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Information on EC 2.7.11.B1 - serine/threonine protein kinase ST1565
for references in articles please use BRENDA:EC2.7.11.B1
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Please check here for current data: EC unknown
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preliminary BRENDA-supplied EC number
EC Tree 2 Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.B1 serine/threonine protein kinase ST1565
The expected taxonomic range for this enzyme is: Archaea, Eukaryota
Reaction Schemes
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[forkhead-associated-domain-containing protein ST0829]
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[forkhead-associated-domain-containing protein ST0829]phosphate
Synonyms
ser/thr protein kinase st1565, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Ser/Thr protein kinase ST1565
STK_15650
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + [forkhead-associated-domain-containing protein ST0829] = ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
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SYSTEMATIC NAME
IUBMB Comments
ATP:[forkhead-associated-domain-containing protein ST0829] phosphotransferase
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: phosphorylation of the forkhead-associated-domain-containing protein negatively regulates its specific DNA-binding activity. The interaction between ST0829 and the archaeal flagellar protein-encoding operon ST2519p can be inhibited by wild-type Ser/Thr protein kinase ST1565, but is not significantly affected by its mutant variant ST1565-K166A that lacks kinase activity
Products: -
Products: -
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ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: Thr329 is part of a major activation site in the kinase, while Thr326 is a negative regulation site. Several mutants with amino acid substitutions in the conserved forkhead-associated-domain sites of ST0829 do not physically interact with the kinase
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: -
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: Thr329 is part of a major activation site in the kinase, while Thr326 is a negative regulation site. Several mutants with amino acid substitutions in the conserved forkhead-associated-domain sites of ST0829 do not physically interact with the kinase
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: phosphorylation of the forkhead-associated-domain-containing protein negatively regulates its specific DNA-binding activity. The interaction between ST0829 and the archaeal flagellar protein-encoding operon ST2519p can be inhibited by wild-type Ser/Thr protein kinase ST1565, but is not significantly affected by its mutant variant ST1565-K166A that lacks kinase activity
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: -
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: phosphorylation of the forkhead-associated-domain-containing protein negatively regulates its specific DNA-binding activity. The interaction between ST0829 and the archaeal flagellar protein-encoding operon ST2519p can be inhibited by wild-type Ser/Thr protein kinase ST1565, but is not significantly affected by its mutant variant ST1565-K166A that lacks kinase activity
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
Products: -
Products: -
?
ATP + [forkhead-associated-domain-containing protein ST0829]
ADP + [forkhead-associated-domain-containing protein ST0829]phosphate
Substrates: phosphorylation of the forkhead-associated-domain-containing protein negatively regulates its specific DNA-binding activity. The interaction between ST0829 and the archaeal flagellar protein-encoding operon ST2519p can be inhibited by wild-type Ser/Thr protein kinase ST1565, but is not significantly affected by its mutant variant ST1565-K166A that lacks kinase activity
Products: -
Products: -
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Mn2+
the enzyme prefers Mn2+ as a cofactor for autophosphorylation and for substrate phosphorylation. Very low levels of activity were observed when several other metal ions, such as Ni2+, Zn2+, Mg2+, and Ca2+ are added
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
4.5 - 8.5
pH 4.5: about 30% of maximal activity, pG 8.5: about 20% of maximal activity
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
37 - 80
37°C: about 55% of maximal activity, 80°C: about 80% of maximal activity
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
physiological function
-
forkhead-associated-domain-containing protein ST0829 is a potential transcriptional regulator. The phosphorylation signal might participate in transcriptional regulation, and may be vital for the extreme acidothermophilic archaeon to exhibit appropriate adaptive responses to environmental cues
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q970N3_SULTO
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
429
0
48322
TrEMBL
-
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K166A
T326A
mutant enzyme exhibits a higher level of autophosphorylation activity than the wild-type protein
K166A
T326A
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mutant enzyme exhibits a higher level of autophosphorylation activity than the wild-type protein
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duan, X.; He, Z.G.
Characterization of the specific interaction between archaeal FHA domain-containing protein and the promoter of a flagellar-like gene-cluster and its regulation by phosphorylation
Biochem. Biophys. Res. Commun.
407
242-247
2010
Sulfurisphaera tokodaii (Q970N3), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii 7 (Q970N3)
brenda
Wang, B.; Yang, S.; Zhang, L.; He, Z.G.
Archaeal eukaryote-like serine/threonine protein kinase interacts with and phosphorylates a forkhead-associated-domain-containing protein
J. Bacteriol.
192
1956-1964
2010
Sulfurisphaera tokodaii (Q970N3), Sulfurisphaera tokodaii 7 (Q970N3)
brenda
EXTERNAL LINKS (specific for EC-Number 2.7.11.B1)
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Release 2026.1 (March 2026)
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