Reference on EC 2.7.11.8 - Fas-activated serine/threonine kinase
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Tian, Q.; Taupin, J.; Elledge, S.; Robertson, M.; Anderson, P.
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis
J. Exp. Med.
182
865-874
1995
Homo sapiens (Q14296)
Li, W.; Kedersha, N.; Chen, S.; Gilks, N.; Lee, G.; Anderson, P.
FAST is a BCL-XL-associated mitochondrial protein
Biochem. Biophys. Res. Commun.
318
95-102
2004
Homo sapiens (Q14296)
Li, W.; Simarro, M.; Kedersha, N.; Anderson, P.
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression
Mol. Cell. Biol.
24
10178-10732
2004
Homo sapiens (Q14296)
Izquierdo, J.M.; Valcarcel, J.
Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing
J. Biol. Chem.
282
1539-1543
2007
Homo sapiens
Jourdain, A.A.; Koppen, M.; Rodley, C.D.; Maundrell, K.; Gueguen, N.; Reynier, P.; Guaras, A.M.; Enriquez, J.A.; Anderson, P.; Simarro, M.; Martinou, J.C.
A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function
Cell Rep.
10
1110-1121
2015
Mus musculus, Mus musculus (Q9JIX9)
Zhi, F.; Zhou, G.; Shao, N.; Xia, X.; Shi, Y.; Wang, Q.; Zhang, Y.; Wang, R.; Xue, L.; Wang, S.; Wu, S.; Peng, Y.; Yang, Y.
miR-106a-5p inhibits the proliferation and migration of astrocytoma cells and promotes apoptosis by targeting FASTK
PLoS ONE
8
e72390
2013
Homo sapiens
Amin, S.A.; Ghosh, K.; Gayen, S.; Jha, T.
Chemical-informatics approach to COVID-19 drug discovery Monte Carlo based QSAR, virtual screening and molecular docking study of some in-house molecules as papain-like protease (PLpro) inhibitors
J. Biomol. Struct. Dyn.
2020
1-10
2020
Homo sapiens (Q14296)
Garcia Del Rio, A.; Delmiro, A.; Martin, M.A.; Cantalapiedra, R.; Carretero, R.; Durantez, C.; Menegotto, F.; Moran, M.; Serrano-Lorenzo, P.; De la Fuente, M.A.; Orduna, A.; Simarro, M.
The mitochondrial isoform of FASTK modulates nonopsonic phagocytosis of bacteria by macrophages via regulation of respiratory complex I
J. Immunol.
201
2977-2985
2018
Mus musculus (Q8C725)
Khan, N.S.; Khan, P.; Ansari, M.F.; Srivastava, S.; Hasan, G.M.; Husain, M.; Hassan, M.I.
Thienopyrimidine-chalcone hybrid molecules inhibit Fas-activated serine/threonine kinase an approach to ameliorate antiproliferation in human breast cancer cells
Mol. Pharm.
15
4173-4189
2018
Homo sapiens (Q14296), Homo sapiens
Zhang, F.; Wang, K.; Zhang, S.; Li, J.; Fan, R.; Chen, X.; Pei, J.
Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy
Redox Biol.
38
101778
2020
Mus musculus (Q9JIX9)
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