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Information on EC 2.7.11.8 - Fas-activated serine/threonine kinase

for references in articles please use BRENDA:EC2.7.11.8
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IUBMB Comments
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
fastkd2, fastk, fast k, fas-activated serine/threonine phosphoprotein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
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