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Information on EC 2.7.11.17 - Ca2+/calmodulin-dependent protein kinase and Organism(s) Oryctolagus cuniculus and UniProt Accession O77708

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EC Tree
IUBMB Comments
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
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This record set is specific for:
Oryctolagus cuniculus
UNIPROT: O77708
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Word Map
The taxonomic range for the selected organisms is: Oryctolagus cuniculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
caldesmon, cam kinase ii, camkiv, cam kinase, calcium/calmodulin-dependent protein kinase ii, calmodulin-dependent protein kinase, camkk2, calcium/calmodulin-dependent protein kinase, ca2+/calmodulin-dependent protein kinase, camk ii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+/calmodulin-dependent protein kinase IIdelta
-
CaMKIIdelta
isozyme
Ca2+/calmodulin-dependent protein kinase II
-
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CAKI
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-
-
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caldesmon
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-
-
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Calspermin
-
-
-
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CAM kinase-GR
-
-
-
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CMPK
-
-
-
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kinase, caldesmon (phosphorylating)
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-
-
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kinase, microtubule-associated protein 2 (phosphorylating)
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-
-
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MAP kinase
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-
-
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MAP-2 kinase
-
-
-
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MAP-2 protein serine kinase
-
-
-
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microtubule associated protein kinase
-
-
-
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microtubule-associated protein 2 kinase
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-
-
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peripheral plasma membrane protein CaMGUK
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
Requires calmodulin and Ca2+ for activity. A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light chains and the microtubule-associated tau protein. Not identical with EC 2.7.11.18 (myosin-light-chain kinase) or EC 2.7.11.26 (tau-protein kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
141467-21-2
-
93229-57-3
-
97350-82-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + histone deacetylase 5
ADP + phosphorylated histone deacetylase 5
show the reaction diagram
-
-
-
?
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
ATP + protein PLB
ADP + phosphorylated protein PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + protein RyR
ADP + phosphorylated protein RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + cAMP-response element binding protein
ADP + phosphorylated cAMP-response element binding protein
show the reaction diagram
-
i.e. CREB, phosphorylation by CaMKII and CaMKIV at Ser133, and phosphorylation by CaMKII at Ser142
-
-
?
ATP + L-type Ca2+ channel
ADP + phosphorylated L-type Ca2+ channel
show the reaction diagram
-
inactivation, leading to increased Ca2+ channel open probability and increased arrhytmias
-
-
?
ATP + protein PLB
ADP + phosphorylated protein PLB
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
ATP + protein RyR
ADP + phosphorylated protein RyR
show the reaction diagram
-
a regulatory protein in Ca2+ signaling
-
-
?
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
dependent on
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
dependent on
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KN62
-
inhibits CaMKII
KN93
-
inhibits CaMKII
peptide AC3-I
-
i.e. autocamtide-2 inhibitory peptide, inhibits CaMKII
peptide AIP
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i.e. autocamtide-2-related inhibitory peptide, comprising 17 amino acids, a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Calmodulin
additional information
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
isozyme CaMKIIdelta splicing variants deltaB and deltaC
Manually annotated by BRENDA team
additional information
-
ubiquitous expression of CaMKII
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
isozyme CaMKIIdelta splicing variant deltaC, CaMKIV
Manually annotated by BRENDA team
-
isozyme CaMKIIdelta splicing variant deltaB, CaMKIV predominantly
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KCC2D_RABIT
533
0
60010
Swiss-Prot
other Location (Reliability: 1)
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
CaMKIV and CaMKI
multimer
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phosphoprotein
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
CaMKIIcelta expression and activation state are increased in heart failure
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, T.; Brown, J.H.
Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure
Cardiovasc. Res.
63
476-486
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Maier, L.S.; Bers, D.M.
Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart
Cardiovasc. Res.
73
631-640
2007
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Bossuyt, J.; Helmstadter, K.; Wu, X.; Clements-Jewery, H.; Haworth, R.S.; Avkiran, M.; Martin, J.L.; Pogwizd, S.M.; Bers, D.M.
Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure
Circ. Res.
102
695-702
2008
Oryctolagus cuniculus (O77708), Oryctolagus cuniculus, Homo sapiens (Q13557), Homo sapiens
Manually annotated by BRENDA team