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Information on EC 2.7.11.15 - beta-adrenergic-receptor kinase and Organism(s) Mesocricetus auratus and UniProt Accession Q64682

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IUBMB Comments
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
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Mesocricetus auratus
UNIPROT: Q64682
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The taxonomic range for the selected organisms is: Mesocricetus auratus
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Synonyms
g protein-coupled receptor kinase 2, beta-adrenergic receptor kinase, betaark1, betaark, g-protein-coupled receptor kinase 2, gprk2, g protein-coupled receptor kinase-2, beta-adrenergic receptor kinase 1, g protein coupled receptor kinase, beta-ark, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
beta-adrenergic receptor kinase 1
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beta-adrenergic receptor kinase
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beta-adrenergic receptor-specific kinase
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-
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beta-AR kinase
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beta-ARK
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-
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beta-ARK 1
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-
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beta-ARK 2
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-
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beta-receptor kinase
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-
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GRK2
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GRK3
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kinase (phosphorylating), beta-adrenergic-receptor
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
phospho group transfer
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-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[beta-adrenergic receptor] phosphotransferase
Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).
CAS REGISTRY NUMBER
COMMENTARY hide
102925-39-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + beta-adrenergic receptor
ADP + phospho-beta-adrenergic receptor
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + beta-adrenergic receptor
ADP + phospho-beta-adrenergic receptor
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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requirement
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
C-terminus of beta-ARK
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betaARKmini, inhibits
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
isoproterenol
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requirement, beta-agonist, beta-adrenergic receptor as substrate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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in unstimulated cells enzyme is mainly located in the cytosol
Manually annotated by BRENDA team
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after beta-AR agonist stimulation beta-ARK is partially translocated to the membranes
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ARBK1_MESAU
689
0
79598
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
80000
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA encoding beta-ARK 1 is cloned from heart and sequenced, 689 amino acids protein, 95% homology to rat and 90% homology to human beta-ARK 1
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Urasawa, K.; Yoshida, I.; Takagi, C.; Onozuka, H.; Mikami, T.; Kawaguchi, H.; Kitabatake, A.
Enhanced expression of beta-adrenergic receptor kinase 1 in the hearts of cardiomyopathic Syrian hamsters, BIO53.58
Biochem. Biophys. Res. Commun.
219
26-30
1996
Mesocricetus auratus, Mesocricetus auratus (Q64682), Rattus norvegicus
Manually annotated by BRENDA team
Benovic, J.L.; Strasser, R.H.; Caron, M.G.; Lefkowitz, R.J.
beta-Adrenergic receptor kinase: Identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor
Proc. Natl. Acad. Sci. USA
83
2797-2801
1986
Mesocricetus auratus, Mus musculus
Manually annotated by BRENDA team
Laugwitz, K.L.; Kronsbein, K.; Schmitt, M.; Hoffmann, K.; Seyfarth, M.; Schmig, A.; Ungerer, M.
Characterization and inhibition of beta-adrenergic receptor kinase in intact myocytes
Cardiovasc. Res.
35
324-333
1997
Mesocricetus auratus, Rattus norvegicus
Manually annotated by BRENDA team