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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Xenopus laevis and UniProt Accession P23437

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IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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Select one or more organisms in this record:
This record set is specific for:
Xenopus laevis
UNIPROT: P23437
Word Map
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
cdk, p34cdc2, cdc2 kinase, cyclin-dependent kinase 5, cdc28, cyclin-dependent kinase 2, cyclin-dependent kinase 4, cyclin-dependent kinase 1, cdc42p, pho85, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Cdk5
266115
-
cell division control protein 2 homolog 1
266099
-
cell division control protein 2 homolog 2
266085
-
cell division protein kinase 2 homolog
266083
-
cell division protein kinase 5
266115
-
cell division protein kinase 7
266080
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cyclin-dependent kinase 5
266115
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Cyclin-dependent kinase pef1
-
-
-
-
p40MO15
266080
-
PHO85 homolog
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + acidic alpha-syntrophin protein
ADP + acidic alpha-syntrophin phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + ADP-ribosylation factor GTPase activating protein 3 protein
ADP + ADP-ribosylation factor GTPase activating protein 3 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + AE binding protein 2 protein
ADP + AE binding protein 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + APEX nuclease protein
ADP + APEX nuclease phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ARAF serine/threonine protein kinase protein
ADP + ARAF serine/threonine protein kinase phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ATRIP protein
ADP + ATRIP phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + cAMP responsive element binding protein 3-like 2 protein
ADP + cAMP responsive element binding protein 3-like 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + CCAAT/enhancer binding protein gamma protein
ADP + CCAAT/enhancer binding protein gamma phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + cdc2
ADP + phosphorylated cdc2
show the reaction diagram
phosphorylation of Thr161
-
-
-
ATP + cdc2-like protein
ADP + phosphorylated cdc2-like protein from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
show the reaction diagram
from Caenorhabditis in chimeric complexes including both mitotic and G1/S cyclins
-
-
-
ATP + Cdc20
ADP + phosphorylated Cdc20
show the reaction diagram
ATP + cdk2
ADP + phosphorylated cdk2
show the reaction diagram
-
-
-
-
ATP + coiled-coil domain protein 52 protein
ADP + coiled-coil domain protein 52 phosphoprotein
show the reaction diagram
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + CPEB-associated factor Maskin protein
ADP + CPEB-associated factor Maskin phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + diacylglycerol kinase epsilon protein
ADP + diacylglycerol kinase epsilon phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + diphthamide biosynthesis protein 2 isoform a protein
ADP + diphthamide biosynthesis protein 2 isoform a phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + distal-less homeobox 1 isoform 1 protein
ADP + distal-less homeobox 1 isoform 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Erp1/emi2 protein
ADP + Erp1/emi2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + establishment of cohesion-1 homologue 2 protein
ADP + establishment of cohesion-1 homologue 2 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + ETS variant gene-1 protein
ADP + ETS variant gene-1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Fizzy1 protein
ADP + Fizzy1 phosphoprotein
show the reaction diagram
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + glycogenin protein
ADP + glycogenin phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + granulin isoform 1 precursor protein
ADP + granulin isoform 1 precursor phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + heat shock transcription factor 1 protein
ADP + heat shock transcription factor 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Hermes protein
ADP + Hermes phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone deacetylase 6 protein
ADP + histone deacetylase 6 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + histone H1
ADP + dephosphorylated hiostone H1
show the reaction diagram
-
-
-
-
ATP + histone stem-loop binding protein
ADP + histone stem-loop binding phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + Kunitz type serine protease inhibitor 2 protein
ADP + Kunitz type serine protease inhibitor 2 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + lamina-associated protein 2-beta isoform protein
ADP + lamina-associated protein 2-beta isoform phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + LOC222229 protein
ADP + LOC222229 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + low density lipoprotein receptor adaptor protein 1 protein
ADP + low density lipoprotein receptor adaptor protein 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + MAP/microtubule affinity regulating kinase 3 protein
ADP + MAP/microtubule affinity regulating kinase 3 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + maternal embryonic leucine zipper kinase protein
ADP + maternal embryonic leucine zipper kinase phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + MGC86234 protein
ADP + MGC86234 phosphoprotein
show the reaction diagram
-
i.e. potassium channel tetramerisation domaincontaining 3, substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + minor histocompatibility antigen HA-1 protein
ADP + minor histocompatibility antigen HA-1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + neuronal cytoskeletal protein NF-H
ADP + phosphorylated neuronal cytoskeletal protein NF-H
show the reaction diagram
-
-
-
-
ATP + neuronal cytoskeletal protein tau
ADP + phosphorylated neuronal cytoskeletal protein tau
show the reaction diagram
-
-
-
-
ATP + neuronal cytoskeletal proteins NF-M
ADP + phosphorylated neuronal cytoskeletal protein NF-M
show the reaction diagram
-
-
-
-
ATP + palmitoylated membrane protein 1 protein
ADP + palmitoylated membrane protein 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + PASCIN protein
ADP + PASCIN phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + phosphatidylinositol-4-phosphate 5-kinase type IIba protein
ADP + phosphatidylinositol-4-phosphate 5-kinase type IIba phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + PIF1 protein
ADP + PIF1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + POM21 protein
ADP + POM21 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + pre-B-cell leukemia transcription factor 1 protein
ADP + pre-B-cell leukemia transcription factor 1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin B/CDK1
-
-
?
ATP + RNA polymerase 1 protein
ADP + RNA polymerase 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SEC14-like 1 isoform a protein
ADP + SEC14-like 1 isoform a phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + semaphorin 6D protein
ADP + semaphorin 6D phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to bicaudal C homologue 1 protein
ADP + similar to bicaudal C homologue 1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + similar to peroxisomal biogenesis factor 5 protein
ADP + similar to peroxisomal biogenesis factor 5 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Trigger of mitotic entry 1 protein
ADP + similar to Trigger of mitotic entry 1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + similar to Zinc finger protein 516 protein
ADP + similar to Zinc finger protein 516 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 protein
ADP + SMARCD2/BAF60:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin d2 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + SmcX-Jumonji/ARID domain-containing protein 1C protein
ADP + SmcX-Jumonji/ARID domain-containing protein 1C phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + striatin protein
ADP + striatin phosphoprotein
show the reaction diagram
-
substrate of cyclin E/CDK2, not of cyclinA/CDK2
-
-
?
ATP + TATA box-binding protein-associated factor 2F protein
ADP + TATA box-binding protein-associated factor 2F phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1, not of cyclinA/CDK2
-
-
?
ATP + telomeric repeat binding factor 2 protein
ADP + telomeric repeat binding factor 2 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Tipin protein
ADP + Tipin phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2 and cyclin E/CDK2
-
-
?
ATP + v-raf murine sarcoma viral oncogene homolog B1 protein
ADP + v-raf murine sarcoma viraloncogene homolog B1 phosphoprotein
show the reaction diagram
-
substrate of cyclin B/CDK1 and cyclinA/CDK2
-
-
?
ATP + Xenopus laevis protein associated with PRK1 protein
ADP + Xenopus laevis protein associated with PRK1 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
ATP + zinc finger protein 46 protein
ADP + zinc finger protein 46 phosphoprotein
show the reaction diagram
-
substrate of cyclinA/CDK2, not of cyclin E/CDK2
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + Cdc20
ADP + phosphorylated Cdc20
show the reaction diagram
-
substrate of Cdk1, rather than of Cdk2
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyclin B
-
stabilizing regulatory subunit of Cdk1
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cyclin E
-
stabilizing regulatory subunit of Cdk2
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p21 protein
-
i.e. Cip1 or Waf1, a Cdk-inhibitor
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roscovitine
-
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cyclin A
-
activates Cdk2
-
cyclin B
-
activates CDK1
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cyclin E
-
activates Cdk2
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
23
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
in cytostatic-arrested M-phase
Manually annotated by BRENDA team
expressed between the midblastula transition and gastrulation
Manually annotated by BRENDA team
differentiated post-mitotic neurons
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
CDK2_XENLA
297
0
33870
Swiss-Prot
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
T14A
-
mutant enzyme does not induce germinal vesicle breakdown upon microinjection into oocytes
T14A/Y15F
-
mutant enzyme does induce germinal vesicle breakdown upon microinjection into oocytes
T14A/Y15F/T161A
-
mutant enzyme fails to induce germinal vesicle breakdown in oocytes and shows a decreased binding to cyclin B1 in coimmunoprecipitations
T14A/Y15F/T161E
-
mutant enzyme fails to induce germinal vesicle breakdown in oocytes and shows a decreased binding to cyclin B1 in coimmunoprecipitations
T161A
-
mutant enzyme fails to induce germinal vesicle breakdown in oocytes and shows a decreased binding to cyclin B1 in coimmunoprecipitations
T161E
-
mutant enzyme fails to induce germinal vesicle breakdown in oocytes and shows a decreased binding to cyclin B1 in coimmunoprecipitations
Y15F
-
mutant enzyme does not induce germinal vesicle breakdown upon microinjection into oocytes
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
isolation of cDNA
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Labbe, J.C.; Martinez, A.M.; Fesquet, D.; Capony, J.P.; Darbon, J.M.; Derancourt, J.; Devault, A.; Morin, N.; Cavadore, J.C.; Doree, M.
p40MO15 associates with a p36 subunit and requires both nuclear translocation and Thr176 phosphorylation to generate cdk-activating kinase activity in Xenopus oocytes
EMBO J.
13
5155-5164
1994
Xenopus laevis (P20911)
Manually annotated by BRENDA team
Shuttleworth, J.; Godfrey, R.; Colman, A.
p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes
EMBO J.
9
3233-3240
1990
Xenopus laevis (P20911)
Manually annotated by BRENDA team
Poon, R.Y.; Yamashita, K.; Adamczewski, J.P.; Hunt, T.; Shuttleworth, J.
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2
EMBO J.
12
3123-3132
1993
Xenopus laevis (P23437)
Manually annotated by BRENDA team
Paris, J.; Le Guellec, R.; Couturier, A.; Le Guellec, K.; Omilli, F.; Camonis, J.; MacNeill, S.; Philippe, M.
Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2
Proc. Natl. Acad. Sci. USA
88
1039-1043
1991
Xenopus laevis (P23437), Xenopus laevis
Manually annotated by BRENDA team
Stern, B.; Ried, G.; Clegg, N.J.; Grigliatti, T.A.; Lehner, C.F.
Genetic analysis of the Drosophila cdc2 homolog
Development
117
219-232
1993
Xenopus laevis (P23437)
Manually annotated by BRENDA team
Clegg, N.J.; Whitehead, I.P.; Williams, J.A.; Spiegelman, G.B.; Grigliatti, T.A.
A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster
Genome
36
676-685
1993
Xenopus laevis (P23437)
Manually annotated by BRENDA team
Jimenez, J.; Alphey, L.; Nurse, P.; Glover, D.M.
Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string
EMBO J.
9
3565-3571
1990
Xenopus laevis (P23437)
Manually annotated by BRENDA team
Lehner, C.F.; O'Farrell, P.H.
Drosophila cdc2 homologul: a functional homolog is coexpressed with a cognate variant
EMBO J.
9
3573-3581
1990
Drosophila melanogaster (P23573), Xenopus laevis (P23437)
Manually annotated by BRENDA team
Fesquet, D.; Labbe, J.C.; Derancourt, J.; Capony, J.P.; Galas, S.; Girard, F.; Lorca, T.; Shuttleworth, J.; Doree, M.; Cavadore, J.C.
The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues
EMBO J.
12
3111-3121
1993
Xenopus laevis (P24033), Xenopus laevis (P35567)
Manually annotated by BRENDA team
Pickham, K.M.; Meyer, A.N.; Li, J.; Donoghue, D.J.
Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites
Mol. Cell. Biol.
12
3192-3203
1992
Xenopus laevis (P24033), Xenopus laevis (P35567)
Manually annotated by BRENDA team
Gervasi, C.; Szaro, B.G.
The Xenopus laevis homologue to the neuronal cyclin-dependent kinase (cdk5) is expressed in embryos by gastrulation
Brain Res. Mol. Brain Res.
33
192-200
1995
Xenopus laevis (P51166), Xenopus laevis
Manually annotated by BRENDA team
D'Angiolella, V.; Mari, C.; Nocera, D.; Rametti, L.; Grieco, D.
The spindle checkpoint requires cyclin-dependent kinase activity
Genes Dev.
17
2520-2525
2003
Homo sapiens, Xenopus laevis
Manually annotated by BRENDA team
Errico, A.; Deshmukh, K.; Tanaka, Y.; Pozniakovsky, A.; Hunt, T.
Identification of substrates for cyclin dependent kinases
Adv. Enzyme Regul.
50
375-399
2010
Xenopus laevis
Manually annotated by BRENDA team
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