Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.7.11.23 - [RNA-polymerase]-subunit kinase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P39073

for references in articles please use BRENDA:EC2.7.11.23
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Saccharomyces cerevisiae
UNIPROT: P39073
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
dna-pk, tfiih, p-tefb, dna-dependent protein kinase, positive transcription elongation factor b, kin28, ctd kinase, srb10, ctdk-i, tfiih kinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C-terminal domain kinase
-
-
C-terminal repeat domain kinase
-
-
-
-
C-terminal repeat domain kinase I
-
-
CTD kinase
CTD kinase I
-
-
CTDK-I kinase
-
-
CTDK1 kinase
-
-
Kin28
kinase, ribonucleate nucleotidyltransferase II C-terminal domain (phosphorylating)
-
-
-
-
kinase, ribonucleate nucleotidyltransferase isozyme II IIa subunit (phosphorylating)
-
-
-
-
RNA pol II C-terminal domain kinase
-
-
RNA polymerase II CTD kinase
RNA polymerase II kinase
-
-
RNA polymerase II Ser2 C-terminal domain kinase
-
-
RNA polymerase II Ser2 CTD kinase
-
-
serine 2 C-terminal domain kinase
-
-
TFIIH CTD kinase
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[DNA-directed RNA polymerase] phosphotransferase
The enzyme appears to be distinct from other protein kinases. It brings about multiple phosphorylations of the unique C-terminal repeat domain of the largest subunit of eukaryotic DNA-directed RNA polymerase (EC 2.7.7.6). The enzyme does not phosphorylate casein, phosvitin or histone.
CAS REGISTRY NUMBER
COMMENTARY hide
122097-00-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
show the reaction diagram
ATP + [DNA-directed RNA polymerase]
ADP + phospho-[DNA-directed RNA polymerase]
show the reaction diagram
SRB10 phosphorylates the C-terminal domain of RNA polymerase II at Ser2 and Ser5
-
-
?
ATP + C-terminal domain of RNA polymerase II
ADP + phosphorylated C-terminal domain of RNA polymerase II
show the reaction diagram
the recombinant GST-tagged CTD substrate is hyperphosphorylated by Kin28
-
-
?
ATP + CTD-containing fusion protein
ADP + phosphorylated CTD-containing fusion protein
show the reaction diagram
-
-
-
-
?
ATP + CTD-containing fusion proteins
ADP + ?
show the reaction diagram
-
-
-
-
?
ATP + histone H3
?
show the reaction diagram
-
Ctk1 is essential for H3K36 methylation, also regulates H3K4 methylation
-
-
?
ATP + holo-RNA polymerase II
?
show the reaction diagram
-
C-terminal domain phosphorylation by the serine 5-specific TFIIH complex, its kinase module TFIIK or by the C-terminal domain serine 2-specific kinase CTDK1
-
-
?
ATP + RNA polymerase II
?
show the reaction diagram
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal domain
show the reaction diagram
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
show the reaction diagram
ATP + RNA polymerase II C-terminal repeat domain
ADP + phosphoylated RNA polymerase II C-terminal repeat domain
show the reaction diagram
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
show the reaction diagram
ATP + RNA polymerase II carboxy terminal domain
ADP + phosphorylated RNA polymerase II carboxy terminal domain
show the reaction diagram
ATP + Rps2
?
show the reaction diagram
-
phosphorylates on Ser 238, phosphorylation of Rps2 is needed for translational accuracy
-
-
?
ATP + Rps2
ADP + phosphorylated Rps2
show the reaction diagram
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
show the reaction diagram
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
show the reaction diagram
ATP + [DNA-directed RNA polymerase]
ADP + phospho-[DNA-directed RNA polymerase]
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
show the reaction diagram
only Rpb1, the largest subunit of RNAPII evolved a unique, highly repetitive carboxy-terminal domain, termed CTD. Dynamic phosphorylation patterns of serine residues in the CTD during gene transcription. Phosphorylation of Ser2, Ser5, Thr4, and Tyr1 in the CTD. CTD is composed of multiple tandem heptapeptides with the evolutionary conserved consensus motif Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7
-
-
?
ATP + [DNA-directed RNA polymerase]
ADP + phospho-[DNA-directed RNA polymerase]
show the reaction diagram
SRB10 phosphorylates the C-terminal domain of RNA polymerase II at Ser2 and Ser5
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal domain
show the reaction diagram
the SRI domain of Set2 interacts with the phosphorylated CTD of elongating RNAPII leading to methylation of the chromatin during transcription
-
-
?
ATP + RNA polymerase II C-terminal domain
ADP + phosphoylated RNA polymerase II C-terminal subunit
show the reaction diagram
ATP + RNA polymerase II C-terminal repeat domain
ADP + phosphoylated RNA polymerase II C-terminal repeat domain
show the reaction diagram
-
hyperphosphorylation, the Mediator complex associates with RNA polymerase II, RNAPII, at least partly via the RNAPII C-terminal repeat domain, CTD, whose phosphorylation is involved in triggering promoter clearance
-
-
?
ATP + RNA polymerase II C-terminal subunit
ADP + phosphoylated RNA polymerase II C-terminal subunit
show the reaction diagram
-
the enzyme regulates transcription elongation at many genes and integrates mRNA synthesis with histone modification, pre-mRNA processing, and mRNA export. Recruitment of P-TEFb to target genes requires deubiquitination of H2Bub, phosphorylation of H3S10, and the bromodomain protein, Brd4, overview. P-TEFb accompanies the mature mRNA to the cytoplasm to promote translation elongation. Enzyme regulation system, detailed overview
-
-
?
ATP + RNA polymerase II carboxy terminal domain
ADP + phosphorylated RNA polymerase II carboxy terminal domain
show the reaction diagram
-
the phosphorylated RNAPII CTD, interacts with BRCA1 for induction of DEF1-dependent cleavage and accumulation of a RNAPII fragment containing the P-CTD, overview
-
-
?
ATP + Rps2
ADP + phosphorylated Rps2
show the reaction diagram
-
a protein of the small ribosomal subunit, Ctk1 interacts with the transcription and mRNA export, TREX, complex, which couples transcription to mRNA export, and Ctk1 enhances efficient and accurate translation of the mRNA, Ctk1 is a prerequisite for correct decoding in vivo overview
-
-
?
ATP + [DNA-directed eukaryotic RNA polymerase II subunit IIa]
ADP + phospho-[DNA-directed RNA polymerase II subunit IIa]
show the reaction diagram
ATP + [DNA-directed RNA polymerase II]
ADP + phospho-[DNA-directed RNA polymerase II]
show the reaction diagram
ATP + [DNA-directed RNA polymerase]
ADP + phospho-[DNA-directed RNA polymerase]
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-NA-PP1
-
potent inhibitor of Kin28as allele kinase activity, Kin28as inhibition reduces transcript capping, overview, but inhibition of Kin28 does not inhibit transcription
anisomycin
-
inhibits translation elongation of wild-type
cycloheximide
-
inhibits translation elongation of wild-type
flavopiridol
-
causes a reduction in Ser2 phosphorylation and a defect in the transcription elongation of heat shock genes
geneticin
-
inhibits translation elongation of wild-type
hygromycin B
-
inhibits translation elongation of wild-type
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Mediator
-
stimulates the CTD kinase activity of TFIIH manyfold, immobilized holo-RNAPII can be separated into RNAPII and Mediator
-
Rsp5
-
stimulates CTD kinase activity
-
Rsp5 protein
-
the unrelated CTD-binding protein, Rsp5, is capable of stimulating this CTD kinase activity
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.027
ATP
-
room temperature, pH 7.8
0.00022
CTD-containing fusion protein
-
room temperature, pH 7.8
-
additional information
additional information
-
kinetics
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
65040
-
after purification with Mono S column
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
budding yeast
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
is associated with translating ribosomes in vivo
Manually annotated by BRENDA team
additional information
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the lethality caused by the substitution of Ser5 to alanine in CTD can be circumvented by covalent tethering of mRNA capping enzymes to the CTD in fission yeast
metabolism
phosphorylation state of the C-terminal domain of RNA polymerase II, detailed overview
physiological function
malfunction
the lethality caused by the substitution of Ser5 to alanine in CTD can be circumvented by covalent tethering of mRNA capping enzymes to the CTD in fission yeast. Mutation of Kin28 phosphorylation site Ser7 in substrate RNAPII CTD is not lethal to yeast cells. The substitution of tyrosine 1 by phenylalanine is lethal in Saccharomyces cerevisiae, indicating an important functional role of this CTD residue
metabolism
physiological function
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
-
glycerol density gradient centrifugation
32000
-
tentatively alphabetagamma, 1 * 58000 + 1 * 38000 + 1 * 32000, SDS-PAGE
38000
-
tentatively alphabetagamma, 1 * 58000 + 1 * 38000 + 1 * 32000, SDS-PAGE
58000
-
tentatively alphabetagamma, 1 * 58000 + 1 * 38000 + 1 * 32000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
trimer
-
tentatively alphabetagamma, 1 * 58000 + 1 * 38000 + 1 * 32000, SDS-PAGE
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D324N
T162A
the kin28-T162A allele, which does not display a slow growth phenotype, has reduced activity in vitro, but does not detectably affect CTD phosphorylation and capping enzymes recruitment in vivo
T17D
the mutant has decreased CTD kinase activity, a defect in capping enzyme recruitment, and is slow growing at 25°C and 37°C
T338A
-
amino acid substitution that does not affect catalytic function
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native Ctk1 complex
-
native TFIIK, and native CTD kinase 1 by a tandem affinity purification method
-
TFIIK, CTDK1 by tandem affinity purification
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
analysis of genetic interaction between ESS1 and CTD kinase genes, overexpression of wild-type and mutant CTD kinases Ctk1, Bur1, Kin28, and Srb10 in wild-type or mutant yeast strains, the latter being deficient in enzyme activity or in Ess1, overview
-
expression of plasmid-encoded Ctk1 in enzyme-deficient ctk1DELTA mutant strain
-
expression of the substrate as GST-CTD fusion protein in Escherichia coli
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cisek, L.J.; Corden, J.L.
Purification of protein kinases that phosphorylate the repetitive carboxyl-terminal domain of eukaryotic RNA polymerase II
Methods Enzymol.
200
301-325
1991
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Triticum aestivum
Manually annotated by BRENDA team
Lee, J.M.; Greenleaf, A.L.
A protein kinase that phosphorylates the C-terminal repeat domain of the largest subunit of RNA polymerase II
Proc. Natl. Acad. Sci. USA
86
3624-3628
1989
Saccharomyces cerevisiae, Drosophila sp. (in: flies), Homo sapiens, Drosophila sp. (in: flies) Kc
Manually annotated by BRENDA team
Morris, D.P.; Lee, J.M.; Sterner, D.E.; Brickey, W.J.; Greenleaf, A.L.
Assaying CTD kinases in vitro and phosphorylation-modulated properties of RNA polymerase II in vivo
Methods
12
264-275
1997
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Skaar, D.A.; Greenleaf, A.L.
The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p
Mol. Cell
10
1429-1439
2002
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Jona, G.; Wittschieben, B.O.; Svejstrup, J.Q.; Gileadi, O.
Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo
Gene
267
31-36
2001
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Prelich, G.
RNA polymerase II carboxy-terminal domain kinases: emerging clues to their function
Eukaryot. Cell
1
153-162
2002
Saccharomyces cerevisiae, Drosophila sp. (in: flies), Mus musculus
Manually annotated by BRENDA team
Hautbergue, G.; Goguel, V.
Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits
J. Biol. Chem.
276
8005-8013
2001
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Patturajan, M.; Conrad, N.K.; Bregman, D.B.; Corden, J.L.
Yeast carboxyl-terminal domain kinase I positively and negatively regulates RNA polymerase II carboxyl-terminal domain phosphorylation
J. Biol. Chem.
274
27823-27828
1999
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Phatnani, H.P.; Jones, J.C.; Greenleaf, A.L.
Expanding the functional repertoire of CTD kinase I and RNA polymerase II: novel phosphoCTD-associating proteins in the yeast proteome
Biochemistry
43
15702-15719
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kim, M.; Ahn, S.H.; Krogan, N.J.; Greenblatt, J.F.; Buratowski, S.
Transitions in RNA polymerase II elongation complexes at the 3' ends of genes
EMBO J.
23
354-364
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Palancade, B.; Bensaude, O.
Investigating RNA polymerase II carboxyl-terminal domain (CTD) phosphorylation
Eur. J. Biochem.
270
3859-3870
2003
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Schizosaccharomyces pombe
Manually annotated by BRENDA team
Xiao, T.; Hall, H.; Kizer, K.O.; Shibata, Y.; Hall, M.C.; Borchers, C.H.; Strahl, B.D.
Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast
Genes Dev.
17
654-663
2003
Saccharomyces cerevisiae, Saccharomyces cerevisiae AS4
Manually annotated by BRENDA team
Wilcox, C.B.; Rossettini, A.; Hanes, S.D.
Genetic interactions with C-terminal domain (CTD) kinases and the CTD of RNA Pol II suggest a role for ESS1 in transcription initiation and elongation in Saccharomyces cerevisiae
Genetics
167
93-105
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Jones, J.C.; Phatnani, H.P.; Haystead, T.A.; MacDonald, J.A.; Alam, S.M.; Greenleaf, A.L.
C-terminal repeat domain kinase I phosphorylates Ser2 and Ser5 of RNA polymerase II C-terminal domain repeats
J. Biol. Chem.
279
24957-24964
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kong, S.E.; Kobor, M.S.; Krogan, N.J.; Somesh, B.P.; Sogaard, T.M.; Greenblatt, J.F.; Svejstrup, J.Q.
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator
J. Biol. Chem.
280
4299-4306
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ahn, S.H.; Kim, M.; Buratowski, S.
Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing
Mol. Cells
13
67-76
2004
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Roether, S.; Straesser, K.
The RNA polymerase II CTD kinase Ctk1 functions in translation elongation
Genes Dev.
21
1409-1421
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Hirose, Y.; Ohkuma, Y.
Phosphorylation of the C-terminal domain of RNA polymerase II plays central roles in the integrated events of eucaryotic gene expression
J. Biochem.
141
601-608
2007
Saccharomyces cerevisiae, Drosophila melanogaster, Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team
Sogaard, T.M.; Svejstrup, J.Q.
Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator
J. Biol. Chem.
282
14113-14120
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Xiao, T.; Shibata, Y.; Rao, B.; Laribee, R.N.; ORourke, R.; Buck, M.J.; Greenblatt, J.F.; Krogan, N.J.; Lieb, J.D.; Strahl, B.D.
The RNA polymerase II kinase Ctk1 regulates positioning of a 5 histone methylation boundary along genes
Mol. Cell. Biol.
27
721-731
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Bres, V.; Yoh, S.M.; Jones, K.A.
The multi-tasking P-TEFb complex
Curr. Opin. Cell Biol.
20
334-340
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Youdell, M.L.; Kizer, K.O.; Kisseleva-Romanova, E.; Fuchs, S.M.; Duro, E.; Strahl, B.D.; Mellor, J.
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36
Mol. Cell. Biol.
28
4915-4926
2008
Saccharomyces cerevisiae (Q03957)
Manually annotated by BRENDA team
Bennett, C.B.; Westmoreland, T.J.; Verrier, C.S.; Blanchette, C.A.; Sabin, T.L.; Phatnani, H.P.; Mishina, Y.V.; Huper, G.; Selim, A.L.; Madison, E.R.; Bailey, D.D.; Falae, A.I.; Galli, A.; Olson, J.A.; Greenleaf, A.L.; Marks, J.R.
Yeast screens identify the RNA polymerase II CTD and SPT5 as relevant targets of BRCA1 interaction
PLoS ONE
3
e1448
2008
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kanin, E.I.; Kipp, R.T.; Kung, C.; Slattery, M.; Viale, A.; Hahn, S.; Shokat, K.M.; Ansari, A.Z.
Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis
Proc. Natl. Acad. Sci. USA
104
5812-5817
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Heidemann, M.; Hintermair, C.; Vo, K.; Eick, D.
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
Biochim. Biophys. Acta
1829
55-62
2013
Schizosaccharomyces pombe (O14098), Schizosaccharomyces pombe (Q12126), Schizosaccharomyces pombe (Q96WV9), Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (P39073), Saccharomyces cerevisiae (Q03957), Homo sapiens (P49336), Homo sapiens (P50613), Homo sapiens (P50750), Homo sapiens (Q9H4B4), Drosophila melanogaster (Q24216), Drosophila melanogaster (Q9VT57), Schizosaccharomyces pombe ATCC 24843 (O14098), Schizosaccharomyces pombe ATCC 24843 (Q12126), Schizosaccharomyces pombe ATCC 24843 (Q96WV9)
Manually annotated by BRENDA team
Bataille, A.R.; Jeronimo, C.; Jacques, P.E.; Laramee, L.; Fortin, M.E.; Forest, A.; Bergeron, M.; Hanes, S.D.; Robert, F.
A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes
Mol. Cell
45
158-170
2012
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (Q03957)
Manually annotated by BRENDA team
Allepuz-Fuster, P.; Martinez-Fernandez, V.; Garrido-Godino, A.I.; Alonso-Aguado, S.; Hanes, S.D.; Navarro, F.; Calvo, O.
Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation
Nucleic Acids Res.
42
13674-13688
2014
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae (P39073), Saccharomyces cerevisiae (Q03957)
Manually annotated by BRENDA team