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ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation of Ca2+/calmodulin-dependent protein kinase II converts the enzyme to a Ca2+-independent form, autophosphorylation site is Thr286 in the alpha subunit
-
-
?
ATP + protein kinase G
ADP + phosphorylated protein kinase G
-
-
-
?
ATP + 40S-ribosomal protein S6
?
-
rat brain
-
-
?
ATP + Akt
ADP + phosphorylated Akt
-
substrate of CaM-KII, phosphorylation at Thr308
-
-
?
ATP + Bcl10
ADP + phosphorylated Bcl10
-
phosphorylation by CaMKII at Ser138, recombinant FLAG-tagged Bcl10 substrate expressed in HEK-293T cells
-
-
?
ATP + beta-Pak-interacting exchange factor
ADP + phosphorylated beta-Pak-interacting exchange factor
beta-Pak-interacting exchange factor is phosphorylated at Ser156
-
-
?
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
i.e. CREB, phosphorylation by CaMK II at Ser133
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
ATP + casein
?
-
rat brain
-
-
?
ATP + CREB
ADP + phosphorylated CREB
-
i.e. cAMP-response element binding protein, substrate of CaM-KI, phosphorylation at Ser133
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
ATP + estrogen-receptor from calf uterus
?
-
-
-
-
?
ATP + GABA A receptor
ADP + phosphorylated GABA A receptor
-
-
-
-
?
ATP + GABA-modulin
?
-
-
-
-
?
ATP + glycogen synthase
?
-
rat brain
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
-
the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
ATP + I-kappaB
ADP + phosphorylated I-kappaB
ATP + MAP2
ADP + phosphorylated MAP2
-
-
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
ATP + microtubule associated protein 2
ADP + phosphorylated microtubule associated protein 2
-
-
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
ATP + microtubule-associated protein tau
?
ATP + myelin basic protein
?
ATP + myosin light chain
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
ATP + NHE-1
ADP + phosphorylated NHE-1
ATP + PC12 pheochromacytoma cell line protein substrate pp250
?
-
-
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
ATP + PLN
ADP + phosphorylated PLN
ATP + PLRRTLSVAA-amide
ADP + phosphorylated PLRRTLSVAA-amide
-
glycogen synthase-derived peptide GSP
-
-
?
ATP + protein
ADP + phosphoprotein
ATP + protein CREB
ADP + phosphorylated protein CREB
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
ATP + ryanodine receptor type 2
ADP + phosphorylated ryanodine receptor type 2
-
-
-
-
?
ATP + synapsin
?
-
rat brain
-
-
?
ATP + synapsin
ADP + phosphorylated synapsin
-
-
-
-
?
ATP + synapsin I
ADP + phosphorylated synapsin I
-
substrate of CaM-KI
-
-
?
ATP + synapsin II
ADP + phosphorylated synapsin II
-
substrate of CaM-KI
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
ATP + syntide-2
ADP + phosphorylated syntide-2
a peptide substrate
-
-
?
ATP + tau peptide 408-420
ADP + phosphorylated tau peptide 408-420
-
recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
ATP + vimentin
?
-
rat brain
-
-
?
ATP + voltage-gated calcium channel beta1b subunit
ADP + phosphorylated voltage-gated calcium channel beta1b subunit
-
-
-
?
ATP + voltage-gated calcium channel beta2a subunit
ADP + phosphorylated voltage-gated calcium channel beta2a subunit
CaMKII phosphorylates at Thr498
-
-
?
ATP + voltage-gated calcium channel beta3 subunit
ADP + phosphorylated voltage-gated calcium channel beta3 subunit
-
-
-
?
ATP + voltage-gated calcium channel beta4 subunit
ADP + phosphorylated voltage-gated calcium channel beta4 subunit
-
-
-
?
ATP + YLRRRLSDSNF
ADP + ?
synapsin site I-derived peptide substrate
-
-
?
additional information
?
-
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
-
i.e. CREB, CaM kinase II, as part of the Ca2+ and CaMK signaling cascade, regulates the phosphorylation of CREB of spinal cord in rats following noxious stimulation, e.g. by capsaicin injection
-
-
?
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
-
i.e. CREB, phosphorylation at Ser133
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
-
the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
-
a nuclear splicing isoform of Dp71, several potential sites for phosphorylation
-
-
?
ATP + histone
?
-
H1 (best substrate)
-
-
?
ATP + histone
?
-
V-S
-
-
?
ATP + histone
?
-
5S, 6S, 7S
-
-
?
ATP + histone
?
-
3S
-
-
?
ATP + histone
?
-
8S
-
-
?
ATP + histone
?
-
not: 2AS
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
-
the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
-
the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
-
CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
-
i.e. MARK2, recombinant myc-tagged MARK2 expressed in HEK-293 cells, mutational determination of phosphorylation sites, overview
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
as good as myelin basic protein
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
rat brain: broad specificity
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
ATP preferred to GTP
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
not MAP-1
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
phosphorylation sites are serine and threonine
-
-
?
ATP + microtubule-associated protein 2
ADP + microtubule-associated protein 2 phosphate
-
i.e. MAP-2, preferred substrate
-
-
?
ATP + microtubule-associated protein tau
?
-
-
-
-
?
ATP + microtubule-associated protein tau
?
-
Ca2+/calmodulin dependent autophosphorylation
-
-
?
ATP + microtubule-associated protein tau
?
-
all 4 tau-species, but about 50% of tau1 and tau2 protein remains resistant to phosphorylation
-
-
?
ATP + myelin basic protein
?
-
-
-
-
?
ATP + myelin basic protein
?
-
best substrate
-
-
?
ATP + myelin basic protein
?
-
phosphorylation sites: serine
-
-
?
ATP + myelin basic protein
?
-
phosphorylation sites: threonine
-
-
?
ATP + myosin light chain
?
-
poor
-
-
?
ATP + myosin light chain
?
-
smooth-muscle, myosin, rat brain
-
-
?
ATP + myosin light chain
?
-
smooth-muscle, cardiac
-
-
?
ATP + myosin light chain
?
-
smooth-muscle, skeletal muscle
-
-
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
-
phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV
-
-
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
-
phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV, determination of phosphorylation sites by analytical SDS-PAGE
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
-
phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
-
a Na+-H+-exchanging protein, phosphorylation by CaMKII at the intracellular cytoplasmic domain
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
-
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation by CaMKII activates the sarcoplasmic reticulum Ca2+-ATPase, increasing both the rate of Ca2+ clearance from the myoplasm and the frequency of localized Ca2+ release events from intracellular stores
-
-
?
ATP + PLN
ADP + phosphorylated PLN
-
phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition
-
-
?
ATP + PLN
ADP + phosphorylated PLN
-
a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation
-
-
?
ATP + protein
ADP + phosphoprotein
autophosphorylation at Thr177
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
-
CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
-
i.e. cyclic AMP-response element binding protein
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
-
-
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
-
the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
-
regulation and activation of the neuron-specific Ras GTPase-activating protein, synGAP, by phosphorylation through CaMKII in the postsynaptic density fraction of the forebrain, synGAP is part of the signaling complex attached to the cytoplasmic tail of the N-methyl-D-aspartate-type glutamate receptor, overview
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
-
activation of the neuron-specific Ras GTPase-activating protein, synGAP, by phosphorylation through CaMKII at Ser1123, Ser1058, Ser750, Ser751, Ser756, Ser764, and Ser/65, reduced activity with synGAP serines phosphorylation site mutants, determination of phosphorylation sites by mass spectrometry, overview
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26
-
-
?
ATP + tubulin
?
-
-
-
-
?
ATP + tubulin
?
-
rat brain
-
-
?
additional information
?
-
the enzyme is proposed to play a variety of important roles in brain function
-
-
?
additional information
?
-
Thr286-autophosphorylation is antagonistic to CaMKII clustering
-
-
?
additional information
?
-
-
poor or no substrates are kinesin, myosin I, phosvitin, ATP-citrate lyase
-
-
?
additional information
?
-
-
cytoskeletal proteins, e.g. vinculin, filamin, fodrin or neurofilament protein
-
-
?
additional information
?
-
-
phosphorylase b
-
-
?
additional information
?
-
-
no substrates are protamine
-
-
?
additional information
?
-
-
no substrates are protamine
-
-
?
additional information
?
-
-
calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview
-
-
?
additional information
?
-
-
CaM kinase II plays a role in diverse cellular processes, the neuronal CaM kinase II is involved in neurotransmitter synthesis and release, modulation of ion cannel activity, cellular transport, cell morphology, regulation of cytoskeleton, and neurite extension, synaptic plasticity, learning and memory, overview, CaM kinase II is involved in memory storage, functional characterization and mechanism, overview, CaMKII is involved in Ca2+-dependent regulation of tyrosine hydroxylase and tryptophan hydroxylase in catecholamin and serotonin biosynthesis, and regulation of monoamine biosynthesis in the brain, CaMKII is involved in PSD in the postsynaptic space, functional analysis including the ion channel activity regulation, e.g. of the NMDA receptor and its NR2B subunit, the glutamate receptor, and the AMPA receptor, and postsynaptic signaling, overview
-
-
?
additional information
?
-
-
CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview
-
-
?
additional information
?
-
CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations
-
-
?
additional information
?
-
-
CaMKII Ca2+/calmodulin-dependently potentiates ATP responses by promoting trafficking of P2X3 receptors, electrical stimulation of dorsal root ganglion neurons or the sciatic nerve enhances the CaMKII-dependent receptor expression in membranes, overview
-
-
?
additional information
?
-
-
CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview
-
-
?
additional information
?
-
-
CaMKII is involved in calcium signaling, synaptic plasticity, learning, and memory, CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning
-
-
?
additional information
?
-
-
CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview
-
-
?
additional information
?
-
-
CASK in inhibited by the plasma membrane Ca2+ pump 4b/CI, PMCA4b, via direct interaction with the C-terminus of the Ca2+ transporter
-
-
?
additional information
?
-
-
glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites
-
-
?
additional information
?
-
-
isozyme CaMKIIdelta3 is involved in the expression of brain-derive neurotrophic factor, BDNF, in the substantia nigra
-
-
?
additional information
?
-
-
the phosphatidylinositol-linked dopamine receptor is involved in regulation of CaMK II enzyme activity in the brain
-
-
?
additional information
?
-
-
Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview
-
-
?
additional information
?
-
-
CaMKII is a multifunctional enzyme
-
-
?
additional information
?
-
-
CaMKII performs autophosphorylation
-
-
?
additional information
?
-
-
CaMKII performs autophosphorylation at Thr286
-
-
?
additional information
?
-
-
isozyme-selective CaMKII binding sequence for interaction with ligand proteins, overview
-
-
?
additional information
?
-
-
CaMKI isozymes play distinct roles in hippocampal dendritic growth and neuronal development, overview
-
-
?
additional information
?
-
-
CaMKII is involved in phorbol ester/ionomycin-induced NFkappaB activation, overview
-
-
?
additional information
?
-
-
CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview
-
-
?
additional information
?
-
-
CaMKII kinase modulates PC12 cell neuronal differentiation
-
-
?
additional information
?
-
-
CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview
-
-
?
additional information
?
-
-
isozyme CaMKIIdelta regulates cell proliferation of vascular smooth muscle cells, overview
-
-
?
additional information
?
-
-
N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview
-
-
?
additional information
?
-
-
the enzyme performs autophosphorylation at Thr286 activating the enzyme activity, and at Thr305/Thr306, which inhibits calmodulin binding and enzyme activation
-
-
?
additional information
?
-
-
autophosphorylation is not dependent on calmodulin and Ca2+
-
-
?
additional information
?
-
activated/autophosphorylated CaMKII does not bind to voltage-gated calcium channel subunits beta3 or beta4 subunits
-
-
?
additional information
?
-
CaMKIIgamma G2 autophosphorylates in the presence of Ca2+/calmodulin and ATP
-
-
?
additional information
?
-
small C-terminal domain phosphatase-3 dephosphorylates CaMKIIgamma G2, the dephosphorylation is site-specific, excluding the Thr287 associated with Ca2+/calmodulin-independent activation of the kinase, as a result the autonomous activity of CaMKIIgamma G-2 is not affected by the phosphatase activity of small C-terminal domain phosphatase-3
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ATP + cAMP response element-binding protein
ADP + phosphorylated cAMP response element-binding protein
-
i.e. CREB, phosphorylation by CaMK II at Ser133
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133
-
-
?
ATP + cAMP-responsive element-binding protein
ADP + phosphorylated cAMP-responsive element-binding protein
-
i.e. CREB, CaM kinase II, as part of the Ca2+ and CaMK signaling cascade, regulates the phosphorylation of CREB of spinal cord in rats following noxious stimulation, e.g. by capsaicin injection
-
-
?
ATP + dystrophin Dp71d
ADP + phosphorylated dystrophin Dp71d
-
the phosphorylation process involves protein kinase C, EC 2.7.11.13, CAMKII-mediated phosphorylation modulates the Dp71 nuclear localization
-
-
?
ATP + histone deacetylase 4
ADP + phosphorylated histone deacetylase 4
-
the enzyme may facilitate transcription factor activities by the neutralization of histone deacetylase 4 by phosphorylation, which may contribute to the phenotypic plasticity of gastrointestinal smooth muscle cells
-
-
?
ATP + human cardiac sodium channel NaV1.5
ADP + phosphorylated human cardiac sodium channel NaV1.5
-
the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5
-
-
?
ATP + I-kappaB
ADP + phosphorylated I-kappaB
-
substrate of CaM-KII in T-lymphocytes and neurons, phosphorylation leads to activation of I-kappa B, which mediates activation of NF-kappaB
-
-
?
ATP + MAP2
ADP + phosphorylated MAP2
-
-
-
-
?
ATP + microtubule affinity regulating kinase 2
ADP + phosphorylated microtubule affinity regulating kinase 2
-
CaMKIalpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth/axonal extension
-
-
?
ATP + neuronal nitric-oxide synthase
ADP + phosphorylated neuronal nitric-oxide synthase
-
phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV
-
-
?
ATP + NHE-1
ADP + phosphorylated NHE-1
-
phosphorylation by CaMKII is regulated by phosphatase PP1 which is associated with the exchanger
-
-
?
ATP + phospholamban
ADP + phosphorylated phospholamban
-
phosphorylation by CaMKII activates the sarcoplasmic reticulum Ca2+-ATPase, increasing both the rate of Ca2+ clearance from the myoplasm and the frequency of localized Ca2+ release events from intracellular stores
-
-
?
ATP + PLN
ADP + phosphorylated PLN
-
phosphorylation contributes to mechanical recovery from acidosis by inhibiting SERCA2a inhibition
-
-
?
ATP + protein CREB
ADP + phosphorylated protein CREB
-
CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
-
-
?
ATP + Raf-1 protein
ADP + phosphorylated Raf-1 protein
-
the enzyme phosphorylates Raf-1 at Ser338 and mediates Ras-stimulated Raf-1 activation
-
-
?
ATP + synapsin
ADP + phosphorylated synapsin
-
-
-
-
?
ATP + synGAP
ADP + phosphorylated synGAP
-
regulation and activation of the neuron-specific Ras GTPase-activating protein, synGAP, by phosphorylation through CaMKII in the postsynaptic density fraction of the forebrain, synGAP is part of the signaling complex attached to the cytoplasmic tail of the N-methyl-D-aspartate-type glutamate receptor, overview
-
-
?
ATP + tau protein
ADP + phosphorylated tau protein
-
phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development
-
-
?
additional information
?
-
additional information
?
-
the enzyme is proposed to play a variety of important roles in brain function
-
-
?
additional information
?
-
-
calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview
-
-
?
additional information
?
-
-
CaM kinase II plays a role in diverse cellular processes, the neuronal CaM kinase II is involved in neurotransmitter synthesis and release, modulation of ion cannel activity, cellular transport, cell morphology, regulation of cytoskeleton, and neurite extension, synaptic plasticity, learning and memory, overview, CaM kinase II is involved in memory storage, functional characterization and mechanism, overview, CaMKII is involved in Ca2+-dependent regulation of tyrosine hydroxylase and tryptophan hydroxylase in catecholamin and serotonin biosynthesis, and regulation of monoamine biosynthesis in the brain, CaMKII is involved in PSD in the postsynaptic space, functional analysis including the ion channel activity regulation, e.g. of the NMDA receptor and its NR2B subunit, the glutamate receptor, and the AMPA receptor, and postsynaptic signaling, overview
-
-
?
additional information
?
-
-
CaM-Ks are involved in cell cycle regulation and centrosome replication, as well as in development of cancer via calmodulin activity, overview, CaM-KI is involved in CDK4/cyclin D1 activity in fibroblasts, CaM-KIV induces CREB-dependent transcription, regulation mechanism, overview, CaM-kinase signaling pathways, it plays a role in anti-apoptotic signaling, overview
-
-
?
additional information
?
-
CaMKIgamma is involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal populations
-
-
?
additional information
?
-
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CaMKII Ca2+/calmodulin-dependently potentiates ATP responses by promoting trafficking of P2X3 receptors, electrical stimulation of dorsal root ganglion neurons or the sciatic nerve enhances the CaMKII-dependent receptor expression in membranes, overview
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CaMKII is a critical Ca2+ signaling transducer, CaMKII isozyme have special roles in regulating cardiac function determined by their subcellular localization, nuclear CaMKIIdeltaB plays a key role in hypertrophic gene expression, cytosolic CaMKIIdeltaC can affect excitation-contraction-coupling through phosphorylation of Ca2+-regulatory proteins and may introduce signals leading to apoptosis, CaMKII is involved in cardiac hypertrophy and heart failure, signaling pathways, overview, CaMK is involved in regulation of various transcription factors and other DNA-binding proteins, overview
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CaMKII is involved in calcium signaling, synaptic plasticity, learning, and memory, CaMKII activity and expression are altered in the hippocampus of Pb2+-exposed rats, reaction velocity is reduced by 41% and substrate affinity is increased by 22%, the rats exhibit deficits in hippocampal log-term potentiation and spatial learning
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CaMKII is reversibly, Ca2+/calmodulin-independently autophosphorylated at Thr286alpha and Thr287beta with inhibitory effect, inactivated and made sedimentable by acute neuronal excitation in rats in vivo, regulation, overview
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CASK in inhibited by the plasma membrane Ca2+ pump 4b/CI, PMCA4b, via direct interaction with the C-terminus of the Ca2+ transporter
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glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites
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isozyme CaMKIIdelta3 is involved in the expression of brain-derive neurotrophic factor, BDNF, in the substantia nigra
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the phosphatidylinositol-linked dopamine receptor is involved in regulation of CaMK II enzyme activity in the brain
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Thr286-autophosphorylated CaMKII is associated with CaMKII-binding proteins densin-180, the N-methyl-D-aspartate receptor NR2B subunit, and alpha-actinin-2 in postsynaptic density-enriched rat brain fractions, the proteins influence each other in binding to CaMKII, interaction of binding proteins with CaMKII splicing variants, overview
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CaMKI isozymes play distinct roles in hippocampal dendritic growth and neuronal development, overview
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CaMKII is involved in phorbol ester/ionomycin-induced NFkappaB activation, overview
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CaMKII isozymes have distinct cellular localizations and function, overview, release of acetylcholine from dual transmitting sympathetic neurons requires activation of both the p75 receptor and activated CaMKII, model for neurotrophin-dependent modulation of cholinergic transmission, neurotrophins can influence CaMKII signaling by regulating the production of CaMKII protein and/or by changing the level of CaMKII activation, overview
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CaMKII kinase modulates PC12 cell neuronal differentiation
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CaMKII signaling, overview, CaMKII is essential in the increasing of Ca2+ transient amplitude and production of mechanical contractile recovery from acidosis, two mechanisms, overview
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isozyme CaMKIIdelta regulates cell proliferation of vascular smooth muscle cells, overview
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N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview
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autophosphorylation is not dependent on calmodulin and Ca2+
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Schulman, H.; Kuret, J.; Bennett Jefferson, A.; Nose, P.S.; Spitzer, K.H.
Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues
Biochemistry
24
5320-5327
1985
Aplysia californica, Rattus norvegicus
brenda
Schanen, N.C.; Landreth, G.
Isolation and characterization of microtubule-associated protein 2 (MAP2) kinase from rat brain
Mol. Brain Res.
14
43-50
1992
Rattus norvegicus
brenda
Baudier, J.; Cole, R.D.
Phosphorylation of tau proteins to a state like that in Alzheimers brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids
J. Biol. Chem.
262
17577-17583
1987
Bos taurus, Rattus norvegicus
brenda
Boulton, T.G.; Gregory, J.S.; Cobb, M.H.
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
Biochemistry
30
278-286
1991
Rattus norvegicus
brenda
Hoshi, M.; Nishida, E.; Sakai, H.
Characterization of a mitogen-activated, Ca2+-sensitive microtubule-associated protein-2 kinase
Eur. J. Biochem.
184
477-486
1989
Rattus norvegicus
brenda
Tokumitsu, H.; Enslen, H.; Soderling, T.R.
Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase
J. Biol. Chem.
270
19320-19324
1995
Rattus norvegicus (P97756)
brenda
Bennett, M.K.; Kennedy, M.B.
Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning
Proc. Natl. Acad. Sci. USA
84
1794-1798
1987
Rattus norvegicus (P08413)
brenda
Hanley, R.M.; Means, A.R.; Ono, T.; Kemp, B.E.; Burgin, K.E.; Waxham, N.; Kelly, P.T.
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II
Science
237
293-297
1987
Rattus norvegicus (P11275)
brenda
Lin, C.R.; Kapiloff, M.S.; Durgerian, S.; Tatemoto, K.; Russo, A.F.; Hanson, P.; Schulman, H.; Rosenfeld, M.G.
Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase
Proc. Natl. Acad. Sci. USA
84
5962-5966
1987
Rattus norvegicus (P11275)
brenda
Sunyer, T.; Sahyoun, N.
Sequence analysis and DNA-protein interactions within the 5' flanking region of the Ca2+/calmodulin-dependent protein kinase II alpha-subunit gene
Proc. Natl. Acad. Sci. USA
87
278-282
1990
Rattus norvegicus (P11275)
brenda
Thiel, G.; Czernik, A.J.; Gorelick, F.; Nairn, A.C.; Greengard, P.
Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity
Proc. Natl. Acad. Sci. USA
85
6337-6341
1988
Rattus norvegicus (P11275)
brenda
Tobimatsu, T.; Kameshita, I.; Fujisawa, H.
Molecular cloning of the cDNA encoding the third polypeptide (gamma) of brain calmodulin-dependent protein kinase II
J. Biol. Chem.
263
16082-16086
1988
Rattus norvegicus (P11730)
brenda
Zhou, Z.L.; Ikebe, M.
New isoforms of Ca2+/calmodulin-dependent protein kinase II in smooth muscle
Biochem. J.
299
489-495
1994
Rattus norvegicus (P11730)
-
brenda
Means, A.R.; Cruzalegui, F.; LeMagueresse, B.; Needleman, D.S.; Slaughter, G.R.; Ono, T.
A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene
Mol. Cell. Biol.
11
3960-3971
1991
Rattus norvegicus (P13234)
brenda
Ohmstede, C.A.; Jensen, K.F.; Sahyoun, N.E.
Ca2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase
J. Biol. Chem.
264
5866-5875
1989
Rattus norvegicus (P13234)
brenda
Ohmstede, C.A.; Bland, M.M.; Merrill, B.M.; Sahyoun, N.
Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: a gene within a gene
Proc. Natl. Acad. Sci. USA
88
5784-5788
1991
Rattus norvegicus (P13234)
brenda
Ono, T.; Slaughter, G.R.; Cook, R.G.; Means, A.R.
Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin-binding protein
J. Biol. Chem.
264
2081-2087
1989
Rattus norvegicus (P13234)
brenda
Sun, Z.; Means, R.L.; LeMagueresse, B.; Means, A.R.
Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene
J. Biol. Chem.
270
29507-29514
1995
Rattus norvegicus (P13234)
brenda
Schworer, C.M.; Rothblum, L.I.; Thekkumkara, T.J.; Singer, H.A.
Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta
J. Biol. Chem.
268
14443-14449
1993
Rattus norvegicus (P15791)
brenda
Tobimatsu, T.; Fujisawa, H.
Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs
J. Biol. Chem.
264
17907-17912
1989
Rattus norvegicus (P15791)
brenda
Cho, F.S.; Phillips, K.S.; Bogucki, B.; Weaver, T.E.
Characterization of a rat cDNA clone encoding calcium/calmodulin-dependent protein kinase I
Biochim. Biophys. Acta
1224
156-160
1994
Rattus norvegicus (Q63450)
brenda
Goldberg, J.; Nairn, A.C.; Kuriyan, J.
Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I
Cell
84
875-887
1996
Rattus norvegicus (Q63450)
brenda
Picciotto, M.R.; Czernik, A.J.; Nairn, A.C.
Calcium/calmodulin-dependent protein kinase I. cDNA cloning and identification of autophosphorylation site
J. Biol. Chem.
268
26512-26521
1993
Rattus norvegicus (Q63450)
brenda
Yamauchi, T.
Neuronal Ca2+/calmodulin-dependent protein kinase II - discovery, progress in a quarter of a century, and perspective: implication for learning and memory
Biol. Pharm. Bull.
28
1342-1354
2005
Drosophila melanogaster, Rattus norvegicus
brenda
Toscano, C.D.; O'Callaghan, J.P.; Guilarte, T.R.
Calcium/calmodulin-dependent protein kinase II activity and expression are altered in the hippocampus of Pb2+-exposed rats
Brain Res.
1044
51-58
2005
Rattus norvegicus
brenda
Zhang, T.; Brown, J.H.
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Cardiovasc. Res.
63
476-486
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
brenda
Rodriguez-Mora, O.; LaHair, M.M.; Howe, C.J.; McCubrey, J.A.; Franklin, R.A.
Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy
Expert Opin. Ther. Targets
9
791-808
2005
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Song, T.; Hatano, N.; Horii, M.; Tokumitsu, H.; Yamaguchi, F.; Tokuda, M.; Watanabe, Y.
Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation
FEBS Lett.
570
133-137
2004
Rattus norvegicus
brenda
Takemoto-Kimura, S.; Terai, H.; Takamoto, M.; Ohmae, S.; Kikumura, S.; Segi, E.; Arakawa, Y.; Furuyashiki, T.; Narumiya, S.; Bito, H.
Molecular cloning and characterization of CLICK-III/CaMKIg, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK)
J. Biol. Chem.
278
18597-18605
2003
Rattus norvegicus, Mus musculus (Q91VB2), Homo sapiens (Q96NX5)
brenda
Schuh, K.; Uldrijan, S.; Gambaryan, S.; Roethlein, N.; Neyses, L.
Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK
J. Biol. Chem.
278
9778-9783
2003
Rattus norvegicus
brenda
Oh, J.S.; Manzerra, P.; Kennedy, M.B.
Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II
J. Biol. Chem.
279
17980-17988
2004
Rattus norvegicus
brenda
Robison, A.J.; Bass, M.A.; Jiao, Y.; MacMillan, L.B.; Carmody, L.C.; Bartlett, R.K.; Colbran, R.J.
Multivalent interactions of calcium/calmodulin-dependent protein kinase II with the postsynaptic density proteins NR2B, densin-180, and alpha-actinin-2
J. Biol. Chem.
280
35329-35336
2005
Mus musculus, Rattus norvegicus, Sus scrofa, Xenopus laevis
brenda
Nishimura, H.; Sakagami, H.; Uezu, A.; Fukunaga, K.; Watanabe, M.; Kondo, H.
Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase Ig in the rat brain
J. Neurochem.
85
1216-1227
2003
Rattus norvegicus (Q7TNJ7)
brenda
Yamagata, Y.; Obata, K.
Ca2+/calmodulin-dependent protein kinase II is reversibly autophosphorylated, inactivated and made sedimentable by acute neuronal excitation in rats in vivo
J. Neurochem.
91
745-754
2004
Rattus norvegicus
brenda
Yamamoto, H.; Hiragami, Y.; Murayama, M.; Ishizuka, K.; Kawahara, M.; Takashima, A.
Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain
J. Neurochem.
94
1438-1447
2005
Homo sapiens, Rattus norvegicus
brenda
Kamata, A.; Takeuchi, Y.; Fukunaga, K.
Identification of the isoforms of Ca2+/calmodulin-dependent protein kinase II and expression of brain-derived neurotrophic factor mRNAs in the substantia nigra
J. Neurochem.
96
195-203
2006
Rattus norvegicus
brenda
Schmitt, J.M.; Guire, E.S.; Saneyoshi, T.; Soderling, T.R.
Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation
J. Neurosci.
25
1281-1290
2005
Mus musculus, Rattus norvegicus
brenda
Hudmon, A.; Lebel, E.; Roy, H.; Sik, A.; Schulman, H.; Waxham, M.N.; De Koninck, P.
A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association
J. Neurosci.
25
6971-6983
2005
Rattus norvegicus
brenda
Zhen, X.; Goswami, S.; Abdali, S.A.; Gil, M.; Bakshi, K.; Friedman, E.
Regulation of cyclin-dependent kinase 5 and calcium/calmodulin-dependent protein kinase II by phosphatidylinositol-linked dopamine receptor in rat brain
Mol. Pharmacol.
66
1500-1507
2004
Rattus norvegicus
brenda
Fang, L.; Wu, J.; Zhang, X.; Lin, Q.; Willis, W.D.
Calcium/calmodulin dependent protein kinase II regulates the phosphorylation of cyclic AMP-responsive element-binding protein of spinal cord in rats following noxious stimulation
Neurosci. Lett.
374
1-4
2005
Rattus norvegicus
brenda
Xu, G.Y.; Huang, L.Y.
Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors
Proc. Natl. Acad. Sci. USA
101
11868-11873
2004
Rattus norvegicus
brenda
House, S.J.; Ginnan, R.G.; Armstrong, S.E.; Singer, H.A.
Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation
Am. J. Physiol. Cell Physiol.
292
C2276-C2287
2007
Rattus norvegicus
brenda
Robison, A.J.; Winder, D.G.; Colbran, R.J.; Bartlett, R.K.
Oxidation of calmodulin alters activation and regulation of CaMKII
Biochem. Biophys. Res. Commun.
356
97-101
2007
Rattus norvegicus
brenda
Takeda, H.; Kitaoka, Y.; Hayashi, Y.; Kumai, T.; Munemasa, Y.; Fujino, H.; Kobayashi, S.; Ueno, S.
Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity
Brain Res.
1184
306-3015
2007
Rattus norvegicus
brenda
Mattiazzi, A.; Vittone, L.; Mundina-Weilenmann, C.
Ca2+/calmodulin-dependent protein kinase: a key component in the contractile recovery from acidosis
Cardiovasc. Res.
73
648-656
2007
Rattus norvegicus
brenda
Calderilla-Barbosa, L.; Ortega, A.; Cisneros, B.
Phosphorylation of dystrophin Dp71d by Ca2+/calmodulin-dependent protein kinase II modulates the Dp71d nuclear localization in PC12 cells
J. Neurochem.
98
713-722
2006
Rattus norvegicus
brenda
Uboha, N.V.; Flajolet, M.; Nairn, A.C.; Picciotto, M.R.
A calcium- and calmodulin-dependent kinase Ialpha/microtubule affinity regulating kinase 2 signaling cascade mediates calcium-dependent neurite outgrowth
J. Neurosci.
27
4413-4423
2007
Rattus norvegicus
brenda
Ishiguro, K.; Ando, T.; Goto, H.; Xavier, R.
Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II
Mol. Immunol.
44
2095-2100
2007
Rattus norvegicus
brenda
Kamata, A.; Sakagami, H.; Tokumitsu, H.; Owada, Y.; Fukunaga, K.; Kondo, H.
Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth
Neurosci. Res.
57
86-97
2007
Mus musculus, Rattus norvegicus
brenda
Slonimsky, J.D.; Mattaliano, M.D.; Moon, J.I.; Griffith, L.C.; Birren, S.J.
Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission
Proc. Natl. Acad. Sci. USA
103
2915-2919
2006
Mus musculus, Rattus norvegicus
brenda
Said, M.; Becerra, R.; Palomeque, J.; Rinaldi, G.; Kaetzel, M.A.; Diaz-Sylvester, P.L.; Copello, J.A.; Dedman, J.R.; Mundina-Weilenmann, C.; Vittone, L.; Mattiazzi, A.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II
Am. J. Physiol. Heart Circ. Physiol.
295
H1669-H1683
2008
Rattus norvegicus
brenda
Chen, G.D.; Peng, M.L.; Wang, P.Y.; Lee, S.D.; Chang, H.M.; Pan, S.F.; Chen, M.J.; Tung, K.C.; Lai, C.Y.; Lin, T.B.
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
Am. J. Physiol. Regul. Integr. Comp. Physiol.
294
R487-R493
2008
Rattus norvegicus (P11275)
brenda
Gangopadhyay, S.S.; Gallant, C.; Sundberg, E.J.; Lane, W.S.; Morgan, K.G.
Regulation of Ca2+/calmodulin kinase II by a small C-terminal domain phosphatase
Biochem. J.
412
507-516
2008
Rattus norvegicus (P11730)
brenda
Grueter, C.E.; Abiria, S.A.; Wu, Y.; Anderson, M.E.; Colbran, R.J.
Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits
Biochemistry
47
1760-1767
2008
Rattus norvegicus (P15791)
brenda
Wang, P.; Wang, W.P.; Sun-Zhang, W.P.; Wang, H.X.; Yan-Lou, H.X.; Fan, Y.H.
Impaired spatial learning related with decreased expression of calcium/calmodulin-dependent protein kinase IIalpha and cAMP-response element binding protein in the pentylenetetrazol-kindled rats
Brain Res.
1238
108-117
2008
Rattus norvegicus (P11275)
brenda
Yousif, M.H.; Akhtar, S.; Walther, T.; Benter, I.F.
Role of Ca2+/calmodulin-dependent protein kinase II in development of vascular dysfunction in diabetic rats with hypertension
Cell Biochem. Funct.
26
256-263
2008
Rattus norvegicus
brenda
Grant, P.A.; Best, S.L.; Sanmugalingam, N.; Alessio, R.; Jama, A.M.; Toeroek, K.
A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons
Cell Calcium
44
465-478
2008
Rattus norvegicus (P11275)
brenda
Houston, C.M.; Hosie, A.M.; Smart, T.G.
Distinct regulation of beta2 and beta3 subunit-containing cerebellar synaptic GABAA receptors by calcium/calmodulin-dependent protein kinase II
J. Neurosci.
28
7574-7584
2008
Rattus norvegicus
brenda
Saneyoshi, T.; Wayman, G.; Fortin, D.; Davare, M.; Hoshi, N.; Nozaki, N.; Natsume, T.; Soderling, T.R.
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex
Neuron
57
94-107
2008
Rattus norvegicus (Q63450)
brenda
Perrino, B.A.
Regulation of gastrointestinal motility by Ca2+/calmodulin-stimulated protein kinase II
Arch. Biochem. Biophys.
510
174-181
2011
Rattus norvegicus
brenda
Hoffman, L.; Farley, M.M.; Waxham, M.N.
Calcium-calmodulin-dependent protein kinase II isoforms differentially impact the dynamics and structure of the actin cytoskeleton
Biochemistry
52
1198-1207
2013
Rattus norvegicus (P08413), Rattus norvegicus (P11275), Homo sapiens (Q13555), Homo sapiens (Q13557)
brenda
Salzano, M.; Rusciano, M.R.; Russo, E.; Bifulco, M.; Postiglione, L.; Vitale, M.
Calcium/calmodulin-dependent protein kinase II (CaMKII) phosphorylates Raf-1 at serine 338 and mediates Ras-stimulated Raf-1 activation
Cell Cycle
11
2100-2106
2012
Rattus norvegicus
brenda
Ashpole, N.M.; Herren, A.W.; Ginsburg, K.S.; Brogan, J.D.; Johnson, D.E.; Cummins, T.R.; Bers, D.M.; Hudmon, A.
Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites
J. Biol. Chem.
287
19856-19869
2012
Rattus norvegicus
brenda
Coultrap, S.J.; Bayer, K.U.
Nitric oxide induces Ca2+-independent activity of the Ca2+/calmodulin-dependent protein kinase II (CaMKII)
J. Biol. Chem.
289
19458-19465
2014
Rattus norvegicus (P08413)
brenda
Fujiwara, Y.; Kawaguchi, Y.; Fujimoto, T.; Kanayama, N.; Magari, M.; Tokumitsu, H.
Differential AMP-activated protein kinase (AMPK) recognition mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms
J. Biol. Chem.
291
13802-13808
2016
Rattus norvegicus (Q63450)
brenda
Yavuz, M.; Ayd?n, B.; Carcak, N.; Akman, O.e.; Raci Yananli, H.; Onat, F.
Atipamezole, a specific alpha2A antagonist, suppresses spike-and-wave discharges and alters Ca2+ /calmodulin-dependent protein kinase II in the thalamus of genetic absence epilepsy rats
Epilepsia
61
2825-2835
2020
Rattus norvegicus
brenda