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Disease on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
CTIP2 is a negative regulator of P-TEFb.
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
[P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets].
Adenocarcinoma of Lung
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Mechanisms underlying regulation of cell cycle and apoptosis by hnRNP B1 in human lung adenocarcinoma A549 cells.
P-TEFb Regulates Transcriptional Activation in Non-coding RNA Genes.
[Comparison of DNA-dependent protein kinase catalytic subunit expression in two lung adenocarcinoma cell lines with different radiosensitivity]
[Effects of hnRNP B1 on DNA-PK activity, cell cycle and apoptosis in human lung adenocarcinoma cell line A549]
Adenoma
Molecular markers of carcinogenesis for risk stratification of individuals with colorectal polyps: a case-control study.
Adenoviridae Infections
Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication.
Alzheimer Disease
DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease.
DNA-PK Deficiency in Alzheimer's Disease.
Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Asthma
Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
Oxidative damage and DNA damage in lungs of an ovalbumin-induced asthmatic murine model.
Astrocytoma
IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK.
Ataxia
Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.
Benzo[a]pyrene induces complex H2AX phosphorylation patterns by multiple kinases including ATM, ATR, and DNA-PK.
Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit.
DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells.
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Induction of H2AX phosphorylation in tumor cells by gossypol acetic acid is mediated by phosphatidylinositol 3-kinase (PI3K) family.
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): phosphoproteomic analysis.
Replication protein A (RPA): the eukaryotic SSB.
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
The double dealing of cyclin D1.
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase.
Tying the loose ends together in DNA double strand break repair with 53BP1.
[Cell cycle regulation after exposure to ionizing radiation]
Ataxia Telangiectasia
A critical role for topoisomerase IIb and DNA double strand breaks in transcription.
A flow cytometry assay that measures cellular sensitivity to DNA-damaging agents, customized for clinical routine laboratories.
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity.
Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes.
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.
ATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancers.
ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells.
BAY-8400: A Novel Potent and Selective DNA-PK Inhibitor which Shows Synergistic Efficacy in Combination with Targeted Alpha Therapies.
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism.
Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome.
Chemical inhibition of DNA repair kinases as a promising tool in oncology.
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.
Cooperative effect of BI-69A11 and celecoxib enhances radiosensitization by modulating DNA damage repair in colon carcinoma.
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.
Detection and Visualization of DNA Damage-induced Protein Complexes in Suspension Cell Cultures Using the Proximity Ligation Assay.
Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.
Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.
DNA damage signaling in response to double-strand breaks during mitosis.
DNA damage-induced BARD1 phosphorylation is critical for the inhibition of messenger RNA processing by BRCA1/BARD1 complex.
DNA protein kinase-dependent G2 checkpoint revealed following knockdown of ataxia-telangiectasia mutated in human mammary epithelial cells.
DNA-dependent protein kinase and Ataxia Telangiectasia Mutated (ATM) promote cell survival in response to NK314, a topoisomerase II? inhibitor.
DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70.
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage.
DNA-dependent protein kinase.
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks.
DNA-PK suppresses a p53-independent apoptotic response to DNA damage.
DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.
Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines.
Elevated DNA damage response in pancreatic cancer.
Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia.
Essential and perilous: V(D)J recombination and DNA damage checkpoints in lymphocyte precursors.
Far-infrared irradiation inhibits breast cancer cell proliferation independently of DNA damage through increased nuclear Ca2+/calmodulin binding modulated-activation of checkpoint kinase 2.
Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells.
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
Functional role for the c-Abl tyrosine kinase in meiosis I.
Functions of human replication protein A (RPA): from DNA replication to DNA damage and stress responses.
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event.
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.
Improving Radiation Response in Glioblastoma Using ECO/siRNA Nanoparticles Targeting DNA Damage Repair.
Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells.
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Inhibition of the G2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine.
Involvement of DNA-PK and ATM in radiation- and heat-induced DNA damage recognition and apoptotic cell death.
Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4(+) T cells.
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Ionizing radiation response of primary normal human lens epithelial cells.
It takes three to the DNA damage response tango.
Long-term in vivo effects of cisplatin on gamma-H2AX foci signaling in peripheral lymphocytes of tumor patients after irradiation.
Measurement of DNA-Dependent Protein Kinase Phosphorylation Using Flow Cytometry Provides a Reliable Estimate of DNA Repair Capacity.
Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin.
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
Molecular aspects of cellular responses to radiotherapy.
Monitoring and signaling of radiation-induced damage in mammalian cells.
mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks.
p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure.
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.
PFG acted as an inducer of premature senescence in TIG-1 normal diploid fibroblast and an inhibitor of mitosis in the HeLa cells.
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts.
Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers.
PTEN expression in U251 glioma cells enhances their sensitivity to ionizing radiation by suppressing DNA repair capacity.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat.
Repair of Chromosomal RAG-Mediated DNA Breaks by Mutant RAG Proteins Lacking Phosphatidylinositol 3-Like Kinase Consensus Phosphorylation Sites.
Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.
Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes.
Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability.
Role of CHK2 in cancer development.
Role of DNA-dependent protein kinase in the process of radiation-induced aberration formation.
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells.
Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses.
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells.
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Targeted cancer therapies based on the inhibition of DNA strand break repair.
Targeting DNA Damage Repair Pathways in Pancreatic Adenocarcinoma.
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219.
Targeting phosphoinositide 3-kinase: moving towards therapy.
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.
The Ataxia Telangiectasia mutated kinase controls Ig? allelic exclusion by inhibiting secondary V?-to-J? rearrangements.
The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect.
The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.
The downregulation of the RNA-binding protein Staufen2 in response to DNA damage promotes apoptosis.
The Future of Radiobiology.
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
The newly synthesized 2-arylnaphthyridin-4-one, CSC-3436, induces apoptosis of non-small cell lung cancer cells by inhibiting tubulin dynamics and activating CDK1.
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase.
The promise of DNA damage response inhibitors for the treatment of glioblastoma.
The role of Ataxia telangiectasia and the DNA-dependent protein kinase in the p53-mediated cellular response to ionising radiation.
Therapeutic effect of sodium iodide symporter gene therapy combined with external beam radiotherapy and targeted drugs that inhibit DNA repair.
Transcriptional Regulation at DSBs: Mechanisms and Consequences.
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
Autoimmune Diseases
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.
Blast Crisis
[Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia]
Bone Marrow Failure Disorders
Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks.
Breast Neoplasms
A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation.
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Caught in the act: binding of Ku and PARP to MARs reveals novel aspects of their functional interaction.
Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition.
DDRI-9: a novel DNA damage response inhibitor that blocks mitotic progression.
DNA damage repair in breast cancer and its therapeutic implications.
DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy.
DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin.
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency.
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.
Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha.
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2.
Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776.
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences.
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
RAD51 inhibition in triple negative breast cancer cells is challenged by compensatory survival signaling and requires rational combination therapy.
Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio.
Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated.
Taking a Bad Turn: Compromised DNA Damage Response in Leukemia.
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
The molecular causes of low ATM protein expression in breast carcinoma; promoter methylation and levels of the catalytic subunit of DNA-dependent protein kinase.
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Burkitt Lymphoma
Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells.
Carcinogenesis
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis.
Decreased expression of DNA-dependent protein kinase, a DNA repair protein, during human colon carcinogenesis.
Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.
Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity.
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
LARP7 is a potential tumor suppressor gene in gastric cancer.
Mechanisms of radiation-induced neoplastic transformation of human bronchial epithelial cells.
Multiple roles of CTDK-I throughout the cell.
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
XPD-The Lynchpin of NER: Molecule, Gene, Polymorphisms, and Role in Colorectal Carcinogenesis.
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Carcinoma
Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma.
Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity.
Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells.
DNA-dependent protein kinase content and activity in lung carcinoma cell lines: correlation with intrinsic radiosensitivity.
DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair.
DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway.
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation.
Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity.
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in ?/? ratio.
The effect of wortmannin on radiation-induced chromosome aberration formation in the radioresistant tumor cell line WiDr.
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
[Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma].
Carcinoma, Hepatocellular
DNA-dependent protein kinase is involved in heat shock protein-mediated accumulation of hypoxia-inducible factor-1alpha in hypoxic preconditioned HepG2 cells.
NU7441 Enhances the Radiosensitivity of Liver Cancer Cells.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction.
Carcinoma, Non-Small-Cell Lung
Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
DNA-dependent protein kinase is inhibited by trifluoperazine.
DNA-PK Inhibition by NU7441 Enhances Chemosensitivity to Topoisomerase Inhibitor in Non-Small Cell Lung Carcinoma Cells by Blocking DNA Damage Repair.
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Carcinoma, Renal Cell
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Squamous Cell
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity.
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Carcinoma, Transitional Cell
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Cardiomegaly
7SK RNA, a non-coding RNA regulating P-TEFb, a general transcription factor.
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.
CTIP2 is a negative regulator of P-TEFb.
Cyclins that don't cycle--cyclin T/cyclin-dependent kinase-9 determines cardiac muscle cell size.
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
P-TEFb as A Promising Therapeutic Target.
Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.
Phosphorylation of RNA polymerase II in cardiac hypertrophy: cell enlargement signals converge on cyclin T/Cdk9.
Pivotal role of cardiac lineage protein-1 (CLP-1) in transcriptional elongation factor P-TEFb complex formation in cardiac hypertrophy.
Positive Transcription Elongation Factor b Activity in Compensatory Myocardial Hypertrophy is Regulated by Cardiac Lineage Protein-1.
RNA-driven cyclin-dependent kinase regulation: when CDK9/cyclin T subunits of P-TEFb meet their ribonucleoprotein partners.
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
[Misregulation of P-TEFb activity: pathological consequences].
Cockayne Syndrome
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Analysis of U1 small nuclear RNA interaction with cyclin H.
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
Cockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growth.
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
TFIIH is an elongation factor of RNA polymerase I.
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH.
The cryo-electron microscopy structure of human transcription factor IIH.
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Transcription by RNA polymerase II: a process linked to DNA repair.
Transcription elongation and human disease.
Transcription factor IIH - the protein complex with multiple functions.
Transcription factor TFIIH and DNA endonuclease Rad2 constitute yeast nucleotide excision repair factor 3: implications for nucleotide excision repair and Cockayne syndrome.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome.
TTDA: Big impact of a small protein.
UVB induces a genome-wide acting negative regulatory mechanism that operates at the level of transcription initiation in human cells.
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients.
Coinfection
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Colonic Neoplasms
Chk1 and DNA-PK mediate TPEN-induced DNA damage in a ROS dependent manner in human colon cancer cells.
Colorectal Neoplasms
Radioresistance in a tumour cell line correlates with radiation inducible Ku 70/80 end-binding activity.
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Communicable Diseases
P-TEFb as A Promising Therapeutic Target.
Cysts
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Dengue
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Diabetes Mellitus, Type 2
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
DNA Virus Infections
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
Epstein-Barr Virus Infections
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.
Equine Infectious Anemia
An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.
Esophageal Neoplasms
DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines.
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Fanconi Anemia
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Fibrosarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Frontotemporal Lobar Degeneration
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Genetic Diseases, Inborn
Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.
Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.
Genomic organization and promoter characterization of two human UHS keratin genes.
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
It takes three to the DNA damage response tango.
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
The cryo-electron microscopy structure of human transcription factor IIH.
The long unwinding road: XPB and XPD helicases in damaged DNA opening.
Transcription factor IIH - the protein complex with multiple functions.
XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha.
Glioblastoma
Activation Mechanism of Protein Kinase B by DNA-dependent Protein Kinase Involved in the DNA Repair System.
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-?B pathway in multidrug-resistant glioblastoma cells in vitro.
Complementation of the radiosensitive M059J cell line.
Differential role of hydrogen peroxide and staurosporine in induction of cell death in glioblastoma cells lacking DNA-dependent protein kinase.
DNA-dependent protein kinase (DNA-PK)-deficient human glioblastoma cells are preferentially sensitized by Zebularine.
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination.
IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
Novel survivin inhibitor YM155 elicits cytotoxicity in glioblastoma cell lines with normal or deficiency DNA-dependent protein kinase activity.
Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J.
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.
SAPSR1 is a bidentate anchor for targeting protein phosphatase-6 to DNA-PK.
The ATM protein is required for sustained activation of NF-kappaB following DNA damage.
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
The DNA-PK inhibitor VX-984 enhances the radiosensitivity of glioblastoma cells grown in vitro and as orthotopic xenografts.
The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor.
Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways.
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells.
Glioma
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line.
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.
Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells.
cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK.
Cloning and characterization of the human novel gene encoding 6.2 kDa protein highly expressed upon ultraviolet irradiation in DNA-PK-deleted human glioma M059J cells.
Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors.
Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase.
Differential stability of the DNA-activated protein kinase catalytic subunit mRNA in human glioma cells.
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage.
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.
DNA-PK is essential only for coding joint formation in V(D)J recombination.
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.
Intact G2-phase checkpoint in cells of a human cell line lacking DNA-dependent protein kinase activity.
Ku70/Ku80 protein complex inhibits the binding of nucleotide excision repair proteins on linear DNA in vitro.
Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity.
Low and high LET radiation-induced apoptosis in M059J and M059K cells.
Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
The role of autophagy in sensitizing malignant glioma cells to radiation therapy.
[Correlation of DNA-PK activity with anti-cancer drug-sensitivity in human gliomas]
Head and Neck Neoplasms
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
Hepatitis B
Hepatitis B virus pX targets TFIIB in transcription coactivation.
Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.
Hepatitis B virus X protein does not influence essential steps of nucleotide excision repair effected by human liver extracts.
Hepatitis B virus X protein impedes the DNA repair via its association with transcription factor, TFIIH.
Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue.
Hepatitis C
Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.
Herpes Simplex
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53.
Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFb.
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase.
Herpesviridae Infections
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
HIV Infections
Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency.
The Yin and Yang of P-TEFb Regulation: Implications for Human Immunodeficiency Virus Gene Expression and Global Control of Cell Growth and Differentiation.
Hypersensitivity
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3.
Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype.
Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.
Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle.
KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity.
P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress.
Saccharomyces cerevisiae RNA polymerase II is affected by Kluyveromyces lactis zymocin.
The life and death of DNA-PK.
Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
[DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation]
Hypertrophy, Left Ventricular
Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice.
Ichthyosis
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Analysis of U1 small nuclear RNA interaction with cyclin H.
Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.
New clinico-genetic classification of trichothiodystrophy.
Suppression of UV-induced apoptosis by the human DNA repair protein XPG.
Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
Infections
Activation of P-TEFb (CycT1/CDK9) at sites of dual HIV/TB infection, and inhibition of MTB-induced HIV transcriptional activation by the inhibitor of CDK9, Indirubin-3'-monoxime.
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
Baculovirus Transduction in Mammalian Cells Is Affected by the Production of Type I and III Interferons, Which Is Mediated Mainly by the cGAS-STING Pathway.
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
Computational analysis of retrovirus-induced scid cell death.
Different views of the dynamic landscape covered by the 5'-hairpin of the 7SK small nuclear RNA.
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
Induction of a Cellular DNA Damage Response by Porcine Circovirus Type 2 Facilitates Viral Replication and Mediates Apoptotic Responses.
Measles Virus Infection Inactivates Cellular Protein Phosphatase 5 with Consequent Suppression of Sp1 and c-Myc Activities.
P-TEFb kinase complex phosphorylates histone H1 to regulate expression of cellular and HIV-1 genes.
Phosphorylation Targets of DNA-PK and Their Role in HIV-1 Replication.
Positive transcription elongation factor b (P-TEFb) contributes to dengue virus-stimulated induction of interleukin-8 (IL-8).
Proteolytic cleavage of the catalytic subunit of DNA-dependent protein kinase during poliovirus infection.
Role of Noncoding RNAs in the Regulation of P-TEFb Availability and Enzymatic Activity.
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.
Transcription elongation and human disease.
XPB mediated retroviral cDNA degradation coincides with entry to the nucleus.
Influenza, Human
Evidence for a novel mechanism of influenza A virus host adaptation modulated by PB2-627.
Insulin Resistance
BRD4 regulates adiponectin gene induction by recruiting the P-TEFb complex to the transcribed region of the gene.
Turning back the clock.
Latent Infection
Latent HIV-1 Infection Occurs in Multiple Subsets of Hematopoietic Progenitor Cells and Is Reversed by NF-?B Activation.
Leukemia
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair.
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes.
Functional diversity of inhibitors tackling the differentiation blockage of MLL-rearranged leukemia.
HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Potentiation of chemosensitivity in multidrug-resistant human leukemia CEM cells by inhibition of DNA-dependent protein kinase using wortmannin.
Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site.
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors.
The little elongation complex regulates small nuclear RNA transcription.
The super elongation complex (SEC) and MLL in development and disease.
Transcription elongation and human disease.
[Expression of DNA-dependent protein kinase catalylic subunit in adult acute leukemia and its significance].
Leukemia, Lymphocytic, Chronic, B-Cell
DNA-Dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards.
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia.
DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells.
Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.
Regulation of DNA-dependent protein kinase activity in leukemic cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia.
[Gene of DNA-dependent protein kinase catalylic subunit in chronic myeloid leukemia]
Leukemia, Myeloid
A novel role for acinus and MCM2 as host-specific signaling enhancers of DNA-damage-induced apoptosis in association with viral protein gp70.
Leukemia, Myeloid, Acute
DNA-PK Inhibitor, M3814, as a New Combination Partner of Mylotarg in the Treatment of Acute Myeloid Leukemia.
Transcription elongation and human disease.
Leukemia-Lymphoma, Adult T-Cell
NK314 potentiates antitumor activity with adult T-cell leukemia-lymphoma cells by inhibition of dual targets on topoisomerase II{alpha} and DNA-dependent protein kinase.
Liver Neoplasms
The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells.
The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo[def,p]chrysene on human hepatocellular cancer cell line HepG2.
The modulating effect of ATM, ATR, DNA-PK inhibitors on the cytotoxicity and genotoxicity of benzo[a]pyrene in human hepatocellular cancer cell line HepG2.
Lung Neoplasms
Co-targeting deoxyribonucleic acid-dependent protein kinase and poly(adenosine diphosphate-ribose) polymerase-1 promotes accelerated senescence of irradiated cancer cells.
Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells.
DNA-dependent protein kinase is inhibited by trifluoperazine.
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
M3814, a DNA-PK Inhibitor, Modulates ABCG2-Mediated Multidrug Resistance in Lung Cancer Cells.
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Reduced DNA-dependent protein kinase activity is associated with lung cancer.
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
Targeting DNA-PK overcomes acquired resistance to third-generation EGFR-TKI osimertinib in non-small-cell lung cancer.
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
[The expression of DNA-PKcs in non-small cell lung cancer and its relationship with apoptosis associated proteins.]
Lupus Erythematosus, Systemic
Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis.
Lymphatic Metastasis
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Protein predictive signatures for lymph node metastasis of gastric cancer.
Lymphoma
Curcumin sensitizes lymphoma cells to DNA damage agents through regulating Rad51-dependent homologous recombination.
The double dealing of cyclin D1.
Lymphoma, B-Cell
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Lymphoma, Large B-Cell, Diffuse
Association of ERCC2 Gene Polymorphisms with Susceptibility to Diffuse Large B-Cell Lymphoma.
Mechanisms of JP-8 jet fuel toxicity. I. Induction of apoptosis in rat lung epithelial cells.
Lymphoma, Mantle-Cell
The double dealing of cyclin D1.
Lymphoma, Non-Hodgkin
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Malaria
Topological polar surface area: a useful descriptor in 2D-QSAR.
Melanoma
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies.
Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma.
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway.
Mouth Neoplasms
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells.
Multiple Myeloma
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma.
Positive transcription elongation factor b (P-TEFb) is a therapeutic target in human multiple myeloma.
Muscular Atrophy, Spinal
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.
Muscular Diseases
Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity.
Nasopharyngeal Carcinoma
DNA-dependent protein kinase activity and radiosensitivity of nasopharyngeal carcinoma cell lines CNE1/CNE2.
Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma.
Knockdown of Annexin A1 Enhances Radioresistance and Inhibits Apoptosis in Nasopharyngeal Carcinoma.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neoplasm Metastasis
Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy.
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer.
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis.
Protein predictive signatures for lymph node metastasis of gastric cancer.
The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts.
Neoplasms
15-Lipoxygenase-1 activates tumor suppressor p53 independent of enzymatic activity.
7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction.
7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.
A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.
A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer.
A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours.
A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis.
A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies.
A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair.
A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours.
A Small Molecule Screen Identifies an Inhibitor of DNA Repair Inducing the Degradation of TFIIH and the Chemosensitization of Tumor Cells to Platinum.
A targeted inhibition of DNA-dependent protein kinase sensitizes breast cancer cells following ionizing radiation.
Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.
Abrogation of the Brd4-P-TEFb Positive Transcription Complex by the Papillomavirus E2 protein Contributes to the Viral Oncogene Repression.
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks.
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas.
AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions.
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy.
Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells.
Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.
Beyond DNA repair: DNA-PK function in cancer.
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases.
Biologic characterization of a secondary glioblastoma with extracranial progression and systemic metastasis.
Biphasic Functional Interaction between the Adenovirus E4orf4 Protein and DNA-PK.
Brd4 and HEXIM1: multiple roles in P-TEFb regulation and cancer.
Camptothecin releases P-TEFb from the inactive 7SK snRNP complex.
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth
CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.
CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38?/MYC/PD-L1 signaling in non-small cell lung cancer.
cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.
cDNA expression array analysis of DNA repair genes in human glioma cells that lack or express DNA-PK.
Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions.
Cell-type specific concentration regulation of the basal transcription factor TFIIH in XPBy/y mice model.
Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy.
Chemo-sensitisation of HeLa cells to Etoposide by a Benzoxazine in the absence of DNA-PK inhibition.
Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K.
Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism.
Complementation of the radiosensitive M059J cell line.
Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production.
CTIP2 is a negative regulator of P-TEFb.
Decreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation.
Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling.
Deletion of the Proline-Rich Region of the Murine Metastasis Susceptibility Gene Brd4 Promotes Epithelial-to-Mesenchymal Transition- and Stem Cell-Like Conversion.
Developments of DNA-dependent Protein Kinase Inhibitors as Anticancer Agents.
Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells.
Differential DNA binding of Ku antigen determines its involvement in DNA replication.
Differential gene expression in human glioma cells: correlation with presence or absence of DNA-dependent protein kinase.
Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer.
DNA damage and the DNA-activated protein kinase.
DNA damage in cancer therapeutics: a boon or a curse?
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR.
DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.
DNA-dependent protein kinase and its inhibition in support of radiotherapy.
DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity.
DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer.
DNA-dependent protein kinase is a molecular target for the development of noncytotoxic radiation-sensitizing drugs.
DNA-dependent protein kinase modulates the anti-cancer properties of silver nanoparticles in human cancer cells.
DNA-dependent protein kinase.
DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines.
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer.
DNA-ligase IV and DNA-protein kinase play a critical role in deficient caspases activation in apoptosis-resistant cancer cells by using doxorubicin.
DNA-PK as an Emerging Therapeutic Target in Cancer.
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
DNA-PK inhibition synergizes with oncolytic virus M1 by inhibiting antiviral response and potentiating DNA damage.
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia.
Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Ectopic TLX1 expression accelerates malignancies in mice deficient in DNA-PK.
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage.
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.
Envisioning how the prototypic molecular machine TFIIH functions in transcription initiation and DNA repair.
Expression of DNA-PKcs and Ku86, but not Ku70, differs between lymphoid malignancies.
Expression of immune checkpoint PD-1 in non-small cell lung cancer is associated with tumor cell DNA-dependent protein kinase.
Expression of Ku70 correlates with survival in carcinoma of the cervix.
Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy.
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy.
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Frameshift mutation in PRKDC, the gene for DNA-PKcs, in the DNA repair-defective, human, glioma-derived cell line M059J.
Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination.
Gene Expression Associated with DNA-Dependent Protein Kinase Activity under Normoxia, Hypoxia, and Reoxygenation.
Glioblastoma cells deficient in DNA-dependent protein kinase are resistant to cell death.
Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.
Heterogeneous nuclear ribonucleoprotein B1 protein impairs DNA repair mediated through the inhibition of DNA-dependent protein kinase activity.
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.
Homologous recombination preferentially repairs heat-induced DNA double-strand breaks in mammalian cells.
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of bisphenol A.
Identification of Novel Interaction Partners of Ets-1: Focus on DNA Repair.
Identification of phosphorylation sites in the repetitive carboxyl-terminal domain of the mouse RNA polymerase II largest subunit.
Identification of proteins binding to E-Box/Ku86 sites and function of the tumor suppressor SAFB1 in transcriptional regulation of the human xanthine oxidoreductase gene.
Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.
Inactivation of DNA-Dependent Protein Kinase Promotes Heat-Induced Apoptosis Independently of Heat-Shock Protein Induction in Human Cancer Cell Lines.
Increased expression of DNA-dependent protein kinase confers resistance to adriamycin.
Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice.
Inhibiting DNA-PKcs in a non-homologous end-joining pathway in response to DNA double-strand breaks.
Inhibition of DNA-dependent protein kinase induces accelerated senescence in irradiated human cancer cells.
Inhibition of DNA-dependent protein kinase promotes ultrasound-induced cell death including apoptosis in human leukemia cells.
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control.
Inhibition of P-TEFb by DRB suppresses SIRT1/CK2? pathway and enhances radiosensitivity of human cancer cells.
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.
Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Is TFIIH the new Achilles heel of cancer cells?
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Ku antigen-DNA conformation determines the activation of DNA-dependent protein kinase and DNA sequence-directed repression of mouse mammary tumor virus transcription.
Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity.
Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.
Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts.
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Methylseleninic acid sensitizes Notch3-activated OVCA429 ovarian cancer cells to carboplatin.
MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3.
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.
Molecular mechanisms of platinum resistance: still searching for the Achilles' heel.
Monitoring and signaling of radiation-induced damage in mammalian cells.
MTA1 Promotes Hepatocellular Carcinoma Progression by Downregulation of DNA-PK-Mediated H1.2T146 Phosphorylation.
New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC).
NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation.
Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair.
Novel DNA targeted therapies for head and neck cancers: clinical potential and biomarkers.
Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex.
Overcoming hypoxia-induced tumor radioresistance in non-small cell lung cancer by targeting DNA-dependent protein kinase in combination with carbon ion irradiation.
P-TEFb as A Promising Therapeutic Target.
P-TEFb inhibitors interfere with activation of p53 by DNA-damaging agents.
P-TEFb joins the family of cdks in oncology, promotes cell growth of cancer cells.
Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models.
Pharmacologic targeting of the P-TEFb complex as a therapeutic strategy for chronic myeloid leukemia.
Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells.
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor.
Potentiation of chlorambucil cytotoxicity in B-cell chronic lymphocytic leukemia by inhibition of DNA-dependent protein kinase activity using wortmannin.
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
Protein kinase Cepsilon activates protein kinase B/Akt via DNA-PK to protect against tumor necrosis factor-alpha-induced cell death.
Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.
PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.
Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS.
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways.
Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.
Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.
Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair.
Radiosensitizing effects of ectopic miR-101 on non-small-cell lung cancer cells depend on the endogenous miR-101 level.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound.
Rare diseases provide rare insights into DNA repair pathways, TFIIH, aging and cancer center.
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.
Reduced DNA-dependent protein kinase activity in two cell lines derived from adult cancer patients with late radionecrosis.
Regulation of cisplatin resistance and homologous recombinational repair by the TFIIH subunit XPD.
Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells.
Relationship between antiapoptotic molecules and metastatic potency and the involvement of DNA-dependent protein kinase in the chemosensitization of metastatic human cancer cells by epidermal growth factor receptor blockade.
Response of heterogeneous ribonuclear proteins (hnRNP) to ionising radiation and their involvement in DNA damage repair.
Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.
Selective inactivation of DNA-dependent protein kinase with antisense oligodeoxynucleotides: consequences for the rejoining of radiation-induced DNA double-strand breaks and radiosensitivity of human cancer cell lines.
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Simple synthesis of carbon-11-labeled chromen-4-one derivatives as new potential PET agents for imaging of DNA-dependent protein kinase (DNA-PK) in cancer.
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010-present).
Small molecule inhibitors of DNA-PK for tumor sensitization to anticancer therapy.
Small molecule inhibitors targeting cyclin-dependent kinases as anticancer agents.
Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.
SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.
SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization.
SV40 large tumor antigen nuclear import is regulated by the double-stranded DNA-dependent protein kinase site (serine 120) flanking the nuclear localization sequence.
Synergistic Effect of a Mesothelin-Targeted 227Th Conjugate in Combination with DNA Damage Response Inhibitors in Ovarian Cancer Xenograft Models.
Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells.
Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts.
Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy.
Targeting DNA repair mechanisms in cancer.
Targeting DNA-Dependent Protein Kinase for Cancer Therapy.
Targeting DNA-PK in cancer.
Targeting of the EGFR/?1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures.
Targeting the DNA-PK complex: Its rationale use in cancer and HIV-1 infection.
Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
TFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer Treatment.
The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer.
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
The basal transcription machinery as a target for cancer therapy.
The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network.
The cryo-electron microscopy structure of human transcription factor IIH.
The development of ataxia telangiectasia mutated kinase inhibitors.
The DNA repair complex DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy.
The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.
The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila.
The immunohistochemical expression of DNA-PKCS and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity.
The level of phosphorylated Akt predominantly reflects the expressive status of CerbB2 in invasive breast cancer.
The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes quiescent but not proliferating MG-63 human osteosarcoma cells to radiation.
The relationship between the down-regulation of DNA-PKcs or Ku70 and the chemosensitization in human cervical carcinoma cell line HeLa.
The requirement for the basal transcription factor IIE is determined by the helical stability of promoter DNA.
The role of autophagy in sensitizing malignant glioma cells to radiation therapy.
The role of nitric oxide in cancer.
Therapeutic Implications of p53 Status on Cancer Cell Fate Following Exposure to Ionizing Radiation and the DNA-PK Inhibitor M3814.
Three targets in one complex: A molecular perspective of TFIIH in cancer therapy.
Threonine 2609 phosphorylation of the DNA-dependent Protein Kinase is a critical prerequisite for epidermal growth factor receptor mediated radiation resistance.
Topological polar surface area: a useful descriptor in 2D-QSAR.
Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.
Transcription elongation and human disease.
Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex.
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-alpha.
Tumor suppressor p53 dependent recruitment of nucleotide excision repair factors XPC and TFIIH to DNA damage.
Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
Vitamin C increases DNA breaks and suppresses DNA damage-independent activation of ATM by bleomycin.
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells.
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
[Cell cycle regulation after exposure to ionizing radiation]
[DNA-dependent protein kinase: a major protein involved in the cellular response to ionizing radiation]
[Effect of Viqi Chutan Recipe on Caspase-4 and DNA-PK of Cell Apoptosis Approach in Transplanted Lung Cancer A549 Cells in Nude Mice].
[Misregulation of P-TEFb activity: pathological consequences].
[P-TEFb and Brd4: actors of the transcription pause release as therapeutical targets].
[The expression of ERCC1, DNA-PKcs protein and the relation to prognosis in non-small cell lung cancer.]
Nervous System Diseases
Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity.
Neuroblastoma
Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells.
Apoptotic human SH-SY5Y neuroblastoma cells have regularly spaced single strand DNA breaks and increased DNA-dependent protein kinase activity.
DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells.
Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA- dependent protein kinase complex in an isoform-dependent manner.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Neuroectodermal Tumors
Upregulation of Ku expression in human neuroectodermal tumor cells after retroviral DNA integration.
Neurofibromatoses
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neurofibromatosis 1
Heat shock factor 1 (HSF1)-targeted anticancer therapeutics: overview of current preclinical progress.
Neuroinflammatory Diseases
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
Bioinformatic Analyses of Canonical Pathways of TSPOAP1 and its Roles in Human Diseases.
Neurologic Manifestations
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
Nijmegen Breakage Syndrome
Role of IFI16 in DNA damage and checkpoint.
non-specific serine/threonine protein kinase deficiency
SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency.
Obesity
DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.
Effects of caloric restriction on peroxisome proliferator-activated receptors and positive transcription elongation factor b expression in obese rats.
Osteosarcoma
Inhibiting DNA-PKCS radiosensitizes human osteosarcoma cells.
Targeting DNA-PKcs increased anticancer drug sensitivity by suppressing DNA damage repair in osteosarcoma cell line MG63.
The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Ovarian Neoplasms
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: predictive value of DNA-PK and phosphorylated ACC.
DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells.
Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells.
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer.
Pancreatic Neoplasms
Elevated DNA damage response in pancreatic cancer.
Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis.
Perspectives on the combination of radiotherapy and targeted therapy with DNA repair inhibitors in the treatment of pancreatic cancer.
Papillomavirus Infections
Implications of tyrosine phosphoproteomics in cervical carcinogenesis.
Parathyroid Neoplasms
Differential expression of kinase genes in primary hyperparathyroidism: adenoma versus normal and hyperplastic parathyroid tissue.
Photophobia
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Polycystic Kidney Diseases
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycythemia Vera
Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells.
Porcine Reproductive and Respiratory Syndrome
Nucleic Acid Immunity and DNA Damage Response: New Friends and Old Foes.
Pre-Eclampsia
Integrative transcriptome analysis reveals dysregulation of canonical cancer molecular pathways in placenta leading to preeclampsia.
Nucleotide excision repair/transcription gene defects in the fetus and impaired TFIIH-mediated function in transcription in placenta leading to preeclampsia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inhibition of DNA-PK enhances chemosensitivity of B-cell precursor acute lymphoblastic leukemia cells to doxorubicin.
Prostatic Neoplasms
Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer.
Androgen receptor interacts with the positive elongation factor P-TEFb and enhances the efficiency of transcriptional elongation.
Androgen Receptor Variants Mediate DNA Repair after Prostate Cancer Irradiation.
DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway.
DNA-PK in human malignant disorders: Mechanisms and implications for pharmacological interventions.
DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer.
Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation.
Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation.
From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator.
Local tumor control and DNA-PK activity of peripheral blood lymphocytes in prostate cancer patients receiving radiotherapy.
Phenylbutyrate attenuates the expression of Bcl-X(L), DNA-PK, caveolin-1, and VEGF in prostate cancer cells.
Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3.
Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
Positive feedback loop mediated by protein phosphatase 1? mobilization of P-TEFb and basal CDK1 drives androgen receptor in prostate cancer.
Rapid Diminution in the Level and Activity of DNA-Dependent Protein Kinase in Cancer Cells by a Reactive Nitro-Benzoxadiazole Compound.
Systemic Administration and Targeted Radiosensitization via Chemically Synthetic Aptamer-siRNA Chimeras in Human Tumor Xenografts.
The second largest subunit of RNA polymerase II interacts with and enhances transactivation of androgen receptor.
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Pulmonary Disease, Chronic Obstructive
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer.
Retinoblastoma
Death substrates come alive.
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.
Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.
The double dealing of cyclin D1.
Rhabdomyosarcoma, Alveolar
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Rheumatic Diseases
Identification of human autoantibodies to the DNA ligase IV/XRCC4 complex and mapping of an autoimmune epitope to a potential regulatory region.
Rift Valley Fever
NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.
Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus.
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.
Sarcoma
Allotype imbalance or microsatellite mutation in low-grade soft tissue sarcomas of the extremities in adults.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Sarcoma, Ewing
Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2.
Severe Combined Immunodeficiency
DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4(+) T-cell function without causing severe combined immunodeficiency.
DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.
DNA-PK autophosphorylation facilitates Artemis endonuclease activity.
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
Dysfunctional mammalian telomeres join with DNA double-strand breaks.
Elongated telomeres in scid mice.
Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase.
Identification of four highly conserved regions in DNA-PKcs.
Involvement of DNA-dependent protein kinase in down-regulation of cell cycle progression.
Irradiation-induced rescue of thymocyte differentiation and V(D)J recombination in mice lacking the catalytic subunit of DNA-dependent protein kinase.
Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts.
Radiation-induced apoptosis in scid mice spleen after low dose irradiation.
Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells.
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity.
The neoplastic transformation of SCID cells by radiation.
Skin Diseases
Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein.
Skin Neoplasms
Analysis of U1 small nuclear RNA interaction with cyclin H.
Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.
Persistence of repair proteins at unrepaired DNA damage distinguishes diseases with ERCC2 (XPD) mutations: cancer-prone xeroderma pigmentosum vs. non-cancer-prone trichothiodystrophy.
Spinal Muscular Atrophies of Childhood
The gene encoding p44, a subunit of the transcription factor TFIIH, is involved in large-scale deletions associated with Werdnig-Hoffmann disease.
Squamous Cell Carcinoma of Head and Neck
Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status.
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma.
Kinase Inhibitors of DNA-PK, ATM and ATR in Combination with Ionizing Radiation Can Increase Tumor Cell Death in HNSCC Cells While Sparing Normal Tissue Cells.
Radiosensitization of head and neck squamous cell carcinoma lines by DNA-PK inhibitors is more effective than PARP-1 inhibition and is enhanced by SLFN11 and hypoxia.
Radiosensitizing Potential of Curcumin in Different Cancer Models.
Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons.
The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma.
Up-regulation of DNA-dependent protein kinase correlates with radiation resistance in oral squamous cell carcinoma.
[Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma].
Starvation
A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, each encoding RNA polymerase II CTD kinase-cyclin pair, stimulates the meiotic development of S. cerevisiae.
DNA-PKcs is activated under nutrient starvation and activates Akt, MST1, FoxO3a, and NDR1.
The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2.
Stomach Neoplasms
Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87.
Telangiectasis
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression.
ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.
Casticin induces DNA damage and inhibits DNA repair-associated protein expression in B16F10 mouse melanoma cancer cells.
Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Double-strand DNA breaks are mainly repaired by the homologous recombination pathway in early developing swine embryos.
Epstein-Barr Virus Hijacks DNA Damage Response Transducers to Orchestrate Its Life Cycle.
Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.
Intersection of Two Checkpoints: Could Inhibiting the DNA Damage Response Checkpoint Rescue Immune Checkpoint-Refractory Cancer?
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
Molecular mechanisms of ionizing radiation-induced apoptosis.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase.
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family.
Targeting DNA repair mechanisms in cancer.
The development of ataxia telangiectasia mutated kinase inhibitors.
The effect of inhibitors of phosphatidylinositol 3-kinase-related kinases on dibenzo[def,p]chrysene genotoxicity measured by ?H2AX levels and neutral comet assay in HepG2 human hepatocellular cancer cells.
Transcription-dependent activation of ataxia telangiectasia-mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Thyroid Neoplasms
Expression of the DNA-dependent protein kinase catalytic subunit is associated with the radiosensitivity of human thyroid cancer cell lines.
Tics
Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest.
Tongue Neoplasms
Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Trichothiodystrophy Syndromes
A mouse model for the basal transcription/DNA repair syndrome trichothiodystrophy.
A new function of TFIIH explains the neurological symptoms in trichothiodystrophy.
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A.
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Analysis of U1 small nuclear RNA interaction with cyclin H.
Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice.
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
Dynamic partnership between TFIIH, PGC-1? and SIRT1 is impaired in trichothiodystrophy.
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Interacting partners of the Tfb2 subunit from yeast TFIIH.
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Mutations in TFIIH causing trichothiodystrophy are responsible for defects in ribosomal RNA production and processing.
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.
p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model.
Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy.
Sequential and ordered assembly of a large DNA repair complex on undamaged chromatin.
Small molecule-based targeting of TTD-A dimerization to control TFIIH transcriptional activity represents a potential strategy for anticancer therapy.
Solution structure and self-association properties of the p8 TFIIH subunit responsible for trichothiodystrophy.
Splitting hairs--discovery of a new DNA repair and transcription factor for the human disease trichothiodystrophy.
Structural basis for group A trichothiodystrophy.
Sublimiting concentration of TFIIH transcription/DNA repair factor causes TTD-A trichothiodystrophy disorder.
Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotide excision repair in yeast.
TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription.
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
The cryo-electron microscopy structure of human transcription factor IIH.
The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
Transcription by RNA polymerase II: a process linked to DNA repair.
Transcription factor IIH - the protein complex with multiple functions.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
Transcriptional changes in trichothiodystrophy cells.
Trichothiodystrophy view from the molecular basis of DNA repair/transcription factor TFIIH.
TTDA: Big impact of a small protein.
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.
Triple Negative Breast Neoplasms
HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer.
Urinary Bladder Neoplasms
Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression.
Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma.
Uterine Cervical Neoplasms
The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.
Uveitis
T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex.
Vaccinia
A Mechanism for the Inhibition of DNA-PK-Mediated DNA Sensing by a Virus.
Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2.
DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing.
Vesicular Stomatitis
The matrix protein of vesicular stomatitis virus inhibits host-directed transcription of target genes via interaction with the TFIIH subunit p8.
Viremia
A Phase 1/2 Randomized, Placebo-Controlled Trial of Romidespin in Persons With HIV-1 on Suppressive Antiretroviral Therapy.
A phase I/II randomized, placebo-controlled trial of romidepsin in persons with HIV-1 on suppressive antiretroviral therapy to assess safety and activation of HIV-1 expression (A5315).
Virus Diseases
Chemoproteomic profiling identifies changes in DNA-PK as markers of early dengue virus infection.
HIV-1 transcription is regulated by splicing factor SRSF1.
Interferon regulatory factor-3 is an in vivo target of DNA-PK.
Role of DNA-PK in the cellular response to DNA double-strand breaks.
Systematic profiling of protein complex dynamics reveals DNA-PK phosphorylation of IFI16 en route to herpesvirus immunity.
The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight.
[Misregulation of P-TEFb activity: pathological consequences].
Werner Syndrome
DNA-dependent protein kinase (DNA-PK)-dependent cisplatin-induced loss of nucleolar facilitator of chromatin transcription (FACT) and regulation of cisplatin sensitivity by DNA-PK and FACT.
Repair of telomeric DNA prior to replicative senescence.
Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks.
Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
Wiskott-Aldrich Syndrome
IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II.
Xeroderma Pigmentosum
A 3' --> 5' XPB helicase defect in repair/transcription factor TFIIH of xeroderma pigmentosum group B affects both DNA repair and transcription.
A temperature-sensitive disorder in basal transcription and DNA repair in humans.
Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.
Affinity purification of human DNA repair/transcription factor TFIIH using epitope-tagged xeroderma pigmentosum B protein.
Analysis of Drosophila p8 and p52 mutants reveals distinct roles for the maintenance of TFIIH stability and male germ cell differentiation.
Analysis of the conserved NER helicases (XPB and XPD) and UV-induced DNA damage in Hydra.
Both XPD alleles contribute to the phenotype of compound heterozygote xeroderma pigmentosum patients.
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.
Common XPD (ERCC2) polymorphisms have no measurable effect on nucleotide excision repair and basal transcription.
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair.
Defective interplay of activators and repressors with TFIH in xeroderma pigmentosum.
Detection and determination of oligonucleotide triplex formation-mediated transcription-coupled DNA repair in HeLa nuclear extracts.
Distinct roles for the helicases of TFIIH in transcript initiation and promoter escape.
Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair.
DNA excision repair.
DNA quality control by a lesion sensor pocket of the xeroderma pigmentosum group D helicase subunit of TFIIH.
DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
Drosophila as a Model Organism to Understand the Effects during Development of TFIIH-Related Human Diseases.
Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.
Functional interplay between TFIIH and KAT2A regulates higher-order chromatin structure and class II gene expression.
GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.
Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.
Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein.
Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair.
Mechanism of promoter melting by the xeroderma pigmentosum complementation group B helicase of transcription factor IIH revealed by protein-DNA photo-cross-linking.
Mechanisms of genome maintenance and rearrangement: current research and recent advances in DNA repair and recombination.
MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Molecular characterization and developmental expression of the TFIIH factor p62 gene from Drosophila melanogaster: effects on the UV light sensitivity of a p62 mutant fly.
Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio).
Mutations in the general transcription factor TFIIH result in beta-thalassaemia in individuals with trichothiodystrophy.
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH.
Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH.
Mutations in XPD helicase prevent its interaction and regulation by p44, another subunit of TFIIH, resulting in Xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) phenotypes.
p8/TTDA overexpression enhances UV-irradiation resistance and suppresses TFIIH mutations in a Drosophila trichothiodystrophy model.
Phenotypic heterogeneity in the XPB DNA helicase gene (ERCC3): xeroderma pigmentosum without and with Cockayne syndrome.
Phosphorylation of XPB helicase regulates TFIIH nucleotide excision repair activity.
Reduced level of the repair/transcription factor TFIIH in trichothiodystrophy.
RNA polymerase II elongation complexes containing the Cockayne syndrome group B protein interact with a molecular complex containing the transcription factor IIH components xeroderma pigmentosum B and p62.
Selective regulation of vitamin D receptor-responsive genes by TFIIH.
Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-?B and AP-1 signalling.
Spironolactone-induced XPB degradation requires TFIIH integrity and ubiquitin-selective segregase VCP/p97.
Strand- and site-specific DNA lesion demarcation by the xeroderma pigmentosum group D helicase.
TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA.
TFIIH Subunit Alterations Causing Xeroderma Pigmentosum and Trichothiodystrophy Specifically Disturb Several Steps during Transcription.
TFIIH with inactive XPD helicase functions in transcription initiation but is defective in DNA repair.
TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.
TFIIH: a link between transcription, DNA repair and cell cycle regulation.
TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair.
The carboxy-terminal domain of xeroderma pigmentosum complementation group C protein, involved in TFIIH and centrin binding, is highly disordered.
The cryo-electron microscopy structure of human transcription factor IIH.
The structure of the TFIIH p34 subunit reveals a von Willebrand factor A like fold.
The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor.
The XPD helicase: XPanDing archaeal XPD structures to get a grip on human DNA repair.
Transcription by RNA polymerase II: a process linked to DNA repair.
Transcription factor IIH - the protein complex with multiple functions.
Transcription preinitiation complex structure and dynamics provide insight into genetic diseases.
TTDA: Big impact of a small protein.
Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene.
Two new XPD patients compound heterozygous for the same mutation demonstrate diverse clinical features.
Xeroderma pigmentosum and molecular cloning of DNA repair genes.
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
XPD mutations prevent TFIIH-dependent transactivation by nuclear receptors and phosphorylation of RARalpha.
[rna-polymerase]-subunit kinase deficiency
DNA-dependent protein kinase defects are linked to deficiencies in DNA repair and V(D)J recombination.
DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus.
DNA-dependent protein kinase.
DNA-PK Deficiency in Alzheimer's Disease.
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells.
Dysfunctional mammalian telomeres join with DNA double-strand breaks.
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells.
Role of DNA-dependent protein kinase in neuronal survival.
Variable diversity joining recombination: nonhairpin coding ends in thymocytes of SCID and wild-type mice.