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Synonyms
g-protein-coupled receptor kinase, g protein-coupled receptor kinase 5, g protein-coupled receptor kinase 4, g protein-coupled receptor kinase 6, grk4gamma, g-protein-coupled receptor kinase 5, g-protein-coupled receptor kinase 6, grk-6, g-protein coupled receptor kinase 5, g-protein coupled receptor kinase 6,
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
ATP + rhodopsin
ADP + phosphorylated rhodopsin
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urea treated outer segments of rhodopsin
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ATP + [G-protein-coupled receptor]
ADP + [G-protein-coupled receptor] phosphate
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additional information
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
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rapid desensitization of the receptor by GRK4 and GRK6, Na+/H+ exchanger activity of the receptor, overview
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
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GRK4 and GRK6
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
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dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization
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additional information
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enzyme mainly involved in homologous desensitization of the TSH receptor
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additional information
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the GRK4-6 family member enzymes mediate beta-adrenergic receptor desensitization, the beta-adrenergic receptor is stimulated by agonists such as isoproterenol, cholera toxin, or forskolin, and induces cAMP production
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ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
ATP + [G-protein-coupled receptor]
ADP + [G-protein-coupled receptor] phosphate
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-
-
?
additional information
?
-
ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
-
rapid desensitization of the receptor by GRK4 and GRK6, Na+/H+ exchanger activity of the receptor, overview
-
-
?
ATP + dopamine D1 receptor
ADP + phosphorylated dopamine D1 receptor
-
dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization
-
-
?
additional information
?
-
enzyme mainly involved in homologous desensitization of the TSH receptor
-
-
?
additional information
?
-
-
the GRK4-6 family member enzymes mediate beta-adrenergic receptor desensitization, the beta-adrenergic receptor is stimulated by agonists such as isoproterenol, cholera toxin, or forskolin, and induces cAMP production
-
-
?
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Fehr, C.; Fickova, M.; Hiemke, C.; Reuss, S.; Dahmen, N.
Molecular cloning of rat G-protein-coupled receptor kinase 6 (GRK6) from brain tissue, and its mRNA expression in different brain regions and peripheral tissues
Brain Res. Mol. Brain Res.
49
278-282
1997
Rattus norvegicus (P97711)
brenda
Nagayama, Y.; Tanaka, K.; Hara, T.; Namba, H.; Yamashita, S.; Taniyama, K.; Niwa, M.
Involvement of G protein-coupled receptor kinase 5 in homologous desensitization of the thyrotropin receptor
J. Biol. Chem.
271
10143-10148
1996
Rattus norvegicus (Q62833)
brenda
Fraga, S.; Jose, P.A.; Soares-da-Silva, P.
Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells
Am. J. Physiol.
287
R772-779
2004
Rattus norvegicus
brenda
Oyama, N.; Urasawa, K.; Kaneta, S.; Sakai, H.; Saito, T.; Takagi, C.; Yoshida, I.; Kitabatake, A.; Tsutsui, H.
Chronic beta-adrenergic receptor stimulation enhances the expression of G-protein coupled receptor kinases, GRK2 and GRK5, in both the heart and peripheral lymphocytes
Circ. J.
69
987-990
2005
Homo sapiens, Rattus norvegicus
brenda
Simon, V.; Robin, M.T.; Legrand, C.; Cohen-Tannoudji, J.
Endogenous G protein-coupled receptor kinase 6 triggers homologous beta-adrenergic receptor desensitization in primary uterine smooth muscle cells
Endocrinology
144
3058-3066
2003
Rattus norvegicus
brenda
Fraga, S.; Luo, Y.; Jose, P.; Zandi-Nejad, K.; Mount, D.B.; Soares-da-Silva, P.
Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6)
Cell. Physiol. Biochem.
18
347-360
2006
Rattus norvegicus
brenda
Bychkov, E.; Zurkovsky, L.; Garret, M.B.; Ahmed, M.R.; Gurevich, E.V.
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
PLoS ONE
7
e48912
2012
Rattus norvegicus
brenda
Franklin, J.M.; Carrasco, G.A.
G-protein receptor kinase 5 regulates the cannabinoid receptor 2-induced up-regulation of serotonin 2A receptors
J. Biol. Chem.
288
15712-15724
2013
Rattus norvegicus (Q62833)
brenda
Park, C.H.; Lee, J.H.; Lee, M.Y.; Lee, J.H.; Lee, B.H.; Oh, K.S.
A novel role of G protein-coupled receptor kinase 5 in urotensin II-stimulated cellular hypertrophy in H9c2UT cells
Mol. Cell. Biochem.
422
151-160
2016
Rattus norvegicus (Q62833)
brenda
Zeng, X.; Chen, S.; Gao, Q.; Zong, W.; Jiang, D.; Zeng, G.; Zhou, L.; Chen, L.; Luo, W.; Xiao, J.; Xiao, B.; Ouyang, D.; Hu, K.
The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus
Epilepsy Res.
138
62-70
2017
Rattus norvegicus (Q62833)
brenda