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Information on EC 2.7.11.27 - [acetyl-CoA carboxylase] kinase and Organism(s) Mus musculus and UniProt Accession Q5EG47

for references in articles please use BRENDA:EC2.7.11.27
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IUBMB Comments
Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form . Phosphorylates serine residues.
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This record set is specific for:
Mus musculus
UNIPROT: Q5EG47
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
ampkalpha, camp-activated protein kinase, 5'-amp activated protein kinase, acetyl-coa carboxylase kinase, acetyl-coa carboxylase kinase-2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
acetyl coenzyme A carboxylase kinase (phosphorylating)
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acetyl-CoA carboxylase kinase
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acetyl-CoA carboxylase kinase (cAMP-independent)
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acetyl-CoA carboxylase kinase-2
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acetyl-CoA carboxylase kinase-3 (AMP-activated)
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acetyl-coenzyme A carboxylase kinase
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ACK2
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ACK3
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AMP-activated protein kinase
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:[acetyl-CoA carboxylase] phosphotransferase
Phosphorylates and inactivates EC 6.4.1.2, acetyl-CoA carboxylase, which can be dephosphorylated and reactivated by EC 3.1.3.17, [phosphorylase] phosphatase. The enzyme is more active towards the dimeric form of acetyl-CoA carboxylase than the polymeric form [5]. Phosphorylates serine residues.
CAS REGISTRY NUMBER
COMMENTARY hide
77000-06-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [acetyl-CoA carboxylase]
ADP + [acetyl-CoA carboxylase] phosphate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [acetyl-CoA carboxylase]
ADP + [acetyl-CoA carboxylase] phosphate
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
adiponectin
adiponectin increases the phosphorylation and activation of AMPK, it increases inactivated acetyl-CoA carboxylase (ACC), which has been phosphorylated by activated AMPK, and subsequently increases expression of agouti-related peptide (AgRP) mRNA
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CTRP1 protein
activates AMP-activated protein kinase (AMPK), which inhibits acetyl-CoA carboxylase (ACC) through phosphorylation. CTRP1 has a direct effect on AMPK signaling, recombinant CTRP1 administration acutely stimulates muscle AMPKalpha and ACC phosphorylation in vivo
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metformin
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an AMPK activator
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
a mouse immortalized hypothalamic neuronal cell line
Manually annotated by BRENDA team
isolated soleus muscle
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AAPK1_MOUSE
559
0
63929
Swiss-Prot
other Location (Reliability: 4)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
recombinant CTRP1 acutely induces AMPKalpha and ACC phosphorylation in skeletal muscle
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
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clinical application of the enzyme activator metformin to obese or early diabetic patients may be helpful in preventing obesity- or diabetes-related kidney disease
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kim, D.; Lee, J.E.; Jung, Y.J.; Lee, A.S.; Lee, S.; Park, S.K.; Kim, S.H.; Park, B.H.; Kim, W.; Kang, K.P.
Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice
Int. J. Mol. Med.
32
1293-1302
2013
Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Peterson, J.M.; Aja, S.; Wei, Z.; Wong, G.W.
CTRP1 protein enhances fatty acid oxidation via AMP-activated protein kinase (AMPK) activation and acetyl-CoA carboxylase (ACC) inhibition
J. Biol. Chem.
287
1576-1587
2012
Mus musculus (Q5EG47 AND Q8BRK8), Mus musculus C57BL/6 (Q5EG47 AND Q8BRK8)
Manually annotated by BRENDA team
Wen, J.P.; Liu, C.E.; Hu, Y.T.; Chen, G.; Lin, L.X.
Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus
Mol. Cell. Biochem.
344
109-115
2010
Mus musculus (Q5EG47 AND Q8BRK8)
Manually annotated by BRENDA team
Mottillo, E.P.; Desjardins, E.M.; Fritzen, A.M.; Zou, V.Z.; Crane, J.D.; Yabut, J.M.; Kiens, B.; Erion, D.M.; Lanba, A.; Granneman, J.G.; Talukdar, S.; Steinberg, G.R.
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis
Mol. Metab.
6
471-481
2017
Mus musculus
Manually annotated by BRENDA team