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Disease on EC 2.7.11.16 - G-protein-coupled receptor kinase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBP?, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells.
Alzheimer Disease
Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice.
GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.
GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity.
Aortic Coarctation
Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6.
Arthritis
G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis.
Atrial Fibrillation
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers.
Breast Neoplasms
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.
Carcinogenesis
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis.
Carcinoma, Hepatocellular
Expression and Significances of G-Protein-Coupled Receptor Kinase 3 in Hepatocellular Carcinoma.
GRK6 expression in patients with hepatocellular carcinoma.
Cardiomegaly
Determining the Absolute Requirement of G Protein-Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy.
Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.
G protein-coupled receptor kinase 5: exploring its hype in cardiac hypertrophy.
GRK5 contributes to impaired cardiac function and immune cell recruitment in post-ischemic heart failure.
KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure.
PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro.
Cardiovascular Diseases
Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo.
Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors.
Colitis
G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice.
Colonic Neoplasms
G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells.
Tazarotene-induced gene 1 inhibits prostaglandin E2-stimulated HCT116 colon cancer cell growth.
Colorectal Neoplasms
Overexpression of GRK6 associates with the progression and prognosis of colorectal carcinoma.
Dementia
Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
Diabetes Mellitus
A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island.
Diabetes Mellitus, Type 2
A variant of GRK5 is associated with the therapeutic efficacy of repaglinide in Chinese Han patients with type 2 diabetes mellitus.
GRK5 Intronic (CA)n Polymorphisms Associated with Type 2 Diabetes in Chinese Hainan Island.
Dyskinesias
Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease.
[Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease].
Essential Hypertension
Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese.
G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.
G protein-coupled receptor kinase 4 gene variants in human essential hypertension.
[G protein kinase 4gammaA142V overexpression induced hypertension by downregulating D1 receptors in transgenic mice]
g-protein-coupled receptor kinase deficiency
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Glioma
G protein-coupled receptor kinase 6 is overexpressed in glioma and promotes glioma cell proliferation.
Heart Diseases
beta-adrenergic mechanisms in cardiac diseases: a perspective.
Heart Failure
A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure.
G-protein-coupled receptor kinase activity in human heart failure: effects of beta-adrenoceptor blockade.
KR-39038, a Novel GRK5 Inhibitor, Attenuates Cardiac Hypertrophy and Improves Cardiac Function in Heart Failure.
Pharmacogenomics of beta-Adrenergic Receptors and Their Accessory Signaling Proteins in Heart Failure.
Regulation of nuclear factor ?B (NF-?B) in the nucleus of cardiomyocytes by G protein-coupled receptor kinase 5 (GRK5).
The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.
The inotropic peptide ?ARKct improves ?AR responsiveness in normal and failing cardiomyocytes through G(??)-mediated L-type calcium current disinhibition.
Hyperalgesia
G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia.
GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling.
Hypertension
Autosomal genome scan for loci linked to blood pressure levels and trends since childhood: the Bogalusa Heart Study.
Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in L-NAME-Induced Hypertension Compared to Spontaneous Hypertension in Rats.
Dopamine and G protein-coupled receptor kinase 4 in the kidney: Role in blood pressure regulation.
Effects of decreased renal cortical expression of G protein-coupled receptor kinase 4 and angiotensin type 1 receptors in rats.
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
G protein-coupled receptor kinase 4: role in hypertension.
G protein-coupled receptor kinase 4gamma interacts with inactive Galpha(s) and Galpha13.
G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension.
G-protein-coupled receptor kinase 4 polymorphisms predict blood pressure response to dietary modification in Black patients with mild-to-moderate hypertension.
G-Protein-coupled receptor kinase activity in hypertension : increased vascular and lymphocyte G-protein receptor kinase-2 protein expression.
G-protein-coupled receptor kinase activity is increased in hypertension.
G-protein-coupled receptor kinase expression in hypertension.
Genetic variants of GRK4 influence circadian rhythm of blood pressure and response to candesartan in hypertensive patients.
Hypertension-Related Gene Polymorphisms of G-Protein-Coupled Receptor Kinase 4 Are Associated with NT-proBNP Concentration in Normotensive Healthy Adults.
Renal Dopamine Receptors and Oxidative Stress: Role in Hypertension.
Structure and Function of the Hypertension Variant A486V of G Protein-coupled Receptor Kinase 4.
The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.
The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment.
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
Lung Neoplasms
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.
Multiple Myeloma
Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma.
Down-regulated G protein-coupled receptor kinase 6 leads to apoptosis in multiple myeloma MM1R cells.
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.
[Effect of G Protein-coupled Receptor Kinase 6 on Proliferation and Apoptosis of Multiple Myeloma Cells and Its Mechanisms].
Myocardial Infarction
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
Neoplasm Metastasis
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
Neoplasms
c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.
G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel.
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
G-protein coupled receptor kinase 5 regulates prostate tumor growth.
GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis.
GRK3 is essential for metastatic cells and promotes prostate tumor progression.
GRK5 functions as an oncogenic factor in non-small-cell lung cancer.
High expression of GRK3 is associated with favorable prognosis in pancreatic ductal adenocarcinoma.
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.
Nephrosclerosis
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions.
Neuroblastoma
Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells.
Obesity
Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans.
Osteoarthritis
GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-?B Signaling.
Parkinson Disease
Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
Effect of Tianqi antitremor granules on behavioral manifestations and expression of G protein-coupled receptor kinase 6 and ?-arrestin1 in levodopa-induced dyskinesia in a rat model of Parkinson's disease.
G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression.
Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease.
Role of G-protein coupled receptor kinase 5 gene in cognitive impairment in Parkinson's disease.
S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.
[Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease].
Pre-Eclampsia
G protein-coupled receptor kinase 4 gene variants are not associated with preeclampsia in Northern Han Chinese.
Prostatic Neoplasms
G protein-coupled receptor kinase GRK5 phosphorylates moesin and regulates metastasis in prostate cancer.
Retinal Neovascularization
Beta-adrenoreceptor (?-AR) agonism influences retinal responses to hypoxia in a mouse model of retinopathy of prematurity.
Retinoblastoma
G-protein-coupled receptor kinase 3- and protein kinase C-mediated desensitization of the PACAP receptor type 1 in human Y-79 retinoblastoma cells.
Spinal Cord Injuries
Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat.
Status Epilepticus
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.
Stillbirth
Enhanced Uterine Contractility and Stillbirth in Mice Lacking G Protein-Coupled Receptor Kinase 6 (GRK6): Implications for Oxytocin Receptor Desensitization.
Stomach Neoplasms
MicroRNA-760 acts as a tumor suppressor in gastric cancer development via inhibiting G-protein-coupled receptor kinase interacting protein-1 transcription.
Takotsubo Cardiomyopathy
G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy.
No association of G-protein-coupled receptor kinase 5 or ?-adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort.
Thyroid Cancer, Papillary
Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma.
Whooping Cough
Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.