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Information on EC 2.7.12.1 - dual-specificity kinase and Organism(s) Arabidopsis thaliana and UniProt Accession P51568

for references in articles please use BRENDA:EC2.7.12.1
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EC Tree
IUBMB Comments
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
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Select one or more organisms in this record:
This record set is specific for:
Arabidopsis thaliana
UNIPROT: P51568
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
The taxonomic range for the selected organisms is: Arabidopsis thaliana
Reaction Schemes
Synonyms
dyrk1a, dyrk2, dyrk1b, dyrk3, dual specificity kinase, dual specificity protein kinase, dual-specificity protein kinase, dyrk1a kinase, dual-specificity tyrosine phosphorylation-regulated kinase 1a, serine/threonine/tyrosine kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AtYak1
307523
-
AtYak1 kinase
307523
-
Clik1
-
-
-
-
dual specificity protein kinase
307523
-
dual-specificity Tyr phosphorylation-regulated kinase
307523
-
leucine-rich repeat-receptor-like protein kinase
302
-
protein kinase AFC1
266589
-
protein kinase AFC2
266590
-
protein kinase AFC3
266591
-
Ser/Thr/Tyr kinase
302
-
Yak1 protein
307523
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating)
This family of enzymes can phosphorylate both Ser/Thr and Tyr residues.
CAS REGISTRY NUMBER
COMMENTARY hide
134549-83-0
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + annexin 1
ADP + phospho-annexin 1
show the reaction diagram
phosphorylation at tyrosine and serine/threonine residues
-
-
?
ATP + annexin 2
ADP + phospho-annexin 2
show the reaction diagram
phosphorylation at tyrosine and serine/threonine residues
-
-
?
ATP + annexin 4
ADP + phospho-annexin 4
show the reaction diagram
phosphorylation at tyrosine residues
-
-
?
ATP + RNA binding family protein
ADP + phospho-RNA binding family protein
show the reaction diagram
phosphorylation at serine/threonine residues
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + annexin 1
ADP + phospho-annexin 1
show the reaction diagram
Q8RWH3
phosphorylation at tyrosine and serine/threonine residues
-
-
?
ATP + annexin 2
ADP + phospho-annexin 2
show the reaction diagram
Q8RWH3
phosphorylation at tyrosine and serine/threonine residues
-
-
?
ATP + annexin 4
ADP + phospho-annexin 4
show the reaction diagram
Q8RWH3
phosphorylation at tyrosine residues
-
-
?
ATP + RNA binding family protein
ADP + phospho-RNA binding family protein
show the reaction diagram
Q8RWH3
phosphorylation at serine/threonine residues
-
-
?
additional information
?
-
-
the enzyme is involved in regulation of Mg-chelatase and chlorophyll biosynthesis
-
-
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
enzme Yak1 is a member of dual-specificity Tyr phosphorylation-regulated kinases (DYRKs) that are evolutionarily conserved
malfunction
-
a T-DNA insertion mutant of AtSARK shows significantly delayed senescence, while inducible overexpression of AtSARK in Arabidopsis thaliana causes precocious senescence and abnormal floral organ development. phenotypes of transgenic lines, overview
physiological function
AtYak1 is a dual specificity protein kinase in Arabidopsis that may regulate the phosphorylation status of the annexin family proteins
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
AFC3_ARATH
400
0
46224
Swiss-Prot
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
enzyme domain determination and analysis, modular organization, the enzyme contains an universal stress induced protein associated domain, USPA, and a C-terminal GUN4 domain, the latter binds magnesium-protoporphyrin IX
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
-
the enzyme autophosphorylates on both serine/threonine and tyrosine residues
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
AtSARK, the gene gene consists of 11 exons, quantitative RT-PCR analysis, inducible overexpression of AtSARK in Arabidopsis thaliana causes precocious senescence and abnormal floral organ development
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sequence analysis for enzyme domain determination
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mayer, K.; Schuller, C.; Wambutt, R.; Murphy, G.; et al.
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Nature
402
769-777
1999
Arabidopsis thaliana (P51567), Arabidopsis thaliana (P51568)
Manually annotated by BRENDA team
Salanoubat, M.; Lemcke, K.; Rieger, M.; Ansorge, W.; Unseld, M.; et al.
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana
Nature
408
820-822
2000
Arabidopsis thaliana (P51566)
Manually annotated by BRENDA team
Bender, J.; Fink, G.R.
AFC1, a LAMMER kinase from Arabidopsis thaliana, activates STE12-dependent processes in yeast
Proc. Natl. Acad. Sci. USA
91
12105-12109
1994
Arabidopsis thaliana (P51566), Arabidopsis thaliana (P51567), Arabidopsis thaliana (P51568)
Manually annotated by BRENDA team
Krupa, A.; Srinivasan, N.
Diversity in domain architectures of Ser/Thr kinases and their homologues in prokaryotes
BMC Genet.
6
129
2005
Arabidopsis thaliana, Bradyrhizobium japonicum, Chlamydia sp., Chloroflexus aurantiacus, Clostridium acetobutylicum, Deinococcus radiodurans, Gloeobacter violaceus, Halobacterium salinarum, Hungateiclostridium thermocellum, Leptospira interrogans, Mesorhizobium loti, Methanocaldococcus jannaschii, Methanosarcina acetivorans, Methanosarcina mazei, Methanothermobacter thermautotrophicus, Mycobacterium avium subsp. paratuberculosis, Mycobacterium tuberculosis, Mycobacterium tuberculosis CDC 1551, Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis variant bovis AF2, Nitrosomonas europaea, Nostoc punctiforme, Nostoc sp., Pirellula sp., Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas syringae, Saccharolobus solfataricus, Streptomyces avermitilis, Streptomyces coelicolor, Sulfurisphaera tokodaii, Thermobifida fusca, Thermoplasma acidophilum, Thermoplasma volcanium, Thermospora curvatum, Trichodesmium erythraeum
Manually annotated by BRENDA team
Kim, D.; Ntui, V.O.; Zhang, N.; Xiong, L.
Arabidopsis Yak1 protein (AtYak1) is a dual specificity protein kinase
FEBS Lett.
589
3321-3327
2015
Arabidopsis thaliana, Arabidopsis thaliana (Q8RWH3), Arabidopsis thaliana Col-0 (Q8RWH3)
Manually annotated by BRENDA team
Xu, F.; Meng, T.; Li, P.; Yu, Y.; Cui, Y.; Wang, Y.; Gong, Q.; Wang, N.N.
A soybean dual-specificity kinase, GmSARK, and its Arabidopsis homolog, AtSARK, regulate leaf senescence through synergistic actions of auxin and ethylene
Plant Physiol.
157
2131-2153
2011
Arabidopsis thaliana, Glycine max
Manually annotated by BRENDA team
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