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Information on EC 2.7.11.21 - polo kinase and Organism(s) Caenorhabditis elegans and UniProt Accession Q20845

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.11 Protein-serine/threonine kinases
                2.7.11.21 polo kinase
IUBMB Comments
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein .
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This record set is specific for:
Caenorhabditis elegans
UNIPROT: Q20845
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Word Map
The taxonomic range for the selected organisms is: Caenorhabditis elegans
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
polo-like kinase 1, polo-like kinase, plk-1, polo kinase, polo-like kinase 4, polo-like kinase-1, tbplk, plk1 kinase, cdc5p, polo-like kinase 2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
serine/threonine-protein kinase plk-3
-
FGF-inducible kinase
-
-
-
-
Plk-2
Polo kinase
-
-
polo-like kinase
-
-
polo-like kinase PLK-1
-
Proliferation-related kinase
-
-
-
-
serine/threonine-protein kinase plk-1
-
serine/threonine-protein kinase plk-2
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (spindle-pole-dependent)
The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein [2].
CAS REGISTRY NUMBER
COMMENTARY hide
149433-93-2
Polo kinase
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + Cdc25C
ADP + phosphorylated Cdc25C
show the reaction diagram
-
-
-
-
?
ATP + HTP-1 protein
ADP + phosphorylated HTP-1 protein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + SYP-4 protein
ADP + phosphorylated SYP-4 protein
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + HTP-1 protein
ADP + phosphorylated HTP-1 protein
show the reaction diagram
-
-
-
-
?
ATP + protein
ADP + phosphoprotein
show the reaction diagram
-
-
-
-
?
ATP + SYP-4 protein
ADP + phosphorylated SYP-4 protein
show the reaction diagram
-
-
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
meiotic chromosome pairing centers localize PLK-2 to the nuclear envelope
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PLK3_CAEEL
615
0
70436
Swiss-Prot
other Location (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
N166A
-
kinase dead mutant
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
for a yeast two-hybrid screen
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chase, D.; Serafinas, C.; Ashcroft, N.; Kosinski, M.; Longo, D.; Ferris, D.K.; Golden, A.
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans
Genesis
26
26-41
2000
Caenorhabditis elegans (P34331), Caenorhabditis elegans
Manually annotated by BRENDA team
Ouyang, B.; Wang, Y.; Wei, D.
Caenorhabditis elegans contains structural homologs of human prk and plk
DNA Seq.
10
109-113
1999
Caenorhabditis elegans (P34331), Caenorhabditis elegans (Q20845)
Manually annotated by BRENDA team
Wilson, R.; Ainscough, R.; Anderson, K.; Baynes, C.; Berks, M.; Bonfield, J.; Burton, J.; Connell, M.; Copsey, T.; Cooper, J.; et al.
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans
Nature
368
32-38
1994
Caenorhabditis elegans (P34331)
Manually annotated by BRENDA team
Chase, D.; Golden, A.; Heidecker, G.; Ferris, D.K.
Caenorhabditis elegans contains a third polo-like kinase gene
DNA Seq.
11
327-334
2000
Caenorhabditis elegans (Q9N2L7), Caenorhabditis elegans
Manually annotated by BRENDA team
Nishi, Y.; Rogers, E.; Robertson, S.M.; Lin, R.
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6
Development
135
687-697
2008
Caenorhabditis elegans, Homo sapiens
Manually annotated by BRENDA team
Labella, S.; Woglar, A.; Jantsch, V.; Zetka, M.
Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairing
Dev. Cell
21
948-958
2011
Caenorhabditis elegans (P34331), Caenorhabditis elegans (Q9N2L7)
Manually annotated by BRENDA team
Roelens, B.; Barroso, C.; Montoya, A.; Cutillas, P.; Zhang, W.; Woglar, A.; Girard, C.; Martinez-Perez, E.; Villeneuve, A.M.
Spatial regulation of polo-like kinase activity during Caenorhabditis elegans meiosis by the nucleoplasmic HAL-2/HAL-3 complex
Genetics
213
79-96
2019
Caenorhabditis elegans
Manually annotated by BRENDA team