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Information on EC 2.7.11.21 - polo kinase and Organism(s) Rattus norvegicus and UniProt Accession Q62673

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     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q62673
Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
polo-like kinase 1, polo-like kinase, plk-1, polo-like kinase-1, tbplk, plk1 kinase, cdc5p, polo-like kinase 4, polo-like kinase 2, polo-like kinase cdc5, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FGF-inducible kinase
-
-
-
-
Plk1
277891
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polo-like kinase-1
277891
-
Proliferation-related kinase
-
-
-
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serine/threonine-protein kinase SNK
266055
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
CAS REGISTRY NUMBER
COMMENTARY hide
149433-93-2
Polo kinase
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
female Wistar rats
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
maturing, after activation
Manually annotated by BRENDA team
additional information
enzyme quantity is stable during meiotic maturation
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
in fertilized eggs between female and male pronuclei at microtubules
Manually annotated by BRENDA team
accumulation of Plk1 in germinal vesicle stage oocytes
Manually annotated by BRENDA team
enzyme is located at and required for microtubule assembly
Manually annotated by BRENDA team
middle region, at anaphase-telophase I and anaphase-telophase II stages
Manually annotated by BRENDA team
after germinal vesicle breakdown, at metaphase I stage, and in MII spindle pole
Manually annotated by BRENDA team
additional information
localization changes with embryonal development, e.g. throughout the division plane during cytokinesis, subcellular localization analysis, overview, colchicine inhibits spindle pole localization of the enzyme, taxol treatment leads to localization in the cytoplasm
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Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
PLK1_RAT
603
0
68291
Swiss-Prot
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kauselmann, G.; Weiler, M.; Wulff, P.; Jessberger, S.; Konietzko, U.; Scafidi, J.; Staubli, U.; Bereiter-Hahn, J.; Strebhardt, K.; Kuhl, D.
The polo-like protein kinases Fnk and Snk associate with a Ca2+- and integrin-binding protein and are regulated dynamically with synaptic plasticity
EMBO J.
18
5528-5539
1999
Rattus norvegicus (Q9R012)
Manually annotated by BRENDA team
Fan, H.Y.; Tong, C.; Teng, C.B.; Lian, L.; Li, S.W.; Yang, Z.M.; Chen, D.Y.; Schatten, H.; Sun, Q.Y.
Characterization of polo-like kinase-1 in rat oocytes and early embryos implies its functional roles in the regulation of meiotic maturation, fertilization, and cleavage
Mol. Reprod. Dev.
65
318-329
2003
Rattus norvegicus (Q62673)
Manually annotated by BRENDA team
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