Disease on EC 2.7.11.16 - G-protein-coupled receptor kinase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenocarcinoma of Lung
Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBP?, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells.
Alzheimer Disease
Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice.
Alzheimer Disease
GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.
Alzheimer Disease
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
Alzheimer Disease
GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity.
Aortic Coarctation
Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6.
Arthritis
G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis.
Atrial Fibrillation
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers.
Breast Neoplasms
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.
Carcinogenesis
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.
Carcinoma, Hepatocellular
Expression and Significances of G-Protein-Coupled Receptor Kinase 3 in Hepatocellular Carcinoma.
Cardiomegaly
Determining the Absolute Requirement of G Protein-Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy.
Cardiomegaly
Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.
Cardiomegaly
G protein-coupled receptor kinase 5: exploring its hype in cardiac hypertrophy.
Cardiomegaly
GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
Cardiomegaly
KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure.
Cardiomegaly
PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro.
Cardiovascular Diseases
Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo.
Cardiovascular Diseases
Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors.
Colitis
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.
Colonic Neoplasms
G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells.
Colonic Neoplasms
Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth.
Colorectal Neoplasms
Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma.
Dementia
Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Diabetes Mellitus
A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
Diabetes Mellitus
GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island.
Diabetes Mellitus, Type 2
A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island.
Dyskinesias
Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease.
Dyskinesias
[Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease].
Essential Hypertension
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Essential Hypertension
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.
Essential Hypertension
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.
Essential Hypertension
G protein-coupled receptor kinase 4 gene variants in human essential hypertension.
Essential Hypertension
[G protein kinase 4gammaA142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice]
g-protein-coupled receptor kinase deficiency
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Glioma
G protein-coupled receptor kinase 6 is overexpressed in glioma and promotes glioma cell proliferation.
Heart Failure
A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
Heart Failure
G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade.
Heart Failure
KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure.
Heart Failure
Pharmacogenomics of beta-Adrenergic Receptors and Their Accessory Signaling Proteins in Heart Failure.
Heart Failure
Regulation of nuclear factor ?B (NF-?B) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5).
Heart Failure
The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.
Heart Failure
The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition.
Hyperalgesia
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
Hyperalgesia
GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling.
Hypertension
Autosomal genome scan for loci linked to blood pressure levels and trends since childhood: the Bogalusa Heart Study.
Hypertension
Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in L-NAME-Induced Hypertension Compared to Spontaneous Hypertension in Rats.
Hypertension
Dopamine and G protein-coupled receptor kinase 4 in the kidney: Role in blood pressure regulation.
Hypertension
Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats.
Hypertension
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
Hypertension
G protein-coupled receptor kinase 4gamma interacts with inactive Galpha(s) and Galpha13.
Hypertension
G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension.
Hypertension
G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.
Hypertension
G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression.
Hypertension
Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.
Hypertension
Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults.
Hypertension
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
Hypertension
The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.
Hypertension
The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.
Hypertension
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
Multiple Myeloma
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
Multiple Myeloma
Down-regulated G protein-coupled receptor kinase 6 leads to apoptosis in multiple myeloma MM1R cells.
Multiple Myeloma
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.
Multiple Myeloma
[Effect of G Protein-coupled Receptor Kinase 6 on Proliferation and Apoptosis of Multiple Myeloma Cells and Its Mechanisms].
Myocardial Infarction
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
Neoplasm Metastasis
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Neoplasm Metastasis
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
Neoplasm Metastasis
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Neoplasms
c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.
Neoplasms
G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.
Neoplasms
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Neoplasms
GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis.
Neoplasms
High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma.
Neoplasms
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.
Nephrosclerosis
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.
Neuroblastoma
Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells.
Obesity
Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans.
Osteoarthritis
GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-?B Signaling.
Parkinson Disease
Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Parkinson Disease
Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease.
Parkinson Disease
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.
Parkinson Disease
Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease.
Parkinson Disease
Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Parkinson Disease
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Parkinson Disease
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.
Parkinson Disease
[Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease].
Pre-Eclampsia
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
Prostatic Neoplasms
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
Retinal Neovascularization
Beta-adrenoreceptor (?-AR) agonism influences retinal responses to hypoxia in a mouse model of retinopathy of prematurity.
Retinoblastoma
G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells.
Spinal Cord Injuries
Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat.
Status Epilepticus
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
Stillbirth
Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
Stomach Neoplasms
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.
Takotsubo Cardiomyopathy
G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy.
Takotsubo Cardiomyopathy
No association of G-protein-coupled receptor kinase 5 or ?-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort.
Thyroid Cancer, Papillary
Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma.
Whooping Cough
Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.
html completed