Reference on EC 2.7.11.22 - cyclin-dependent kinase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
MacKintosh, C.; MacKintosh, R.W.
Inhibitors of protein kinases and phosphatases
Trends Biochem. Sci.
19
444-448
1994
eukaryota
Adams, M.D.; Celniker, S.E.; Holt, R.A.; Evans, C.A.; Gocayne, J.D.; et al.
The genome sequence of Drosophila melanogaster
Science
287
2185-2195
2000
Drosophila melanogaster (Q9VPC0)
Gilardi-Hebenstreit, P.; Nieto, M.A.; Frain, M.; Mattei, M.G.; Chestier, A.; Wilkinson, D.G.; Charnay, P.
An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain
Oncogene
7
2499-2506
1992
Mus musculus (P30285), Mus musculus (Q03147), Mus musculus
Hunter, T.
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling
Cell
80
225-236
1995
eukaryota
Kemp, B.E.; Parker, M.W.; Hu, S.; Tiganis, T.; House, C.
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity
Trends Biochem. Sci.
19
440-444
1994
Mammalia
Johnson, L.N.; Noble, M.E.M.; Owen, D.J.
Active and inactive protein kinases: structural basis for regulation
Cell
85
149-158
1996
Homo sapiens
Adams Joseph, A.
Activation loop phosphorylation and catalysis in protein kinases: is there functional evidence for the autoinhibitor model?
Biochemistry
42
601-607
2003
eukaryota
Adams, J.A.
Kinetic and catalytic mechanisms of protein kinases
Chem. Rev.
101
2271-2290
2001
eukaryota
Wood, V.; Gwilliam, R.; Rajandream, M.A.; Lyne, M.; Lyne, R.; et al.
The genome sequence of Schizosaccharomyces pombe
Nature
415
871-880
2002
Schizosaccharomyces pombe (O13958), Schizosaccharomyces pombe (O74456), Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe (P36615)
Hanks, S.K.
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family
Proc. Natl. Acad. Sci. USA
84
388-392
1987
Homo sapiens (P11802)
Wilson, R.; Ainscough, R.; Anderson, K.; Baynes, C.; Berks, M.; Bonfield, J.; Burton, J.; Connell, M.; Copsey, T.; Cooper, J.; et al.
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans
Nature
368
32-38
1994
Caenorhabditis elegans (P34556)
Saiz, J.E.; Buitrago, M.J.; Garcia, R.; Revuelta, J.L.; Del Rey, F.
The sequence of a 20.3 kb DNA fragment from the left arm of Saccharomyces cerevisiae chromosome IV contains the KIN28, MSS2, PHO2, POL3 and DUN1 genes, and six new open reading frames
Yeast
12
1077-1084
1996
Saccharomyces cerevisiae (P06242)
Biggs, W.H.; Zipursky, S.L.
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase
Proc. Natl. Acad. Sci. USA
89
6295-6299
1992
Drosophila melanogaster (P23573), Drosophila melanogaster (Q9VPC0)
Irie, K.; Nomoto, S.; Miyajima, I.; Matsumoto, K.
SGV1 encodes a CDC28/cdc2-related kinase required for a G alpha subunit-mediated adaptive response to pheromone in S. cerevisiae
Cell
65
785-795
1991
Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae
Montini, E.; Andolfi, G.; Caruso, A.; Buchner, G.; Walpole, S.M.; Mariani, M.; Consalez, G.; Trump, D.; Ballabio, A.; Franco, B.
Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region
Genomics
51
427-433
1998
Homo sapiens (O76039)
Roemer, T.; Fortin, N.; Bussey, H.
DNA sequence analysis of a 10.4 kbp region on the right arm of yeast chromosome XVI positions GPH1 and SGV1 adjacent to KRE6, and identifies two novel tRNA genes
Yeast
10
1527-1530
1994
Saccharomyces cerevisiae (P23293)
Sauer, K.; Weigmann, K.; Sigrist, S.; Lehner, C.F.
Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase
Mol. Biol. Cell
7
1759-1769
1996
Drosophila melanogaster (P48609), Drosophila melanogaster (Q9VPC0)
Tanaka, K.; Okayama, H.
A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast
Mol. Biol. Cell
11
2845-2862
2000
Schizosaccharomyces pombe (O74456), Schizosaccharomyces pombe
Watson, P.; Davey, J.
Characterization of the Prk1 protein kinase from Schizosaccharomyces pombe
Yeast
14
485-492
1998
Schizosaccharomyces pombe (O13958), Schizosaccharomyces pombe
Hirose, T.; Tamaru, T.; Okumura, N.; Nagai, K.; Okada, M.
PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons
Eur. J. Biochem.
249
481-488
1997
Rattus norvegicus (O35831), Rattus norvegicus (O35832)
Ellenrieder, C.; Bartosch, B.; Lee, G.Y.; Murphy, M.; Sweeney, C.; Hergersberg, M.; Carrington, M.; Jaussi, R.; Hunt, T.
The long form of CDK2 arises via alternative splicing and forms an active protein kinase with cyclins A and E
DNA Cell Biol.
20
413-423
2001
Cricetulus griseus (O55076)
Baur, S.; Becker, J.; Li, Z.; Niegemann, E.; Wehner, E.; Wolter, R.; Brendel, M.
Sequence analysis of a 5.6 kb fragment of chromosome II from Saccharomyces cerevisiae reveals two new open reading frames next to CDC28
Yeast
11
455-458
1995
Saccharomyces cerevisiae (P00546), Saccharomyces cerevisiae
Lorincz, A.T.; Reed, S.I.
Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes
Nature
307
183-185
1984
Saccharomyces cerevisiae (P00546), Saccharomyces cerevisiae
MacCoss, M.J.; McDonald, W.H.; Saraf, A.; Sadygov, R.; Clark, J.M.; Tasto, J.J.; Gould, K.L.; Wolters, D.; Washburn, M.; Weiss, A.; Clark, J.I.; Yates, J.R.
Shotgun identification of protein modifications from protein complexes and lens tissue
Proc. Natl. Acad. Sci. USA
99
7900-7905
2002
Schizosaccharomyces pombe (P04551)
Machida, M.; Yamazaki, S.; Kunihiro, S.; Tanaka, T.; Kushida, N.; Jinnno, K.; Haikawa, Y.; Yamazaki, J.; Yamamoto, S.; Sekine, M.; Oguchi, A.; Nagai, Y.; Sakai, M.; Aoki, K.; Ogura, K.; Kudoh, Y.; Kikuchi, H.; Zhang, M.Q.; Yanagida, M.
A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment
Yeast
16
71-80
2000
Schizosaccharomyces pombe (P04551)
MacNeill, S.A.; Nurse, P.
Mutational analysis of the fission yeast p34cdc2 protein kinase gene
Mol. Gen. Genet.
236
415-426
1993
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
Gould, K.L.; Nurse, P.
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
Nature
342
39-45
1989
Schizosaccharomyces pombe (P04551)
Brizuela, L.; Draetta, G.; Beach, D.
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase
EMBO J.
6
3507-3514
1987
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
Hindley, J.; Phear, G.A.
Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases
Gene
31
129-134
1984
Schizosaccharomyces pombe (P04551), Schizosaccharomyces pombe
Korsisaari, N.; Makela, T.P.
Interactions of Cdk7 and Kin28 with Hint/PKCI-1 and Hnt1 histidine triad proteins
J. Biol. Chem.
275
34837-34840
2000
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae
Valay, J.G.; Simon, M.; Faye, G.
The kin28 protein kinase is associated with a cyclin in Saccharomyces cerevisiae
J. Mol. Biol.
234
307-310
1993
Saccharomyces cerevisiae (P06242)
Simon, M.; Seraphin, B.; Faye, G.
KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28
EMBO J.
5
2697-2701
1986
Saccharomyces cerevisiae (P06242), Saccharomyces cerevisiae
Ohta, T.; Okamoto, K.; Isohashi, F.; Shibata, K.; Fukuda, M.; Yamaguchi, S.; Xiong, Y.
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21
Cancer Res.
58
1095-1098
1998
Homo sapiens (P06493), Homo sapiens
Draetta, G.; Beach, D.
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement
Cell
54
17-26
1988
Homo sapiens (P06493)
Lee, M.G.; Nurse, P.
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
Nature
327
31-35
1987
Homo sapiens (P06493)
Th'ng, J.P.; Wright, P.S.; Hamaguchi, J.; Lee, M.G.; Norbury, C.J.; Nurse, P.; Bradbury, E.M.
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product
Cell
63
313-324
1990
Mus musculus (P11440)
Spurr, N.K.; Gough, A.C.; Lee, M.G.
Cloning of the mouse homologue of the yeast cell cycle control gene cdc2
DNA Seq.
1
49-54
1990
Mus musculus (P11440)
Cisek, L.J.; Corden, J.L.
Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2
Nature
339
679-684
1989
Mus musculus (P11440)
Soufir, N.; Avril, M.F.; Chompret, A.; Demenais, F.; Bombled, J.; Spatz, A.; Stoppa-Lyonnet, D.; Benard, J.; Bressac-de Paillerets, B.
Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group
Hum. Mol. Genet.
7
209-216
1998
Homo sapiens (P11802)
Elkahloun, A.G.; Krizman, D.B.; Wang, Z.; Hofmann, T.A.; Roe, B.; Meltzer, P.S.
Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers
Genomics
42
295-301
1997
Homo sapiens (P11802)
Zuo, L.; Weger, J.; Yang, Q.; Goldstein, A.M.; Tucker, M.A.; Walker, G.J.; Hayward, N.; Dracopoli, N.C.
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
Nat. Genet.
12
97-99
1996
Homo sapiens (P11802)
Wolfel, T.; Hauer, M.; Schneider, J.; Serrano, M.; Wolfel, C.; Klehmann-Hieb, E.; De Plaen, E.; Hankeln, T.; Meyer zum Buschenfelde, K.H.; Beach, D.
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
Science
269
1281-1284
1995
Homo sapiens (P11802), Homo sapiens
Khatib, Z.A.; Matsushime, H.; Valentine, M.; Shapiro, D.N.; Sherr, C.J.; Look, A.T.
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
Cancer Res.
53
5535-5541
1993
Homo sapiens (P11802), Homo sapiens
Krek, W.; Nigg, E.A.
Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites
EMBO J.
10
305-316
1991
Gallus gallus (P13863), Gallus gallus
Krek, W.; Nigg, E.A.
Structure and developmental expression of the chicken CDC2 kinase
EMBO J.
8
3071-3078
1989
Gallus gallus (P13863), Gallus gallus
Kaffman, A.; Herskowitz, I.; Tjian, R.; O'Shea, E.K.
Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85
Science
263
1153-1156
1994
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Toh-e, A.; Tanaka, K.; Uesono, Y.; Wickner, R.B.
PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae
Mol. Gen. Genet.
214
162-164
1988
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Uesono, Y.; Tanaka, K.; Toh-e, A.
Negative regulators of the PHO system in Saccharomyces cerevisiae: isolation and structural characterization of PHO85
Nucleic Acids Res.
15
10299-10309
1987
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Matsushime, H.; Jinno, A.; Takagi, N.; Shibuya, M.
A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis
Mol. Cell. Biol.
10
2261-2268
1990
Rattus norvegicus (P20793), Homo sapiens (P20794)
Labbe, J.C.; Martinez, A.M.; Fesquet, D.; Capony, J.P.; Darbon, J.M.; Derancourt, J.; Devault, A.; Morin, N.; Cavadore, J.C.; Doree, M.
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes
EMBO J.
13
5155-5164
1994
Xenopus laevis (P20911)
Shuttleworth, J.; Godfrey, R.; Colman, A.
p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes
EMBO J.
9
3233-3240
1990
Xenopus laevis (P20911)
Eipers, P.G.; Lahti, J.M.; Kidd, V.J.
Structure and expression of the human p58clk-1 protein kinase chromosomal gene
Genomics
13
613-621
1992
Homo sapiens (P21127), Homo sapiens
Bunnell, B.A.; Heath, L.S.; Adams, D.E.; Lahti, J.M.; Kidd, V.J.
Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle
Proc. Natl. Acad. Sci. USA
87
7467-7471
1990
Homo sapiens (P21127), Homo sapiens
Colasanti, J.; Tyers, M.; Sundaresan, V.
Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays
Proc. Natl. Acad. Sci. USA
88
3377-3381
1991
Zea mays (P23111), Zea mays
Poon, R.Y.; Yamashita, K.; Adamczewski, J.P.; Hunt, T.; Shuttleworth, J.
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
EMBO J.
12
3123-3132
1993
Xenopus laevis (P23437)
Paris, J.; Le Guellec, R.; Couturier, A.; Le Guellec, K.; Omilli, F.; Camonis, J.; MacNeill, S.; Philippe, M.
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2
Proc. Natl. Acad. Sci. USA
88
1039-1043
1991
Xenopus laevis (P23437), Xenopus laevis
Stern, B.; Ried, G.; Clegg, N.J.; Grigliatti, T.A.; Lehner, C.F.
Genetic analysis of the Drosophila cdc2 homolog
Development
117
219-232
1993
Xenopus laevis (P23437)
Clegg, N.J.; Whitehead, I.P.; Williams, J.A.; Spiegelman, G.B.; Grigliatti, T.A.
A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
Genome
36
676-685
1993
Xenopus laevis (P23437)
Jimenez, J.; Alphey, L.; Nurse, P.; Glover, D.M.
Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string
EMBO J.
9
3565-3571
1990
Xenopus laevis (P23437)
Lehner, C.F.; O'Farrell, P.H.
Drosophila cdc2 homologul: a functional homolog is coexpressed with a cognate variant
EMBO J.
9
3573-3581
1990
Drosophila melanogaster (P23573), Xenopus laevis (P23437)
Fesquet, D.; Labbe, J.C.; Derancourt, J.; Capony, J.P.; Galas, S.; Girard, F.; Lorca, T.; Shuttleworth, J.; Doree, M.; Cavadore, J.C.
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
EMBO J.
12
3111-3121
1993
Xenopus laevis (P24033), Xenopus laevis (P35567)
Pickham, K.M.; Meyer, A.N.; Li, J.; Donoghue, D.J.
Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites
Mol. Cell. Biol.
12
3192-3203
1992
Xenopus laevis (P24033), Xenopus laevis (P35567)
Inze, D.; Ferreira, P.; Hemerly, A.; Van Montagu, M.
Control of cell division in plants
Biochem. Soc. Trans.
20
80-84
1992
Arabidopsis thaliana (P24100)
Imajuku, Y.; Hirayama, T.; Endoh, H.; Oka, A.
Exon-intron organization of the Arabidopsis thaliana protein kinase genes CDC2a and CDC2b
FEBS Lett.
304
73-77
1992
Arabidopsis thaliana (P24100), Arabidopsis thaliana (P25859), Arabidopsis thaliana
Hirayama, T.; Imajuku, Y.; Anai, T.; Matsui, M.; Oka, A.
Identification of two cell-cycle-controlling cdc2 gene homologs in Arabidopsis thaliana
Gene
105
159-165
1991
Arabidopsis thaliana (P24100), Arabidopsis thaliana (P25859), Arabidopsis thaliana
Ferreira, P.C.; Hemerly, A.S.; Villarroel, R.; Van Montagu, M.; Inze, D.
The Arabidopsis functional homolog of the p34cdc2 protein kinase
Plant Cell
3
531-540
1991
Arabidopsis thaliana (P24100), Arabidopsis thaliana
Kidd, V.J.; Luo, W.; Xiang, J.L.; Tu, F.; Easton, J.; McCune, S.; Snead, M.L.
Regulated expression of a cell division control-related protein kinase during development
Cell Growth Differ.
2
85-93
1991
Mus musculus (P24788), Mus musculus
Gray, N.S.; Wodicka, L.; Thunnissen, A.M.; Norman, T.C.; Kwon, S.; Espinoza, F.H.; Morgan, D.O.; Barnes, G.; LeClerc, S.; Meijer, L.; Kim, S.H.; Lockhart, D.J.; Schultz, P.G.
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
Science
281
533-538
1998
Homo sapiens (P24941), Homo sapiens
Lawrie, A.M.; Noble, M.E.; Tunnah, P.; Brown, N.R.; Johnson, L.N.; Endicott, J.A.
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2
Nat. Struct. Biol.
4
796-801
1997
Homo sapiens (P24941)
Schulze-Gahmen, U.; De Bondt, H.L.; Kim, S.H.
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design
J. Med. Chem.
39
4540-4546
1996
Homo sapiens (P24941), Homo sapiens
Russo, A.A.; Jeffrey, P.D.; Pavletich, N.P.
Structural basis of cyclin-dependent kinase activation by phosphorylation
Nat. Struct. Biol.
3
696-700
1996
Homo sapiens (P24941)
Russo, A.A.; Jeffrey, P.D.; Patten, A.K.; Massague, J.; Pavletich, N.P.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
Nature
382
325-331
1996
Homo sapiens (P24941), Homo sapiens
De Azevedo, W.F., Jr.; Mueller-Dieckmann, H.J.; Schulze-Gahmen, U.; Worland, P.J.; Sausville, E.; Kim, S.H.
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
Proc. Natl. Acad. Sci. USA
93
2735-2740
1996
Homo sapiens (P24941)
Bourne, Y.; Watson, M.H.; Hickey, M.J.; Holmes, W.; Rocque, W.; Reed, S.I.; Tainer, J.A.
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1
Cell
84
863-874
1996
Homo sapiens (P24941), Homo sapiens
Jeffrey, P.D.; Russo, A.A.; Polyak, K.; Gibbs, E.; Hurwitz, J.; Massague, J.; Pavletich, N.P.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
Nature
376
313-320
1995
Homo sapiens (P24941), Homo sapiens
De Bondt, H.L.; Rosenblatt, J.; Jancarik, J.; Jones, H.D.; Morgan, D.O.; Kim, S.H.
Crystal structure of cyclin-dependent kinase 2
Nature
363
595-602
1993
Homo sapiens (P24941), Homo sapiens
Gu, Y.; Rosenblatt, J.; Morgan, D.O.
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
EMBO J.
11
3995-4005
1992
Homo sapiens (P24941), Homo sapiens
Tsai, L.H.; Harlow, E.; Meyerson, M.
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
Nature
353
174-177
1991
Homo sapiens (P24941), Homo sapiens
Ninomiya-Tsuji, J.; Nomoto, S.; Yasuda, H.; Reed, S.I.; Matsumoto, K.
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation
Proc. Natl. Acad. Sci. USA
88
9006-9010
1991
Homo sapiens (P24941), Homo sapiens
Elledge, S.J.; Spottswood, M.R.
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1
EMBO J.
10
2653-2659
1991
Homo sapiens (P24941), Homo sapiens
Ershler, M.; Nagorskaya, T.V.; Visser, J.W.; Belyavsky, A.V.
Novel CDC2-related protein kinases produced in murine hematopoietic stem cells
Gene
124
305-306
1993
Mus musculus (P30285), Mus musculus (P49615), Mus musculus (Q03147)
Kato, J.Y.; Matsuoka, M.; Strom, D.K.; Sherr, C.J.
Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase
Mol. Cell. Biol.
14
2713-2721
1994
Mus musculus (P30285)
Matsushime, H.; Ewen, M.E.; Strom, D.K.; Kato, J.Y.; Hanks, S.K.; Roussel, M.F.; Sherr, C.J.
Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins
Cell
71
323-334
1992
Mus musculus (P30285), Mus musculus
Rasmussen, S.W.
A 37.5 kb region of yeast chromosome X includes the SME1, MEF2, GSH1 and CSD3 genes, a TCP-1-related gene, an open reading frame similar to the DAL80 gene, and a tRNA(Arg)
Yeast
11
873-883
1995
Saccharomyces cerevisiae (P32581)
Yoshida, M.; Kawaguchi, H.; Sakata, Y.; Kominami, K.; Hirano, M.; Shima, H.; Akada, R.; Yamashita, I.
Initiation of meiosis and sporulation in Saccharomyces cerevisiae requires a novel protein kinase homologue
Mol. Gen. Genet.
221
176-186
1990
Saccharomyces cerevisiae (P32581)
Michaelis, C.; Weeks, G.
Isolation and characterization of a cdc 2 cDNA from Dictyostelium discoideum
Biochim. Biophys. Acta
1132
35-42
1992
Dictyostelium discoideum (P34112), Dictyostelium discoideum
Michaelis, C.; Weeks, G.
The isolation from a unicellular organism, Dictyostelium discoideum, of a highly-related cdc2 gene with characteristics of the PCTAIRE subfamily
Biochim. Biophys. Acta
1179
117-124
1993
Dictyostelium discoideum (P34117), Dictyostelium discoideum
Boxem, M.; Srinivasan, D.G.; van den Heuvel, S.
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase
Development
126
2227-2239
1999
Caenorhabditis elegans (P34556), Caenorhabditis elegans
Mori, H.; Palmer, R.E.; Sternberg, P.W.
The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase
Mol. Gen. Genet.
245
781-786
1994
Caenorhabditis elegans (P34556), Caenorhabditis elegans
Cho, F.S.; Phillips, K.S.; Khan, S.A.; Weaver, T.E.
Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues
Biochem. Biophys. Res. Commun.
191
860-865
1993
Rattus norvegicus (P35426)
Molz, L.; Beach, D.
Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity
EMBO J.
12
1723-1732
1993
Schizosaccharomyces pombe (P36615)
Mottram, J.C.; Smith, G.
A family of trypanosome cdc2-related protein kinases
Gene
162
147-152
1995
Trypanosoma brucei brucei (P38973), Trypanosoma brucei brucei (P54665), Trypanosoma brucei brucei (P54666)
Riabowol, K.; Draetta, G.; Brizuela, L.; Vandre, D.; Beach, D.
The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells
Cell
57
393-401
1989
Rattus norvegicus (P39951)
Damagnez, V.; Cottarel, G.
Candida albicans CDK1 and CYB1: cDNA homologues of the cdc2/CDC28 and cdc13/CLB1/CLB2 cell cycle control genes
Gene
172
137-141
1996
Candida albicans (P43063), Candida albicans
Sherlock, G.; Bahman, A.M.; Mahal, A.; Shieh, J.C.; Ferreira, M.; Rosamond, J.
Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans
Mol. Gen. Genet.
245
716-723
1994
Candida albicans (P43063), Candida albicans
Navarro-Garcia, F.; Sanchez, M.; Pla, J.; Nombela, C.
Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity
Mol. Cell. Biol.
15
2197-2206
1995
Candida albicans (P43063)
Mayer, K.; Schuller, C.; Wambutt, R.; Murphy, G.; et al.
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana
Nature
402
769-777
1999
Arabidopsis thaliana (P43294)
Moran, T.V.; Walker, J.C.
Molecular cloning of two novel protein kinase genes from Arabidopsis thaliana
Biochim. Biophys. Acta
1216
9-14
1993
Arabidopsis thaliana (P43294)
Hirai, T.; Yamashita, M.; Yoshikuni, M.; Tokumoto, T.; Kajiura, H.; Sakai, N.; Nagahama, Y.
Isolation and characterization of goldfish cdk2, a cognate variant of the cell cycle regulator cdc2
Dev. Biol.
152
113-120
1992
Carassius auratus (P43450)
Kerr, M.; Fischer, J.E.; Purushotham, K.R.; Gao, D.; Nakagawa, Y.; Maeda, N.; Ghanta, V.; Hiramoto, R.; Chegini, N.; Humphreys-Beher, M.G.
Characterization of the synthesis and expression of the GTA-kinase from transformed and normal rodent cells
Biochim. Biophys. Acta
1218
375-387
1994
Rattus norvegicus (P46892)
Hellmich, M.R.; Kennison, J.A.; Hampton, L.L.; Battey, J.F.
Cloning and characterization of the Drosophila melanogaster CDK5 homolog
FEBS Lett.
356
317-321
1994
Drosophila melanogaster (P48609), Drosophila melanogaster
Yang, L.; Farin, C.E.
Identification of cDNAs encoding bovine cyclin B and Cdk1/Cdc2
Gene
141
283-286
1994
Bos taurus (P48734)
Noguchi, E.; Sekiguchi, T.; Yamashita, K.; Nishimoto, T.
Molecular cloning and identification of two types of hamster cyclin-dependent kinases: cdk2 and cdk2L
Biochem. Biophys. Res. Commun.
197
1524-1529
1993
Mesocricetus auratus (P48963), Mesocricetus auratus
Tassan, J.P.; Jaquenoud, M.; Leopold, P.; Schultz, S.J.; Nigg, E.A.
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
Proc. Natl. Acad. Sci. USA
92
8871-8875
1995
Homo sapiens (P49336), Homo sapiens
Ohshima, T.; Nagle, J.W.; Pant, H.C.; Joshi, J.B.; Kozak, C.A.; Brady, R.O.; Kulkarni, A.B.
Molecular cloning and chromosomal mapping of the mouse cyclin-dependent kinase 5 gene
Genomics
28
585-588
1995
Mus musculus (P49615), Mus musculus
Ino, H.; Ishizuka, T.; Chiba, T.; Tatibana, M.
Expression of CDK5 (PSSALRE kinase), a neural cdc2-related protein kinase, in the mature and developing mouse central and peripheral nervous systems
Brain Res.
661
196-206
1994
Mus musculus (P49615)
Tirode, F.; Busso, D.; Coin, F.; Egly, J.M.
Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7
Mol. Cell
3
87-95
1999
Homo sapiens (P50613)
Akoulitchev, S.; Reinberg, D.
The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7
Genes Dev.
12
3541-3550
1998
Homo sapiens (P50613)
Wu, L.; Yee, A.; Liu, L.; Carbonaro-Hall, D.; Venkatesan, N.; Tolo, V.T.; Hall, F.L.
Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase
Oncogene
9
2089-2096
1994
Homo sapiens (P50613)
Tassan, J.P.; Schultz, S.J.; Bartek, J.; Nigg, E.A.
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
J. Cell. Biol.
127
467-478
1994
Homo sapiens (P50613), Homo sapiens
Levedakou, E.N.; He, M.; Baptist, E.W.; Craven, R.J.; Cance, W.G.; Welcsh, P.L.; Simmons, A.; Naylor, S.L.; Leach, R.J.; Lewis, T.B.; et al.
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern
Oncogene
9
1977-1988
1994
Homo sapiens (P50613), Homo sapiens
Fisher, R.P.; Morgan, D.O.
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
Cell
78
713-724
1994
Homo sapiens (P50613)
Darbon, J.M.; Devault, A.; Taviaux, S.; Fesquet, D.; Martinez, A.M.; Galas, S.; Cavadore, J.C.; Doree, M.; Blanchard, J.M.
Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase
Oncogene
9
3127-3138
1994
Homo sapiens (P50613), Homo sapiens
Liu, H.; Rice, A.P.
Genomic organization and characterization of promoter function of the human CDK9 gene
Gene
252
51-59
2000
Homo sapiens (P50750)
Fu, T.J.; Peng, J.; Lee, G.; Price, D.H.; Flores, O.
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription
J. Biol. Chem.
274
34527-34530
1999
Homo sapiens (P50750)
Best, J.L.; Presky, D.H.; Swerlick, R.A.; Burns, D.K.; Chu, W.
Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells
Biochem. Biophys. Res. Commun.
208
562-568
1995
Homo sapiens (P50750), Homo sapiens
Grana, X.; De Luca, A.; Sang, N.; Fu, Y.; Claudio, P.P.; Rosenblatt, J.; Morgan, D.O.; Giordano, A.
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro
Proc. Natl. Acad. Sci. USA
91
3834-3838
1994
Homo sapiens (P50750), Homo sapiens
Gervasi, C.; Szaro, B.G.
The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation
Brain Res. Mol. Brain Res.
33
192-200
1995
Xenopus laevis (P51166), Xenopus laevis
Di Lallo, G.; Gargano, S.; Maresca, B.
The Histoplasma capsulatum cdc2 gene is transcriptionally regulated during the morphologic transition
Gene
140
51-57
1994
Histoplasma capsulatum (P54119), Histoplasma capsulatum
Michaelis, C.; Luo, Q.; Weeks, G.
A Dictyostelium discoideum gene, which is highly related to mo15 from Xenopus, is expressed during growth but not during development
Biochem. Cell Biol.
73
51-58
1995
Dictyostelium discoideum (P54685), Dictyostelium discoideum
Meyerson, M.; Enders, G.H.; Wu, C.L.; Su, L.K.; Gorka, C.; Nelson, C.; Harlow, E.; Tsai, L.H.
A family of human cdc2-related protein kinases
EMBO J.
11
2909-2917
1992
Homo sapiens (Q00526), Homo sapiens (Q00532), Homo sapiens (Q00534), Homo sapiens (Q00535), Homo sapiens (Q00536), Homo sapiens (Q00537), Homo sapiens (Q07002), Homo sapiens
Russo, A.A.; Tong, L.; Lee, J.O.; Jeffrey, P.D.; Pavletich, N.P.
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
Nature
395
237-243
1998
Homo sapiens (Q00534)
Osmani, A.H.; van Peij, N.; Mischke, M.; O'Connell, M.J.; Osmani, S.A.
A single p34cdc2 protein kinase (encoded by nimXcdc2) is required at G1 and G2 in Aspergillus nidulans
J. Cell Sci.
107
1519-1528
1994
Aspergillus nidulans (Q00646)
-
Brown, L.; Hines, J.C.; Ray, D.S.
The Crithidia fasciculata CRK gene encodes a novel cdc2-related protein containing large inserts between highly conserved domains
Nucleic Acids Res.
20
5451-5456
1992
Crithidia fasciculata (Q01917), Crithidia fasciculata
Lew, J.; Winkfein, R.J.; Paudel, H.K.; Wang, J.H.
Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2
J. Biol. Chem.
267
25922-25926
1992
Bos taurus (Q02399), Bos taurus
Xiong, Y.; Zhang, H.; Beach, D.
D Type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA
Cell
71
505-514
1992
Rattus norvegicus (Q03114)
Hellmich, M.R.; Pant, H.C.; Wada, E.; Battey, J.F.
Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression
Proc. Natl. Acad. Sci. USA
89
10867-10871
1992
Rattus norvegicus (Q03114)
Stepanova, L.; Ershler, M.A.; Belyavsky, A.V.
Sequence of the cDNA encoding murine CRK4 protein kinase
Gene
149
321-324
1994
Mus musculus (Q03147), Mus musculus
Matsuoka, M.; Kato, J.Y.; Fisher, R.P.; Morgan, D.O.; Sherr, C.J.
Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase
Mol. Cell. Biol.
14
7265-7275
1994
Mus musculus (Q03147), Mus musculus
Ershler, M.A.; Nagorskaia, T.V.; Fisser Ia, V.; Beliavskii, A.V.
Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells
Dokl. Akad. Nauk
324
893-897
1992
Mus musculus (Q03147)
Lee, J.M.; Greenleaf, A.L.
CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae
Gene Expr.
1
149-167
1991
Saccharomyces cerevisiae (Q03957), Saccharomyces cerevisiae
Okuda, T.; Cleveland, J.L.; Downing, J.R.
PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family
Oncogene
7
2249-2258
1992
Mus musculus (Q04735), Mus musculus (Q04899), Mus musculus
Lohia, A.; Samuelson, J.
Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34cdc2 homologue
Gene
127
203-207
1993
Entamoeba histolytica (Q04770), Entamoeba histolytica
Bladt, F.; Birchmeier, C.
Characterization and expression analysis of the murine rck gene: a protein kinase with a potential function in sensory cells
Differentiation
53
115-122
1993
Mus musculus (Q04859)
Hirt, H.; Pay, A.; Bogre, L.; Meskiene, I.; Heberle-Bors, E.
cdc2MsB, a cognate cdc2 gene from alfalfa, complements the G1/S but not the G2/M transition of budding yeast cdc28 mutants
Plant J.
4
61-69
1993
Medicago sativa (Q05006), Medicago sativa
Mottram, J.C.; Kinnaird, J.H.; Shiels, B.R.; Tait, A.; Barry, J.D.
A novel CDC2-related protein kinase from Leishmania mexicana, LmmCRK1, is post-translationally regulated during the life cycle
J. Biol. Chem.
268
21044-21052
1993
Leishmania mexicana (Q06309), Leishmania mexicana
Ross-Macdonald, P.B.; Graeser, R.; Kappes, B.; Franklin, R.; Williamson, D.H.
Isolation and expression of a gene specifying a cdc2-like protein kinase from the human malaria parasite Plasmodium falciparum
Eur. J. Biochem.
220
693-701
1994
Plasmodium falciparum (Q07785), Plasmodium falciparum
Crawford, J.; Ianzano, L.; Savino, M.; Whitmore, S.; Cleton-Jansen, A.M.; Settasatian, C.; d'apolito, M.; Seshadri, R.; Pronk, J.C.; Auerbach, A.D.; Verlander, P.C.; Mathew, C.G.; Tipping, A.J.; Doggett, N.A.; Zelante, L.; Callen, D.F.; Savoia, A.
The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer
Genomics
56
90-97
1999
Homo sapiens (Q15131)
Grana, X.; Claudio, P.P.; De Luca, A.; Sang, N.; Giordano, A.
PISSLRE, a human novel CDC2-related protein kinase
Oncogene
9
2097-2103
1994
Homo sapiens (Q15131), Homo sapiens
Brambilla, R.; Draetta, G.
Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases
Oncogene
9
3037-3041
1994
Homo sapiens (Q15131), Homo sapiens
Fobert, P.R.; Gaudin, V.; Lunness, P.; Coen, E.S.; Doonan, J.H.
Distinct classes of cdc2-related genes are differentially expressed during the cell division cycle in plants
Plant Cell
8
1465-1476
1996
Antirrhinum majus (Q38772), Antirrhinum majus (Q38774), Antirrhinum majus (Q38775)
Hong, Z.; Miao, G.H.; Verma, D.P.
p34cdc2 protein kinase homolog from mothbean (Vigna aconitifolia)
Plant Physiol.
101
1399-1400
1993
Vigna aconitifolia (Q41639)
Kotani, S.; Endo, T.; Kitagawa, M.; Higashi, H.; Onaya, T.
A variant form of cyclin-dependent kinase 2 (Cdk2) in a malignantly transformed rat thyroid (FRTL-Tc) cell line
Oncogene
10
663-669
1995
Rattus norvegicus (Q63699)
Hosokawa, Y.; Yang, M.; Kaneko, S.; Tanaka, M.; Nakashima, K.
Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells
Biochem. Mol. Biol. Int.
37
393-399
1995
Rattus norvegicus (Q63699)
Hadano, S.; Hand, C.K.; Osuga, H.; Yanagisawa, Y.; Otomo, A.; Devon, R.S.; Miyamoto, N.; Showguchi-Miyata, J.; Okada, Y.; Singaraja, R.; Figlewicz, D.A.; Kwiatkowski, T.; Hosler, B.A.; Sagie, T.; Skaug, J.; Nasir, J.; Brown, R.H., Jr.; Scherer, S.W.; Rouleau, G.A.; Hayden, M.R.; Ikeda, J.E.
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
Nat. Genet.
29
166-173
2001
Homo sapiens (Q96Q40)
Nagase, T.; Ishikawa, K.; Suyama, M.; Kikuno, R.; Hirosawa, M.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
DNA Res.
5
355-364
1998
Homo sapiens (Q9NYV4)
Bandyopadhyay, J.; Bandyopadhyay, A.; Choi, H.S.; Kwon, H.B.; Kang, H.M.
Cloning and characterization of cDNA encoding cdc2 kinase, a component of maturation-promoting factor, in Rana dybowskii
Gen. Comp. Endocrinol.
117
313-322
2000
Rana dybowskii (Q9W739), Rana dybowskii
Bussey, H.; Storms, R.K.; Ahmed, A.; Albermann, K.; et al.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI
Nature
387
103-105
1997
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae (P23293), Saccharomyces cerevisiae (P39073)
Salanoubat, M.; Lemcke, K.; Rieger, M.; Ansorge, W.; Unseld, M.; et al.
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana
Nature
408
820-822
2000
Arabidopsis thaliana (P24100), Arabidopsis thaliana (P25859)
Murakami, Y.; Naitou, M.; Hagiwara, H.; Shibata, T.; Ozawa, M.; Sasanuma, S.; Sasanuma, M.; Tsuchiya, Y.; Soeda, E.; Yokoyama, K.; et al.
Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae
Nat. Genet.
10
261-268
1995
Saccharomyces cerevisiae (P43568)
Kaldis, P.; Sutton, A.; Solomon, M.J.
The Cdk-activating kinase (CAK) from budding yeast
Cell
86
553-564
1996
Saccharomyces cerevisiae (P43568), Saccharomyces cerevisiae
Osmani, S.A.; Pu, R.T.; Morris, N.R.
Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase
Cell
53
237-244
1988
Aspergillus nidulans (P11837)
Pu, R.T.; Osmani, S.A.
Mitotic destruction of the cell cycle regulated NIMA protein kinase of Aspergillus nidulans is required for mitotic exit
EMBO J.
14
995-1003
1995
Aspergillus nidulans (P11837), Aspergillus nidulans
Pu, R.T.; Xu, G.; Wu, L.; Vierula, J.; O'Donnell, K.; Ye, X.S.; Osmani, S.A.
Isolation of a functional homolog of the cell cycle-specific NIMA protein kinase of Aspergillus nidulans and functional analysis of conserved residues
J. Biol. Chem.
270
18110-18116
1995
Aspergillus nidulans (P11837), Aspergillus nidulans, Neurospora crassa (P48479), Neurospora crassa
Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
The specificities of protein kinase inhibitors: an update
Biochem. J.
371
199-204
2003
Homo sapiens
Takahashi, S.; Saito, T.; Hisanaga, S.; Pant, H.C.; Kulkarni, A.B.
Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules
J. Biol. Chem.
278
10506-10515
2003
Mus musculus
Hamdane, M.; Sambo, A.V.; Delobel, P.; Begard, S.; Violleau, A.; Delacourte, A.; Bertrand, P.; Benavides, J.; Buee, L.
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex
J. Biol. Chem.
278
34026-34034
2003
Homo sapiens
Darios, F.; Muriel, M.P.; Khondiker, M.E.; Brice, A.; Ruberg, M.
Neurotoxic calcium transfer from endoplasmic reticulum to mitochondria is regulated by cyclin-dependent kinase 5-dependent phosphorylation of tau
J. Neurosci.
25
4159-4168
2005
Rattus norvegicus
Shelton, S.B.; Krishnamurthy, P.; Johnson, G.V.
Effects of cyclin-dependent kinase-5 activity on apoptosis and tau phosphorylation in immortalized mouse brain cortical cells
J. Neurosci. Res.
76
110-120
2004
Mus musculus
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Zhu, H.; Klemic, J.F.; Chang, S.; Bertone, P.; Casamayor, A.; Klemic, K.G.; Smith, D.; Gerstein, M.; Reed, M.A.; Snyder, M.
Analysis of yeast protein kinases using protein chips
Nat. Genet.
26
283-289
2000
Saccharomyces cerevisiae
Bukczynska, P.; Klingler-Hoffmann, M.; Mitchelhill, K.I.; Lam, M.H.C.; Ciccomancini, M.; Tonks, N.K.; Sarcevic, B.; Kemp, B.E.; Tiganis, T.
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis
Biochem. J.
380
939-949
2004
Homo sapiens
Li, J.; Joo, S.H.; Tsai, M.D.
An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4
Biochemistry
42
13476-13483
2003
Homo sapiens
Li, J.; Melvin, W.S.; Tsai, M.D.; Muscarella, P.
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
Biochemistry
43
4394-4399
2004
Homo sapiens
Sachs, N.A.; Vaillancourt, R.R.
Cyclin-dependent kinase 11p110 activity in the absence of CK2
Biochim. Biophys. Acta
1624
98-108
2003
Homo sapiens (P21127)
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Yang, L.; MacLellan, W.R.; Han, Z.; Weiss, J.N.; Qu, Z.
Multisite phosphorylation and network dynamics of cyclin-dependent kinase signaling in the eukaryotic cell cycle
Biophys. J.
86
3432-3443
2004
eukaryota
Andres, V.
Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential
Cardiovasc. Res.
63
11-21
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Furet, P.
X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research
Curr. Med. Chem. Anticancer Agents
3
15-23
2003
Homo sapiens
Zong, H.; Li, Z.; Liu, L.; Hong, Y.; Yun, X.; Jiang, J.; Chi, Y.; Wang, H.; Shen, X.; Hu, Y.; Niu, Z.; Gu, J.
Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity
FEBS Lett.
579
3579-3588
2005
Homo sapiens
D'Angiolella, V.; Mari, C.; Nocera, D.; Rametti, L.; Grieco, D.
The spindle checkpoint requires cyclin-dependent kinase activity
Genes Dev.
17
2520-2525
2003
Homo sapiens, Xenopus laevis
Dou, X.; Wu, D.; An, W.; Davies, J.; Hashmi, S.B.; Ukil, L.; Osmani, S.A.
The PHOA and PHOB cyclin-dependent kinases perform an essential function in Aspergillus nidulans
Genetics
165
1105-1115
2003
Aspergillus nidulans
Li, B.S.; Ma, W.; Jaffe, H.; Zheng, Y.; Takahashi, S.; Zhang, L.; Kulkarni, A.B.; Pant, H.C.
Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
J. Biol. Chem.
278
35702-35709
2003
Mus musculus, Rattus norvegicus
Harwell, R.M.; Mull, B.B.; Porter, D.C.; Keyomarsi, K.
Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells
J. Biol. Chem.
279
12695-12705
2004
Homo sapiens
Habran, L.; Bontems, S.; Di Valentin, E.; Sadzot-Delvaux, C.; Piette, J.
Varicella-Zoster Virus IE63 Protein Phosphorylation by Roscovitine-sensitive Cyclin-dependent Kinases Modulates Its Cellular Localization and Activity
J. Biol. Chem.
280
29135-29143
2005
Chlorocebus aethiops
Vax, V.V.; Bibi, R.; Diaz-Cano, S.; Gueorguiev, M.; Kola, B.; Borboli, N.; Bressac-de Paillerets, B.; Walker, G.J.; Dedov, II; Grossman, A.B.; Korbonits, M.
Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours
J. Endocrinol.
178
301-310
2003
Homo sapiens
Freeman, D.; Riou-Khamlichi, C.; Oakenfull, E.A.; Murray, J.A.
Isolation, characterization and expression of cyclin and cyclin-dependent kinase genes in Jerusalem artichoke (Helianthus tuberosus L.)
J. Exp. Bot.
54
303-308
2003
Helianthus tuberosus (Q8GVD7), Helianthus tuberosus (Q8GVD8), Helianthus tuberosus
Woodard, C.L.; Li, Z.; Kathcart, A.K.; Terrell, J.; Gerena, L.; Lopez-Sanchez, M.; Kyle, D.E.; Bhattacharjee, A.K.; Nichols, D.A.; Ellis, W.; Prigge, S.T.; Geyer, J.A.; Waters, N.C.
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases
J. Med. Chem.
46
3877-3882
2003
Homo sapiens, Plasmodium falciparum
VanderWel, S.N.; Harvey, P.J.; McNamara, D.J.; Repine, J.T.; Keller, P.R.; Quin, J.3rd.; Booth, R.J.; Elliott, W.L.; Dobrusin, E.M.; Fry, D.W.; Toogood, P.L.
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4
J. Med. Chem.
48
2371-2387
2005
Homo sapiens
Brana, M.F.; Cacho, M.; Garcia, M.L.; Mayoral, E.P.; Lopez, B.; de Pascual-Teresa, B.; Ramos, A.; Acero, N.; Llinares, F.; Munoz-Mingarro, D.; Lozach, O.; Meijer, L.
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases
J. Med. Chem.
48
6843-6854
2005
Marthasterias glacialis, Homo sapiens (P24941)
Lu, H.; Chang, D.J.; Baratte, B.; Meijer, L.; Schulze-Gahmen, U.
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
J. Med. Chem.
48
737-743
2005
Homo sapiens
Van Dross, R.; Yao, S.; Asad, S.; Westlake, G.; Mays, D.J.; Barquero, L.; Duell, S.; Pietenpol, J.A.; Browning, P.J.
Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells
J. Natl. Cancer Inst.
97
656-666
2005
Homo sapiens
Wei, F.Y.; Tomizawa, K.; Ohshima, T.; Asada, A.; Saito, T.; Nguyen, C.; Bibb, J.A.; Ishiguro, K.; Kulkarni, A.B.; Pant, H.C.; Mikoshiba, K.; Matsui, H.; Hisanaga, S.
Control of cyclin-dependent kinase 5 (Cdk5) activity by glutamatergic regulation of p35 stability
J. Neurochem.
93
502-512
2005
Mus musculus, Mus musculus ICR
Zhu, Y.S.; Saito, T.; Asada, A.; Maekawa, S.; Hisanaga, S.
Activation of latent cyclin-dependent kinase 5 (Cdk5)-p35 complexes by membrane dissociation
J. Neurochem.
94
1535-1545
2005
Rattus norvegicus
Rideout, H.J.; Wang, Q.; Park, D.S.; Stefanis, L.
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition
J. Neurosci.
23
1237-1245
2003
Rattus norvegicus
Davido, D.J.; Von Zagorski, W.F.; Maul, G.G.; Schaffer, P.A.
The differential requirement for cyclin-dependent kinase activities distinguishes two functions of herpes simplex virus type 1 ICP0
J. Virol.
77
12603-12616
2003
Homo sapiens
Sanchez, V.; McElroy, A.K.; Spector, D.H.
Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus
J. Virol.
77
13214-13224
2003
Homo sapiens
Sanchez, V.; McElroy, A.K.; Yen, J.; Tamrakar, S.; Clark, C.L.; Schwartz, R.A.; Spector, D.H.
Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production
J. Virol.
78
11219-11232
2004
Homo sapiens
Pic-Taylor, A.; Darieva, Z.; Morgan, B.A.; Sharrocks, A.D.
Regulation of cell cycle-specific gene expression through cyclin-dependent kinase-mediated phosphorylation of the forkhead transcription factor Fkh2p
Mol. Cell. Biol.
24
10036-10046
2004
Saccharomyces cerevisiae
Narayanan, R.; Adigun, A.A.; Edwards, D.P.; Weigel, N.L.
Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
Mol. Cell. Biol.
25
264-277
2005
Homo sapiens
Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain
Mol. Pharmacol.
66
1500-1507
2004
Rattus norvegicus
Loog, M.; Morgan, D.O.
Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Nature
434
104-108
2005
Saccharomyces cerevisiae
Hahn, C.M.; Kleinholz, H.; Koester, M.P.; Grieser, S.; Thelen, K.; Pollerberg, G.E.
Role of cyclin-dependent kinase 5 and its activator P35 in local axon and growth cone stabilization
Neuroscience
134
449-465
2005
Gallus gallus
Hisanaga, S.; Saito, T.
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
Neurosignals
12
221-229
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Gompel, M.; Soulie, C.; Ceballos-Picot, I.; Meijer, L.
Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation
Neurosignals
13
134-143
2004
Homo sapiens
Boudolf, V.; Vlieghe, K.; Beemster, G.T.; Magyar, Z.; Torres Acosta, J.A.; Maes, S.; Van Der Schueren, E.; Inze, D.; De Veylder, L.
The plant-specific cyclin-dependent kinase CDKB1;1 and transcription factor E2Fa-DPa control the balance of mitotically dividing and endoreduplicating cells in Arabidopsis
Plant Cell
16
2683-2692
2004
Arabidopsis thaliana
Shimotohno, A.; Umeda-Hara, C.; Bisova, K.; Uchimiya, H.; Umeda, M.
The plant-specific kinase CDKF;1 is involved in activating phosphorylation of cyclin-dependent kinase-activating kinases in Arabidopsis
Plant Cell
16
2954-2966
2004
Arabidopsis thaliana
Gutierrez, R.; Quiroz-Figueroa, F.; Vazquez-Ramos, J.M.
Maize cyclin D2 expression, associated kinase activity, and effect of phytohormones during germination
Plant Cell Physiol.
46
166-173
2005
Zea mays
Vanstraelen, M.; Torres Acosta, J.A.; De Veylder, L.; Inze, D.; Geelen, D.
A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization
Plant Physiol.
135
1417-1429
2004
Arabidopsis thaliana
Corellou, F.; Camasses, A.; Ligat, L.; Peaucellier, G.; Bouget, F.Y.
Atypical regulation of a green lineage-specific B-type cyclin-dependent kinase
Plant Physiol.
138
1627-1636
2005
Ostreococcus tauri
Yamaguchi, M.; Kato, H.; Yoshida, S.; Yamamura, S.; Uchimiya, H.; Umeda, M.
Control of in vitro organogenesis by cyclin-dependent kinase activities in plants
Proc. Natl. Acad. Sci. USA
100
8019-8023
2003
Oryza sativa
Fu, A.K.; Fu, W.Y.; Ng, A.K.; Chien, W.W.; Ng, Y.P.; Wang, J.H.; Ip, N.Y.
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity
Proc. Natl. Acad. Sci. USA
101
6728-6733
2004
Mus musculus
Watanabe, N.; Arai, H.; Iwasaki, J.i.; Shiina, M.; Ogata, K.; Hunter, T.; Osada, H.
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic wee1 via multiple pathways
Proc. Natl. Acad. Sci. USA
102
11663-11668
2005
Homo sapiens
Lim, J.T.; Mansukhani, M.; Weinstein, I.B.
Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells
Proc. Natl. Acad. Sci. USA
102
5156-5161
2005
Homo sapiens
Bartova, I.; Otyepka, M.; Kriz, Z.; Koca, J.
The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK
Protein Sci.
14
445-451
2005
Homo sapiens
Choi, J.S.; Shin, S.; Jin, Y.H.; Yim, H.; Koo, K.T.; Chun, K.H.; Oh, Y.T.; Lee, W.H.; Lee, S.K.
Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis
Apoptosis
12
1229-1241
2007
Homo sapiens
Li, T.; Hawkes, C.; Qureshi, H.Y.; Kar, S.; Paudel, H.K.
Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
Biochemistry
45
3134-3145
2006
Bos taurus, Homo sapiens, Rattus norvegicus
Gu, J.; Bourne, P.E.
Identifying allosteric fluctuation transitions between different protein conformational states as applied to cyclin dependent kinase 2
BMC Bioinformatics
8
45
2007
Homo sapiens
Yang, H.S.; Hinds, P.W.
Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells
Cancer Res.
66
2708-2715
2006
Homo sapiens
den Hollander, P.; Kumar, R.
Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells
Cancer Res.
66
5941-5949
2006
Homo sapiens
Strock, C.J.; Park, J.I.; Nakakura, E.K.; Bova, G.S.; Isaacs, J.T.; Ball, D.W.; Nelkin, B.D.
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
Cancer Res.
66
7509-7515
2006
Homo sapiens
Bayart, E.; Dutertre, S.; Jaulin, C.; Guo, R.B.; Xi, X.G.; Amor-Gueret, M.
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase
Cell Cycle
5
1681-1686
2006
Homo sapiens
Wohlbold, L.; Larochelle, S.; Liao, J.C.; Livshits, G.; Singer, J.; Shokat, K.M.; Fisher, R.P.
The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity
Cell Cycle
5
546-554
2006
Mus musculus (Q9JHU3)
Sengupta, A.; Novak, M.; Grundke-Iqbal, I.; Iqbal, K.
Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level
FEBS Lett.
580
5925-5933
2006
Homo sapiens
Enders, G.H.; Maude, S.L.
Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability
Gene
371
1-6
2006
Saccharomyces cerevisiae, Homo sapiens
Ikui, A.E.; Archambault, V.; Drapkin, B.J.; Campbell, V.; Cross, F.R.
Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition
Genetics
175
1011-1022
2007
Saccharomyces cerevisiae
Baatout, S.; Mueller, W.; Michaux, A.; Buset, J.; Schoonjans, W.; Jacquet, P.
Histone H1 and cdk1 kinase activities in early embryos of four mouse strains after X-irradiation
In Vivo
21
571-582
2007
Mus musculus
Avraham, E.; Rott, R.; Liani, E.; Szargel, R.; Engelender, S.
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
J. Biol. Chem.
282
12842-12850
2007
Homo sapiens, Rattus norvegicus, Rattus norvegicus (Q03114)
Sanchez, V.; Spector, D.H.
Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles
J. Virol.
80
5886-5896
2006
Homo sapiens
Chen, Y.; Jirage, D.; Caridha, D.; Kathcart, A.K.; Cortes, E.A.; Dennull, R.A.; Geyer, J.A.; Prigge, S.T.; Waters, N.C.
Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase
Mol. Biochem. Parasitol.
149
48-57
2006
Plasmodium falciparum
Yamasaki, F.; Zhang, D.; Bartholomeusz, C.; Sudo, T.; Hortobagyi, G.N.; Kurisu, K.; Ueno, N.T.
Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity
Mol. Cancer Ther.
6
2168-2177
2007
Homo sapiens, Homo sapiens (P24941)
Larochelle, S.; Merrick, K.A.; Terret, M.E.; Wohlbold, L.; Barboza, N.M.; Zhang, C.; Shokat, K.M.; Jallepalli, P.V.; Fisher, R.P.
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
Mol. Cell
25
839-850
2007
Homo sapiens
Kino, T.; Ichijo, T.; Amin, N.D.; Kesavapany, S.; Wang, Y.; Kim, N.; Rao, S.; Player, A.; Zheng, Y.L.; Garabedian, M.J.; Kawasaki, E.; Pant, H.C.; Chrousos, G.P.
Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress
Mol. Endocrinol.
21
1552-1568
2007
Rattus norvegicus
Kanungo, J.; Li, B.S.; Goswami, M.; Zheng, Y.L.; Ramchandran, R.; Pant, H.C.
Cloning and characterization of zebrafish (Danio rerio) cyclin-dependent kinase 5
Neurosci. Lett.
412
233-238
2007
Danio rerio
Harashima, H.; Shinmyo, A.; Sekine, M.
Phosphorylation of threonine 161 in plant cyclin-dependent kinase A is required for cell division by activation of its associated kinase
Plant J.
52
435-448
2007
Nicotiana tabacum, Arabidopsis thaliana (P24100)
Pareek, T.K.; Keller, J.; Kesavapany, S.; Pant, H.C.; Iadarola, M.J.; Brady, R.O.; Kulkarni, A.B.
Cyclin-dependent kinase 5 activity regulates pain signaling
Proc. Natl. Acad. Sci. USA
103
791-796
2006
Mus musculus, Rattus norvegicus
Shu, F.; Lv, S.; Qin, Y.; Ma, X.; Wang, X.; Peng, X.; Luo, Y.; Xu, B.E.; Sun, X.; Wu, J.
Functional characterization of human PFTK1 as a cyclin-dependent kinase
Proc. Natl. Acad. Sci. USA
104
9248-9253
2007
Homo sapiens
Moore, N.L.; Narayanan, R.; Weigel, N.L.
Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity
Steroids
72
202-209
2007
Homo sapiens, Rattus norvegicus
Liu, M.; Choi, S.; Cuny, G.D.; Ding, K.; Dobson, B.C.; Glicksman, M.A.; Auerbach, K.; Stein, R.L.
Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors
Biochemistry
47
8367-8377
2008
Homo sapiens
Fukasawa, K.
P53, cyclin-dependent kinase and abnormal amplification of centrosomes
Biochim. Biophys. Acta
1786
15-23
2008
Mus musculus
Chen, S.; Chen, L.; Le, N.T.; Zhao, C.; Sidduri, A.; Lou, J.P.; Michoud, C.; Portland, L.; Jackson, N.; Liu, J.J.; Konzelmann, F.; Chi, F.; Tovar, C.; Xiang, Q.; Chen, Y.; Wen, Y.; Vassilev, L.T.
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
Bioorg. Med. Chem. Lett.
17
2134-2138
2007
Homo sapiens (P06493), Homo sapiens
Lee, J.; Choi, H.; Kim, K.H.; Jeong, S.; Park, J.W.; Baek, C.S.; Lee, S.H.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
Bioorg. Med. Chem. Lett.
18
2292-2295
2008
Homo sapiens, Homo sapiens (P06493), Homo sapiens (P24941)
Finlay, M.R.; Acton, D.G.; Andrews, D.M.; Barker, A.J.; Dennis, M.; Fisher, E.; Graham, M.A.; Green, C.P.; Heaton, D.W.; Karoutchi, G.; Loddick, S.A.; Morgentin, R.; Roberts, A.; Tucker, J.A.; Weir, H.M.
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Bioorg. Med. Chem. Lett.
18
4442-4446
2008
Homo sapiens (P24941)
Anderson, M.; Andrews, D.M.; Barker, A.J.; Brassington, C.A.; Breed, J.; Byth, K.F.; Culshaw, J.D.; Finlay, M.R.; Fisher, E.; McMiken, H.H.; Green, C.P.; Heaton, D.W.; Nash, I.A.; Newcombe, N.J.; Oakes, S.E.; Pauptit, R.A.; Roberts, A.; Stanway, J.J.; Thomas, A.P.; Tucker, J.A.; Walker, M.; Weir, H.M.
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors
Bioorg. Med. Chem. Lett.
18
5487-5492
2008
Homo sapiens (P11802), Homo sapiens (P24941)
Cheung, Z.H.; Ip, N.Y.
The roles of cyclin-dependent kinase 5 in dendrite and synapse development
Biotechnol. J.
2
949-957
2007
Mus musculus
Chen, X.; Huang, T.; Zhang, J.; Song, J.; Chen, L.; Zhu, Y.
Involvement of calpain and p25 of CDK5 pathway in ginsenoside Rb1s attenuation of beta-amyloid peptide25-35-induced tau hyperphosphorylation in cortical neurons
Brain Res.
1200
99-106
2008
Rattus norvegicus
Meuer, K.; Suppanz, I.E.; Lingor, P.; Planchamp, V.; Goericke, B.; Fichtner, L.; Braus, G.H.; Dietz, G.P.; Jakobs, S.; Baehr, M.; Weishaupt, J.H.
Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis
Cell Death Differ.
14
651-661
2007
Rattus norvegicus
De Vivo, M.; Cavalli, A.; Carloni, P.; Recanatini, M.
Computational study of the phosphoryl transfer catalyzed by a cyclin-dependent kinase
Chemistry
13
8437-8444
2007
Homo sapiens
Peng, Y.; Weisman, L.S.
The cyclin-dependent kinase Cdk1 directly regulates vacuole inheritance
Dev. Cell
15
478-485
2008
Saccharomyces cerevisiae
Sen, A.; Thom, M.; Nikolic, M.; Sisodiya, S.M.
The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia
Dev. Neurosci.
30
96-104
2008
Mus musculus (P49615)
North, B.J.; Verdin, E.
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
J. Biol. Chem.
282
19546-19555
2007
Homo sapiens (P06493), Homo sapiens
Taniguchi, M.; Taoka, M.; Itakura, M.; Asada, A.; Saito, T.; Kinoshita, M.; Takahashi, M.; Isobe, T.; Hisanaga, S.
Phosphorylation of adult type Sept5 (CDCrel-1) by cyclin-dependent kinase 5 inhibits interaction with syntaxin-1
J. Biol. Chem.
282
7869-7876
2007
Mus musculus
Liem, D.A.; Zhao, P.; Angelis, E.; Chan, S.S.; Zhang, J.; Wang, G.; Berthet, C.; Kaldis, P.; Ping, P.; Maclellan, W.R.
Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury
J. Mol. Cell. Cardiol.
45
610-616
2008
Mus musculus (P97377)
Saito, T.; Konno, T.; Hosokawa, T.; Asada, A.; Ishiguro, K.; Hisanaga, S.
p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons
J. Neurochem.
102
133-140
2007
Rattus norvegicus
Anne, S.L.; Saudou, F.; Humbert, S.
Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons
J. Neurosci.
27
7318-7328
2007
Mus musculus, Rattus norvegicus
Paoletti, P.; Vila, I.; Rife, M.; Lizcano, J.M.; Alberch, J.; Gines, S.
Dopaminergic and glutamatergic signaling crosstalk in Huntingtons disease neurodegeneration: the role of p25/cyclin-dependent kinase 5
J. Neurosci.
28
10090-10101
2008
Mus musculus, Homo sapiens (Q00535), Homo sapiens
Amin, N.D.; Zheng, Y.L.; Kesavapany, S.; Kanungo, J.; Guszczynski, T.; Sihag, R.K.; Rudrabhatla, P.; Albers, W.; Grant, P.; Pant, H.C.
Cyclin-dependent kinase 5 phosphorylation of human septin SEPT5 (hCDCrel-1) modulates exocytosis
J. Neurosci.
28
3631-3643
2008
Mus musculus, Rattus norvegicus
Cheung, Z.H.; Gong, K.; Ip, N.Y.
Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2
J. Neurosci.
28
4872-4877
2008
Mus musculus
Hsiao, Y.H.; Chen, P.S.; Yeh, S.H.; Lin, C.H.; Gean, P.W.
N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons
J. Neurosci. Res.
86
2685-2695
2008
Rattus norvegicus
Sanchez, V.; Mahr, J.A.; Orazio, N.I.; Spector, D.H.
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter
J. Virol.
81
11730-11736
2007
Homo sapiens
Kono, K.; Nogami, S.; Abe, M.; Nishizawa, M.; Morishita, S.; Pellman, D.; Ohya, Y.
G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae
Mol. Biol. Cell
19
1763-1771
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae YOC3388
Sabo, A.; Lusic, M.; Cereseto, A.; Giacca, M.
Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription
Mol. Cell. Biol.
28
2201-2212
2008
Homo sapiens (P50750)
Lewis, A.E.; Rusten, M.; Hoivik, E.A.; Vikse, E.L.; Hansson, M.L.; Wallberg, A.E.; Bakke, M.
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7
Mol. Endocrinol.
22
91-104
2008
Homo sapiens (P50613), Mus musculus (Q03147)
Huang, D.; Friesen, H.; Andrews, B.
Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast
Mol. Microbiol.
66
303-314
2007
Saccharomyces cerevisiae
Costoya, J.A.; Hobbs, R.M.; Pandolfi, P.P.
Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation
Oncogene
27
3789-3796
2008
Homo sapiens (P06493), Homo sapiens (P24941), Homo sapiens
Marchetti, F.; Sayle, K.L.; Bentley, J.; Clegg, W.; Curtin, N.J.; Endicott, J.A.; Golding, B.T.; Griffin, R.J.; Haggerty, K.; Harrington, R.W.; Mesguiche, V.; Newell, D.R.; Noble, M.E.; Parsons, R.J.; Pratt, D.J.; Wang, L.Z.; Hardcastle, I.R.
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2
Org. Biomol. Chem.
5
1577-1585
2007
Homo sapiens
Cui, X.; Fan, B.; Scholz, J.; Chen, Z.
Roles of Arabidopsis cyclin-dependent kinase C complexes in cauliflower mosaic virus infection, plant growth, and development
Plant Cell
19
1388-1402
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q8W4P1)
Kitsios, G.; Alexiou, K.G.; Bush, M.; Shaw, P.; Doonan, J.H.
A cyclin-dependent protein kinase, CDKC2, colocalizes with and modulates the distribution of spliceosomal components in Arabidopsis
Plant J.
54
220-235
2008
Arabidopsis thaliana (Q8W4P1)
Bartova, I.; Koca, J.; Otyepka, M.
Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation
Protein Sci.
17
22-33
2008
Homo sapiens (P24941), Homo sapiens
Chen, H.; Van Duyne, R.; Zhang, N.; Kashanchi, F.; Zeng, C.
A novel binding pocket of cyclin-dependent kinase 2
Proteins
74
122-132
2008
Homo sapiens (P24941)
Hume, A.J.; Finkel, J.S.; Kamil, J.P.; Coen, D.M.; Culbertson, M.R.; Kalejta, R.F.
Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function
Science
320
797-799
2008
Human betaherpesvirus 5
Wang, Q.S.; Zhang, C.L.; Hou, L.Y.; Zhao, X.L.; Yang, X.W.; Xie, K.Q.
Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy
Toxicology
248
1-7
2008
Rattus norvegicus
Wang, S.; Fischer, P.M.
Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology
Trends Pharmacol. Sci.
29
302-313
2008
Homo sapiens (P50750)
Kanungo, J.; Zheng, Y.L.; Amin, N.D.; Kaur, S.; Ramchandran, R.; Pant, H.C.
Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo
Biochem. Biophys. Res. Commun.
386
263-267
2009
Danio rerio
Lin, H.; Hu, G.X.; Dong, L.; Dong, Q.; Mukai, M.; Chen, B.B.; Holsberger, D.R.; Sottas, C.M.; Cooke, P.S.; Lian, Q.Q.; Li, X.K.; Ge, R.S.
Increased proliferation but decreased steroidogenic capacity in Leydig cells from mice lacking cyclin-dependent kinase inhibitor 1B
Biol. Reprod.
80
1232-1238
2009
Mus musculus
Chen, R.; Wierda, W.G.; Chubb, S.; Hawtin, R.E.; Fox, J.A.; Keating, M.J.; Gandhi, V.; Plunkett, W.
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia
Blood
113
4637-4645
2009
Homo sapiens
Leitch, A.E.; Haslett, C.; Rossi, A.G.
Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents
Br. J. Pharmacol.
158
1004-1016
2009
Homo sapiens
Ali, S.; Heathcote, D.A.; Kroll, S.H.; Jogalekar, A.S.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.J.; Periyasamy, M.; Tolhurst, R.S.; Kanneganti, S.K.; Snyder, J.P.; Liotta, D.C.; Aboagye, E.O.; Barrett, A.G.; Coombes, R.C.
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity
Cancer Res.
69
6208-6215
2009
Homo sapiens
Uchiyama, H.; Sowa, Y.; Wakada, M.; Yogosawa, M.; Nakanishi, R.; Horinaka, M.; Shimazaki, C.; Taniwaki, M.; Sakai, T.
Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells
Cancer Sci.
101
728-734
2010
Homo sapiens
Buck, S.H.; Chiu, D.; Saito, R.M.
The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development
Cell Cycle
8
2613-2620
2009
Caenorhabditis elegans
Jhou, R.S.; Sun, K.H.; Sun, G.H.; Wang, H.H.; Chang, C.I.; Huang, H.C.; Lu, S.Y.; Tang, S.J.
Inhibition of cyclin-dependent kinases by olomoucine and roscovitine reduces lipopolysaccharide-induced inflammatory responses via down-regulation of nuclear factor kappaB
Cell Prolif.
42
141-149
2009
Mus musculus
Bonvini, P.; Zorzi, E.; Mussolin, L.; Monaco, G.; Pigazzi, M.; Basso, G.; Rosolen, A.
The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity
Haematologica
94
944-955
2009
Homo sapiens
Kim, H.S.; Lee, W.J.; Lee, S.W.; Chae, H.W.; Kim, D.H.; Oh, Y.
Insulin-like growth factor binding protein-3 induces G1 cell cycle arrest with inhibition of cyclin-dependent kinase 2 and 4 in MCF-7 human breast cancer Ccells
Horm. Metab. Res.
42
165-172
2009
Homo sapiens
Mohapatra, S.; Chu, B.; Zhao, X.; Djeu, J.; Cheng, J.Q.; Pledger, W.J.
Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
Int. J. Biochem. Cell Biol.
41
595-602
2009
Homo sapiens
Chan, K.C.; Ho, H.H.; Peng, C.H.; Lan, K.P.; Lin, M.C.; Chen, H.M.; Wang, C.J.
Polyphenol-rich extract from mulberry leaf inhibits vascular smooth muscle cell proliferation involving upregulation of p53 and inhibition of cyclin-dependent kinase
J. Agric. Food Chem.
58
2536-2542
2010
Rattus norvegicus
Moss, S.C.; Lightell, D.J.; Marx, S.O.; Marks, A.R.; Woods, T.C.
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor, p27Kip1
J. Biol. Chem.
285
11991-11997
2010
Homo sapiens
Hao, Y.; Pan, D.; Zhang, M.; Xu, J.; Li, L.; Wei, J.; Wang, X.
The neuroprotective effects of cyclin-dependent kinase-5 inhibition in mice with Niemann-Pick disease type C
J. Huazhong Univ. Sci. Technol. Med. Sci.
29
324-329
2009
Mus musculus
Wang, H.; Zhou, Y.; Bird, D.A.; Fowke, L.C.
Functions, regulation and cellular localization of plant cyclin-dependent kinase inhibitors
J. Microsc.
231
234-246
2008
Arabidopsis thaliana
Tan, V.B.; Zhang, B.; Lim, K.M.; Tay, T.E.
Explaining the inhibition of cyclin-dependent kinase 5 by peptides derived from p25 with molecular dynamics simulations and MM-PBSA
J. Mol. Model.
16
1-8
2010
Homo sapiens
Mairet-Coello, G.; Tury, A.; DiCicco-Bloom, E.
Insulin-like growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol 3-kinase/Akt pathway in developing rat cerebral cortex
J. Neurosci.
29
775-788
2009
Rattus norvegicus
Ivanov, A.; Tyzio, R.; Zilberter, Y.; Ben-Ari, Y.
(R)-roscovitine, a cyclin-dependent kinase inhibitor, enhances tonic GABA inhibition in rat hippocampus
Neuroscience
156
277-288
2008
Rattus norvegicus
Errico, A.; Deshmukh, K.; Tanaka, Y.; Pozniakovsky, A.; Hunt, T.
Identification of substrates for cyclin dependent kinases
Adv. Enzyme Regul.
50
375-399
2010
Xenopus laevis
Malmstroem, J.; Viklund, J.; Slivo, C.; Costa, A.; Maudet, M.; Sandelin, C.; Hiller, G.; Olsson, L.L.; Aagaard, A.; Geschwindner, S.; Xue, Y.; Vasaenge, M.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors
Bioorg. Med. Chem. Lett.
22
5919-5923
2012
Homo sapiens (Q00535)
Aggarwal, P.; Vaites, L.P.; Kim, J.K.; Mellert, H.; Gurung, B.; Nakagawa, H.; Herlyn, M.; Hua, X.; Rustgi, A.K.; McMahon, S.B.; Diehl, J.A.
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
Cancer Cell
18
329-340
2010
Homo sapiens, Mus musculus
Leitch, A.E.; Lucas, C.D.; Marwick, J.A.; Duffin, R.; Haslett, C.; Rossi, A.G.
Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
Cell Death Differ.
19
1950-1961
2012
Homo sapiens
Flores, O.; Wang, Z.; Knudsen, K.E.; Burnstein, K.L.
Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition
Endocrinology
151
896-908
2010
Homo sapiens
Ngompaza-Diarra, J.; Bettayeb, K.; Gresh, N.; Meijer, L.; Oumata, N.
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
Eur. J. Med. Chem.
56
210-216
2012
Asteroidea, Homo sapiens
Moshe, Y.; Bar-On, O.; Ganoth, D.; Hershko, A.
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases
J. Biol. Chem.
286
16647-16657
2011
Homo sapiens
Cuomo, M.E.; Platt, G.M.; Pearl, L.H.; Mittnacht, S.
Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition
J. Biol. Chem.
286
9713-9725
2011
Homo sapiens, Human gammaherpesvirus 8
Traquandi, G.; Ciomei, M.; Ballinari, D.; Casale, E.; Colombo, N.; Croci, V.; Fiorentini, F.; Isacchi, A.; Longo, A.; Mercurio, C.; Panzeri, A.; Pastori, W.; Pevarello, P.; Volpi, D.; Roussel, P.; Vulpetti, A.; Brasca, M.G.
Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors
J. Med. Chem.
53
2171-2187
2010
Homo sapiens
Hisanaga, S.; Endo, R.
Regulation and role of cyclin-dependent kinase activity in neuronal survival and death
J. Neurochem.
115
1309-1321
2010
Homo sapiens, Mus musculus
Rovnak, J.; Brewster, C.D.; Quackenbush, S.L.
Retroviral cyclin enhances cyclin-dependent kinase-8 activity
J. Virol.
86
5742-5751
2012
Homo sapiens
Menoyo, S.; Ricco, N.; Bru, S.; Hernandez-Ortega, S.; Escote, X.; Aldea, M.; Clotet, J.
Phosphate-activated cyclin-dependent kinase stabilizes G1 cyclin to trigger cell cycle entry
Mol. Cell. Biol.
33
1273-1284
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Hizli, A.A.; Chi, Y.; Swanger, J.; Carter, J.H.; Liao, Y.; Welcker, M.; Ryazanov, A.G.; Clurman, B.E.
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase
Mol. Cell. Biol.
33
596-604
2013
Homo sapiens
Ishikawa, M.; Murata, T.; Sato, Y.; Nishiyama, T.; Hiwatashi, Y.; Imai, A.; Kimura, M.; Sugimoto, N.; Akita, A.; Oguri, Y.; Friedman, W.E.; Hasebe, M.; Kubo, M.
Physcomitrella cyclin-dependent kinase A links cell cycle reactivation to other cellular changes during reprogramming of leaf cells
Plant Cell
23
2924-2938
2011
Physcomitrium patens, Physcomitrium patens Gransden-2004
Gaamouche, T.; Manes, C.L.; Kwiatkowska, D.; Berckmans, B.; Koumproglou, R.; Maes, S.; Beeckman, T.; Vernoux, T.; Doonan, J.H.; Traas, J.; Inze, D.; De Veylder, L.
Cyclin-dependent kinase activity maintains the shoot apical meristem cells in an undifferentiated state
Plant J.
64
26-37
2010
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Abreu, C.M.; Kumar, R.; Hamilton, D.; Dawdy, A.W.; Creavin, K.; Eivers, S.; Finn, K.; Balsbaugh, J.L.; OConnor, R.; Kiely, P.A.; Shabanowitz, J.; Hunt, D.F.; Grenon, M.; Lowndes, N.F.
Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1
PLoS Genet.
9
e1003310
2013
Saccharomyces cerevisiae
Wang, H.; Xu, Y.; Fang, Z.; Chen, S.; Balk, S.P.; Yuan, X.
Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation
PLoS ONE
7
e41330
2012
Homo sapiens
Liberal, V.; Martinsson-Ahlzen, H.S.; Liberal, J.; Spruck, C.H.; Widschwendter, M.; McGowan, C.H.; Reed, S.I.
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins
Proc. Natl. Acad. Sci. USA
109
2754-2759
2012
Homo sapiens
Chen, N.; Yang, H.; Niu, J.; Liu, S.
Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent kinase 5/p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry
Rapid Commun. Mass Spectrom.
27
985-992
2013
Homo sapiens
Huysman, M.J.; Tanaka, A.; Bowler, C.; Vyverman, W.; De Veylder, L.
Functional characterization of the diatom cyclin-dependent kinase A2 as a mitotic regulator reveals plant-like properties in a non-green lineage
BMC Plant Biol.
15
86
2015
Phaeodactylum tricornutum
Harashima, H.; Dissmeyer, N.; Hammann, P.; Nomura, Y.; Kramer, K.; Nakagami, H.; Schnittger, A.
Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of cyclin-dependent kinase A;1
BMC Plant Biol.
16
209
2016
Arabidopsis thaliana
Albert, T.K.; Rigault, C.; Eickhoff, J.; Baumgart, K.; Antrecht, C.; Klebl, B.; Mittler, G.; Meisterernst, M.
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor
Br. J. Pharmacol.
171
55-68
2014
Homo sapiens
Yan, G.X.; Zhang, J.; Shodhan, A.; Tian, M.; Miao, W.
Cdk3, a conjugation-specific cyclin-dependent kinase, is essential for the initiation of meiosis in Tetrahymena thermophila
Cell Cycle
15
2506-2514
2016
Tetrahymena thermophila, Tetrahymena thermophila CU427
Vymetalova, L.; Havlicek, L.; Sturc, A.; Skraskova, Z.; Jorda, R.; Pospisil, T.; Strnad, M.; Krystof, V.
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases
Eur. J. Med. Chem.
110
291-301
2016
Homo sapiens
Zheng, F.; Quiocho, F.A.
New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition
J. Biol. Chem.
288
30682-30692
2013
Saccharomyces cerevisiae (P17157), Saccharomyces cerevisiae
Fujino, A.; Fukushima, K.; Kubota, T.; Kosugi, T.; Takimoto-Kamimura, M.
Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity
J. Synchrotron Radiat.
20
905-909
2013
Homo sapiens
Liang, K.; Gao, X.; Gilmore, J.M.; Florens, L.; Washburn, M.P.; Smith, E.; Shilatifard, A.
Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing
Mol. Cell. Biol.
35
928-938
2015
Homo sapiens (Q14004), Homo sapiens (Q9NYV4), Homo sapiens
Petrone, A.; Adamo, M.E.; Cheng, C.; Kettenbach, A.N.
Identification of candidate cyclin-dependent kinase 1 (Cdk1) substrates in mitosis by quantitative phosphoproteomics
Mol. Cell. Proteomics
15
2448-2461
2016
Homo sapiens
Monnerat, S.; Almeida Costa, C.I.; Forkert, A.C.; Benz, C.; Hamilton, A.; Tetley, L.; Burchmore, R.; Novo, C.; Mottram, J.C.; Hammarton, T.C.
Identification and functional characterisation of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei
PLoS ONE
8
e67327
2013
Trypanosoma brucei, Trypanosoma brucei Lister 427
Talapati, S.; Nataraj, V.; Pothuganti, M.; Gore, S.; Ramachandra, M.; Antony, T.; More, S.; Krishnamurthy, N.
Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313
Acta Crystallogr. Sect. F
76
350-356
2020
Homo sapiens (P24941), Homo sapiens
Oi, A.; Katayama, S.; Hatano, N.; Sugiyama, Y.; Kameshita, I.; Sueyoshi, N.
Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Biochem. Biophys. Res. Commun.
482
239-245
2017
Mus musculus (Q3UTQ8), Mus musculus
Beaujois, R.; Ottoni, E.; Zhang, X.; Gagnon, C.; HSine, S.; Mollet, S.; Viranaicken, W.; DesGroseillers, L.
The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1
BMC Cell Biol.
18
25
2017
Homo sapiens (P06493)
Li, Y.; Jiang, F.; Shi, X.; Liu, X.; Yang, H.; Zhang, Z.
Identification and characterization of the cyclin-dependent kinases gene family in silkworm, Bombyx mori
DNA Cell Biol.
35
13-23
2016
Bombyx mori (D2IGZ3), Bombyx mori (D2IGZ4), Bombyx mori (D2IGZ5), Bombyx mori (D2IGZ6), Bombyx mori (D2IGZ7), Bombyx mori (H6VMF4), Bombyx mori (H6VMF5), Bombyx mori (H6VMF6), Bombyx mori (H6VMF7), Bombyx mori (H6VMF9), Bombyx mori (O17507), Bombyx mori (O17508), Bombyx mori
Naseh, G.; Mohammadifard, M.; Mohammadifard, M.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer
IUBMB Life
2020
799-805
2016
Homo sapiens (P50613)
Mbonye, U.; Wang, B.; Gokulrangan, G.; Shi, W.; Yang, S.; Karn, J.
Cyclin-dependent kinase 7 (CDK7)-mediated phosphorylation of the CDK9 activation loop promotes P-TEFb assembly with Tat and proviral HIV reactivation
J. Biol. Chem.
293
10009-10025
2018
Homo sapiens (P50613)
Badjatia, N.; Park, S.; Ambrsio, D.; Kirkham, J.; Gnzl, A.
Cyclin-dependent kinase CRK9, required for spliced leader trans splicing of pre-mRNA in trypanosomes, functions in a complex with a new L-type cyclin and a kinetoplastid-specific protein
PLoS Pathog.
12
e1005498
2016
Trypanosoma brucei (Q580M5), Trypanosoma brucei, Trypanosoma brucei 927/4 GUTat10.1 (Q580M5)
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