Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + protein
ADP + phosphoprotein
proline-directed kinase
-
-
?
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
ATP + Elk1
ADP + phosphorylated Elk1
ATP + Ets-1
ADP + phosphorylated Ets-1
-
-
-
-
?
ATP + JunD
ADP + phosphorylated JunD
-
-
-
-
?
ATP + MEK
ADP + phosphorylated MEK
-
-
binding to ERK requires docking domain and the kinase interaction motif
-
?
ATP + p38
ADP + phosphorylated p38
-
-
-
-
?
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
ATP + protein
ADP + phosphoprotein
ATP + RSK
ADP + phosphorylated RSK
-
-
binding to ERK requires docking domain
-
?
ATP + sodium channel Na(v)1.6
ADP + phosphorylated sodium channel Na(v)1.6
-
-
-
-
?
ATP + sodium channel Na(v)1.7
ADP + phosphorylated sodium channel Na(v)1.7
-
-
-
-
?
ATP + sodium channel Na(v)1.8
ADP + phosphorylated sodium channel Na(v)1.8
-
-
-
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
additional information
?
-
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated JNK3
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
-
-
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated JNK3
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
recombinant GST-tagged substrate, the reaction is performed by activated phosphorylated JNK3
-
-
?
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1
-
-
?
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
recombinant substrate, the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + protein
ADP + phosphoprotein
proline-directed kinase
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation on both tyrosine and threonine residues, autophosphorylation is probably involved in the MAP kinase activation process in vitro, but it may not be sufficient for full activation
-
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
-
phosphorylation of tyrosine hydroxylase at Ser8 and Ser31 by ERK1 and ERK2 is involved in regulation of catecholamine biosynthesis
-
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
-
recombinant rat wild-type and S8A, S31A, S19A, and S40A mutant tyrosine hydroxylase substrates, phosphorylation at Ser8 and Ser31 by ERK1 and ERK2, ERK2 prefers the Ser31 phosphorylation site, no activity with substrate mutant S8A/S31A
-
-
?
additional information
?
-
p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase
-
-
?
additional information
?
-
the enzyme is involved in regulating the response of eukaryotic cells to extracellular signals
-
-
?
additional information
?
-
the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression
-
-
?
additional information
?
-
-
p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview
-
-
?
additional information
?
-
-
signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
-
-
?
additional information
?
-
-
tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process
-
-
?
additional information
?
-
-
MAPK phosphorylation consensus sequences
-
-
?
additional information
?
-
MAPK phosphorylation consensus sequences
-
-
?
additional information
?
-
-
stoichiometry of phosphorylation of wild-type and mutant tyrosine hydroxylase substrates by ERK2
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
ATP + Elk1
ADP + phosphorylated Elk1
ATP + phospholipase C-gamma1
ADP + phosphorylated phospholipase C-gamma1
the reaction is performed by activated phosphorylated ERK2, phosphorylation inhibits phospholipase C-gamma1
-
-
?
ATP + tyrosine hydroxylase
ADP + phosphorylated tyrosine hydroxylase
-
phosphorylation of tyrosine hydroxylase at Ser8 and Ser31 by ERK1 and ERK2 is involved in regulation of catecholamine biosynthesis
-
-
?
additional information
?
-
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + c-Jun
ADP + phosphorylated c-Jun
the reaction is performed by activated phosphorylated JNK3
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated ERK2
-
-
?
ATP + Elk1
ADP + phosphorylated Elk1
the reaction is performed by activated phosphorylated JNK3
-
-
?
additional information
?
-
p38-delta is activated by environmental stress, extracellular stimulants, and MAPK kinase-3, -4, -6, and -7, suggesting that p38-delta is a unique stress-responsive protein kinase
-
-
?
additional information
?
-
the enzyme is involved in regulating the response of eukaryotic cells to extracellular signals
-
-
?
additional information
?
-
the enzyme plays a crucial role in stress and inflammatory responses and is also involved in activation of the human immunodeficiency virus gene expression
-
-
?
additional information
?
-
-
p38 MAPK, but not ERKs or JNKs, regulates the serotonin transporter, SERT, and subsequent signaling induced by 5-hydroxytryptamine, overview
-
-
?
additional information
?
-
-
signaling pathways overview, the enzyme is important in transduction of external stimuli and signals from the cell membrane to nuclear and other intracellular targets, the enzyme is involved in regulation of several cellular processes in cell growth, differentiation, development cell cycle, death and survival, the enzyme is also involved in pathogenesis of several processes in the heart, e.g. hypertrophy, ischemic and reperfusion injury, aas well as in cardioprotection, the MAPK family enzymes have regulatory function in the myocardium, overview
-
-
?
additional information
?
-
-
tert-butyl hydroperoxide activation of MAPK might be involved in vascular dysfunction in oxidative stress responses and the vascular inflammatory process
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk1, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk1 pathway, mechanism, overview
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of Erk2, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of Erk2 pathway, mechanism, overview
-
-
?
additional information
?
-
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
additional information
?
-
cadmium induces neuronal apoptosis in part through activation of JNK, Cd-induced reactive oxygen species inhibit serine/threonine protein phosphatases 2A and 5, PP2A andPP5, leading to activation of JNK pathway, mechanism, overview
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
1,4-diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene
-
U0126
2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one
-
PD98059
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
-
PD98059
6-[1-(2-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[1-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[1-(3-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[1-(4-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazole
-
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine
-
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine
-
6-[5-amino-1-ethyl-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
-
6-[5-amino-3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
-
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)-2,3-dihydro-1,3-benzothiazol-2-amine
-
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
-
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1S)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
-
hypericin
-
hypericin-mediated inhibition of glutamate release appears to involve the suppression of mitogen-activated protein kinase pathway
MKP1/2
-
may dampen ERK activity during the G1/S transition, is involved in reducing strength and duration of ERK signaling
-
MKP3
-
selective for ERK1 and 2
-
N-(1-methylethyl)-6-(1-phenyl-1H-pyrazol-5-yl)-1,3-benzothiazol-2-amine
-
N-(1-methylethyl)-6-(4-phenyl-1,3-oxazol-5-yl)-1,3-benzothiazol-2-amine
-
N-(1-methylethyl)-6-(4-phenyl-1H-imidazol-5-yl)-1,3-benzothiazol-2-amine
-
N-(1-methylethyl)-6-[1-(2-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
-
N-(1-methylethyl)-6-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
-
N-(1-methylethyl)-6-[1-(4-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
-
N-ethyl-6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine
-
PD169316
-
i.e. 4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation
phospholipase C-gamma1 D-domain
-
SB202190
-
inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h
PD98059
-
inhibits ERK1 and ERK2
PD98059
-
inhibition of neurite outgrowth induced by ADAMTS4 treatment
phospholipase C-gamma1 D-domain
a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by ERK2, overview
-
phospholipase C-gamma1 D-domain
a peptide containing the phospholipase C-gamma1 D-domain competitively inhibits the phosphorylation of Elk1 and c-Jun by JNK3, overview
-
SB203580
-
SB203580
-
i.e. 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole, a specific p38 MAPK inhibitor, reduces 5-hydroxytryptamine uptake in cells, inhibits SERT phosphorylation
SB203580
-
inhibits p38 MAP kinase
SB203580
-
inhibition of p38 MAPK and modulation of ERK, enhanced strain-induced ERK1/2 activation at 20 min and its restriction after 24 h
SP600125
-
-
SP600125
inhibitor of JNK
U0126
-
-
U0126
-
inhibition of neurite outgrowth induced by ADAMTS4 treatment
additional information
-
in vitro the recombinant phospholipase C-gamma1 activity is not inhibited by phosphorylation through activated ERK2
-
additional information
in vitro the recombinant phospholipase C-gamma1 activity is not inhibited by phosphorylation through activated ERK2
-
additional information
-
genes encoding Sef prevent dissociation of the MEK-ERK complex, thereby inhibiting translocation of ERK to the nucleus, but ERK can still signal to cytoplasmic targets
-
additional information
-
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk1
-
additional information
-
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of Erk2
-
additional information
-
overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK
-
additional information
overexpression of PP2A or PP5 partially prevents Cd-induced activation of JNK
-
additional information
synthesis of benzothiazole based inhibitors of p38alpha MAP kinase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000175
6-[1-(2-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.00002
6-[1-(2-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000072
6-[1-(3-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000033
6-[1-(3-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.001
6-[1-(4-chlorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
above, inhibition of p38alpha MAP kinase
0.000048
6-[1-(4-fluorophenyl)-1H-pyrazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000016
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000047
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazole
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000064
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.00001
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000065
6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000033
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000027
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1R)-1-methylpropyl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000016
6-[4-(2-fluorophenyl)-1H-imidazol-5-yl]-N-[(1S)-1-methylpropyl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000017
6-[5-amino-1-ethyl-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000011
6-[5-amino-3-(2-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000037
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-(1-methylethyl)-2,3-dihydro-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000032
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1R)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000055
6-[5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl]-N-[(1S)-1-methylpropyl]-2,3-dihydro-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000021
N-(1-methylethyl)-6-(1-phenyl-1H-pyrazol-5-yl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000021
N-(1-methylethyl)-6-(4-phenyl-1,3-oxazol-5-yl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.0000033
N-(1-methylethyl)-6-(4-phenyl-1H-imidazol-5-yl)-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000146
N-(1-methylethyl)-6-[1-(2-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.000033
N-(1-methylethyl)-6-[1-(3-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
0.001
N-(1-methylethyl)-6-[1-(4-methylphenyl)-1H-pyrazol-5-yl]-1,3-benzothiazol-2-amine
Rattus norvegicus
above, inhibition of p38alpha MAP kinase
0.000012
N-ethyl-6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-1,3-benzothiazol-2-amine
Rattus norvegicus
inhibition of p38alpha MAP kinase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Boulton, T.G.; Gregory, J.S.; Cobb, M.H.
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
Biochemistry
30
278-286
1991
Rattus norvegicus (P21708)
brenda
Hu, M.C.; Wang, Y.P.; Mikhail, A.; Qiu, W.R.; Tan, T.H.
Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines
J. Biol. Chem.
274
7095-7102
1999
Homo sapiens (O15264), Homo sapiens, Rattus norvegicus (Q9WTY9)
brenda
Yung, Y.; Yao, Z.; Hanoch, T.; Seger, R.
ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK
J. Biol. Chem.
275
15799-15808
2000
Rattus norvegicus (P21708)
brenda
Marquardt, B.; Stabel, S.
Sequence of a rat cDNA encoding the ERK1-MAP kinase
Gene
120
297-299
1992
Rattus norvegicus (P21708)
brenda
Seger, R.; Ahn, N.G.; Boulton, T.G.; Yancopoulos, G.D.; Panayotatos, N.; Radziejewska, E.; Ericsson, L.; Bratlien, R.L.; Cobb, M.H.; Krebs, E.G.
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation
Proc. Natl. Acad. Sci. USA
88
6142-6146
1991
Rattus norvegicus (P21708)
brenda
De Miguel, C.; Kligman, D.; Patel, J.; Detera-Wadleigh, S.D.
Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain
DNA Cell Biol.
10
505-514
1991
Rattus norvegicus (P21708)
brenda
Boulton, T.G.; Yancopoulos, G.D.; Gregory, J.S.; Slaughter, C.; Moomaw, C.; Hsu, J.; Cobb, M.H.
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
Science
249
64-67
1990
Rattus norvegicus (P21708)
brenda
Boulton, T.G.; Nye, S.H.; Robbins, D.J.; Ip, N.Y.; Radziejewska, E.; Morgenbesser, S.D.; DePinho, R.A.; Panayotatos, N.; Cobb, M.H.; Yancopoulos, G.D.
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Cell
65
663-675
1991
Rattus norvegicus (P27704), Mus musculus (P63085)
brenda
Clerk, A.; Fuller, S.J.; Michael, A.; Sugden, P.H.
Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses
J. Biol. Chem.
273
7228-7234
1998
Rattus norvegicus (P49185)
brenda
Kyriakis, J.M.; Banerjee, P.; Nikolakaki, E.; Dai, T.; Rubie, E.A.; Ahmad, M.F.; Avruch, J.; Woodgett, J.R.
The stress-activated protein kinase subfamily of c-Jun kinases
Nature
369
156-160
1994
Rattus norvegicus (P49185), Rattus norvegicus (P49186), Rattus norvegicus (P49187)
brenda
Royo, M.; Daubner, S.C.; Fitzpatrick, P.F.
Specificity of the MAP kinase ERK2 for phosphorylation of tyrosine hydroxylase
Arch. Biochem. Biophys.
423
247-252
2004
Rattus norvegicus
brenda
Lee, J.Y.; Yu, B.P.; Chung, H.Y.
Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide
Free Radic. Res.
39
399-409
2005
Rattus norvegicus
brenda
Buckley, C.T.; Sekiya, F.; Kim, Y.J.; Rhee, S.G.; Caldwell, K.K.
Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrate
J. Biol. Chem.
279
41807-41814
2004
Rattus norvegicus, Rattus norvegicus (P63086)
brenda
Samuvel, D.J.; Jayanthi, L.D.; Bhat, N.R.; Ramamoorthy, S.
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression
J. Neurosci.
25
29-41
2005
Rattus norvegicus
brenda
Bind, E.; Kleyner, Y.; Skowronska-Krawczyk, D.; Bien, E.; Dynlacht, B.D.; Sanchez, I.
A novel mechanism for mitogen-activated protein kinase localization
Mol. Biol. Cell
15
4457-4466
2004
Rattus norvegicus (P27704)
brenda
Ravingerova, T.; Barancik, M.; Strniskova, M.
Mitogen-activated protein kinases: a new therapeutic target in cardiac pathology
Mol. Cell. Biochem.
247
127-138
2003
Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Lewthwaite, J.C.; Bastow, E.R.; Lamb, K.J.; Blenis, J.; Wheeler-Jones, C.P.; Pitsillides, A.A.
A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation
J. Biol. Chem.
281
11011-11018
2006
Gallus gallus, Rattus norvegicus
brenda
Murphy, L.O.; Blenis, J.
MAPK signal specificity: the right place at the right time
Trends Biochem. Sci.
31
268-275
2006
Rattus norvegicus, Xenopus sp.
brenda
Liu, C.; Lin, J.; Pitt, S.; Zhang, R.F.; Sack, J.S.; Kiefer, S.E.; Kish, K.; Doweyko, A.M.; Zhang, H.; Marathe, P.H.; Trzaskos, J.; Mckinnon, M.; Dodd, J.H.; Barrish, J.C.; Schieven, G.L.; Leftheris, K.
Benzothiazole based inhibitors of p38alpha MAP kinase
Bioorg. Med. Chem. Lett.
18
1874-1879
2008
Rattus norvegicus (P70618)
brenda
Chen, L.; Liu, L.; Huang, S.
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
Free Radic. Biol. Med.
45
1035-1044
2008
Homo sapiens, Homo sapiens (P27361), Homo sapiens (P28482), Rattus norvegicus, Rattus norvegicus (P21708), Rattus norvegicus (P63086)
brenda
Hamel, M.G.; Ajmo, J.M.; Leonardo, C.C.; Zuo, F.; Sandy, J.D.; Gottschall, P.E.
Multimodal signaling by the ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) promotes neurite extension
Exp. Neurol.
210
428-440
2008
Rattus norvegicus
brenda
Chen, B.; Ma, Y.; Meng, R.; Xiong, Z.; Zhang, C.; Chen, G.; Zhang, A.; Dong, Y.
MG132, a proteasome inhibitor, attenuates pressure-overload-induced cardiac hypertrophy in rats by modulation of mitogen-activated protein kinase signals
Acta Biochim. Biophys. Sin. (Shanghai)
42
253-258
2010
Rattus norvegicus
brenda
Li, F.; Ruan, H.; Fan, C.; Zeng, B.; Wang, C.; Wang, X.
Efficient inhibition of the formation of joint adhesions by ERK2 small interfering RNAs
Biochem. Biophys. Res. Commun.
391
795-799
2010
Rattus norvegicus
brenda
Fahrenholz, M.; Real, R.; Kueken, A.; Saxena, A.; Orzechowski, H.D.
Single low-dose administration of pharmacological inhibitor of mitogen-activated ERK kinase to the adventitia of the injured rat carotid artery suppresses neointima formation and inhibits nuclear ERK signaling
Eur. J. Pharmacol.
617
90-96
2009
Rattus norvegicus
brenda
Chang, Y.; Wang, S.J.
Hypericin, the active component of St. Johns wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway
Eur. J. Pharmacol.
634
53-61
2010
Rattus norvegicus
brenda
Hanajiri, K.; Mitsui, H.; Maruyama, T.; Hashimoto, N.; Sata, M.; Omata, M.
Echographic detection of diethylnitrosamine-induced liver tumors in rats and the effect of the intratumoral injection of an inhibitor of c-Jun N-terminal kinase
J. Gastroenterol. Hepatol.
24
866-871
2009
Rattus norvegicus
brenda
Lizarraga-Mollinedo, E.; Fernandez-Millan, E.; de Miguel-Santos, L.; Martinez-Honduvilla, C.J.; Alvarez, C.; Escriva, F.
Early undernutrition increases glycogen content and reduces the activated forms of GSK3, AMPK, p38 MAPK, and JNK in the cerebral cortex of suckling rats
J. Neurochem.
112
123-133
2010
Rattus norvegicus
brenda
Stamboulian, S.; Choi, J.S.; Ahn, H.S.; Chang, Y.W.; Tyrrell, L.; Black, J.A.; Waxman, S.G.; Dib-Hajj, S.D.
ERK1/2 mitogen-activated protein kinase phosphorylates sodium channel Na(v)1.7 and alters its gating properties
J. Neurosci.
30
1637-1647
2010
Rattus norvegicus
brenda
Onali, P.; Dedoni, S.; Olianas, M.C.
Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes
J. Pharmacol. Exp. Ther.
332
255-265
2010
Homo sapiens, Rattus norvegicus
brenda
Vikram, A.; Jena, G.B.; Ramarao, P.
Increased cell proliferation and contractility of prostate in insulin resistant rats: linking hyperinsulinemia with benign prostate hyperplasia
Prostate
70
79-89
2010
Rattus norvegicus
brenda
Blaha, L.; Babica, P.; Hilscherova, K.; Upham, B.L.
Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts--indications of novel tumor-promoting cyanotoxins?
Toxicon
55
126-134
2010
Rattus norvegicus
brenda
Xiao, Y.; Warner, L.R.; Latham, M.P.; Ahn, N.G.; Pardi, A.
Structure-based assignment of Ile, Leu, and Val methyl groups in the active and inactive forms of the mitogen-activated protein kinase extracellular signal-regulated kinase 2
Biochemistry
54
4307-4319
2015
Rattus norvegicus (P63086)
brenda