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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Danio rerio and UniProt Accession Q568I9
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2.7.11.17 Ca2+/calmodulin-dependent protein kinaseIUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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Word Map
- 2.7.11.17
- synaptic
- actin
- hippocampal
- myosin
-
camks
- autophosphorylation
- cardiac
-
postsynaptic
-
ca2+-dependent
- nmda
- pkc
-
contractile
- agonist
- synapses
- dendritic
- n-methyl-d-aspartate
- tropomyosin
-
amp-activated
- calponin
-
calmodulin-binding
-
calcium-dependent
- calcineurin
-
excitatory
- myocytes
-
l-type
- desmin
-
signal-regulated
- actomyosin
-
activity-dependent
- sarcoplasmic
- gizzard
-
presynaptic
-
element-binding
-
glutamatergic
-
actin-binding
- phosphopeptide
-
ryanodine
-
cam-binding
- phospholamban
- ca2+-calmodulin
- calmidazolium
-
nonmuscle
-
actin-activated
-
ca2+-calmodulin-dependent
- mlck
- trifluoperazine
- meromyosin
-
myosin-binding
-
ampars
-
actin-myosin
- medicine
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CAKI
-
-
-
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caldesmon
-
-
-
-
Calspermin
-
-
-
-
CAM kinase-GR
-
-
-
-
CMPK
-
-
-
-
kinase, caldesmon (phosphorylating)
-
-
-
-
kinase, microtubule-associated protein 2 (phosphorylating)
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-
-
-
MAP kinase
-
-
-
-
MAP-2 kinase
-
-
-
-
MAP-2 protein serine kinase
-
-
-
-
microtubule associated protein kinase
-
-
-
-
microtubule-associated protein 2 kinase
-
-
-
-
peripheral plasma membrane protein CaMGUK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY
141467-21-2
-
93229-57-3
-
97350-82-8
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + histone H1
ADP + phosphorylated histone H1
rat CaMKIV prefers histone H1 over myelin basic protein, while Danio rerio CaMKIV does not
-
-
?
ATP + myelin basic protein
ADP + phosphorylated myelin basic protein
rat CaMKIV prefers histone H1 over myelin basic protein, while Danio rerio CaMKIV does not
-
-
?
additional information
?
-
the C-terminal region of rat CaMKIV, which is absent from Danio rerio CaMKIV, is involved in the regulation of both its substrate specificity and its susceptibility to dephosphorylation by nuclear CaMK phosphatase
-
-
?
additional information
?
-
-
the C-terminal region of rat CaMKIV, which is absent from Danio rerio CaMKIV, is involved in the regulation of both its substrate specificity and its susceptibility to dephosphorylation by nuclear CaMK phosphatase
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
weakly expressed in the embryo at 48 and 72 hours post-fertilization stages, and strongly expressed in the embryo at 96 hours post-fertilization stage
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
the enzyme plays some roles in the embryogenesis in zebrafish
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Q568I9_DANRE
364
0
40622
TrEMBL
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
weakly expressed in the embryo at 48 and 72 hours post-fertilization stages, and strongly expressed in the embryo at the hours post-fertilization stage
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
EXTERNAL LINKS (specific for EC-Number 2.7.11.17)
Transporter Classification Database (TCDB): 8.A.104.1.12, 8.A.24.1.11
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