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EC Tree
IUBMB Comments Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
The taxonomic range for the selected organisms is: Drosophila melanogaster The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
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a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii,
more
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calcium/calmodulin-dependent protein kinase type II alpha chain
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Ca2+/calmodulin-dependent protein kinase II
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calcium-independent calcium/calmodulin-dependent protein kinase II
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calcium/calmodulin-dependent protein kinase
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calcium/calmodulin-dependent protein kinase II
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kinase, caldesmon (phosphorylating)
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kinase, microtubule-associated protein 2 (phosphorylating)
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MAP-2 protein serine kinase
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microtubule associated protein kinase
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microtubule-associated protein 2 kinase
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peripheral plasma membrane protein CaMGUK
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CAKI
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phospho group transfer
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ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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ATP + protein
ADP + phosphoprotein
autophosphorylation
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additional information
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additional information
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involved in neuroplasticity. Mutant caki flies show reduced walking speed in 'Buridan's paradigm'
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additional information
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CaM kinase II plays a role in diverse cellular processes, overview
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additional information
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CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview
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additional information
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additional information
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involved in neuroplasticity. Mutant caki flies show reduced walking speed in 'Buridan's paradigm'
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?
additional information
?
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CaM kinase II plays a role in diverse cellular processes, overview
-
-
?
additional information
?
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CaMKII is crucial for cellular and behavioral plasticity, autophosphorylation renders the enzyme independent on Ca2+ and calmodulin, which allows it to act as a molecular memory switch, CaMKII is required for memory formation of the brain in specific neurons, Ca2+-independent CaMKII mutant T287D in the adult Drosophila melanogaster CNS enhances plasticity and the training of pheromonal cues, mechanism, overview
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?
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Ca2+
activity becomes partially independent of Ca2+ after autophosphorylation
Ca2+
Ca2+/calmodulin-dependent
Ca2+
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dependent on
Ca2+
Ca2+/calmodulin-dependent
Ca2+
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the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not
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Calmodulin
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dependent on
Calmodulin
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the unphosphorylated CaMK1 is dependent on Ca2+ and calmodulin, while the autophosphorylated enzyme is not
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SwissProt
brenda
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expressed in great quantities in the central nervous system in the late embryonic stage of development
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expressed in great quantities in the central nervous system in the late embryonic stage of development
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expressed at much higher levels in the fly head than in the body
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expressed at much higher levels in the fly head than in the body
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during embryogenesis, larval and pupal life, transcription of caki is restricted almost exclusively to the central nervous system
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in the adult head, immunohistochemistry reveals Caki protein in the lamina, the neuropil of the medulla, lobula, lobula plate and in the central brain
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neuronal Ca2+/calmodulin-dependent protein kinase II is a major component in neurons
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high CaM kinase II expression, highly regulated activity in brain development
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during embryogenesis, larval and pupal life, transcription of caki is restricted almost exclusively to the central nervous system
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additional information
no differential tissue distribution of isoforms
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additional information
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CaM kinase II is ubiquitously expressed in tissues
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KCC2A_DROME
530
0
59920
Swiss-Prot
other Location (Reliability: 1 )
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phosphoprotein
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the enzyme performs Ca2+/calmodulin-dependent autophosphorylation, which renders the enzyme independent on Ca2+ and calmodulin
additional information
diversity of CaM kinase in Drosophila is generated by alternative splicing of a single gene
additional information
four forms of the enzyme generated from a single gene by alternative splicing
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T287D
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site-directed mutagenesis, the Ca2+-independent mutant expression leads to reduced viability of flies, the toxic effect can be rescued by tetracycline, expression of the mutant in brain mushroom bodies does not affect the immediate memory, overview
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CaMKII, DNA and amino acid sequence determination and analysis, gene structure and genomic organization
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Cho, K.O.; Wall, J.B.; Pugh, P.C.; Ito, M.; Mueller, S.A.; Kennedy, M.B.
The alpha subunit of type II Ca2+/calmodulin-dependent protein kinase is highly conserved in Drosophila
Neuron
7
439-450
1991
Drosophila melanogaster (Q00168)
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Griffith, L.C.; Greenspan, R.J.
The diversity of calcium/calmodulin-dependent protein kinase II isoforms in Drosophila is generated by alternative splicing of a single gene
J. Neurochem.
61
1534-1537
1993
Drosophila melanogaster (Q00168)
brenda
Ohsako, S.; Nishida, Y.; Ryo, H.; Yamauchi, T.
Molecular characterization and expression of the Drosophila Ca2+/calmodulin-dependent protein kinase II gene. Identification of four forms of the enzyme generated from a single gene by alternative splicing
J. Biol. Chem.
268
2052-2062
1993
Drosophila melanogaster (Q00168)
brenda
Dimitratos, S.D.; Woods, D.F.; Bryant, P.J.
Camguk, Lin-2, and CASK: novel membrane-associated guanylate kinase homologs that also contain CaM kinase domains
Mech. Dev.
63
127-130
1997
Drosophila melanogaster (Q24210)
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Martin, J.R.; Ollo, R.
A new Drosophila Ca2+/calmodulin-dependent protein kinase (Caki) is localized in the central nervous system and implicated in walking speed
EMBO J.
15
1865-1876
1996
Drosophila melanogaster (Q24210)
brenda
Yamauchi, T.
Neuronal Ca2+/calmodulin-dependent protein kinase II - discovery, progress in a quarter of a century, and perspective: implication for learning and memory
Biol. Pharm. Bull.
28
1342-1354
2005
Drosophila melanogaster, Rattus norvegicus
brenda
Mehren, J.E.; Griffith, L.C.
Calcium-independent calcium/calmodulin-dependent protein kinase II in the adult Drosophila CNS enhances the training of pheromonal cues
J. Neurosci.
24
10584-10593
2004
Drosophila melanogaster
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