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Information on EC 2.7.11.24 - mitogen-activated protein kinase and Organism(s) Drosophila melanogaster and UniProt Accession O62618

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EC Tree
IUBMB Comments
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline . A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
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This record set is specific for:
Drosophila melanogaster
UNIPROT: O62618
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Word Map
The taxonomic range for the selected organisms is: Drosophila melanogaster
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
mapk, p38, erk1/2, p38 mapk, mitogen-activated protein kinase, map kinase, extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, p38mapk, p38 map kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
mitogen-activated protein kinase 14A
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cp38a
-
-
-
-
cp38b
-
-
-
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CSAID binding protein
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-
-
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CSBP
-
-
-
-
Cytokine suppressive anti-inflammatory drug binding protein
-
-
-
-
ERK5
-
-
-
-
Jun-amino-terminal kinase
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MAP kinase MXI2
-
-
-
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MAP kinase p38 beta
-
-
-
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MAP kinase p38 delta
-
-
-
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MAP kinase p38 gamma
-
-
-
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MAP kinase p38a
-
-
-
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MAP kinase p38alpha
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-
-
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MAP kinase p38b
-
-
-
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MAPK
-
-
-
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mitogen-activated protein kinase
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-
-
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mitogen-activated protein kinase 14B
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mitogen-activated protein kinase ERK-A
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Mitogen-activated protein kinase p38 beta
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-
-
-
Mitogen-activated protein kinase p38 delta
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-
-
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Mitogen-activated protein kinase p38 gamma
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-
-
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Mitogen-activated protein kinase p38a
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-
-
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Mitogen-activated protein kinase p38alpha
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-
-
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Mitogen-activated protein kinase p38b
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-
-
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p38b
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-
-
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SAPK2A
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-
-
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stress-activated protein kinase 2a
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-
-
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stress-activated protein kinase JNK
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (MAPKK-activated)
Phosphorylation of specific tyrosine and threonine residues in the activation loop of this enzyme by EC 2.7.12.2, mitogen-activated protein kinase kinase (MAPKK) is necessary for enzyme activation. Once activated, the enzyme phosphorylates target substrates on serine or threonine residues followed by a proline [6]. A distinguishing feature of all MAPKs is the conserved sequence Thr-Xaa-Tyr (TXY). Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
CAS REGISTRY NUMBER
COMMENTARY hide
142243-02-5
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + transcription factor Djun
ADP + phosphorylated transcription factor Djun
show the reaction diagram
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-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
addition of lipopolysaccharide does not significantly affect the phosphorylation of Dp38 in the LPS-responsive l(2)mbn cell line
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
neoplasmic l(2)mbn cell line
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MK38A_DROME
366
0
42256
Swiss-Prot
other Location (Reliability: 2)
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
rapidly Tyr186-phosphorylated in response to osmotic stress, heat shock, serum starvation, and H2O2
phosphoprotein
DJNK is phosphorylated and activated by the Drosophila MAP kinase kinase HEP
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (O61443), Drosophila melanogaster (O62618), Drosophila melanogaster (P40417), Drosophila melanogaster (P92208)
Manually annotated by BRENDA team
Biggs, W.H.; Zipursky, S.L.
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase
Proc. Natl. Acad. Sci. USA
89
6295-6299
1992
Drosophila melanogaster (O62618), Drosophila melanogaster (P40417)
Manually annotated by BRENDA team
Ashburner, M.; Misra, S.; Roote, J.; et al.
An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster: the Adh region
Genetics
153
179-219
1999
Drosophila melanogaster (O61443)
Manually annotated by BRENDA team
Adachi-Yamada, T.; Nakamura, M.; Irie, K.; Tomoyasu, Y.; Sano, Y.; Mori, E.; Goto, S.; Ueno, N.; Nishida, Y.; Matsumoto, K.
P38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis
Mol. Cell. Biol.
19
2322-2329
1999
Drosophila melanogaster (O61443), Drosophila melanogaster
Manually annotated by BRENDA team
Han, Z.S.; Enslen, H.; Hu, X.; Meng, X.; Wu, I.H.; Barrett, T.; Davis, R.J.; Ip, Y.T.
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
Mol. Cell. Biol.
18
3527-3539
1998
Drosophila melanogaster (O61443), Drosophila melanogaster (O62618)
Manually annotated by BRENDA team
Han, S.J.; Choi, K.Y.; Brey, P.T.; Lee, W.J.
Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase
J. Biol. Chem.
273
369-374
1998
Drosophila melanogaster (O62618)
Manually annotated by BRENDA team
Biggs, W.H.; Zavitz, K.H.; Dickson, B.; van der Straten, A.; Brunner, D.; Hafen, E.; Zipursky, S.L.
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway
EMBO J.
13
1628-1635
1994
Drosophila melanogaster (P40417), Drosophila melanogaster
Manually annotated by BRENDA team
Ramet, M.; Lanot, R.; Zachary, D.; Manfruelli, P.
JNK signaling pathway is required for efficient wound healing in Drosophila
Dev. Biol.
241
145-156
2002
Drosophila melanogaster (P92208)
Manually annotated by BRENDA team
Zeitlinger, J.; Bohmann, D.
Thorax closure in Drosophila: involvement of Fos and the JNK pathway
Development
126
3947-3956
1999
Drosophila melanogaster (P92208)
Manually annotated by BRENDA team
Riesgo-Escovar, J.R.; Hafen, E.
Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure
Genes Dev.
11
1717-1727
1997
Drosophila melanogaster (P92208)
Manually annotated by BRENDA team
Sluss, H.K.; Han, Z.; Barrett, T.; Davis, R.J.; Ip, Y.T.
A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila
Genes Dev.
10
2745-2758
1996
Drosophila melanogaster (P92208)
Manually annotated by BRENDA team
Riesgo-Escovar, J.R.; Jenni, M.; Fritz, A.; Hafen, E.
The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye
Genes Dev.
10
2759-2768
1996
Drosophila melanogaster (P92208)
Manually annotated by BRENDA team