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Disease on EC 2.7.11.15 - beta-adrenergic-receptor kinase and Organism(s) Homo sapiens and UniProt Accession P25098

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acromegaly
?-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly.
Alzheimer Disease
?-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy?
Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease.
Angioedema
Role of Endothelial G Protein-Coupled Receptor Kinase 2 in Angioedema.
Arrhythmias, Cardiac
Suppression of autonomic-mediated triggered firing in pulmonary vein preparations, 24 hours postcoronary artery ligation in dogs.
Arthritis
CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation.
CP-25 reverses prostaglandin E4 receptor desensitization-induced fibroblast-like synoviocyte dysfunction via the G protein-coupled receptor kinase 2 in autoimmune arthritis.
Arthritis, Experimental
GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice.
Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis.
Arthritis, Rheumatoid
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
beta-adrenergic-receptor kinase deficiency
Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice.
Bone Neoplasms
A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2.
Brain Death
Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death.
Role of the beta-adrenergic receptor kinase in myocardial dysfunction after brain death.
Breast Neoplasms
G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.
The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.
Carcinogenesis
G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis.
Carcinoma
G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
Carcinoma, Hepatocellular
Angiotensin II and tumor necrosis factor-? stimulate the growth, migration and invasion of BEL-7402 cells via down-regulation of GRK2 expression.
Expression of GRK2 and IGF1R in hepatocellular carcinoma: clinicopathological and prognostic significance.
G protein-coupled receptor kinase 2 regulating ?2-adrenergic receptor signaling in M2-polarized macrophages contributes to hepatocellular carcinoma progression.
Growth inhibition of human hepatocellular carcinoma cells by overexpression of G protein-coupled receptor kinase 2.
Carcinoma, Squamous Cell
G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
Protein kinase C deficiency blocks recovery from agonist-induced desensitization.
Cardiomegaly
Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
G protein-coupled receptor kinases in normal and failing myocardium.
Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction.
Mechanism of beta-adrenergic receptor desensitization in cardiac hypertrophy is increased beta-adrenergic receptor kinase.
Physiological induction of a beta-adrenergic receptor kinase inhibitor transgene preserves ss-adrenergic responsiveness in pressure-overload cardiac hypertrophy.
Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors.
The myocardial beta-adrenergic system in spontaneously hypertensive heart failure (SHHF) rats.
Cardiomyopathies
Calpains mediate isoproterenol-induced hypertrophy through modulation of GRK2.
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Cardiomyopathy, Dilated
Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine.
Cardiovascular Diseases
G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms.
G-protein-coupled receptor kinases in cardiovascular conditions: focus on G-protein-coupled receptor kinase 2, a gain in translational medicine.
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
The GRK2 Promoter Is Regulated by Early-Growth Response Transcription Factor EGR-1.
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.
Cholera
Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.
Diabetes Mellitus, Type 2
G protein-coupled receptor kinase 2 inhibition improves erectile function through amelioration of endothelial dysfunction and oxidative stress in a rat model of type 2 diabetes.
Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving ?-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.
Diabetic Cardiomyopathies
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor.
Sustaining Circulating Regulatory T Cell Subset Contributes to the Therapeutic Effect of Paroxetine on Mice With Diabetic Cardiomyopathy.
Encephalomyelitis
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Escherichia coli Infections
Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-{kappa}B Signaling.
Essential Hypertension
GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
Fatty Liver
Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.
Glioma
Desensitization of endogenously expressed delta-opioid receptors: no evidence for involvement of G protein-coupled receptor kinase 2.
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Rapid agonist-induced beta-adrenergic receptor kinase translocation in C6 glioma cells.
Rat beta-adrenergic receptor kinases 1 and 2 in mouse neuroblastoma X rat glioma NG 108-15 hybrid cells.
Heart Arrest
Adenoviral ?ARKct Cardiac Gene Transfer Ameliorates Post-resuscitation Myocardial Injury in a Porcine Model of Cardiac Arrest.
Adenoviral ?ARKct Cardiac Gene Transfer Ameliorates Postresuscitation Myocardial Injury in a Porcine Model of Cardiac Arrest.
Heart Diseases
beta-adrenergic mechanisms in cardiac diseases: a perspective.
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
Heart failure-specific changes in protein kinase signalling.
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Therapeutic potential of G-protein coupled receptor kinases in the heart.
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.
Heart Failure
A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic.
AAV-mediated gene therapy for heart failure: enhancing contractility and calcium handling.
Acute aerobic exercise mediates G protein-coupled receptor kinase 2 expression in human PBMCs.
Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure.
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure.
Analysis of the human G protein-coupled receptor kinase 2 (GRK2) gene promoter: regulation by signal transduction systems in aortic smooth muscle cells.
betaARK1 inhibition improves survival in a mouse model of heart failure induced by myocardial infarction.
Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure.
Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury.
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Cellular and functional defects in a mouse model of heart failure.
Computational study of paroxetine-like inhibitors reveals new molecular insight to inhibit GRK2 with selectivity over ROCK1.
Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.
Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion.
Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure.
Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure ethiology and correlates to clinical variables.
Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.
Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment.
Effects of two Gbetagamma-binding proteins--N-terminally truncated phosducin and beta-adrenergic receptor kinase C terminus (betaARKct)--in heart failure.
Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure.
G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.
G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.
Genetic and phenotypic targeting of beta-adrenergic signaling in heart failure.
Gi-biased ?2AR signaling links GRK2 upregulation to heart failure.
GRK2 compromises cardiomyocyte mitochondrial function by diminishing fatty acid-mediated oxygen consumption and increasing superoxide levels.
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Heart failure-specific changes in protein kinase signalling.
Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Hope for a broken heart?
Hypothesis: Paroxetine, a G Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor Reduces Morbidity and Mortality in Patients With Heart Failure.
Induction of cardiac beta-adrenergic receptor kinase 1 in rat heart failure caused by coronary ligation.
Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
Inhibition of G-protein-coupled Receptor Kinase 2 (GRK2) Triggers the Growth-promoting Mitogen-activated Protein Kinase (MAPK) Pathway.
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.
Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction.
Modification of beta-adrenoceptor signal transduction pathway by genetic manipulation and heart failure.
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity.
Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy.
Molecular signaling of G-protein-coupled receptor in chronic heart failure and associated complications.
Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure.
Myocardial distribution and regulation of GRK and beta-arrestin isoforms in congestive heart failure in rats.
Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury.
Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility.
Pharmacological and Activated Fibroblast Targeting of G??-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression.
Positive inotropic stimulation.
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure.
Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade.
Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure.
Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling.
Restoration of myocardial beta-adrenergic receptor signaling after left ventricular assist device support.
Sensitization of the Angiotensin II AT1 Receptor Contributes to RKIP-Induced Symptoms of Heart Failure.
Signalling pathways in cardiac failure.
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression.
Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure.
Targeting the ?-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside.
The adrenergic pathway and heart failure.
The beta-adrenergic receptor kinase in heart failure.
The GRK2 Promoter Is Regulated by Early-Growth Response Transcription Factor EGR-1.
Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets.
Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling.
[Gene expression of beta-adrenoceptor signal transmitters in heart failure]
Hyperalgesia
A role for G protein-coupled receptor kinase 2 in mechanical allodynia.
Dexmedetomidine alleviates rat post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia.
Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.
Monocytes/Macrophages control resolution of transient inflammatory pain.
Paroxetine alleviates rat limb post-ischemia induced allodynia through GRK2 upregulation in superior cervical ganglia.
The role of G-protein-coupled receptor kinase 2 in diabetic mechanical hyperalgesia in rats.
Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain.
Hyperglycemia
Tonic Inhibition by G Protein-Coupled Receptor Kinase 2 of Akt/Endothelial Nitric-Oxide Synthase Signaling in Human Vascular Endothelial Cells under Conditions of Hyperglycemia with High Insulin Levels.
Hypertension
Acute aerobic exercise mediates G protein-coupled receptor kinase 2 expression in human PBMCs.
Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in L-NAME-Induced Hypertension Compared to Spontaneous Hypertension in Rats.
Co-treatment with clonidine and a GRK2 inhibitor prevented rebound hypertension and endothelial dysfunction after withdrawal in diabetes.
Enhanced GRK2 Expression and Desensitization of betaAR Vasodilatation in Hypertensive Patients.
G-Protein-Coupled Receptor Kinase 2 and Hypertension : Molecular Insights and Pathophysiological Mechanisms.
Hypertensive left ventricular hypertrophy: relation to beta-adrenergic receptor kinase-1 (betaARK1) in peripheral lymphocytes.
Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
The Hypertension Related Gene G-Protein Coupled Receptor Kinase 4 Contributes to Breast Cancer Proliferation.
Hypothyroidism
Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart.
Effect of Hypothyroidism on G Protein-Coupled Receptor Kinase 2 Expression Levels in Rat Liver, Lung, and Heart.
Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development: effect of hypothyroidism.
Infections
Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-{kappa}B Signaling.
GRK2 mediates ?-arrestin interactions with 5-HT2 receptors for JC polyomavirus endocytosis.
Insulin Resistance
Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.
G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.
Inactivation of MAPK in epididymal fat and amelioration of triglyceride secretion by injection of GRK2 siRNA in ob/ob mice.
Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.
Statement of Retraction. Lucia Garcia-Guerra, Iria Nieto-Vázquez, Rocio Vila-Bedmar, María Jurado-Pueyo, Guillermo Zalba, Javier Díez, Cristina Murga, Sonia Fernández-Veledo, Federico Mayor, and Margarita Lorenzo. G Protein-Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity. Diabetes 2010;59:2407-2417. https://doi.org/10.2337/db10-0771.
Suppression of GRK2 expression reduces endothelial dysfunction by restoring glucose homeostasis.
The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance.
Lymphoma
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
Lymphopenia
Activation of lymphocyte autophagy/apoptosis reflects haemodynamic inefficiency and functional aerobic impairment in patients with heart failure.
Malaria
Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.
Metabolic Diseases
G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases.
Multiple Sclerosis
G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.
Myocardial Infarction
betaARK1 inhibition improves survival in a mouse model of heart failure induced by myocardial infarction.
Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction.
Effect of Paroxetine-Mediated G-Protein Receptor Kinase 2 Inhibition vs Placebo in Patients With Anterior Myocardial Infarction: A Randomized Clinical Trial.
Effects of paroxetine-mediated inhibition of GRK2 expression on depression and cardiovascular function in patients with myocardial infarction.
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
G protein-coupled receptor kinase 2 in patients with acute myocardial infarction.
GRK 2 level in peripheral blood lymphocytes of elderly patients with acute myocardial infarction.
In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction.
MCARD-Mediated Gene Transfer of GRK2 Inhibitor in Ovine Model of Acute Myocardial Infarction.
Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway.
Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction.
Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol.
Myocardial Ischemia
Activation of beta-adrenergic receptor kinase during myocardial ischemia.
Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1).
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.
Myocardial Reperfusion Injury
Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.
Neoplasm Metastasis
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains.
Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays.
G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.
Neoplasms
Angiotensin II and tumor necrosis factor-? stimulate the growth, migration and invasion of BEL-7402 cells via down-regulation of GRK2 expression.
Cloning and real-time PCR testing of 14 potential biomarkers in Eisenia fetida following cadmium exposure.
G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.
G-Protein-Coupled Receptor Kinase 2 as a Potential Modulator of the Hallmarks of Cancer.
G-protein-coupled receptor kinase 2 in pancreatic cancer: clinicopathologic and prognostic significance.
G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
G??-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor ?-induced cardiac ?-adrenergic receptor dysfunction.
Modulation of CXCR4-Mediated Gi1 Activation by EGF Receptor and GRK2.
Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer.
Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth.
The influence of TNF-? and Ang II on the proliferation, migration and invasion of HepG2 cells by regulating the expression of GRK2.
The strong induction of metallothionein gene following cadmium exposure transiently affects the expression of many genes in Eisenia fetida: a trade-off mechanism?
Neuralgia
Inhibition of MicroRNA-15a/16 Expression Alleviates Neuropathic Pain Development through Upregulation of G Protein-Coupled Receptor Kinase 2.
Suppression of the morphine-induced rewarding effect and G-protein activation in the lower midbrain following nerve injury in the mouse: involvement of G-protein-coupled receptor kinase 2.
The glial-neuronal GRK2 pathway participates in the development of trigeminal neuropathic pain in rats.
Neuroblastoma
Enhanced expression of G protein-coupled receptor kinase 2 selectively increases the sensitivity of A2A adenosine receptors to agonist-induced desensitization.
Rat beta-adrenergic receptor kinases 1 and 2 in mouse neuroblastoma X rat glioma NG 108-15 hybrid cells.
Obesity
G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.
GRK2 overexpression inhibits IGF1-induced proliferation and migration of human hepatocellular carcinoma cells by downregulating EGR1.
Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.
Statement of Retraction. Lucia Garcia-Guerra, Iria Nieto-Vázquez, Rocio Vila-Bedmar, María Jurado-Pueyo, Guillermo Zalba, Javier Díez, Cristina Murga, Sonia Fernández-Veledo, Federico Mayor, and Margarita Lorenzo. G Protein-Coupled Receptor Kinase 2 Plays a Relevant Role in Insulin Resistance and Obesity. Diabetes 2010;59:2407-2417. https://doi.org/10.2337/db10-0771.
Pancreatic Neoplasms
G-protein-coupled receptor kinase 2 in pancreatic cancer: clinicopathologic and prognostic significance.
Pheochromocytoma
Cardioprotective effect of histamine H3-receptor activation: pivotal role of G beta gamma-dependent inhibition of voltage-operated Ca2+ channels.
Pituitary Neoplasms
?-Arrestin 1 and 2 and G protein-coupled receptor kinase 2 expression in pituitary adenomas: role in the regulation of response to somatostatin analogue treatment in patients with acromegaly.
Prostatic Neoplasms
GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells.
Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth.
Pulmonary Fibrosis
Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis.
Reperfusion Injury
Carvedilol protects against hepatic ischemia reperfusion injury in high-fructose high-fat diet-fed mice: Role of G protein-coupled receptor kinase 2 and 5.
GPCR kinase 2-interacting protein-1 protects against ischemia-reperfusion injury of the spinal cord by modulating ASK1/JNK/p38 signaling.
Myocardial recovery after ischemia and reperfusion injury is significantly impaired in hearts with transgenic overexpression of beta-adrenergic receptor kinase.
Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions.
The protective effort of GPCR kinase 2-interacting protein-1 in neurons via promoting Beclin1-Parkin induced mitophagy at the early stage of spinal cord ischemia-reperfusion injury.
Sepsis-Associated Encephalopathy
Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy.
Shock, Septic
G-protein coupled receptor kinase 2 is altered during septic shock in rats.
Spinal Cord Injuries
Exosomes derived from GIT1-overexpressing bone marrow mesenchymal stem cells promote traumatic spinal cord injury recovery in a rat model.
GPCR kinase 2-interacting protein-1 protects against ischemia-reperfusion injury of the spinal cord by modulating ASK1/JNK/p38 signaling.
Squamous Cell Carcinoma of Head and Neck
G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.
Takotsubo Cardiomyopathy
L41Q polymorphism of the G protein coupled receptor kinase 5 is associated with left ventricular apical ballooning syndrome.
Thyroid Neoplasms
Immunohistochemical detection, regulation and antiproliferative function of G-protein-coupled receptor kinase 2 in thyroid carcinomas.
Thyroid Nodule
Decreased expression of G-protein coupled receptor kinase 2 in cold thyroid nodules.
Vascular System Injuries
In vivo adenoviral-mediated gene transfer of the beta ARKct to study the role of G beta gamma in arterial restenosis.
Ventricular Dysfunction
Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated beta-adrenergic signaling modulation.
Role of the beta-adrenergic receptor kinase in myocardial dysfunction after brain death.
Ventricular dysfunction after cardioplegic arrest is improved after myocardial gene transfer of a beta-adrenergic receptor kinase inhibitor.
Whooping Cough
Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins.
Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.
Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.
Cell type-specific angiotensin II-evoked signal transduction pathways: critical roles of Gbetagamma subunit, Src family, and Ras in cardiac fibroblasts.
Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma.
Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity.
Differential superactivation of adenylyl cyclase isozymes after chronic activation of the CB(1) cannabinoid receptor.
Essential role for G proteins in prostate cancer cell growth and signaling.
Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy.
Interactions of phosducin with defined G protein beta gamma-subunits.
Prolactin-releasing peptide activation of the prolactin promoter is differentially mediated by extracellular signal-regulated protein kinase and c-Jun N-terminal protein kinase.
Regulation of myogenesis by fibroblast growth factors requires beta-gamma subunits of pertussis toxin-sensitive G proteins.
Regulation of the PRL promoter by Akt through cAMP response element binding protein.
Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.
Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction.
Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.
Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII.
The activation of G-protein gated inwardly rectifying K+ channels by a cloned Drosophila melanogaster neuropeptide F-like receptor.
Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium.