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Information on EC 2.7.11.8 - Fas-activated serine/threonine kinase and Organism(s) Mus musculus and UniProt Accession Q9JIX9

for references in articles please use BRENDA:EC2.7.11.8
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EC Tree
IUBMB Comments
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
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This record set is specific for:
Mus musculus
UNIPROT: Q9JIX9
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
fastk, fast k, fas-activated serine/threonine kinase, fas-activated serine/threonine phosphoprotein, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FASTK
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[Fas-activated serine/threonine protein] phosphotransferase
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
CAS REGISTRY NUMBER
COMMENTARY hide
170347-50-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
-
-
-
?
ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
-
-
-
?
ATP + [Fas-activated serine/threonine protein]
ADP + [Fas-activated serine/threonine phosphoprotein]
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
localizes to mitochondrial RNA granules
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug target
restoration of FASTK expression through genetic approaches might be a promising therapeutic strategy for alcoholic cardiomyopathy (ACM)
malfunction
physiological function
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
FASTK_MOUSE
511
0
57726
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jourdain, A.A.; Koppen, M.; Rodley, C.D.; Maundrell, K.; Gueguen, N.; Reynier, P.; Guaras, A.M.; Enriquez, J.A.; Anderson, P.; Simarro, M.; Martinou, J.C.
A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function
Cell Rep.
10
1110-1121
2015
Mus musculus, Mus musculus (Q9JIX9)
Manually annotated by BRENDA team
Garcia Del Rio, A.; Delmiro, A.; Martin, M.A.; Cantalapiedra, R.; Carretero, R.; Durantez, C.; Menegotto, F.; Moran, M.; Serrano-Lorenzo, P.; De la Fuente, M.A.; Orduna, A.; Simarro, M.
The mitochondrial isoform of FASTK modulates nonopsonic phagocytosis of bacteria by macrophages via regulation of respiratory complex I
J. Immunol.
201
2977-2985
2018
Mus musculus (Q8C725)
Manually annotated by BRENDA team
Zhang, F.; Wang, K.; Zhang, S.; Li, J.; Fan, R.; Chen, X.; Pei, J.
Accelerated FASTK mRNA degradation induced by oxidative stress is responsible for the destroyed myocardial mitochondrial gene expression and respiratory function in alcoholic cardiomyopathy
Redox Biol.
38
101778
2020
Mus musculus (Q9JIX9)
Manually annotated by BRENDA team