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ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + Axl2
ADP + phospho-Axl2
-
substrate of Hog1
-
-
?
ATP + casein
ADP + phosphocasein
-
substrate of Hog1
-
-
?
ATP + cdc42
ADP + phosphorylated cdc42
-
substrate of Gic2
-
-
?
ATP + DNA polymerase II
ADP + phosphorylated DNA polymerase II
-
substrate of Hog1p
-
-
?
ATP + Gic2
ADP + phosphorylated Gic2
-
substrate of Fus3, and of Hog1
-
-
?
ATP + histone H1
ADP + phospho-histone H1
-
substrate of Hog1
-
-
?
ATP + Hog1D
ADP + phospho-Hog1D
-
substrate of Hog1
-
-
?
ATP + Hot1p
ADP + phosphorylated Hot1p
ATP + Hsl1
ADP + phospho-Hsl1
-
substrate of Hog1
-
-
?
ATP + MBP
ADP + phospho-MBP
-
substrate of Hog1
-
-
?
ATP + Mek1
ADP + phospho-Mek1
-
substrate of Hog1
-
-
?
ATP + protein tyrosine kinase 2
ADP + phosphorylated protein tyrosine kinase 2
-
substrate of Hog1
-
-
?
ATP + RAD9
ADP + phospho-RAD9
-
high activity with Fus3, low activity with Hog1
-
-
?
ATP + RAD9p
ADP + phospho-RAD9p
-
substrate of Hog1
-
-
?
ATP + Rck2
ADP + phosphorylated Rck2
-
-
-
-
?
ATP + Red1
ADP + phospho-Red1
-
preferred substrate of Hog1
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
ATP + Swe1
ADP + phospho-Swe1
-
substrate of Hog1
-
-
?
ATP + Swi6
ADP + phospho-Swi6
-
substrate of Hog1
-
-
?
ATP + Tub4p
ADP + phospho-Tub4
-
substrate of Hog1
-
-
?
additional information
?
-
ATP + Hot1p
ADP + phosphorylated Hot1p
-
substrate of Hog1p
-
-
?
ATP + Hot1p
ADP + phosphorylated Hot1p
-
substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview
-
-
?
additional information
?
-
enzyme is required for the transition from mitosis into conjugation
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway
-
-
?
additional information
?
-
enzyme is required for restoring the osmotic gradient across the cell membrane
-
-
?
additional information
?
-
-
enzyme is required for restoring the osmotic gradient across the cell membrane
-
-
?
additional information
?
-
enzyme is involved in polarized cell growth
-
-
?
additional information
?
-
-
enzyme is involved in polarized cell growth
-
-
?
additional information
?
-
enzyme is required for spore wall assembly
-
-
?
additional information
?
-
-
enzyme is required for spore wall assembly
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
enzyme is involved in growth control pathway
-
-
?
additional information
?
-
-
Hog1 is related to osmotic stress
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation
-
-
?
additional information
?
-
-
Fus3, Kss1, and Hog1 function during the mating pheromone response, the switch of filamentous growth, and the response to high osmolarity, respectively, detailed pathway overview, MAPK signaling pathways and specificity, pathway sequestering mechanism modeling, separation via subcellular compartmentalization, temporal separation, scaffolding, combinatorial signaling, detailed overview
-
-
?
additional information
?
-
-
MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview
-
-
?
additional information
?
-
-
transcription factor protein domains consisting of the LXL motif, the FXFP motif, the LXLXXXF motif, or the ETS motif, are involved in stable interaction of MAPKs with transcription complexes
-
-
?
additional information
?
-
-
kinase activity of Hog1 is required to promote its own dephosphorylation after hyperosmotic-stress-induced activation, moreover, catalytic activity of Hog1 is required continuously to prevent cross talk between the the high-osmolarity glycerol pathway and both the pheromone response and invasive growth pathways
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
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ATP + a protein
ADP + a phosphoprotein
-
-
-
-
?
ATP + DNA polymerase II
ADP + phosphorylated DNA polymerase II
-
substrate of Hog1p
-
-
?
ATP + Hot1p
ADP + phosphorylated Hot1p
-
substrate of Hog1p, phosphorylation of Hot1p is not required for Hot1p-mediated gene expression
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
additional information
?
-
ATP + Ste50
ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Hog1, regulation, overview
-
-
?
ATP + Ste50
ADP + phosphorylated Ste50
Hog1 phosphorylates Ste50 in response to osmotic stress, and phosphorylation of Ste50 limits the duration of Kss1 activation and prevents invasive growth under high osmolarity growth conditions. The feedback phosphorylation event leads to more transient activation of Kss1, regulation, overview
-
-
?
additional information
?
-
enzyme is required for the transition from mitosis into conjugation
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
DAC2/FUS3 protein kinase is not essential for transcriptional activation of the mating pheromone response pathway
-
-
?
additional information
?
-
enzyme is required for restoring the osmotic gradient across the cell membrane
-
-
?
additional information
?
-
-
enzyme is required for restoring the osmotic gradient across the cell membrane
-
-
?
additional information
?
-
enzyme is involved in polarized cell growth
-
-
?
additional information
?
-
-
enzyme is involved in polarized cell growth
-
-
?
additional information
?
-
enzyme is required for spore wall assembly
-
-
?
additional information
?
-
-
enzyme is required for spore wall assembly
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
signal transduction in Saccharomyces cerevisiae requires Tyr and Thr phosphorylation of FUS3 and KSS1
-
-
?
additional information
?
-
enzyme is involved in growth control pathway
-
-
?
additional information
?
-
-
Hog1 is related to osmotic stress
-
-
?
additional information
?
-
-
Fus3, Kss1, and Hog1 function during the mating pheromone response, the switch of filamentous growth, and the response to high osmolarity, respectively, detailed pathway overview, MAPK signaling pathways and specificity, pathway sequestering mechanism modeling, separation via subcellular compartmentalization, temporal separation, scaffolding, combinatorial signaling, detailed overview
-
-
?
additional information
?
-
-
MAPK pathways overview, the MAPKs act as structural adaptors and enzymatic activators in transcription complexes, e.g. Hog1p, Hot1p, and Sko1p, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Hog1 activity is transient and promotes cell adaptation to osmotic stress, Ste50 is a target for feedback regulation of the two pathways, overview. Hog1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
additional information
?
-
-
the adaptor protein Ste50 functions in multiple MAP kinase pathways, each with unique dynamical and developmental properties. Kss1 activity is sustained and promotes invasive growth, Ste50 is a target for feedback regulation of the two pathways, overview. Kss1 mediates gene induction, e.g. the Ty1 or TEC1 promoters, overview
-
-
?
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sorbitol
-
upon exposure to 1000 mM sorbitol, Hog1 is phosphorylated rapidly, with modification peaking at 10 to 20 min and then declining as cells adapt
additional information
Fus3 is phosphorylated and activated by Ste7. Building synthetic feedback loops by dynamically regulating recruitment of modulators to the Ste5 scaffold, negative- and positive-feedback loop design, leads to activation of inhibition of the Fus3, overview
-
additional information
-
Fus3 is phosphorylated and activated by Ste7. Building synthetic feedback loops by dynamically regulating recruitment of modulators to the Ste5 scaffold, negative- and positive-feedback loop design, leads to activation of inhibition of the Fus3, overview
-
additional information
-
pheromones can influence the phosphorylation of MAPKs, the scaffolding proteins Ste mediate MAPK function in signaling by recruitment of the kinases to reaction sites, e.g. the plasma membrane, or by concentrating and maybe also by orientating relevant reaction components, e.g. Ste5, overview
-
additional information
-
upon hyperosmotic stress, Hog1 is activated by phosphorylation
-
additional information
osmotic stress activates Hog1. Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
additional information
osmotic stress activates Hog1. Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
additional information
-
osmotic stress activates Hog1. Ste11 is a MAP kinase kinase kinase upstream of Hog1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
additional information
osmotic stress activates Kss1. Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
additional information
osmotic stress activates Kss1. Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
additional information
-
osmotic stress activates Kss1. Ste11 is a MAP kinase kinase kinase upstream of Kss1. Ste50 is an adaptor protein required for the catalytic activity of Ste11
-
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Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII
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13
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8
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Saccharomyces cerevisiae (P16892)
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FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation
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13
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An osmosensing signal transduction pathway in yeast
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8
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5
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26
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