzel, K.; Eirmbter, K.; Tejedor, F.J.; Joost, H.G.
Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases
J. Biol. Chem.
273
25893-25902
1998
Homo sapiens (O43781), Homo sapiens (Q92630), Rattus norvegicus (Q63470)
Hanes, J.; von der Kammer, H.; Klaudiny, J.; Scheit, K.H.
Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases
J. Mol. Biol.
244
665-672
1994
Mus musculus (P22518), Homo sapiens (P49759), Homo sapiens (P49760), Homo sapiens (P49761)
Johnson, K.W.; Smith, K.A.
Molecular cloning of a novel human cdc2/CDC28-like protein kinase
J. Biol. Chem.
266
3402-3407
1991
Homo sapiens (P49759), Homo sapiens
Winfield, S.L.; Tayebi, N.; Martin, B.M.; Ginns, E.I.; Sidransky, E.
Identification of three additional genes contiguous to the glucocerebrosidase locus on chromosome 1q21: implications for Gaucher disease
Genome Res.
7
1020-1026
1997
Homo sapiens (P49760)
Guimera, J.; Casas, C.; Estivill, X.; Pritchard, M.
Human minibrain homologue (MNBH/DYRK1): characterization, alternative splicing, differential tissue expression, and overexpression in Down syndrome
Genomics
57
407-418
1999
Homo sapiens (Q13627), Homo sapiens
Dahmane, N.; Ghezala, G.A.; Gosset, P.; Chamoun, Z.; et al.
Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome
Genomics
48
12-23
1998
Homo sapiens (Q13627)
Song, W.J.; Sternberg, L.R.; Kasten-Sportes, C.; et al.
Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome "critical region"
Genomics
38
331-339
1996
Homo sapiens (Q13627), Homo sapiens, Mus musculus (Q61214), Mus musculus
Shindoh, N.; Kudoh, J.; Maeda, H.; Yamaki, A.; Minoshima, S.; Shimizu, Y.; Shimizu, N.
Cloning of a human homolog of the Drosophila minibrain/rat Dyrk gene from "the Down syndrome critical region" of chromosome 21
Biochem. Biophys. Res. Commun.
225
92-99
1996
Homo sapiens (Q13627), Homo sapiens
Guimera, J.; Casas, C.; Pucharcos, C.; et al.
A human homologue of Drosophila minibrain (MNB) is expressed in the neuronal regions affected in Down syndrome and maps to the critical region
Hum. Mol. Genet.
5
1305-1310
1996
Homo sapiens (Q13627)
Leder, S.; Weber, Y.; Altafaj, X.; Estivill, X.; Joost, H.G.; Becker, W.
Cloning and characterization of DYRK1B, a novel member of the DYRK family of protein kinases
Biochem. Biophys. Res. Commun.
254
474-479
1999
Homo sapiens (Q9Y463), Homo sapiens
Mills, G.B.; Schmandt, R.; McGill, M.; Amendola, A.; Hill, M.; Jacobs, K.; May, C.; Rodricks, A.M.; Campbell, S.; Hogg, D.
Expression of TTK, a novel human protein kinase, is associated with cell proliferation
J. Biol. Chem.
267
16000-16006
1992
Homo sapiens (P33981)
Hanks, S.K.; Quinn, A.M.
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members
Methods Enzymol.
200
38-62
1991
Homo sapiens (P33981)
Leder, S.; Czajkowska, H.; Maenz, B.; De Graaf, K.; Barthel, A.; Joost, H.G.; Becker, W.
Alternative splicing variants of dual specificity tyrosine phosphorylated and regulated kinase 1B exhibit distinct patterns of expression and functional properties
Biochem. J.
372
881-888
2003
Homo sapiens, Mus musculus (Q9Z188), Mus musculus
Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.
Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
Proc. Natl. Acad. Sci. USA
102
7109-7114
2005
Homo sapiens
Liu, F.; Liang, Z.; Wegiel, J.; Hwang, Y.W.; Iqbal, K.; Grundke-Iqbal, I.; Ramakrishna, N.; Gong, C.X.
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
FASEB J.
22
3224-3233
2008
Homo sapiens (Q13627)
Liang, Y.J.; Chang, H.S.; Wang, C.Y.; Yu, W.C.
DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues
Int. J. Biochem. Cell Biol.
40
2431-2441
2008
Homo sapiens (Q13627)
Shi, J.; Zhang, T.; Zhou, C.; Chohan, M.O.; Gu, X.; Wegiel, J.; Zhou, J.; Hwang, Y.W.; Iqbal, K.; Grundke-Iqbal, I.; Gong, C.X.; Liu, F.
Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome
J. Biol. Chem.
283
28660-28669
2008
Homo sapiens (Q13627), Homo sapiens
Ryoo, S.R.; Cho, H.J.; Lee, H.W.; Jeong, H.K.; Radnaabazar, C.; Kim, Y.S.; Kim, M.J.; Son, M.Y.; Seo, H.; Chung, S.H.; Song, W.J.
Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A-mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimers disease
J. Neurochem.
104
1333-1344
2008
Homo sapiens (Q13627), Homo sapiens
Kapitulnik, J.; Maines, M.D.
Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
Trends Pharmacol. Sci.
30
129-137
2009
Homo sapiens
Wegiel, J.; Dowjat, K.; Kaczmarski, W.; Kuchna, I.; Nowicki, K.; Frackowiak, J.; Mazur Kolecka, B.; Wegiel, J.; Silverman, W.P.; Reisberg, B.; Deleon, M.; Wisniewski, T.; Gong, C.X.; Liu, F.; Adayev, T.; Chen-Hwang, M.C.; Hwang, Y.W.
The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
Acta Neuropathol.
116
391-407
2008
Homo sapiens
Koo, K.A.; Kim, N.D.; Chon, Y.S.; Jung, M.S.; Lee, B.J.; Kim, J.H.; Song, W.J.
QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors
Bioorg. Med. Chem. Lett.
19
2324-2328
2009
Homo sapiens
Goeckler, N.; Jofre, G.; Papadopoulos, C.; Soppa, U.; Tejedor, F.J.; Becker, W.
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation
FEBS J.
276
6324-6337
2009
Homo sapiens
Yamashita, S.; Chujo, M.; Tokuishi, K.; Anami, K.; Miyawaki, M.; Yamamoto, S.; Kawahara, K.
Expression of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 2 (DYRK2) can be a favorable prognostic marker in pulmonary adenocarcinoma
J. Thorac. Cardiovasc. Surg.
138
1303-1308
2009
Homo sapiens
Kimbro, K.S.; Duschene, K.; Willard, M.; Moore, J.; Freeman, S.
A novel gene STYK1/NOK is upregulated in estrogen receptor-alpha negative estrogen receptor-beta positive breast cancer cells following estrogen treatment
Mol. Biol. Rep.
35
23-27
2008
Homo sapiens
Alexeeva, M.; Aberg, E.; Engh, R.A.; Rothweiler, U.
The structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteine
Acta Crystallogr. Sect. D
71
1207-1215
2015
Homo sapiens (Q13627), Homo sapiens (Q9Y463)
Coombs, T.; Tanega, C.; Shen, M.; Wang, J.; Auld, D.; Gerritz, S.; Schoenen, F.; Thomas, C.; Aube, J.
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: Development of chemical probe ML315
Bioorg. Med. Chem. Lett.
23
3654-3661
2013
Homo sapiens (Q13627), Homo sapiens (Q9Y463)
Kaistha, B.P.; Honstein, T.; Mueller, V.; Bielak, S.; Sauer, M.; Kreider, R.; Fassan, M.; Scarpa, A.; Schmees, C.; Volkmer, H.; Gress, T.M.; Buchholz, M.
Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells
Br. J. Cancer
111
1780-1787
2014
Homo sapiens (P33981), Homo sapiens
Wippich, F.; Bodenmiller, B.; Trajkovska, M.G.; Wanka, S.; Aebersold, R.; Pelkmans, L.
Dual specificity kinase DYRK3 couples stress granule condensation/dissolution to mTORC1 signaling
Cell
152
791-805
2013
Homo sapiens (O43781)
Leal, F.D.; da Silva Lima, C.H.; de Alencastro, R.B.; Castro, H.C.; Rodrigues, C.R.; Albuquerque, M.G.
Hologram QSAR models of a series of 6-arylquinazolin-4-amine inhibitors of a new Alzheimers disease target: dual specificity tyrosine-phosphorylation-regulated kinase-1A enzyme
Int. J. Mol. Sci.
16
5235-5253
2015
Homo sapiens (Q13627)
Qian, W.; Jin, N.; Shi, J.; Yin, X.; Jin, X.; Wang, S.; Cao, M.; Iqbal, K.; Gong, C.X.; Liu, F.
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression
J. Alzheimers Dis.
37
529-538
2013
Homo sapiens (Q13627)
Huang, S.-H.; Long, M.; Wu, C.-H.; Kwon-Chung, K.J.; Chang, Y.C.; Chi, F.; Lee, S.; Jong, A.
Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3)
J. Biol. Chem.
286
34761-34769
2011
Homo sapiens (O43781), Homo sapiens
Papadopoulos, C.; Arato, K.; Lilienthal, E.; Zerweck, J.; Schutkowski, M.; Chatain, N.; Mueller-Newen, G.; Becker, W.; de la Luna, S
Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity
J. Biol. Chem.
286
5494-5505
2011
Mus musculus (Q8BI55), Homo sapiens (Q9NR20)
Pan, Y.; Wang, Y.; Bryant, S.H.
Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitors
J. Chem. Inf. Model.
53
938-947
2013
Homo sapiens (Q13627)
Zhou, N.; Yuan, S.; Wang, R.; Zhang, W.; Chen, J.J.
Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence
Oncotarget
6
30745-30761
2015
Homo sapiens
Yan, H.; Hu, K.; Wu, W.; Li, Y.; Tian, H.; Chu, Z.; Koeffler, H.P.; Yin, D.
Low expression of DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) correlates with poor prognosis in colorectal cancer
PLoS ONE
11
e0159954
2016
Homo sapiens (Q92630), Homo sapiens
Heizmann, B; Reth, M.; Infantino, S.
Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor
Proc. Natl. Acad. Sci. USA
107
18563-18568
2010
Homo sapiens (P43405)
Miao, R.; Wu, Y.; Zhang, H.; Zhou, H.; Sun, X.; Csizmadia, E.; He, L.; Zhao, Y.; Jiang, C.; Miksad, R.A.; Ghaziani, T.; Robson, S.C.; Zhao, H.
Utility of the dual-specificity protein kinase TTK as a therapeutic target for intrahepatic spread of liver cancer
Sci. Rep.
6
33121
2016
Homo sapiens (P33981), Homo sapiens
Morrugares, R.; Correa-Saez, A.; Moreno, R.; Garrido-Rodriguez, M.; Munoz, E.; de la Vega, L.; Calzado, M.A.
Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2
Cell. Mol. Life Sci.
77
2621-2639
2020
Homo sapiens (Q92630)
Guterman-Ram, G.; Pesic, M.; Orenbuch, A.; Czeiger, T.; Aflalo, A.; Levaot, N.
Dual-specificity tyrosine phosphorylation-regulated kinase 2 regulates osteoclast fusion in a cell heterotypic manner
J. Cell. Physiol.
233
617-629
2018
Homo sapiens (Q92630)
Kim, K.; Cha, J.S.; Cho, Y.S.; Kim, H.; Chang, N.; Kim, H.J.; Cho, H.S.
Crystal structure of human dual-specificity tyrosine-regulated kinase 3 reveals new structural features and insights into its auto-phosphorylation
J. Mol. Biol.
430
1521-1530
2018
Homo sapiens (O43781), Homo sapiens
