Any feedback?
Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Schizosaccharomyces pombe and UniProt Accession Q92398
for references in articles please use BRENDA:EC2.7.11.24Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
2.7.11.24 mitogen-activated protein kinaseIUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
Specify your search results
Word Map
- 2.7.11.24
- endothelial
- necrosis
- tnf
- agonist
- lipopolysaccharide
- 3-kinase
- pkc
- lps
- nf-kappab
- sirnas
- phosphatidylinositol
- caspase-3
- cardiac
- metastasis
-
lps-induced
- artery
- camp
- bcl-2
- monocyte
- chemokine
- collagen
- angiogenesis
- cox-2
- fibrosis
-
toll-like
- cyclins
-
neuroprotective
- melanoma
- stat3
- tnf-alpha
- prostaglandin
- c-fos
- phosphoinositide
- mtor
- cardiomyocytes
- factor-alpha
- osteoblast
-
dominant-negative
- creb
-
anti-apoptotic
- integrins
- cyclooxygenase-2
- angiotensin
- wortmannin
-
protein-coupled
- microglia
- mmp-9
- il-1beta
-
platelet-derived
- fak
- medicine
- drug development
- analysis
- pharmacology
The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
cp38a
-
-
-
-
cp38b
-
-
-
-
CSAID binding protein
-
-
-
-
CSBP
-
-
-
-
Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
-
ERK5
-
-
-
-
MAP kinase MXI2
-
-
-
-
MAP kinase p38 beta
-
-
-
-
MAP kinase p38 delta
-
-
-
-
MAP kinase p38 gamma
-
-
-
-
MAP kinase p38a
-
-
-
-
MAP kinase p38alpha
-
-
-
-
MAP kinase p38b
-
-
-
-
MAPK
-
-
-
-
mitogen-activated protein kinase
-
-
-
-
Mitogen-activated protein kinase p38 beta
-
-
-
-
Mitogen-activated protein kinase p38 delta
-
-
-
-
Mitogen-activated protein kinase p38 gamma
-
-
-
-
Mitogen-activated protein kinase p38a
-
-
-
-
Mitogen-activated protein kinase p38alpha
-
-
-
-
Mitogen-activated protein kinase p38b
-
-
-
-
p38b
-
-
-
-
SAPK2A
-
-
-
-
stress-activated protein kinase 2a
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY
142243-02-5
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
-
-
?
additional information
?
-
-
stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
-
-
?
additional information
?
-
enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
-
enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
enzyme functions as a part of the fission yeast growth control pathway
-
-
?
additional information
?
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
additional information
?
-
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
-
the enzyme regulates cell integrity and functions coordinately with the protein kinase C pathway
-
-
?
additional information
?
-
stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
-
-
?
additional information
?
-
-
stress-activated MAP kinase regulates morphogenesis in Schizosaccharomyces pombe
-
-
?
additional information
?
-
enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
-
enzyme plays a pivotal role in a variety of signal transduction pathways
-
-
?
additional information
?
-
enzyme functions as a part of the fission yeast growth control pathway
-
-
?
additional information
?
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
-
conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
-
-
?
additional information
?
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
additional information
?
-
-
acts downstream of the Wis1 MAP kinase kinase to control cell size at division in fission yeast
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphoprotein
the enzyme is Tyr phosphorylated and activated in response to osmotic and heat stress. Spk1 is required for sexual differentiation and sporulation
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (P41892)
Gonzalez, F.A.; Raden, D.L.; Rigby, M.R.; Davis, R.J.
Heterogeneous expression of four MAP kinase isoforms in human tissues
FEBS Lett.
304
170-178
1992
Schizosaccharomyces pombe (P27638), Homo sapiens (P28482), Homo sapiens (P31152), Homo sapiens
Gotoh, Y.; Nishida, E.; Shimanuki, M.; Toda, T.; Imai, Y.; Yamamoto, M.
Schizosaccharomyces pombe Spk1 is a tyrosine-phosphorylated protein functionally related to Xenopus mitogen-activated protein kinase
Mol. Cell. Biol.
13
6427-6434
1993
Schizosaccharomyces pombe (P27638), Schizosaccharomyces pombe
Toda, T.; Shimanuki, M.; Yanagida, M.
Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases
Genes Dev.
5
60-73
1991
Schizosaccharomyces pombe (P27638)
Shiozaki, K.; Russell, P.
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
Genes Dev.
10
2276-2288
1996
Schizosaccharomyces pombe (Q09892), Schizosaccharomyces pombe
Millar, J.B.; Buck, V.; Wilkinson, M.G.
Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
Genes Dev.
9
2117-2130
1995
Schizosaccharomyces pombe (Q09892), Schizosaccharomyces pombe
Zaitsevskaya-Carter, T.; Cooper, J.A.
Spm1, a stress-activated MAP kinase that regulates morphogenesis in S. pombe
EMBO J.
16
1318-1331
1997
Schizosaccharomyces pombe (Q92398), Schizosaccharomyces pombe
Toda, T.; Dhut, S.; Superti-Furga, G.; Gotoh, Y.; Nishida, E.; Sugiura, R.; Kuno, T.
The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
Mol. Cell. Biol.
16
6752-6764
1996
Schizosaccharomyces pombe (Q92398), Schizosaccharomyces pombe
EXTERNAL LINKS (specific for EC-Number 2.7.11.24)
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
