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Information on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Zea mays and UniProt Accession P23111

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IUBMB Comments
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
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This record set is specific for:
Zea mays
UNIPROT: P23111
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Word Map
The taxonomic range for the selected organisms is: Zea mays
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
cyclin-dependent kinase, cdk, p34cdc2, cdkl5, cdc2 kinase, cyclin-dependent kinase 5, cyclin-dependent kinase 2, cdc28, cyclin-dependent kinase 4, cyclin-dependent kinase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cell division control protein 2 homolog
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p34cdc2 homologue
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A-type cyclin-dependent kinase
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Cdk-A
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cyclin-dependent kinase A
-
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Cyclin-dependent kinase pef1
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-
-
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PHO85 homolog
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:cyclin phosphotransferase
Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation.
CAS REGISTRY NUMBER
COMMENTARY hide
150428-23-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
show the reaction diagram
additional information
?
-
-
Cdk-A/cyclin D2 is involved in DNA replication progress and cell proliferation
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + histone H1
ADP + phosphorylated histone H1
show the reaction diagram
-
substrate of Cdk-A/cyclin D2
-
-
?
ATP + retinoblastoma-related protein
ADP + phosphorylated retinoblastoma-related protein
show the reaction diagram
-
i.e. RBR, substrate of Cdk-A/cyclin D2
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-
?
additional information
?
-
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Cdk-A/cyclin D2 is involved in DNA replication progress and cell proliferation
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-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ATP
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cyclin D2
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expression analysis in response to Cdk-Activity and phytohormone levels, e.g. of cytokinin and abscisic acid, cytokinin stimulates sucrose-dependently the expression of cyclin D2 at the late germination state of the embryo
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5
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assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
contains two type A CDKs, expression of cyclin D2 cofactor during germination in absence or presence of benzyladenine, cytokinin and abscisic acid, overview
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CDC2_MAIZE
294
0
33834
Swiss-Prot
other Location (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isolation of cDNA
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Colasanti, J.; Tyers, M.; Sundaresan, V.
Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays
Proc. Natl. Acad. Sci. USA
88
3377-3381
1991
Zea mays (P23111), Zea mays
Manually annotated by BRENDA team
Gutierrez, R.; Quiroz-Figueroa, F.; Vazquez-Ramos, J.M.
Maize cyclin D2 expression, associated kinase activity, and effect of phytohormones during germination
Plant Cell Physiol.
46
166-173
2005
Zea mays
Manually annotated by BRENDA team