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Information on EC 2.7.11.18 - myosin-light-chain kinase
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2.7.11.18 myosin-light-chain kinaseIUBMB Comments
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
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Word Map
- 2.7.11.18
-
contractile
- actin
- junction
- artery
- rho
- pkc
- agonist
- gizzard
- cytoskeletal
- actomyosin
-
tension
- occludin
-
rock
-
calmodulin-binding
-
actin-activated
-
isometric
-
rho-associated
- mlc20
-
paracellular
-
ca2+-independent
-
actin-myosin
-
rho-kinase
- wortmannin
-
zonula
- mypt1
-
cam-binding
-
actin-binding
-
cam-dependent
- trifluoperazine
- caldesmon
-
myofilament
-
hyperpermeability
-
thrombin-induced
-
thiophosphorylation
- mg2+-atpase
- calyculin
-
pseudosubstrate
- blebbistatin
- idella
-
diphosphorylation
- calponin
-
cross-bridge
- meromyosin
- medicine
-
mgatpase
-
myosin-binding
-
monoxime
-
n-6-aminohexyl-5-chloro-1-naphthalenesulfonamide
-
calmodulin-activated
-
superprecipitation
- cak
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mlck, myosin light chain kinase, myosin light-chain kinase, mlc kinase, smooth muscle myosin light chain kinase, smmlck, nmmlck, myosin kinase, cmlck, skmlck, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
calcium/calmodulin-dependent myosin light chain kinase
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kinase, myosin light-chain (phosphorylating)
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-
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myosin kinase
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-
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myosin light chain protein kinase
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-
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myosin light-chain kinase
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smooth-muscle-myosin-light-chain kinase
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[myosin light chain] O-phosphotransferase
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
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CAS REGISTRY NUMBER
COMMENTARY
51845-53-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
-
-
?
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myosin II
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-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + [myosin light chain]
ADP + [myosin light chain] phosphate
myyosin II
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-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
ML-7
chemical inhibition of myosin light chain kinase (MLCK) slows down endocytosis
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.
Acute Kidney Injury
Identification of phosphorylated MYL12B as a potential plasma biomarker for septic acute kidney injury using a quantitative proteomic approach.
Acute Lung Injury
An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.
Acute Lung Injury
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.
Acute Lung Injury
Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia.
Acute Lung Injury
Injury of cell tight junctions and changes of actin level in acute lung injury caused by the perfluoroisobutylene exposure and the role of Myosin light chain kinase.
Acute Lung Injury
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease.
Acute Lung Injury
MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.
Acute Lung Injury
Myosin light chain kinase gene and acute lung injury in trauma and sepsis: opposite effects but confirmatory.
Acute Lung Injury
Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.
Acute Lung Injury
Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.
Acute Lung Injury
Variation in the MYLK gene is associated with development of acute lung injury after major trauma.
Acute Lung Injury
Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.
Acute Lung Injury
[Protective effect of myosin light-chain kinase inhibitor on acute lung injury.]
Acute Lung Injury
[The effects of vitamin E and dexamethasone on inflammation of acute lung injury and expression of myosin light chain kinase]
Adenocarcinoma
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
Adenocarcinoma of Lung
A novel all-trans retinoid acid derivative N-(3-trifluoromethyl- phenyl)- retinamide inhibits lung adenocarcinoma A549 cell migration through down-regulating expression of myosin light chain kinase.
Anaphylaxis
Increased myosin light chain kinase content in sensitized canine saphenous vein.
Aneurysm
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
Aneurysm
The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm.
Aneurysm, Dissecting
Mutations in myosin light chain kinase cause familial aortic dissections.
Aortic Aneurysm, Thoracic
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Aortic Diseases
Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.
Aortic Diseases
Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.
Aortic Diseases
MYLK pathogenic variants aortic disease presentation, pregnancy risk, and characterization of pathogenic missense variants.
Aortic Valve Stenosis
Rapid response of cardiac obscurin gene cluster to aortic stenosis: differential activation of Rho-GEF and MLCK and involvement in hypertrophic growth.
Arteriosclerosis
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Arteriosclerosis
[Targeting of myosin light chain kinase in vascular smooth muscle cells, and its implication for drug discovery]
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Ascorbic Acid Deficiency
Dietary vitamin C deficiency depresses the growth, head kidney and spleen immunity and structural integrity by regulating NF-?B, TOR, Nrf2, apoptosis and MLCK signaling in young grass carp (Ctenopharyngodon idella).
Asthma
A common cortactin gene variation confers differential susceptibility to severe asthma.
Asthma
A MYLK variant regulates asthmatic inflammation via alterations in mRNA secondary structure.
Asthma
A nonmuscle myosin light chain kinase-dependent gene signature in peripheral blood mononuclear cells is linked to human asthma severity and exacerbation status.
Asthma
A variant of the myosin light chain kinase gene is associated with severe asthma in African Americans.
Asthma
An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.
Asthma
Chronic oscillatory strain induces MLCK associated rapid recovery from acute stretch in airway smooth muscle cells.
Asthma
Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.
Asthma
ML-7 attenuates airway inflammation and remodeling via inhibiting the secretion of Th2 cytokines in mice model of asthma.
Asthma
Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
Asthma
Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma.
Asthma
Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.
Asthma
Variation in the MYLK gene is associated with development of acute lung injury after major trauma.
Asthma
Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.
Atherosclerosis
Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.
Atherosclerosis
Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits.
Atherosclerosis
MicroRNA-92a promotes vascular smooth muscle cell proliferation and migration through the ROCK/MLCK signalling pathway.
Atherosclerosis
Myosin light chain kinase inhibitor attenuates atherosclerosis and permeability via reduced endothelial tight junction in rabbits.
Atherosclerosis
Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction and permeability via the mitogen-activated protein kinase pathway in a rabbit model of atherosclerosis.
Atherosclerosis
Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis.
Atherosclerosis
Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability.
Atherosclerosis
Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration.
Atherosclerosis
Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway.
Blister
Bleb formation is induced by alkaline but not acidic pH in estrogen receptor silenced breast cancer cells.
Blister
Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration.
Blister
Distinct signaling pathways are involved in leukosialin (CD43) down-regulation, membrane blebbing, and phospholipid scrambling during neutrophil apoptosis.
Blister
Myosin light chain kinase and Src control membrane dynamics in volume recovery from cell swelling.
Blister
Myosin light chain kinase-driven myosin II turnover regulates actin cortex contractility during mitosis.
Blister
Switching between blebbing and lamellipodia depends on the degree of non-muscle myosin II activity.
Brain Diseases
Proteome Analysis of Differential Protein Expression in Brain of Rats with Type 1 Diabetes Mellitus.
Brain Diseases
The Protective Effect of Radix Polygoni Multiflori on Diabetic Encephalopathy via Regulating Myosin Light Chain Kinase Expression.
Brain Edema
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
Brain Edema
Inhibition of Myosin Light-Chain Kinase Attenuates Cerebral Edema after Traumatic Brain Injury in Postnatal Mice.
Brain Edema
Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice.
Brain Injuries
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
Brain Injuries, Traumatic
Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase.
Brain Injuries, Traumatic
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
Brain Injuries, Traumatic
Inhibition of Myosin Light-Chain Kinase Attenuates Cerebral Edema after Traumatic Brain Injury in Postnatal Mice.
Brain Injuries, Traumatic
Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice.
Breast Carcinoma In Situ
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
Breast Neoplasms
A novel all-trans retinoid acid derivatives inhibits the migration of breast cancer cell lines MDA-MB-231 via myosin light chain kinase involving p38-MAPK pathway.
Breast Neoplasms
Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo.
Breast Neoplasms
Integrin ?1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.
Breast Neoplasms
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
Breast Neoplasms
Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway.
Breast Neoplasms
Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study.
Breast Neoplasms
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.
Carcinogenesis
A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Carcinogenesis
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Carcinogenesis
Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.
Carcinogenesis
Resveratrol down-regulates Myosin light chain kinase, induces apoptosis and inhibits diethylnitrosamine-induced liver tumorigenesis in rats.
Carcinoma
Long Non-Coding RNA Myosin Light Chain Kinase Antisense 1 Plays an Oncogenic Role in Gallbladder Carcinoma by Promoting Chemoresistance and Proliferation.
Carcinoma
Myosin light chain kinase inhibitors ML-7 and ML-9 inhibit mouse lung carcinoma cell attachment to the fibronectin substratum.
Carcinoma, Ductal
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
Carcinoma, Hepatocellular
Increase of vinblastine accumulation by inhibitors of calmodulin-dependent cell functions in rat ascites hepatoma AH66 cells.
Carcinoma, Non-Small-Cell Lung
Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer.
Carcinosarcoma
Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells.
Cardiomegaly
?-adrenergic activation may promote myosin light chain kinase degradation through calpain in pressure overload-induced cardiac hypertrophy: ?-adrenergic activation results in MLCK degradation.
Cardiomegaly
Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
Cardiomegaly
Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy.
Cardiomegaly
Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.
Cardiomegaly
Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro.
Cardiomegaly
Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction.
Cardiomegaly
The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation.
Cardiomyopathies
Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not.
Cardiomyopathies
Striated Preferentially Expressed Protein Kinase (SPEG) in Muscle Development, Function, and Disease.
Cardiomyopathy, Dilated
Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations.
Cardiomyopathy, Dilated
Identification of MYLK3 mutations in familial dilated cardiomyopathy.
Cardiomyopathy, Dilated
Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy.
Cardiomyopathy, Dilated
[Content of myosin-activating protein kinases in myocardium of patients with dilated cardiomyopathy and in the animal heart]
Cardiomyopathy, Hypertrophic
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Cardiomyopathy, Hypertrophic
Right Ventricular Perforation Presenting as Tingling of the Left Breast.
Cardiotoxicity
Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction.
Cardiovascular Diseases
Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study.
Cardiovascular Diseases
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases.
Cataract
Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse.
Cholera
Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction.
Cholera
Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction.
Cholestasis
Early alterations of bile canaliculi dynamics and the ROCK/MLCK pathway are characteristics of drug-induced intrahepatic cholestasis.
Colitis
1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway.
Colitis
Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats.
Colitis
Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis.
Colitis
Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity.
Colitis
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Colitis
IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction.
Colitis
Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.
Colitis
Myosin Light Chain Kinase Inhibitor Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice.
Colitis
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
Colitis
Salvianolic Acid B Restored Impaired Barrier Function via Downregulation of MLCK by microRNA-1 in Rat Colitis Model.
Colitis, Ulcerative
1,25-Dihydroxyvitamin D Protects Intestinal Epithelial Barrier by Regulating the Myosin Light Chain Kinase Signaling Pathway.
Colitis, Ulcerative
Myosin Light Chain Kinase Inhibitor Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice.
Colonic Neoplasms
Melatonin inhibits the Migration of Colon Cancer RKO cells by Down-regulating Myosin Light Chain Kinase Expression through Cross-talk with p38 MAPK.
Colonic Neoplasms
Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans.
Colorectal Neoplasms
A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Colorectal Neoplasms
All-Trans Retinoic Acid Inhibits Human Colorectal Cancer Cells RKO Migration via Downregulating Myosin Light Chain Kinase Expression through MAPK Signaling Pathway.
Congenital Abnormalities
Effects of Dietary Zearalenone on Oxidative Stress, Cell Apoptosis, and Tight Junction in the Intestine of Juvenile Grass Carp (Ctenopharyngodon idella).
Contracture
cAMP-dependent reduction in membrane fluxes during relaxation of arterial smooth muscle.
Crohn Disease
Myosin light chain kinase regulates intestinal permeability of mucosal homeostasis in Crohn's disease.
Dementia
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
Dengue
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Diabetes Mellitus
Effect of Electroacupuncture on Bladder Dysfunction via Regulation of MLC and MLCK Phosphorylation in a Rat Model of Type 2 Diabetes Mellitus.
Diabetes Mellitus
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Diabetes Mellitus
Serum Myosin light chain kinase in type 2 diabetes mellitus: a cross-sectional study.
Diabetes Mellitus, Type 2
Effect of Electroacupuncture on Bladder Dysfunction via Regulation of MLC and MLCK Phosphorylation in a Rat Model of Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Serum Myosin light chain kinase in type 2 diabetes mellitus: a cross-sectional study.
Diabetic Cardiomyopathies
Myosin light-chain phosphorylation in diabetic cardiomyopathy in rats.
Feline Infectious Peritonitis
Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytes.
Fibroma
Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.
Fibrosarcoma
Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells.
Fibrosarcoma
[Functional regulation of endothelial Myosin light chain kinase in extravascular migration of fibrosarcoma cells.]
Folic Acid Deficiency
Folic acid deficiency impairs the gill health status associated with the NF-?B, MLCK and Nrf2 signaling pathways in the gills of young grass carp (Ctenopharyngodon idella).
Folic Acid Deficiency
Immunity decreases, antioxidant system damages and tight junction changes in the intestine of grass carp (Ctenopharyngodon idella) during folic acid deficiency: Regulation of NF-?B, Nrf2 and MLCK mRNA levels.
Giardiasis
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion.
Glaucoma
A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes.
Glioma
Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration.
Heart Diseases
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Heart Failure
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.
Heart Failure
Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
Heart Failure
Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.
Heart Failure
Heart Failure Induced by Perinatal Ablation of Cardiac Myosin Light Chain Kinase.
Heart Failure
Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.
Heart Failure
Heterozygous Mylk3 Knockout Mice Partially Recapitulate Human DCM With Heterozygous MYLK3 Mutations.
Heart Failure
Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction.
Hepatitis C
TNF superfamily members promote hepatitis C virus entry via an NF-?B and myosin light chain kinase dependent pathway.
Herpes Zoster
MiRNA-155-5p Reduces Corneal Epithelial Permeability by Remodeling Epithelial Tight Junctions during Corneal Wound Healing.
Herpes Zoster
Myosin light chain kinase inhibitor ML7 improves vascular endothelial dysfunction via tight junction regulation in a rabbit model of atherosclerosis.
Herpes Zoster
PGE2 promotes Ca2+-mediated epithelial barrier disruption through EP1 and EP4 receptors in Caco-2 cell monolayers.
Herpes Zoster
[Protective effects of valproic acid on gut barrier function after major burn injury and its mechanism].
Hyperalgesia
Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase.
Hyperalgesia
Inhibition of Peripheral ERK Signaling Ameliorates Persistent Muscle Pain Around Trigger Points in Rats.
Hypercholesterolemia
Association of aorta intima permeability with myosin light chain kinase expression in hypercholesterolemic rabbits.
Hypercholesterolemia
Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction.
Hyperglycemia
High glucose upregulates myosin light chain kinase to induce microfilament cytoskeleton rearrangement in hippocampal neurons.
Hyperglycemia
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Hyperhomocysteinemia
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
Hyperlipidemias
Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.
Hyperlipidemias
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Hyperlipidemias
MicroRNA1 modulates oxLDL-induced hyperlipidemia by down-regulating MLCK and ERK/p38 MAPK pathway.
Hypersensitivity
Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase.
Hypersensitivity
MLCK-mediated intestinal permeability promotes immune activation and visceral hypersensitivity in PI-IBS mice.
Hypertension
Cyclic AMP dependent and myosin light chain kinase: relationship to altered vascular reactivity in hypertension and development of direct pharmacological modulators.
Hypertension
Enhanced contractility and myosin phosphorylation induced by Ca2+-independent MLCK activity in hypertensive rats.
Hypertension
Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter.
Hypertension
Metformin-induced AMP-activated protein kinase activation regulates phenylephrine-mediated contraction of rat aorta.
Hypertension
Molecular pharmacology of calcium, calmodulin-dependent myosin phosphorylation in vascular smooth muscle.
Hypertension
Naturally extended CT . AG repeats increase H-DNA structures and promoter activity in the smooth muscle myosin light chain kinase gene.
Hypertension
Quercetin-Induced AMP-Activated Protein Kinase Activation Attenuates Vasoconstriction Through LKB1-AMPK Signaling Pathway.
Hypertension
Regulation of myosin light chain kinase expression by angiotensin II in hypertension.
Hypertension
Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension.
Hypertension
[Changes of activities of MLCK and dephosphatase in different arterial vessels from hypertensive rats]
Hypopharyngeal Neoplasms
Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment.
Infections
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Infections
Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability.
Infections
Evaluation of Alpha-Ketoglutarate Supplementation on the Improvement of Intestinal Antioxidant Capacity and Immune Response in Songpu Mirror Carp (Cyprinus carpio) After Infection With Aeromonas hydrophila.
Infections
Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation.
Infections
Impaired intestinal immune barrier and physical barrier function by phosphorus deficiency: Regulation of TOR, NF-?B, MLCK, JNK and Nrf2 signalling in grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.
Infections
Impairing the function of MLCK, myosin Va or myosin Vb disrupts Rhinovirus B14 replication.
Infections
Increased phosphorylation of myosin light chain prevents in vitro decidualization.
Infections
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against HSV-1 infection.
Infections
Lactobacillus reuteri LR1 Improved Expression of Genes of Tight Junction Proteins via the MLCK Pathway in IPEC-1 Cells during Infection with Enterotoxigenic Escherichia coli K88.
Infections
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.
Infections
Phosphorylation is required for myosin regulatory light chain (PmMRLC) to control yellow head virus infection in shrimp hemocytes.
Infections
Role of the short isoform of myosin light chain kinase in the contraction of cultured smooth muscle cells as examined by its down-regulation.
Infections
The impaired immune function and structural integrity by dietary iron deficiency or excess in gill of fish after infection with Flavobacterium columnare: Regulation of NF-?B, TOR, JNK, p38MAPK, Nrf2 and MLCK signalling.
Inflammatory Bowel Diseases
Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.
Inflammatory Bowel Diseases
Beyond Ussing's chambers: contemporary thoughts on integration of transepithelial transport.
Inflammatory Bowel Diseases
Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.
Inflammatory Bowel Diseases
Epithelial MLCK and Smooth Muscle MLCK May Play Different Roles in the Development of Inflammatory Bowel Disease.
Inflammatory Bowel Diseases
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease.
Inflammatory Bowel Diseases
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases.
Inflammatory Bowel Diseases
Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.
Inflammatory Bowel Diseases
Wogonoside alleviates colitis by improving intestinal epithelial barrier function via the MLCK/pMLC2 pathway.
Insulin Resistance
GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.
Intestinal Diseases
A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.
Intestinal Diseases
A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase.
Intestinal Diseases
Claudin-2 Regulates Colorectal Inflammation via Myosin Light Chain Kinase-Dependent Signaling.
Intestinal Diseases
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
Intestinal Diseases
Myosin light chain kinase: pulling the strings of epithelial tight junction function.
Intestinal Obstruction
Role of myosin light chain kinase in intestinal epithelial barrier defects in a rat model of bowel obstruction.
Intracranial Aneurysm
The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm.
Iron Deficiencies
The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngodon idella).
Iron Deficiencies
The impaired immune function and structural integrity by dietary iron deficiency or excess in gill of fish after infection with Flavobacterium columnare: Regulation of NF-?B, TOR, JNK, p38MAPK, Nrf2 and MLCK signalling.
Irritable Bowel Syndrome
Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.
Kidney Neoplasms
Cancer cells regulate biomechanical properties of human microvascular endothelial cells.
Leiomyoma
Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Leiomyosarcoma
Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Leukemia
Differentiation of human monoblastic leukemia U937 cells induced by inhibitors of myosin light chain kinase and prevention of differentiation by granulocyte-macrophage colony-stimulating factor.
Leukemia
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability.
Leukemia
Induction of differentiation of human leukemia cells by inhibitors of myosin light chain kinase.
Leukemia
Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors.
Leukemia
Reversible differentiation of human monoblastic leukemia U937 cells by ML-9, an inhibitor of myosin light chain kinase.
Leukemia
Surface CD3 expression proceeds through both myosin regulatory light chain 9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells.
Leukemia
The decreased growth performance and impaired immune function and structural integrity by dietary iron deficiency or excess are associated with TOR, NF-?B, p38MAPK, Nrf2 and MLCK signaling in head kidney, spleen and skin of grass carp (Ctenopharyngodon idella).
Leukemia, Erythroblastic, Acute
Reversible differentiation of human monoblastic leukemia U937 cells by ML-9, an inhibitor of myosin light chain kinase.
Leukemia, T-Cell
Surface CD3 expression proceeds through both myosin regulatory light chain 9 (MYL9)-dependent and MYL9-independent pathways in Jurkat cells.
Liver Diseases
Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice.
Liver Neoplasms
Fenretinide inhibits the proliferation and migration of human liver cancer HepG2 cells by downregulating the activation of myosin light chain kinase through the p38?MAPK signaling pathway.
Lung Diseases
An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.
Lung Diseases
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease.
Lung Diseases
Structure-Function Analysis of the Non-Muscle Myosin Light Chain Kinase (nmMLCK) Isoform by NMR Spectroscopy and Molecular Modeling: Influence of MYLK Variants.
Lung Injury
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.
Lung Injury
Genes influenced by the non-muscle isoform of Myosin light chain kinase impact human cancer prognosis.
Lung Injury
Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia.
Lung Injury
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease.
Lung Injury
LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK.
Lung Injury
MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice.
Lung Injury
Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
Lung Injury
Nonmuscle myosin light chain kinase activity modulates radiation-induced lung injury.
Lung Injury
Novel role for non-muscle MLCK in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation and reactive oxygen species generation in lung endothelium.
Lung Injury
Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment.
Lung Injury
RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression.
Lung Injury
The Non Muscle Myosin Light Chain Kinase Isoform is a Viable Molecular Target in Acute Inflammatory Lung Injury.
Lung Injury
TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells.
Lung Injury
[Role of prostacyclin and thromboxane A2 in pulmonary hyper-permeability induced by mechanical ventilation in rabbits].
Lung Neoplasms
Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer.
Lymphoma
Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase.
Lymphoma, B-Cell
Deficiency of dietary pyridoxine disturbed the intestinal physical barrier function of young grass carp (Ctenopharyngodon idella).
Lymphoma, B-Cell
Dietary protein levels regulated antibacterial activity, inflammatory response and structural integrity in the head kidney, spleen and skin of grass carp (Ctenopharyngodon idella) after challenged with Aeromonas hydrophila.
Lymphoma, B-Cell
Dietary vitamin C deficiency depressed the gill physical barriers and immune barriers referring to Nrf2, apoptosis, MLCK, NF-?B and TOR signaling in grass carp (Ctenopharyngodon idella) under infection of Flavobacterium columnare.
Lymphoma, B-Cell
Effect of dietary phosphorus deficiency on the growth, immune function and structural integrity of head kidney, spleen and skin in young grass carp (Ctenopharyngodon idella).
Lymphoma, B-Cell
Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp (Ctenopharyngodon idella) after challenged with Flavobacterium columnare.
Lymphoma, B-Cell
Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella).
Melanoma
Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells.
Melanoma
Synthetic peptides corresponding to the calmodulin-binding domains of skeletal muscle myosin light chain kinase and human erythrocyte Ca2+ pump interact with and permeabilize liposomes and cell membranes.
Migraine Disorders
Effect of acupuncture at Fengchi (GB 20) on the activity of myosin light chain kinase in the middle meningeal artery of migraine modeled rats.
Moyamoya Disease
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Muscle Spasticity
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Myocardial Infarction
Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin.
Myocardial Infarction
Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction.
Myopathies, Structural, Congenital
Striated Preferentially Expressed Protein Kinase (SPEG) in Muscle Development, Function, and Disease.
myosin-light-chain kinase deficiency
Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration.
myosin-light-chain kinase deficiency
Role of non-muscle Myosin light chain kinase in neutrophil-mediated intestinal barrier dysfunction during thermal injury.
Neoplasm Metastasis
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.
Neoplasm Metastasis
Cytotoxic Effects on HL-60 Cells of Myosin Light Chain Kinase Inhibitor ML-7 Alone and in Combination with Flavonoids.
Neoplasm Metastasis
Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer.
Neoplasm Metastasis
MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial-mesenchymal transition.
Neoplasm Metastasis
MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma.
Neoplasm Metastasis
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines.
Neoplasm Metastasis
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.
Neoplasm Metastasis
[Screening of a sub-clone of human breast cancer cells with high metastasis potential]
Neoplasms
A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis.
Neoplasms
Anti-mouse CD52 monoclonal antibody ameliorates intestinal epithelial barrier function in interleukin-10 knockout mice with spontaneous chronic colitis.
Neoplasms
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.
Neoplasms
Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo.
Neoplasms
Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity.
Neoplasms
Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p.
Neoplasms
Complementary Roles of Nod2 in Hematopoietic and Nonhematopoietic Cells in Preventing Gut Barrier Dysfunction Dependent on MLCK Activity.
Neoplasms
Cytotoxic Effects on HL-60 Cells of Myosin Light Chain Kinase Inhibitor ML-7 Alone and in Combination with Flavonoids.
Neoplasms
Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells.
Neoplasms
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
Neoplasms
Dietary choline regulates antibacterial activity, inflammatory response and barrier function in the gills of grass carp (Ctenopharyngodon idella).
Neoplasms
Dietary pantothenic acid deficiency and excess depress the growth, intestinal mucosal immune and physical functions by regulating NF-?B, TOR, Nrf2 and MLCK signaling pathways in grass carp (Ctenopharyngodon idella).
Neoplasms
Dietary pantothenic acid depressed the gill immune and physical barrier function via NF-?B, TOR, Nrf2, p38MAPK and MLCK signaling pathways in grass carp (Ctenopharyngodon idella).
Neoplasms
Dual regulation of tumor necrosis factor-? on myosin light chain phosphorylation in vascular smooth muscle.
Neoplasms
Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.
Neoplasms
Effects of ??hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor.
Neoplasms
Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.
Neoplasms
Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity.
Neoplasms
Epithelial Nuclear Factor-x03BA;B Activation in Inflammatory Bowel Diseases and Colitis-Associated Carcinogenesis.
Neoplasms
Genes influenced by the non-muscle isoform of Myosin light chain kinase impact human cancer prognosis.
Neoplasms
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.
Neoplasms
Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to IBD.
Neoplasms
Host epithelial interactions with Helicobacter pylori: a role for disrupted gastric barrier function in the clinical outcome of infection?
Neoplasms
Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-?B/AMP-activated kinase/myosin light chain kinase pathway.
Neoplasms
Identification of differentially expressed genes in microsatellite stable HNPCC and sporadic colon cancer.
Neoplasms
Increased expression of myosin light chain kinase mRNA is related to metastasis in non-small cell lung cancer.
Neoplasms
Inhibition of neutrophil migration by a protein kinase inhibitor for the treatment of ischemic brain infarction.
Neoplasms
Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.
Neoplasms
Intestinal immune function, antioxidant status and tight junction proteins mRNA expression in young grass carp (Ctenopharyngodon idella) fed riboflavin deficient diet.
Neoplasms
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.
Neoplasms
Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling.
Neoplasms
Mass spectrometry based quantitative proteomics and integrative network analysis accentuates modulating roles of annexin-1 in mammary tumorigenesis.
Neoplasms
Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression.
Neoplasms
Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study.
Neoplasms
Modulation of immune response, physical barrier and related signaling factors in the gills of juvenile grass carp (Ctenopharyngodon idella) fed supplemented diet with phospholipids.
Neoplasms
Modulation of the cytoskeleton and intracellular calcium in leukocytes exhibiting a cancer-associated chemotaxis defect.
Neoplasms
MYLK and MYL9 expression in non-small cell lung cancer identified by bioinformatics analysis of public expression data.
Neoplasms
MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial-mesenchymal transition.
Neoplasms
Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1.
Neoplasms
Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis.
Neoplasms
Myosin light chain kinase is a potential target for hypopharyngeal cancer treatment.
Neoplasms
Myosin light chain kinase mediates transcellular intravasation of breast cancer cells through the underlying endothelial cells: a three-dimensional FRET study.
Neoplasms
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases.
Neoplasms
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.
Neoplasms
Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.
Neoplasms
Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase.
Neoplasms
Polygenic Profile and Exercise-Induced Muscle Damage by a Competitive Half-Ironman.
Neoplasms
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
Neoplasms
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.
Neoplasms
Tight junctions on the move: molecular mechanisms for epithelial barrier regulation.
Neoplasms
TNF-? Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-? Axis Activation of the Canonical NF-?B Pathway.
Neoplasms
Tumor necrosis factor alpha and inflammation disrupt the polarity complex in intestinal epithelial cells by a posttranslational mechanism.
Neoplasms
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter.
Neoplasms
Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells.
Neoplasms
Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance.
Neoplasms
[Screening of a sub-clone of human breast cancer cells with high metastasis potential]
Neoplastic Processes
Genes influenced by the non-muscle isoform of Myosin light chain kinase impact human cancer prognosis.
Nervous System Diseases
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
Neural Tube Defects
Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism.
Neuroinflammatory Diseases
Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.
Non-alcoholic Fatty Liver Disease
[Myosin light chain kinase involved in change of intestinal mucosal barrier function in nonalcoholic steatohepatitis mice model].
Osteosarcoma
MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma.
Ovarian Neoplasms
Methylation of MYLK3 gene promoter region: a biomarker to stratify surgical care in ovarian cancer in a multicentre study.
Pancreatic Neoplasms
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines.
Pancreatic Neoplasms
Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2.
Pancreaticobiliary Maljunction
Altered expression levels of occludin, claudin-1 and myosin light chain kinase in the common bile duct of pediatric patients with pancreaticobiliary maljunction.
Pancreaticobiliary Maljunction
Higher expression of phosphorylated myosin regulatory light chain in the common bile duct in pancreaticobiliary maljunction accompanied by bile duct dilatation in children: a post-mortem observational study.
Pancreatitis
Myosin Light Chain Kinase: A Potential Target for Treatment of Inflammatory Diseases.
Peritonitis
Myosins 1 and 6, myosin light chain kinase, actin and microtubules cooperate during antibody-mediated internalisation and trafficking of membrane-expressed viral antigens in feline infectious peritonitis virus infected monocytes.
Pheochromocytoma
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells.
Pneumonia
Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.
Pneumonia
Genes influenced by the non-muscle isoform of Myosin light chain kinase impact human cancer prognosis.
Pneumonia
Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia.
Pneumonia
Inhibition of Myosin Light-Chain Kinase Enhances the Clearance of Lipopolysaccharide-Induced Lung Inflammation Possibly by Accelerating Neutrophil Apoptosis.
Pneumonia
LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK.
Pneumonia
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
Pneumonia
Novel role for non-muscle MLCK in hyperoxia-induced recruitment of cytoskeletal proteins, NADPH oxidase activation and reactive oxygen species generation in lung endothelium.
Pneumonia
The Non Muscle Myosin Light Chain Kinase Isoform is a Viable Molecular Target in Acute Inflammatory Lung Injury.
Pneumonia
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation.
Prostatic Neoplasms
Androgens down-regulate myosin light chain kinase in human prostate cancer cells.
Prostatic Neoplasms
Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression through Modulating Mir-29a Expression.
Prostatic Neoplasms
Inhibiting myosin light chain kinase retards the growth of mammary and prostate cancer cells.
Pulmonary Disease, Chronic Obstructive
Airway structural alterations selectively associated with severe asthma.
Pulmonary Edema
Injury of cell tight junctions and changes of actin level in acute lung injury caused by the perfluoroisobutylene exposure and the role of Myosin light chain kinase.
Pulmonary Edema
[Protective effect of myosin light-chain kinase inhibitor on acute lung injury.]
Pulmonary Edema
[The effects of vitamin E and dexamethasone on inflammation of acute lung injury and expression of myosin light chain kinase]
Reperfusion Injury
Effect of the myosin light chain kinase inhibitor ML-7 on the proteome of hearts subjected to ischemia-reperfusion injury.
Reperfusion Injury
Role of calmodulin and myosin light-chain kinase in lung ischemia-reperfusion injury.
Respiratory Distress Syndrome
Epigenetic contribution of the myosin light chain kinase gene to the risk for acute respiratory distress syndrome.
Respiratory Distress Syndrome
Genetic and epigenetic regulation of the non-muscle myosin light chain kinase isoform by lung inflammatory factors and mechanical stress.
Respiratory Distress Syndrome
Genetic variation in MYLK and lung injury in children and adults with community-acquired pneumonia.
Respiratory Distress Syndrome
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
Respiratory Distress Syndrome
Sp1-mediated nonmuscle myosin light chain kinase expression and enhanced activity in vascular endothelial growth factor-induced vascular permeability.
Respiratory Distress Syndrome
The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.
Respiratory Hypersensitivity
Nonmuscle Myosin Light Chain Kinase Regulates Murine Asthmatic Inflammation.
Sarcoma
Expression of subtype-specific group 1 leiomyosarcoma markers in a wide variety of sarcomas by gene expression analysis and immunohistochemistry.
Sepsis
Identification of potential genes and miRNAs associated with sepsis based on microarray analysis.
Sepsis
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.
Sepsis
Myosin light chain kinase gene and acute lung injury in trauma and sepsis: opposite effects but confirmatory.
Sepsis
Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
Sepsis
Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma.
Shock, Septic
Interaction in endothelium of non-muscular myosin light-chain kinase and the NF-?B pathway is critical to lipopolysaccharide-induced vascular hyporeactivity.
Shock, Septic
Non-muscular myosin light chain kinase triggers intermittent hypoxia-induced interleukin-6 release, endothelial dysfunction and permeability.
Shock, Septic
Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice.
Sick Sinus Syndrome
Right Ventricular Perforation Presenting as Tingling of the Left Breast.
Sjogren's Syndrome
Right Ventricular Perforation Presenting as Tingling of the Left Breast.
Squamous Cell Carcinoma of Head and Neck
Data on the negative regulation of invadopodia activity by MLCK.
Stomach Diseases
Host epithelial interactions with Helicobacter pylori: a role for disrupted gastric barrier function in the clinical outcome of infection?
Stroke
Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.
Subarachnoid Hemorrhage
Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride.
Subarachnoid Hemorrhage
[Role of protein kinase C isozymes in cellular functions and pathological conditions]
Thrombosis
Mlck1a is expressed in zebrafish thrombocytes and is an essential component of thrombus formation.
Tics
Constitutive activation of Myosin-dependent contractility sensitizes glioma tumor-initiating cells to mechanical inputs and reduces tissue invasion.
Triple Negative Breast Neoplasms
Integrin ?1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.
Urinary Bladder Neoplasms
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
Uterine Cervical Neoplasms
Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells.
Vasospasm, Intracranial
Continuous elevation of intracellular Ca2+ is essential for the development of cerebral vasospasm.
Vasospasm, Intracranial
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Ventilator-Induced Lung Injury
Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury.
Ventilator-Induced Lung Injury
The Splicing Factor hnRNPA1 Regulates Alternate Splicing of the MYLK Gene.
Virus Diseases
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
West Nile Fever
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Whooping Cough
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
Whooping Cough
Coexpression of Y1, Y2, and Y4 receptors in smooth muscle coupled to distinct signaling pathways.
Whooping Cough
Intracellular Signal-transducing elements involved in transendothelial migration of lymphoma cells.
Whooping Cough
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
induced endocytosis is slowed by acute inhibition of MLCK and by downregulation of MLCK via RNA interference while the total amount of vesicle exocytosis and somatic Ca2+channel current does not change with MLCK down-regulation. Downregulation of MLCK prevents depolarization-induced phosphorylation of myosin light chain, an effect shared by blockers of Ca2+ channels and calmodulin. Downregulation of MLCK does not decrease the amount of exocytosis
physiological function
myosin light chain kinase (MLCK) facilitates endocytosis of synaptic vesicles at hippocampal boutons through activity-dependent phosphorylation of myosin downstream of Ca2+/calmodulin. MLCK is an important activity-dependent regulator of vesicle recycling in hippocampal neurons, which are critical for learning and memory. MLCK positively regulates vesicle endocytosis at hippocampal boutons. MLCK regulates endocytosis by functioning between Ca2+/calmodulin and myosin
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
knockdown of endogenous MLCK by two shRNA sequences: shMLCK1 is 5-GCTAGATTTGACTGCAAGATT-3' and shMLCK 2 is 5'-ACTGTCCTCTATGGCAATGAT-3'
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Li, L.; Wu, X.; Yue, H.Y.; Zhu, Y.C.; Xu, J.
Myosin light chain kinase facilitates endocytosis of synaptic vesicles at hippocampal boutons
J. Neurochem.
138
60-73
2016
Rattus norvegicus (P18666)
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Release 2023.1 (January 2023)
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