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ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + BpaKKRAARATSNVFA
ADP + ?
-
Bpa is the photoreactive amino acid p-benzoylphenylalanine
-
-
?
ATP + KKRAARATSNVFA
ADP + ?
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
ATP + myosin light chain
ADP + myosin light chain phosphate
ATP + myosin light chain
ADP + phosphorylated myosin light chain
ATP + myosin regulatory light chain
?
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
ATP + [rabbit white skeletal muscle myosin P-light chain]
ADP + [rabbit white skeletal muscle myosin P-light chain] phosphate
-
-
-
-
?
additional information
?
-
-
the enzyme binds to thin filaments with high affinity, myofilament binding by Ig-like modules is blocked by disassembling of the filaments, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of cardiac muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
ITP, GTP, CTP or UTP cannot replace ATP
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are 15 kDa and 22 kDa light-chain or heavy-chain fractions of myosin from white skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 18.5 kDa Dictyostelium or 19 kDa skeletal muscle light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is molluscan adductor myosin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-19 and Thr-18 in smooth muscle myosin light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of Ml3-myosin rabbit muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone III-S from thymus
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
ATP + myosin light chain
ADP + myosin light chain phosphate
ATP + myosin light chain
ADP + phosphorylated myosin light chain
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
additional information
?
-
-
the enzyme binds to thin filaments with high affinity, myofilament binding by Ig-like modules is blocked by disassembling of the filaments, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
event in initiation of smooth-muscle contraction
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
-
?
ATP + myosin light chain
ADP + phosphorylated myosin light chain
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
-
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
-
the non-muscle myosin light chain kinase is involved in regulation of hepatic functions in response to intra- and extracellular signals
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Davis, J.S.; Hassanzadeh, S.; Winitsky, S.; Lin, H.; Satorius, C.; Vemuri, R.; Aletras, A.H.; Wen, H.; Epstein, N.D.
The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation
Cell
107
631-641
2001
Oryctolagus cuniculus (P07313), Homo sapiens (Q9H1R3), Homo sapiens
brenda
Herring, B.P.; Stull, J.T.; Gallagher, P.J.
Domain characterization of rabbit skeletal muscle myosin light chain kinase
J. Biol. Chem.
265
1724-1730
1990
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
brenda
Ikura, M.; Clore, G.M.; Gronenborn, A.M.; Zhu, G.; Klee, C.B.; Bax, A.
Solution structure of a calmodulin-target peptide complex by multidimensional NMR
Science
256
632-638
1992
Oryctolagus cuniculus (P07313)
brenda
Takio, K.; Blumenthal, D.K.; Edelman, A.M.; Walsh, K.A.; Krebs, E.G.; Titani, K.
Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase
Biochemistry
24
6028-6037
1985
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
brenda
Takio, K.; Blumenthal, D.K.; Walsh, K.A.; Titani, K.; Krebs, E.G.
Amino acid sequence of rabbit skeletal muscle myosin light chain kinase
Biochemistry
25
8049-8057
1986
Oryctolagus cuniculus (P07313), Oryctolagus cuniculus
brenda
Gallagher, P.J.; Herring, B.P.; Griffin, S.A.; Stull, J.T.
Molecular characterization of a mammalian smooth muscle myosin light chain kinase [published erratum appears in J Biol Chem 1992 May 5;267(13):9450]
J. Biol. Chem.
266
23936-23944
1991
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Oryctolagus cuniculus (P29294), Rattus norvegicus
brenda
Gallagher, P.J.; Herring, B.P.
The carboxyl terminus of the smooth muscle myosin light chain kinase is expressed as an independent protein, telokin
J. Biol. Chem.
266
23945-23952
1991
Oryctolagus cuniculus (P29294)
brenda
Pires, E.; Perry, S.V.; Thomas, M.A.W.
Myosin light-chain kinase, a new enzyme from striated muscle
FEBS Lett.
41
292-296
1974
Oryctolagus cuniculus
brenda
Pires, E.M.V.; Perry, S.V.
Purification and properties of myosin light-chain kinase from fast skeletal muscle
Biochem. J.
167
137-146
1977
Oryctolagus cuniculus
brenda
Nagamoto, H.; Yagi, K.
Properties of myosin light chain kinase prepared from rabbit skeletal muscle by an improved method
J. Biochem.
95
1119-1130
1984
Oryctolagus cuniculus
brenda
Yang, H.H.; Boxer, L.A.
Purification of myosin light chain kinase from rabbit polymorphonuclear leukocytes
Pediatr. Res.
15
229-234
1981
Oryctolagus cuniculus
brenda
Conti, M.A.; Adelstein, R.S.
Purification and properties of myosin light chain kinases
Methods Enzymol.
196
34-47
1991
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus, Sus scrofa
brenda
Nunnally, M.H.; Rybicki, S.B.; Stull, J.T.
Characterization of chicken skeletal muscle myosin light chain kinase. Evidence for muscle-specific isozymes
J. Biol. Chem.
260
1020-1026
1985
Gallus gallus, Oryctolagus cuniculus
brenda
Bailin, G.
Structure and function of a calmodulin-dependent smooth muscle myosin light chain kinase
Experientia
40
1185-1188
1984
Bos taurus, Gallus gallus, Oryctolagus cuniculus, Meleagris gallopavo
brenda
Gao, Z.H.; Zhi, G.; Herring, B.P.; Moomaw, C.; Deogny, L.; Slaughter, C.A.; Stull, J.T.
Photoaffinity labeling of a peptide substrate to myosin light chain kinase
J. Biol. Chem.
270
10125-10135
1995
Oryctolagus cuniculus
brenda
Lin, P.; Luby-Phelps, K.; Stull, J.T.
Properties of filament-bound myosin light chain kinase
J. Biol. Chem.
274
5987-5994
1999
Oryctolagus cuniculus
brenda
Padre, R.C.; Stull, J.T.
Conformational requirements for Ca2+/calmodulin binding and activation of myosin light chain kinase
FEBS Lett.
472
148-152
2000
Oryctolagus cuniculus
brenda
Dulyaninova, N.G.; Bresnick, A.R.
The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis
Exp. Cell Res.
299
303-314
2004
Oryctolagus cuniculus, Homo sapiens
brenda
Zhu, H.Q.; Wang, Y.; Hu, R.L.; Ren, B.; Zhou, Q.; Jiang, Z.K.; Gui, S.Y.
Distribution and expression of non-muscle myosin light chain kinase in rabbit livers
World J. Gastroenterol.
9
2715-2719
2003
Homo sapiens, Oryctolagus cuniculus
brenda
Yang, C.X.; Chen, H.Q.; Chen, C.; Yu, W.P.; Zhang, W.C.; Peng, Y.J.; He, W.Q.; Wei, D.M.; Gao, X.; Zhu, M.S.
Microfilament-binding properties of N-terminal extension of the isoform of smooth muscle long myosin light chain kinase
Cell Res.
16
367-376
2006
Oryctolagus cuniculus
brenda
Ryder, J.W.; Lau, K.S.; Kamm, K.E.; Stull, J.T.
Enhanced skeletal muscle contraction with myosin light chain phosphorylation by a calmodulin-sensing kinase
J. Biol. Chem.
282
20447-20454
2007
Oryctolagus cuniculus
brenda