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Information on EC 2.7.11.19 - phosphorylase kinase

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EC Tree
IUBMB Comments
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b . The gamma subunit of the tetrameric enzyme is the catalytic subunit.
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This record set is specific for:
UNIPROT: P18688
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
phosphorylase kinase, phosphorylase b kinase, glycogen phosphorylase kinase, phkg1, phk alpha, dphk-gamma, glycogen phosphorylase b kinase, psk-c3, kpi-2 kinase, phosphorylase kinase beta, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EC 2.7.1.38
formerly, transferred to EC 2.7.11.19
dephosphophosphorylase kinase
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Glycogen phosphorylase kinase
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kinase, phosphorylase (phosphorylating)
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Phosphorylase b kinase
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PSK-C3
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:phosphorylase-b phosphotransferase
Requires Ca2+ and calmodulin for activity. The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. The enzyme couples muscle contraction with energy production via glycogenolysis---glycolysis by catalysing the Ca2+-dependent phosphorylation and activation of glycogen phosphorylase b [5]. The gamma subunit of the tetrameric enzyme is the catalytic subunit.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-88-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
glycogen phosphorylase b + ATP
glycogen phosphorylase a + ADP
show the reaction diagram
catalyzes phosphorylation and activation of glycogen phosphorylase b
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
glycogen phosphorylase b + ATP
glycogen phosphorylase a + ADP
show the reaction diagram
catalyzes phosphorylation and activation of glycogen phosphorylase b
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?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
alpha subunit
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KPB1_RABIT
1237
0
138413
Swiss-Prot
Secretory Pathway (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexadecamer
4 * alpha + 4 * beta + 4 * gamma + 4 * delta, gamma subunit is the catalytic subunit, alpha, beta and delta subunits are regulatory
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Carriere, C.; Mornon, J.; Venien-Bryan, C.; Boisset, N.; Callebaut, I.
Calcineurin B-like domains in the large regulatory alpha /beta subunits of phosphorylase kinase
Proteins Struct. Funct. Bioinform.
71
1597-1606
2008
Oryza sativa (A2WRR1), Oryctolagus cuniculus (P12798), Oryctolagus cuniculus (P18688), Caenorhabditis elegans (P34335), Aedes aegypti (Q171G3), Tetraodon nigroviridis (Q4S8G1), Takifugu rubripes (Q9W6R1)
Manually annotated by BRENDA team