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Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Agaricus bisporus and UniProt Accession P14681

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EC Tree
IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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Agaricus bisporus
UNIPROT: P14681
Word Map
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
At2g43790, ATMPK1, ATMPK2, BMK1, c-Jun amino-terminal kinase, c-Jun N-terminal kinase, c-jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3, c-Jun NH2-terminal kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cp38a
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cp38b
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CSAID binding protein
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CSBP
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Cytokine suppressive anti-inflammatory drug binding protein
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ERK5
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MAP kinase MXI2
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MAP kinase p38 beta
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MAP kinase p38 delta
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MAP kinase p38 gamma
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MAP kinase p38a
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MAP kinase p38alpha
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MAP kinase p38b
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MAPK
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mitogen-activated protein kinase
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Mitogen-activated protein kinase p38 beta
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Mitogen-activated protein kinase p38 delta
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Mitogen-activated protein kinase p38 gamma
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Mitogen-activated protein kinase p38a
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Mitogen-activated protein kinase p38alpha
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Mitogen-activated protein kinase p38b
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p38b
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SAPK2A
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stress-activated protein kinase 2a
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
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